• The Plant Pathology Journal
• /
• v.33 no.6
• /
• pp.529-542
• /
• 2017

Control of plant diseases is largely dependent on use of agrochemicals. However, there are widening gaps between our knowledge on plant diseases gained from genetic/mechanistic studies and rapid translation of the knowledge into target-oriented development of effective agrochemicals. Here we propose that the time is ripe for computer-aided drug discovery/design (CADD) in molecular plant pathology. CADD has played a pivotal role in development of medically important molecules over the last three decades. Now, explosive increase in information on genome sequences and three dimensional structures of biological molecules, in combination with advances in computational and informational technologies, opens up exciting possibilities for application of CADD in discovery and development of agrochemicals. In this review, we outline two categories of the drug discovery strategies: structure- and ligand-based CADD, and relevant computational approaches that are being employed in modern drug discovery. In order to help readers to dive into CADD, we explain concepts of homology modelling, molecular docking, virtual screening, and de novo ligand design in structure-based CADD, and pharmacophore modelling, ligand-based virtual screening, quantitative structure activity relationship modelling and de novo ligand design for ligand-based CADD. We also provide the important resources available to carry out CADD. Finally, we present a case study showing how CADD approach can be implemented in reality for identification of potent chemical compounds against the important plant pathogens, Pseudomonas syringae and Colletotrichum gloeosporioides.

• Journal of Korean Elementary Science Education
• /
• v.17 no.1
• /
• pp.75-87
• /
• 1998

The problem solving processes of elementary school children who are talented in science have been seldom studied. Researchers often resort to thinking aloud method to collect data of problem solving processes. The major purpose of the study is investigating high ability elementary school students' problem solving processes through the analysis of written responses to science problems in everyday context. 67 elementary students were participated Chungcheongbuk-do Elementary Science Contest held on October, 1997. The written responses of the contest participants to science problems in everyday context were analyzed in terms of problem solving processes. The findings of the research are as follows. (1) High ability elementary students use various concepts about air and water in the process of problem solving. (2) High ability elementary students use content specific problem solving strategies. (3) The problem solving processes of the high ability elementary students consist of problem representation, problem solution, and answer stages. Problem representation stage is further divided into translation and integration phases. Problem solving stage is composed of deciding relevant knowledge, strategy, and info..ins phases. (4) High ability elementary students' problem solving processes could be categorized into 11 qualitatively different groups. (5) Students failures in problem solving are explained by many phases of problem solving processes. Deciding relevant knowledge and inferring phases play major roles in problem solving. (6) The analysis of students' written responses, although has some limitations, could provide plenty of information about high ability elementary students' problem solving precesses.

• The Journal of Korean Medical History
• /
• v.14 no.2
• /
• pp.59-82
• /
• 2001

The book, "Euibangyoochui醫方類聚"(A.D. 1445) is called the treasure-house of the knowledge of medical science, due to the 50,000 prescriptions and an enormous amount of medical information that it contains. But in spite of the importance of this book, a convenient and efficient method to use the information in this book isn't developed yet and as a result the use of this book in a low state. Therefore before than anything else, there is necessity to establish the database on "Euibangyoochui". Before the establishment of database on "Euibangyoochui", there are basic works that should be preceded as follows; like the correction through investigating and comparing between the texts that are related with "Euibangyoochui", interpretation, proofread and translation to Korean of the original. And also bibliographical research on "Euibangyoochui". The compilatory course and transmissional system of the medical books in first term of Chosun(朝鮮) was able to apprehend through the bibliographical research about "Euibangyoochui". Also, many emergency medical books and books about the prevention of the infectious diseases mostly based on "Euibangyoochui" were wrote and put to practical use. And this fact, tells us that the compilation of "Euibangyoochui" was supported by the government of Chosun as means to accumulate the medical knowledge.

• Annual Conference on Human and Language Technology
• /
• 1999.10e
• /
• pp.55-62
• /
• 1999

교차언어 문서검색에서는 단일언어 문서 상황을 만들기 위하여 질의나 문서를 다른 언어로 변환하게 되는데, 일반적으로 간단하면서도 실용적인 질의 변환의 방법을 주로 사용하고 있다. 하지만 단순한 대역 사전을 사용한 질의 변환의 경우에 변환 모호성 때문에 40% 이상의 검색 효과의 감소를 가져온다. 본 논문에서는 이러한 변환 모호성을 해결하기 위하여 대역 코퍼스로부터 추출한 상호 정보를 이용하는 단순하지만 효과적인 사전 기반 질의 변환 방법을 제안한다. 본 연구에서는 변환 모호성으로 발생한 다수의 후보들에서 가장 좋은 후보를 선택하는 모호성 해소 뿐 아니라 후보 단어들에 적절히 가중치를 부여하는 방법을 사용한다. 본 질의 변환 방법은 단순히 가장 큰 상호 정보의 단어를 선택하여 모호성 해소만을 적용하는 방법과 Krushall의 최소 스패닝 트리 구성과 유사한 방법으로 상호 정보가 큰 순서대로 간선들을 연결하여 모호성 해소와 가중치 부여를 적용하는 방법들과 질의 변환의 검색 효과를 비교한다. 본 질의 변환 방법은 TREC-6 교차언어 문서검색 환경의 실험에서 단일 언어 문서검색의 경우의 85%, 수작업 모호성 해소의 경우의 96%에 도달하는 성능을 얻었다.

• The Plant Pathology Journal
• /
• v.39 no.1
• /
• pp.28-38
• /
• 2023

Plant viruses are responsible for worldwide production losses of numerous economically important crops. The most common plant RNA viruses are positivesense single-stranded RNA viruses [(+)ss RNA viruses]. These viruses have small genomes that encode a limited number of proteins. The viruses depend on their host's machinery for the replication of their RNA genome, assembly, movement, and attraction to the vectors for dispersal. Recently researchers have reported that chloroplast proteins are crucial for replicating (+)ss plant RNA viruses. Some chloroplast proteins, including translation initiation factor [eIF(iso)4E] and 75 DEAD-box RNA helicase RH8, help viruses fulfill their infection cycle in plants. In contrast, other chloroplast proteins such as PAP2.1, PSaC, and ATPsyn-α play active roles in plant defense against viruses. This is also consistent with the idea that reactive oxygen species, salicylic acid, jasmonic acid, and abscisic acid are produced in chloroplast. However, knowledge of molecular mechanisms and functions underlying these chloroplast host factors during the virus infection is still scarce and remains largely unknown. Our review briefly summarizes the latest knowledge regarding the possible role of chloroplast in plant virus replication, emphasizing chloroplast-related proteins. We have highlighted current advances regarding chloroplast-related proteins' role in replicating plant (+)ss RNA viruses.

• English Language & Literature Teaching
• /
• v.12 no.3
• /
• pp.1-24
• /
• 2006

This study investigated differences in beliefs about English learning of 286 EFL college students and 52 English teachers in Korea. Data was collected using Horwitz's Beliefs About Language Learning Inventory and compared between students and teachers in beliefs. To address the research questions, the data were analyzed through descriptive statistics including frequencies, factor analysis, MANOVA, ANOVA, t-test, and reliability coefficients. The results showed four factors in student beliefs: Difficulty of learning English, nature of learning English, importance of correctness in learning English, and motivation and perceived importance of learning English. Clear differences were found in students and teachers' beliefs in English learning aptitude and importance of translation, error correction, and grammar rules. A few belief differences were also identified between Koreans and native-speaking English teachers related to the importance of vocabulary learning, pronunciation, and cultural knowledge. The findings of the study indicated that background variables such as gender and major field of study have an effect on student beliefs about L2 learning. The present study also provided pedagogical considerations to reduce mismatch between students and teachers beliefs and to improve the L2 planning and instruction.

• 제어로봇시스템학회:학술대회논문집
• /
• 2004.08a
• /
• pp.1307-1312
• /
• 2004

Word sense disambiguation is one of the most important problems in natural language processing research topics such as information retrieval and machine translation. Many approaches can be employed to resolve word ambiguity with a reasonable degree of accuracy. These strategies are: knowledge-based, corpus-based, and hybrid-based. This paper pays attention to the corpus-based strategy. The purpose of this paper is to compare three famous machine learning techniques, Snow, SVM and Naive Bayes in Word-Sense Disambiguation on Thai language. 10 ambiguous words are selected to test with word and POS features. The results show that SVM algorithm gives the best results in solving of Thai WSD and the accuracy rate is approximately 83-96%.

• Annual Conference on Human and Language Technology
• /
• 1995.10a
• /
• pp.105-111
• /
• 1995

본 논문에서는 중간언어 설계의 일부분으로, 중간의미 표현을 위한 어휘지식 표현 방안에 관하여 논한다. 기존 중간언어들은 단어의 의미 구별법이 단순한 선택적 제한을 기반으로 하고 있으며, 시소러스체계도 단일하게 유지하고 있다. 따라서, 단어의 의미간 중첩성이 반영되지 못하고 단어의 창조적 사용(creative use)에 대한 대처능력도 떨어진다. 또한 단일 시소러스체계를 통해서는 단어들의 명확한 분류기준을 파악할 수가 없다. 이러한 어휘지식 표현체계의 문제점들을 극복하기 위한 해결책으로서 생성사전(Generative Lexicon)을 도입하고, 중간표현의 관계기호를 효과적으로 파악하기 위한 관점에서의 시소러스 분류체계를 제안한다. 또한 이 같은 어휘지식 표현체계를 이용하여 문장의 구문구조로부터 중간표현을 나타내는 과정을 제시한다.

• Mycobiology
• /
• v.43 no.2
• /
• pp.174-178
• /
• 2015

Fusarium wilt of zucchini in Jeonju, Korea, was first noticed in May 2013. Symptoms included wilting of the foliage, drying and withering of older leaves, and stunting of plants. Infected plants eventually died during growth. Based on morphological characteristics and phylogenetic analyses of the molecular markers (internal transcribed spacer rDNA and translation elongation factor $1{\alpha}$), the fungus was identified as Fusarium oxysporum. Pathogenicity of a representative isolate was demonstrated via artificial inoculation, and it satisfied Koch's postulates. To our knowledge, this is the first report of F. oxysporum causing wilt of zucchini in Korea.

• Journal of Korean Medical classics
• /
• v.33 no.1
• /
• pp.17-28
• /
• 2020

Objectives : Classical texts such as 『Donguibogam』 and 『Yixuerumen』 have previously been used as primers to students of Korean Medicine. However, their massiveness in volume and comprehensiveness in contents make it unfit for students whose school curriculum lacked classical chinese. This paper suggests another introductory text that would be more practical in the current situation. Methods :Based on the translation of the main text and annotations, the clinical meanings of the contents were studied. Afterwards its practical application as a primer was considered. Results : The text focuses on the medically important issues in simple and accessible form, making it an important text for beginners to establish the foundation in medicine. Conclusions : Beginners will be able to establish a standard for basic medical knowledge through this text and also apply its contents to diseases that are relatively easy to treat.