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Congenital central hypoventilation syndrome combined with Hirschsprung disease diagnosed in the neonatal period (신생아에서 진단된 Hirschsprung 병을 동반한 congenital central hypoventilation syndrome 1례)

  • Choi, Jin Hyun;Oh, Jin Hee;Kim, Jong-Hyun;Koh, Dae Kyun;Hong, Seung-Chul
    • Clinical and Experimental Pediatrics
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    • v.49 no.4
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    • pp.446-450
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    • 2006
  • Congenital central hypoventilation syndrome (CCHS) or Ondine's curse is a very rare sleep disorder that is the result of a congenital failure of the autonomic control of ventilation caused by insensitivity of the chemoreceptor to hypercapnea during sleep. Gastrointestinal motility disorders, particularly a congenital megacolon (Hirschsprung disease) is often combined with CCHS. This combination can be explained by a defect in the migration of neuronal cells from the neural crest (neurocristopathy) during the intrauterine period. A diagnosis of CCHS is made by confirming the failure of adequate ventilation in response to hypercapnea and hypoxia during sleep and the exclusion of other diseases. Young infants frequently show atypical clinical courses, and their conditions are frequently complicated with the long-term sequela of hypoxemic episodes. Therefore, a high index of suspicion and active treatment with mechanical ventilation are important for reducing recurrent hypoxemic episodes in the neonatal period. This paper reports the follow up of a case of CCHS in a neonate who showed frequent intractable apnea and cyanosis and was given artificial mechanical ventilation during sleep.

Mitigation of Insufficient Capacity Problems of Central Bus Stops by Controlling Effective Green Time (유효녹색시간 조정을 활용한 중앙버스정류장 용량 부족 완화 방안 연구)

  • Koo, Kyo Min;Lee, Jae Duk;Ahn, Se Young;Chang, Iljoon
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.21 no.1
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    • pp.35-50
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    • 2022
  • After the introduction of the central bus lane system, bus traffic was prioritized. This resulted in improved trust from bus users. However, the low capacity at the central bus stop reduces traffic speed and punctuality. In addition, physical constraints are inevitable because the construction of central bus lanes and bus stops considers the city's road geometry. Therefore, this study attempted to optimize the effective green time of the traffic signal system at the entrance and exit of the central bus stop to remedy its insufficient operational capacity. The Transit Capacity and Quality of Service Manual and Korea Highway Capacity Manual were used as the analysis methodologies. The number of stop areas for central bus stops to be built was determined by excluding variable physical factors, and field survey data collected from nine randomly selected central bus stops currently installed in Seoul were used. A scenario analysis was conducted on the central bus stops with insufficient capacity by adjusting the effective green time, and the capacity of the central bus stop was set as the dependent variable. According to the results, 26.7 percent of the central bus stops with insufficient capacity can solve the problem of insufficient capacity. Therefore, the results of this study can be verified by improving the operation level, and it can be effective even if the number of central bus stops calculated by engineering is not guaranteed during the planning stage of the central bus stop. As the number of central bus stops is expected to increase further as the number of central bus stops increases, it is necessary to improve the number of central bus stops. Therefore, it is hoped that the results presented in this study will be used as basic data for the improvement plan at the operational level before introducing the physical improvement plan.

A study on exposure length of Maxillary central incisor in rest position in Korean (한국인의 안정위시 상악중절치 노출량에 관한 연구)

  • Park, Jun-Seob;Ryu, Jae-Jun
    • Journal of the Korean Academy of Esthetic Dentistry
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    • v.13 no.1
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    • pp.19-24
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    • 2004
  • This study is intended to provide a referable information of exposed amount of maxillary central incisor of Korean by ages and gender under rest position. The result of this study will give guidelines for making prothesis. The subjects of this study are patients of Charmgoun Dental Hospital in Busan, Korea. A statistical analysis was conducted after taking digital photos of patients' teeth with a ruler and measuring the length of teeth on the computer program. The results of this study were as follows : 1. The length of maxillary central incisor that exposed under upper lip is decreased by increasing age in rest position.; the average length is 3.455mm in 20s, 2.525mm in 30s, and 1.543mm in 40s. 2. The exposal length in females is more than males, average length is 2.796mm in female and 2.342mm in male. However, there is not significant difference between the genders. 3. The exposed average length of maxiallry central incisor under upper lip is 2.618mm at rest. 4. The clinical crown average length of maxillary central incisor is 10.195mm, but incresing age, there is no significant defference. 5. There is significant difference between the genders in the clinical crown length of maxillary central incisor.; the length is 10.637mm in men, 9.90mm in women.

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Phrenic Nerve Stimulation for Diaphragm Pacing in a Quadriplegic Patient

  • Son, Byung-Chul;Kim, Deog-Ryung;Kim, Il-Sup;Hong, Jae Taek
    • Journal of Korean Neurosurgical Society
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    • v.54 no.4
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    • pp.359-362
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    • 2013
  • Chronic hypoventilation due to injury to the brain stem respiratory center or high cervical cord (above the C3 level) can result in dependence to prolonged mechanical ventilation with tracheostomy, frequent nosocomial pneumonia, and prolonged hospitalization. Diaphragm pacing through electrical stimulation of the phrenic nerve is an established treatment for central hypoventilation syndrome. We performed chronic phrenic nerve stimulation for diaphragm pacing with the spinal cord stimulator for pain control in a quadriplegic patient with central apnea due to complete spinal cord injury at the level of C2 from cervical epidural hematoma. After diaphragmatic pacing, the patient who was completely dependent on the mechanical ventilator could ambulate up to three hours every day without aid of mechanical ventilation during the 12 months of follow-up. Diaphragm pacing through unilateral phrenic nerve stimulation with spinal cord stimulator was feasible in an apneic patient with complete quadriplegia who was completely dependent on mechanical ventilation. Diaphragm pacing with the spinal cord stimulator is feasible and effective for the treatment of the central hypoventilation syndrome.

Performance Analysis on Early Detection of Fault Symptom of a Pump with Abnormal Signals (오신호 입력에 따른 펌프의 고장징후 조기감지 성능분석)

  • Jung, Jae-Young;Lee, Byoung-Oh;Kim, Hyoung-Kyun;Kim, Dae-Woong
    • Journal of Power System Engineering
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    • v.20 no.2
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    • pp.66-72
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    • 2016
  • As a method to improve the equipment reliability, early warning researches that can be detected fault symptom of an equipment at an early stage are being performed out among developed countries. In this paper, when abnormal signal is input to actual normal signal of a pump, early detection studies on pump's fault symptom were carried out with auto-associative kernel regression as an advanced pattern recognition algorithm. From analysis, correlations among power of motor driving pump, discharge flow of pump, power output of pump, and discharge pressure of pump are exited. When the abnormal signal is input to one of those normal signals, the other expected values are changed due to the influence of the abnormal signal. Therefore, the fault symptom of pump through the early-warning index is able to detect at an early stage.

Review of Aging Management for Concrete Silo Dry Storage Systems

  • Donghee Lee;Sunghwan Chung;Yongdeog Kim;Taehyung Na
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.21 no.4
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    • pp.531-541
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    • 2023
  • The Wolsong Nuclear Power Plant (NPP) operates an on-site spent fuel dry storage facility using concrete silo and vertical module systems. This facility must be safely maintained until the spent nuclear fuel (SNF) is transferred to an external interim or final disposal facility, aligning with national policies on spent nuclear fuel management. The concrete silo system, operational since 1992, requires an aging management review for its long-term operation and potential license renewal. This involves comparing aging management programs of different dry storage systems against the U.S. NRC's guidelines for license renewal of spent nuclear fuel dry storage facilities and the U.S. DOE's program for long-term storage. Based on this comparison, a specific aging management program for the silo system was developed. Furthermore, the facility's current practices-periodic checks of surface dose rate, contamination, weld integrity, leakage, surface and groundwater, cumulative dose, and concrete structure-were evaluated for their suitability in managing the silo system's aging. Based on this review, several improvements were proposed.

Preventing Extracellular Diffusion of Trigeminal Nitric Oxide Enhances Formalin-induced Orofacial Pain

  • Jung, Hwi-Seok;Jeon, Hong-Bin;Jeon, Ik-Sung;Lee, Bum-Jun;Yoo, Hyun-Woo;Ahn, Dong-Kuk;Youn, Dong-Ho
    • The Korean Journal of Physiology and Pharmacology
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    • v.13 no.5
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    • pp.379-383
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    • 2009
  • Nitric oxide (NO), a diffusible gas, is produced in the central nervous system, including the spinal cord dorsal horn and the trigeminal nucleus, the first central areas processing nociceptive information from periphery. In the spinal cord, it has been demonstrated that NO acts as pronociceptive or antinociceptive mediators, apparently in a concentration-dependent manner. However, the central role of NO in the trigeminal nucleus remains uncertain in support of processing the orofacial nociception. Thus, we here investigated the central role of NO in formalin (3%)-induced orofacial pain in rats by administering membrane-permeable or -impermeable inhibitors, relating to the NO signaling pathways, into intracisternal space. The intracisternal pretreatments with the NO synthase inhibitor L-NAME, the NO-sensitive guanylate cyclase inhibitor ODQ, and the protein kinase C inhibitor GF109203X, all of which are permeable to the cell membrane, significantly reduced the formalin-induced pain, whereas the membrane-impermeable NO scavenger PTIO significantly enhanced it, compared to vehicle controls. These data suggest that an overall effect of NO production in the trigeminal nucleus is pronociceptive, but NO extracellularly diffused out of its producing neurons would have an antinociceptive action.

A Rheological Study of Topical Vehicles

  • Min, Shin-Hong;Rhee, Shanghi;Kim, Yong-Bae
    • Archives of Pharmacal Research
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    • v.2 no.2
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    • pp.89-97
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    • 1979
  • To find out the rheological characteristics of several pharamaceutical semisolid products, experiments were carriedout over the temperature range of 20 to 30 .deg.C . From continuous shear rheograms obtained with a Ferranti-Shirley cone and plate viscometer, loop area, shear rates, ryild values, limiting viscosities and activation energies were calculated. The systems were metastable and their viscosity decreased with time. As the temperature was raised, products studied showed a decrease in viscosity and yield value.

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A Central Shariah Regulatory Authority for the Islamic Banks in Bangladesh: Legalization or Formation

  • ALAM, Md. Kausar;TABASH, Mosab I.;THAKUR, Oli Ahad;SAHABUDDIN, Mohammad;HOSEN, Sharif;HASSAN, Md. Farjin
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.1
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    • pp.91-100
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    • 2020
  • This study aims to find out the legalization status of a central Shariah regulatory authority for the Islamic banks in Bangladesh. In this regard, the central bank can legalize the existing Centralized Shariah Board for Islamic Banks of Bangladesh (CSBIB) or form a new Centralized Shariah Supervisory Board (CSBB) under the management of the central bank in Bangladesh. Based on the data obtained by the semi-structured interviews, this research finds diversified opinions regarding the legalization of CSBIB or the formation of a new CSBB. Initially, without the law, it would be difficult to form CSSB under the central bank as the Islamic banks and banking environment are still not ready. In addition, it is difficult to legalize the existing CSBIB because the format of its structure is different from the CSSB structure in Malaysia and Bahrain. The existing banking company act authorizes the central bank to provide circulars regarding banking issues and it will be considered as an act. The central bank can legalize the existing CSBIB or form a new CSSB through a circular which will be helpful to monitor the overall Shariah issues. The presence of a CSSB will fulfill the expectations of all Islamic banks, and the concerned stakeholders.