• Toxicological Research
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• v.33 no.1
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• pp.63-69
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• 2017

Transmembrane protein 39A (TMEM39A) belongs to the TMEM39 family. TMEM39A gene is a susceptibility locus for multiple sclerosis. In addition, TMEM39A seems to be implicated in systemic lupus erythematosus. However, any possible involvement of TMEM39A in cancer remains largely unknown. In the present report, we provide evidence that TMEM39A may play a role in brain tumors. Western blotting using an anti-TMEM39A antibody indicated that TMEM39A was overexpressed in glioblastoma cell lines, including U87-MG and U251-MG. Deep-sequencing transcriptomic profiling of U87-MG and U251-MG cells revealed that TMEM39A transcripts were upregulated in such cells compared with those of the cerebral cortex. Confocal microscopic analysis of U251-MG cells stained with anti-TMEM39A antibody showed that TMEM39A was located in dot-like structures lying close to the nucleus. TMEM39A probably located to mitochondria or to endosomes. Immunohistochemical analysis of glioma tissue specimens indicated that TMEM39A was markedly upregulated in such samples. Bioinformatic analysis of the Rembrandt knowledge base also supported upregulation of TMEM39A mRNA levels in glioma patients. Together, the results afford strong evidence that TMEM39A is upregulated in glioma cell lines and glioma tissue specimens. Therefore, TMEM39A may serve as a novel diagnostic marker of, and a therapeutic target for, gliomas and other cancers.

• Journal of the Economic Geographical Society of Korea
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• v.14 no.3
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• pp.241-262
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• 2011

The aim of this study is to examine the changes of institution, quantity and approach methods of research results in the history of Korean economic geography during the last fifty-five years (1956-2010) and to offer the preparations for the future research. The history Korean economic geography can be divided into four periods: 'period of cradle' (1956-1962), 'period of establishment' (1963-later 1970s)', 'period of leap (the former half of 1980s-the former half of 1990s)', and 'period of transition (since later 1990s)'. Many departments of geography education and geography have been founded in the 'period of establishment' and 'period of leap'. Among the total research matters (1,621), 44.4 percent of research results have been made in 2000s and the most researched field was that of manufacturing geography, which occupied 27.7 percent. In the approach methods, about two-thirds of the results are the empirical inductive approach and the research frameworks method which clarified the regional structures and theory of spatial system occupied each about 40 percent. In the future, each research field of Korean economic geography is expected to take more serious view of nature environment, thorough regional survey, and preference of economy-society-culture-knowledge in the research framework of spatial network theory.

• Journal of the Korean earth science society
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• v.34 no.3
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• pp.274-285
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• 2013

The purpose of this study was to develop geological field study sites for learning topography and geology of the area with igneous rocks, specifically in Duibaejae volcanic edifice and Seonang-bawi that were distributed in Goseong-gun, Gangwon-do area. As a follow up, we conducted a study to examine the effect of the study sites when applied to high school freshmen Earth science course. The study proceeded based on the Orion's model in the order of preparatory unit, field trip, and summary unit. The geological field study sites were developed based on the geological study elements presented in the Korean Earth science curriculum. Before the field trip, students simply memorized factual knowledge on minerals, rocks and etc., and showed very low level of understanding on the formation process of the region that was distributed with granite and basalt. Especially, their understanding showed that granite and basalt were formed from the same magma at the same time. After the field trip, they increased in-depth level of understanding about minerals, rocks, and geological structures, but were not able to explain the topographical characteristics of the two rocks because they did not recognize the times of the creation of granite and basalt. The reason is that they have learned the simple concept of the process of forming granite and basalt in their middle school, but that they have not learned the meaning of the difference between two the geological eras when each of the two rocks, granite and basalt, were formed.

• Journal of KIISE:Computing Practices and Letters
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• v.6 no.3
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• pp.364-372
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• 2000

Subcategorization, defining dependency relation between predicates and their complements, is an important source of knowledge for resolving syntactic and semantic ambiguities arising in analyzing sentences. This paper describes a Korean subcategorization dictionary, particularly annotated with semantic roles of complements coupled with thesaural semantic hierarchy as well as syntactic dependencies. For annotating roles, we defined 25 semantic roles associated with surface case markers that can be used to derive semantic structures directly from syntactic ones. In addition, we used more than 120,000 entries of thesaurus to specify concept markers of noun complements, and also used 47 and 17 predicate patterns for verbs and adjectives, respectively, to express dependency relation between predicates and their complements. Using a full-fledged thesaurus for specifying concept markers makes it possible to build an effective selectional restriction mechanism coupled with the subcategorization dictionary, and using the standard predicate patterns for specifying dependency relations makes it possible to avoid inconsistency in the results and to reduce the costs for constructing the dictionary. On the bases of these, we built a Korean subcategorization dictionary for frequently used 13,000 predicates found in corpora with the aid of a tool specially designed to support this task. An experimental result shows that this dictionary can provide 72.7% of predicates in corpora with appropriate subcategorization information.

• Journal of Engineering Education Research
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• v.6 no.2
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• pp.22-29
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• 2003

The ultimate goal of a hardware design course is to equip the students with the system design ability. However, the majority of the current structures of the design courses are focused on the understanding of the operational principles of each device which is used later as a building block for the design of a system. The shortcomings of this approach are, first, that it is very hard to keep the students motivated to the end of the course where system design concepts are dealt, and, second, the students do not have enough experience of the system design which is usually required in the field. As an alternative to solve these problems, it is necessary to reverse the order of contents of the course. Namely we introduce the high level of the abstract concept of the system design in the very beginning of the course and later by lowering the level of abstraction to the operational principle of the internal devices. In this paper, we propose a new top-down methodology for the introductory hardware design course of logic design, where the design expression and verification in the system-level are introduced first and then detail knowledge on each device is introduced later. Also, we report a case result from a student's working group as part of an extracurricular education in order to verify the validity of our proposed approach

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.1
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• pp.672-679
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• 2018

This paper describes a methodology for shape design using an optimal design system, whereas generally a three dimensional analysis is required for such designs. An automatic finite element mesh generation technique, which is based on fuzzy knowledge processing and computational geometry techniques, is incorporated into the system, together with a commercial FE analysis code and a commercial solid modeler. Also, with the aid of multilayer neural networks, the present system allows us to automatically obtain a design window, in which a number of satisfactory design solutions exist in a multi-dimensional design parameter space. The developed optimal design system is successfully applied to evaluate the structures that are used. This study used a stress gauge to measure the maximum stress affecting the parts of the side housing bracket which are most vulnerable to cracking. Thereafter, we used a tool to interpret the maximum stress value, while maintaining the same stress as that exerted on the spot. Furthermore, a stress analysis was performed with the typical shape maintained intact, SM490 used for the material and the minimizing weight safety coefficient set to 3, while keeping the maximum stress the same as or smaller than the allowable stress. In this paper, a side housing bracket with a comparably simple structure for 36 tons was optimized, however if the method developed in this study were applied to side housing brackets of different classes (tons), their quality would be greatly improved.

• Steel and Composite Structures
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• v.34 no.5
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• pp.681-698
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• 2020

The paper addresses contribution to the modeling and optimization of major machinability parameters (cutting force, surface roughness, and tool wear) in finish dry hard turning (FDHT) for machinability evaluation of hardened AISI grade die steel D₃ with PVD-TiN coated (Al₂O₃-TiCN) mixed ceramic tool insert. The turning trials are performed based on Taguchi's L₁₈ orthogonal array design of experiments for the development of regression model as well as adequate model prediction by considering tool approach angle, nose radius, cutting speed, feed rate, and depth of cut as major machining parameters. The models or correlations are developed by employing multiple regression analysis (MRA). In addition, statistical technique (response surface methodology) followed by computational approaches (genetic algorithm and particle swarm optimization) have been employed for multiple response optimization. Thereafter, the effectiveness of proposed three (RSM, GA, PSO) optimization techniques are evaluated by confirmation test and subsequently the best optimization results have been used for estimation of energy consumption which includes savings of carbon footprint towards green machining and for tool life estimation followed by cost analysis to justify the economic feasibility of PVD-TiN coated Al₂O₃+TiCN mixed ceramic tool in FDHT operation. Finally, estimation of energy savings, economic analysis, and sustainability assessment are performed by employing carbon footprint analysis, Gilbert approach, and Pugh matrix, respectively. Novelty aspects, the present work: (i) contributes to practical industrial application of finish hard turning for the shaft and die makers to select the optimum cutting conditions in a range of hardness of 45-60 HRC, (ii) demonstrates the replacement of expensive, time-consuming conventional cylindrical grinding process and proposes the alternative of costlier CBN tool by utilizing ceramic tool in hard turning processes considering technological, economical and ecological aspects, which are helpful and efficient from industrial point of view, (iii) provides environment friendliness, cleaner production for machining of hardened steels, (iv) helps to improve the desirable machinability characteristics, and (v) serves as a knowledge for the development of a common language for sustainable manufacturing in both research field and industrial practice.

• Journal of Intelligence and Information Systems
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• v.15 no.4
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• pp.65-78
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• 2009

The rapid changes of financial environment have increased the need and demand for personal financial advisory service from financial experts. In particular, as the individual customers want to get more customized financial services, the financial institutions created the private banking (PB) sector and have constantly expanded their PB services. However, it remains still problematic that the private banking system requires high costs so that the number of eligible customers who can have proper PB services is quite limited. To solve this problem, we propose an intelligent agent that can provides specialized and customized personal financial advisory services to the customers with low costs. The proposed agent systemizes and structures the information and knowledge of financial experts in private banking services so that individual customers can easily access to high-quality PB services when they need. On the first attempt we develop a framework of U-smart PB, an intelligent agent for personal financial management based on different scenarios related to personal financial decisions, and derive its core services. This system not only provides information simply, but also proposes to support personal investment decisions technically as an intelligent agent that embodies real-time customized financial management in a ubiquitous environment, regardless of time and place.

• Journal of Navigation and Port Research
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• v.32 no.8
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• pp.645-652
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• 2008

The interest on the marine leisure sports is rapidly increasing with the advent of the five-day week and with increments of GNP. The self-governing bodies are trying to drag large investments into the marine leisures industry through international exhibitions and yacht rallies. Unfortunately, the demands in the domestic area don't increase differently from those demand patterns in the advanced countries. In this study, several suggestions for vitalizations on the marine leisure industry are made after surveying the recognition degree of the domestic people on the marine leisures and the current states of their spending on the marine leisures. As results, it has been shown that the policies based upon negative factors coming from negative understandings on the leisure activities should be largely revised. Further, it seems that the policies for the preparations of the laws and the regulations for the marine leisures as well as for the R&D policies should be taken systematically so that the infra structures are constructed while improving the negative understandings on the leisures. The fundamental databases investigated in this study will help the policy makers and the investors reduce the risks of the policy and the investments in the field of marine leisure sports.

• Journal of Korean Library and Information Science Society
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• v.36 no.2
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• pp.197-220
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• 2005

This paper examined the structure of internet bookstore users' subjectivity by focusing on their beliefs, values and attitudes.0 methodology was utilized for the study. After constituting 36 Q sample and 28 P sample, data were collect from April 15, 2005 to April 22 2005. The analyses showed 3 types of subjectivity structures. The first one was 'the economic benefit-seeking type.' Those in this type were motivated to use internet bookstores to achieve economic benefits. They paid more attention to the Prices discounted than the web site contents provided by internet bookstores. This type was conspicuously found among college students. The second one was the 'information-seeking type.' People in this category made visits to internet bookstores in order to obtain new information or professional materials. This type was dominantly found among women. The third one was the 'convenience-seeking type.' Those in this type were concerned not only with the accessibility and convenience, but also with such practical issues as delivery, price, applicability, payment, and bonus. This type was conspicuously observed among white collar workers. These findings suggests that in order to make internet bookstores more attractive to users, it is demanded to understand various needs held by users and map out sophisticated marketing strategies on the basis of such a knowledge.