• 대한중풍순환신경학회지
• /
• 제8권1호
• /
• pp.48-57
• /
• 2007

Stroke is a disease which results in impairment of body functions and affects everyday life. The ability of cerebral neurons to become reorganized and restore function after damage is called plasticity. Motor impairment typically appears contralateral to the affected cerebral hemisphere in patients with cerebral lesions. The authors report a case of a patient with hemiplegia ipsilateral to affected cerebral hemisphere, along with its conjectured mechanism.

• 생물환경조절학회지
• /
• 제21권1호
• /
• pp.33-38
• /
• 2012

덩굴쪼김병 저항성 수박 유전자원과 대목으로서 잠재력이 있는 박과작물의 수박 대목으로의 이용 가능성을 검토하기 위하여 수박대목 4계통을 포함한 7종류의 대목묘에 접목한 삼복꿀 수박을 저온조건과 적온조건의 하우스에서 재배하면서 그 생육 반응을 조사하였다. 저온에서의 생장정도는 적온에 비해 덩굴길이 40~47%, 엽면적 39~51%, 지상부 생체중 38~59%, 식물체 건물중 57~87% 수준이었다. 수박 유전자원인 PI 482322는 대목으로 이용했을 경우 저온에서 접수의 생장이 '신토좌' 대목과 유사할 정도로 좋았다. 또한 'PI 271769 ${\times}$ PI 296341'과 'PI 271769 ${\times}$ Calhoun Gray' 대목은 'FR 단토스' 대목구와 유사하였다. 저온신장성 지수는 $C.$ $martinezii$, '신토좌', PI 482322와 'PI 271769 ${\times}$ PI 296341'를 대목으로 이용한 처리에서 50 이상으로 비교적 높았으며, 무접목묘와 'Knight'에서 낮았다. 수박 대목으로 많이 이용하고 있는 'FR 단토스' 박 대목에 비해 PI 482322, 'PI 271769 ${\times}$ PI 296341', 'PI 271769 ${\times}$ Calhoun Gray' 대목은 저온신장성이 좋거나 유사한 것으로 나타나서 저온기재배에서 이들 수박 대목의 이용 가능성을 확인할 수 있었다.

• 한국육종학회지
• /
• 제42권6호
• /
• pp.695-698
• /
• 2010

우리나라 수박 주산단지에 심한 피해를 주고 있는 수박 탄저병에 대한 저항성 계통 육성을 위하여 국내 외에서 수집한 수박 유전자원의 병 저항성 검정으로 탄저병 저항성이 강한 'AU-Producer'를 선발하여 저항성 친으로, 고품질 계통인 '920533'을 반복친으로 1993년 인공교배를 하였으며 1994년부터 1998년까지 BC4F1세대를 진전하였다. 1998년부터 2001년까지 원예적 특성 고정을 위해 6회 자가수분하여 세대를 진전하였으며 원예적 특성이 우수한 것으로 최종 선발된 'WCR16-1C-5C'를 농촌진흥청 농작물 직무육성 신품종 선정위원회를 거쳐 '한결'으로 명명하였다. '한결'은 수박 탄저병 race1과 3에 저항성이며 식물체 생장형은 덩굴성이며 주지길이는 중간정도이다. 평균과중은 5.3~10.1 kg 범위로 중대과종이며, 평균 과피 두께는 1.2~1.6 cm로 시판품종 등과 유사하였다. 과피는 녹색이며 과피의 줄무늬는 중간정도이다. 과육색은 적색이며 당도는 9.8~$11.8^{\circ}Bx$. 범위이고 중생종으로 과실의 품질을 비롯한 원예적 특성은 대비 품종과 유사하였다. 수박 탄저병 저항성 계통 '한결'은 탄저병 race 1과 3에 강한 저항성이고, race 2에는 중간저항성으로 품종육성 재료로 이용하거나 노지 및 시설재배 품종으로 재배할 수 있을 것으로 기대되며 재배시 탄저병 방제 노력과 비용을 절감할 수 있을 것으로 예상된다.

• 한국육종학회지
• /
• 제42권6호
• /
• pp.699-702
• /
• 2010

탄저병 저항성 수박 계통을 육성하기 위하여 저항성 계통인 'AU-Producer'를 선발하여 탄저병 저항성 친으로, 고품질 계통인 '920533'을 반복친으로 1993년 교배하여 $F_1$세대를 작성하였으며, 1994년부터 1996년까지 $BC_3F_1$세대를 진전하였고 중만생종인 '920532'를 반복친으로 추가하여 1997년$BC_4F_1$세대를 작성하였다. 1998년부터 2001년까지 원예적 특성 고정을 위해 6회 자가수분하여 세대를 진전하였으며, 원예적 특성이 우수한 것으로 최종 선발한 'WCR8-2C-3K'를 농촌진흥청 농작물직무육성신품종선정위원회를 거쳐 '한빛'으로 명명하였다. '한빛'은 수박 탄저병 race 1과 3에 저항성인 중만생종으로 식물체 생장형은 덩굴성이며 덩굴길이는 중간정도이다. 평균과중은 5.4~9.1 kg 범위로 중대과종이며, 평균과피 두께는 1.2~1.5 cm로 시판품종 등과 유사하였다. 과피는 녹색이며 과피의 줄무늬는 중간정도이다. 과육색은 적색이며 당도는 10.4~$11.2^{\circ}Bx$ 범위로 과실의 품질을 비롯한 원예적 특성은 대비 품종과 유사하였다. 수박 탄저병 저항성 계통 '한빛'은 탄저병 저항성 및 품질개량을 위한 품종재료로 이용하거나, 노지 및 시설재배 품종으로 재배할 수 있을 것으로 기대되며 재배시 탄저병 방제 노력과 비용을 절감할 수 있을 것으로 예상된다.

• 정신신체의학
• /
• 제4권2호
• /
• pp.170-181
• /
• 1996

Objective : This study was tried to investigate the specific relationships among cognitve function, neurbehavioral symptoms, and daily living functions, as well as provide the guidline of more proper clinical approches for patients with subcortical cerebrovascular disease. Objects and Methods Subjects were 85 patients whose diagnosis was confirmed by brain CT or MRI and controls were 195 normal persons matched by educational level with the subjects. The cognitive functions were evaluated by BNA(Benton neuropsychiatric assessment), subjective neurobehavioral symptoms by SCL-90-R(Sympton Check List-90-Revised), objective neurobehavioral symptoms by NRS(Neurobehavioral Rating Scale), and daily living function symptoms by NRS(Neurobehavioral Rating Scale), and daily living function by GERRI(Geriatric Evaluation by Relative's Rating Instrument) and IADL(Instrumental Activities of Daily Living Scale). Results: 1) Subjects showed significantly lower cognitive functions than controls in all tests of BNA except Lt-Rt Orientation Test(p=0.09) and facial Recognition Test(p=0.186). 2) In subjective neurobehavioral symptoms, subjects showed significantly lower scores in all symptoms except anxiety(p=0.059), hostility(p=0.159), and phobic anxiety(p=0.849). But in objects neurobehavioral symptoms, subjects showed significantly higher in scores in psychoticism (p=0.000) and neuroticism(p=0.025) of NRS. 3) The score of social functioning of GERRI(p=0.000) and that of IADL(p=0.000) were significantly higher in subjects than in controls. 4) for correlation between cognitive and daily living functions, there were significant correlations between the scores of all items on BNA and the score of cognitive or social function of GERRI and the socre of MDL in corntrols, whereas in subjects, there were significant correlations only between the scores of BNA and the score of IADL. 5) for correlation between neuroehavioral symptoms and daily living functions, there were significant correlatons between the socre of subjective neurobehavioral symptoms and the scores of all subscales of GERRI and the score of MDL in controls. On the contrary, in subjects, there were significant correlations between the score of social function of GERRI and the score of objective neurobehavioral symptoms such as psychoticism, agitiation-hostility, and decrease d motivation-emotional withdrawl. Conclusion : Above results suggest that disturbances in specific function of brain may play a role as a predictor of impairments with specific daily living functions and also suggest that specific correlations among various functions may be useful as clinical parameters for setting of the treatment goal and for assessing the ongoing process in the treatment and rehavilitation of the patients with subcortical cerebrovascular disease.

• 수면정신생리
• /
• 제3권1호
• /
• pp.56-67
• /
• 1996

Objectives : This study was designed to find clinical factors that could be differentiated by the lateralization of lesion and also find clinical factors to predict the lateralization of lesion. Methods : The subjects were 65 cooperative inpatients and outpatients with non-traumatic subcortical cerebrovascular disease without neurologic and psychiatric history from January 1995 to September 1995 ; 48 patients in Kyung Hee University, Oriental Medicine Hospital, 35 patients in Anam Hospital, Korea University were examined as subjects, but authors excluded 20 patients whose data were incomplete or who had uncertain lesions on brain CT or MRI. The 65 patients were divided into three groups-group with left hemispheric lesion, group with right hemispheric lesion, group with both hemispheric lesion-according to the finding of brain imaging study. Their cognitive functions were evaluated by the Benton Neuropsychological Assessment(BNA), their subjective neurobehavioral symptoms by Symptom Check List-90-R(SCL-90-R), their objective neurobehavioral symptoms by Neurobehavioral Rating Scale, and their daily living functions by Geriatric Evaluation by Relative's Rating Instrument(GERRl) and Instrumental Activities of Daily Living Scale(IADLs). Results : The results were as follows : 1) The results of cognitive function test indicated that the group with right hemispheric lesion showed low functions in Tactile Form Perception(left), the group with left hemispheric lesion showed low functions in Finger localization(right), the group with right hemispheric lesion showed low functions in Finger Localization(left). 2) Though, there were little significant differences in subjective neurobehavioral symptoms, the group with right hemispheric lesion showed higher scores in all symptoms except hostility. 3) Though, there were little significant differences in objective neurobehavioral symptoms, the group with both hemispheric lesion showed higher scores in cognition, guilty/disinhibition, the group with left hemispheric lesion showed higher scores in lability of mood, the group with right hemispheric lesion showed highest scores in psychotism, neurotism, agitation-hostility and decreased motivation/emotional withdrawal. 4) There were little significant differences among three groups in Daily Living Functions, but the group with right hemispheric lesion showed the lowest functions in Instrumental Activities of Daily Living. 5) As a result of discriminant analysis on each factor's contribution to the prediction of lesion, Finger Localization(left), Phoneme Discrimination and Tactile Form Perception(right) showed that they had the potentiality to predict lesion. Conclusion : The results suggest that there are little significant differences among the groups of three non-traumatic subcortical cerebrovascular disease in cognitive functions, but the group with right hemispheric lesion showed more serious and various changes in subjective and objective neurobehavioral symptoms, and showed low functions in Instrumental Activities of Daily Living. This results suggest the possibility that the decline of the daily living function in the group with right hemispheric lesion were due to various symptoms, not due to cognitive dysfunction. The confirmation of the possibility should be worked out through the follow-up study of some groups containing cortical lesion. Apart from these findings, Finger Localization, Tactile Form Perception(right) and Phoneme Discrimination suggest that they can be used as clinically valuable cognitive parameters that predict the lateralization of lesion in non-traumatic cerebrovascular disease.

• 한국콘텐츠학회논문지
• /
• 제12권8호
• /
• pp.77-86
• /
• 2012

항공전자 시스템은 중요한 임무를 수행하는 다양한 전자 장치들로 구성되어지며 항공기의 성능을 위해 전자 장치의 수가 점차적으로 증가되고 있다. 이에 따라 개발 비용, 유지보수 비용, 운영비용 등이 증가되었고, 이를 해결하기 위해 항공전자 시스템의 기술 패러다임은 시스템을 독립적으로 관리하는 연방형 항공전자(Federated Avionics) 시스템에서 모듈 통합형 항공전자(IMA: Integrated Modular Avionics) 시스템으로 발전하고 있다. 모듈 통합형 항공전자 시스템은 연방형 시스템과는 달리 항공기의 각 기능들을 IMA 시스템에서 통합 처리하기 때문에 fault 발생 시 시스템 운용에 큰 영향을 미치게 되므로 고장 허용 기술이 필수 사항으로 적용되고 있다. 본 논문에서는 ARINC 653 기반의 모듈 통합형 항공전자 시스템에서 발생할 수 있는 fault를 정의하고 fault 발생 시 시스템이 지속적으로 정상 동작할 수 있도록 고장 허용 기법 설계 및 ARINC 653 표준에 따른 HM(Health Monitoring) 시스템 설계 방법을 제안한다.

• Journal of Microbiology and Biotechnology
• /
• 제28권1호
• /
• pp.109-114
• /
• 2018

Coxsackievirus Type B3 (CVB3) is an enterovirus that belongs to the Picornaviridae and causes various diseases such as myocarditis and hand-foot-mouth disease. However, an effective antiviral drug is still not developed. In this study, we looked for potential inhibitors of CVB3 replication by examining the survival of CVB3-infected HeLa cells. We detected an antiviral effect by cholic acid and identified it as a candidate inhibitor of CVB3 replication. Cholic acid circulates in the liver and intestines, and it helps the digestion and absorption of lipids in the small intestine. HeLa cells were cultured in 12-well plates and treated with cholic acid (1 and $10{\mu}g/ml$) and $10^6PFU/ml$ of CVB3. After 16 h post-infection, the cells were lysed and subjected to western blot analysis and RT-PCR. The production of the viral capsid protein VP1 was dramatically decreased, and translation initiation factor eIF4G1 cleavage was significantly inhibited by treatment with $10{\mu}g/ml$ cholic acid. Moreover, cholic acid inhibited ERK signaling in CVB3-infected HeLa cells. RT-PCR showed that the amounts of the CVB3 RNA genome and mRNA for the ER stress-related transcription factor ATF4 were significantly reduced. These results showed that cholic acid strongly reduced ER stress and CVB3 proliferation. This compound can be developed as a safe natural therapeutic agent for enterovirus infections.

• BMB Reports
• /
• 제43권4호
• /
• pp.225-232
• /
• 2010

Parkinson's Disease (PD) is a common neurodegenerative disease characterized by the progressive degeneration of nigrostriatal dopaminergic (DA) neurons. Although the causative factors of PD remain elusive, many studies on PD animal models or humans suggest that glial activation along with neuroinflammatory processes contribute to the initiation or progression of PD. Additionally, several groups have proposed that dysfunction of the blood-brain barrier (BBB) combined with infiltration of peripheral immune cells play important roles in the degeneration of DA neurons. However, these neuroinflammatory events have only been investigated separately, and the issue of whether these phenomena are neuroprotective or neurotoxic remains controversial. We here review the current knowledge regarding the functions of these neuroinflammatory processes in the brain. Finally, we describe therapeutic strategies for the regulation of neuroinflammation with the goal of improving the symptoms of PD.

• 한국전산유체공학회지
• /
• 제20권3호
• /
• pp.94-103
• /
• 2015

The turbulent flow characteristics in the channel flow are investigated using large eddy simulation(LES) of FDS code, built in NIST(USA), in which the near-wall flow is solved by Werner-Wengle wall function. The periodic flow condition is applied in streamwise direction to get the fully developed turbulent flow and symmetric condition is applied in lateral direction. The height of the channel is H=1m, and the length of the channel is 6H, and the lateral length is H. The total grid is $32{\times}32{\times}32$ and $y^+$ is kept above 11 to fulfill the near-wall flow requirement. The Smagorinsky model is used to solve the sub-grid scale stress. Smagorinsky constant $C_s$ is 0.2(default in FDS). Three cases of Reynolds number(10,700, 26,000, 49,000.), based on the channel height, are analyzed. The simulated results are compared with direct numerical simulation(DNS) and particle image velocimetry(PIV) experimental data. The linear low-Re eddy viscosity model of Launder & Sharma and non-linear low-Re eddy viscosity model of Abe-Jang-Leschziner are utilized to compare the results with LES of FDS. Reynolds normal stresses, Reynolds shear stresses, turbulent kinetic energys and mean velocity flows are well compared with DNS and PIV data.