• Journal of Korean Academy of Nursing
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• v.29 no.6
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• pp.1455-1468
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• 1999

The purpose of this study was to investigate the objectives and contents of basic medical sciences at department of nursing in college of nursing, and junior college of nursing, thus ultimately providing the basic data to standardize the curriculum of the basic medical sciences in nursing education. Seventy eight professors who were in charge of teaching basic medical sciences to at 22 colleges of nursing/ department of nursing, and 20 junior colleges of nursing responded to the questionnaires that consisted of the questions regarding objectives and contents, of basic medical sciences. Based on the description of objectives, the description related to nursing, nurse, nursing science was cathegorized as on objective applicable to nursing science, the description related to medicine or clinical medicine as medical model, the description without description related to medicine was cathegorized as knowledge acquisition. The number of schools corresponding to each category were summerized in descending order. The objectives of basic medical sciences were categorized by concepts and number of schools corresponding to the categorized concept. The findings of the study are as follows ; 1. The subjects of basic medical science identified were physiology, anatomy, biochemistry, pathology, microbiology, and pharmacology in most colleges of nursing and junior colleges. Two colleges of nursing/department of nursing (9.1%) and 19 junior colleges of nursing(95%) did not offer biochemistry, 1 college of nursing /department of nursing(5%) did not offer pathology & pharmacology. 2 junior colleges of nursing (10%) did not offer pharmacology, 1 junior college of nursing(5%) did not offer pathology. The other 1 junior college of nursing did not offer microbiology. 2. Objectives of physiology were to acquire knowledge and understanding on human function in both 6 (50%) colleges and 5 junior colleges. Objectives of anatomy were to acquire knowledge on human structure in both 4 (57%) colleges and 2 (50%) junior colleges; knowledge applicable to nursing sciences in both 3 (42.8%) colleges and 2 (50%) junior colleges. Objectives of biochemistry was to obtain knowledge and understanding on biochemistry, and understanding of basic concepts about biochemistry. Objectives of pathology were to obtain knowledge and understanding on pathology in both 4 (57.1%) colleges and 5(62.5%) junior colleges. Objectives of microbiology were to acquire knowledge and understanding on microbiology in both 5(83.8%) colleges and 6(85.7%) junior colleges. Objectives of pharmacology were to acquire knowledge on pharmacology in both 7(100%) colleges and 8(100%) junior colleges. 3. Contents of physiology in 19 (100%) schools were membrane transport, digestion, circulation, nervous system and respiration. In 16(84.2%) were kidney and muscle, that in 13(68.4%) were endocrine physiology. In 11(57.9%) were introduction and that in 9(47.4%) were structure and function of cells. Contents of anatomy in 11(100%) schools were skeletal system, muscle system, digestive system, circulatory system, concepts regarding human structure. In 10(90.9%) schools were endocrine system and nervous system, and in 5(45.5%) schools were blood, urinary system and cell. Contents of biochemistry in 6(100%) schools were history of biochemistry, body regulating factor, bioenergy, health and nutrition, nutrition of cell, energy production system. In 5(83.3%) schools were metabolism of protein and carbohydrate and enzyme, and in 3(50%) schools were metabolism of energy and fat. Contents of microbiology in 13(100%) schools were environment and influenc of bacteria, virus, G(-) rods, purulent cocci, G(+) rods. In 10 (76.9%) were immunity, diphtheria, enterobacteria, and in 9(69.2%) were spirochete, rickettsia and clamydia, and that in 6(46.2%) were sterilization and disinfection. Contents of pathology in 14(100%) schools were cell injury and adaptation, inflammation, respiratory diseases, circulatory diseases. In 10(71.4%) were neurological disorders, in 8(57.1%) were immunity and disease, and in 7 (50%) were tumor and progressive changes. Contents of pharmacology in 15(100%) were cardivascular drugs, introduction to pharmacology, hypnotics, analgesics, local anesthetics, an ticonvulsants. In 12(80%) were drugs activity on sympathetic and parasympathetic nervous system, and in 11(73%) were sulfa drugs, antibiotics, drug abuse and addiction.

• Journal of Technology Innovation
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• v.22 no.1
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• pp.149-175
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• 2014

This study analyzed the effect of corporate innovation strategies on patent production and ultimately on technological change and new product development of firms in South Korea. The intent was to derive efficient strategies for enhancing technological performance of the firms. For the empirical analysis, three sources of data were combined: four waves of the Human Capital Corporate Panel Survey (HCCP) data collected by the Korea Research Institute for Vocational Education and Training (KRIVET), corporate financial data obtained from the Korea Information Service (KIS), and corporate patent data provided by the Korean Intellectual Property Office (KIPO). The patent production function was estimated by zero-inflated negative binomial (ZINB) regression. The technological performance function was estimated by two-stage regression, taking into account the endogeneity of patent production. An ordered logit model was applied for the second stage regression. Empirical results confirmed the critical role of corporate innovation strategies in patent production and in facilitating technological change and new product development of the firms. In patent production, the firms' R&D investment and human resources were key determinants. Higher R&D intensity led to more patents, yet with decreasing marginal productivity. A larger stock of registered patents also led to a larger flow of new patent production. Firms were more prolific in patent production when they had high-quality personnel, intensely investing in human resource development, and adopting market-leading or fast-follower strategy as compared to stability strategy. In technological performance, the firms' human resources played a key role in accelerating technological change and new product development. R&D intensity expedited new product development of the firm. Firms adopting market-leading or fast-follower strategy were at an advantage than those with stability strategy in technological performance. Firms prolific in patent production were also advanced in terms of technological change and new product development. However, the nexus between patent production and technological performance measures was substantially reduced when controlling for the endogeneity of patent production. These results suggest that firms need to strengthen the linkage between patent production and technological performance, and take strategies that address each firm's capacities and needs.

• Korean Journal of Agricultural and Forest Meteorology
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• v.9 no.3
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• pp.161-169
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• 2007

Global climate changes including elevated $CO_2$, drought, and global warming may influence greenhouse gas emissions in wetlands. A variety of microbial communities including denitrifiers and methanogens play a key role in determining such processes. In this paper we summarize current knowledge on the effects of climate changes on $CO_2,\;CH_4$, and $N_2O$ production and microbial communities mediating those processes in wetlands. Elevated atmospheric $CO_2$ and warming generally increase gas emissions, but effects of droughts differ with gas type and drying level. The responses of microbial community to climate changes in terms of composition, diversity and abundance are still in question due to lack of studies in wetlands. Based on the present review, it is suggested that future studies on microbial processes should consider microbial community and relationships between microbial function and structure with diverse environmental factors including climate changes. Such knowledge would be crucial to better understand and predict accurately any shifts in ecological functions of wetlands.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1326-1331
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• 2005

A product is designed through the collaboration among engineers in several fields such as design, analysis, and manufacturing. These series of functions are performed repeatedly during the design process. An easy access and exchange of the model data is one of the important elements that help to shorten production development time. Especially, the importance of data exchange between CAD and CAE applications is increasing in the field of verification and estimation of the products. However, information and knowledge of model which is generated by a CAD software cannot be transferred by a function of CAE software, as an exchange of product data between CAD and CAE applications. It causes a delay in design analysis and eventually discourages a designer's effort in improving his design. Therefore, we need to integrate a commercial CAD and CAE applications effectively and to use the same interface on a product model obtained in a distributed environment. This paper shows how to implement a model exchange between CAD and CAE by a web-service and how to provide a communication environment among engineers.

• Journal of the Korean Society for Precision Engineering
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• v.23 no.12 s.189
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• pp.95-102
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• 2006

A product is designed through the collaboration among engineers in several fields such as design, analysis, and manufacturing. These series of functions are performed repeatedly during the design process. An easy access and exchange of the model data is one of the important elements that help to shorten production development time. Especially, the importance of data exchange between CAD and CAE applications is increasing in the field of verification and estimation of the products. However, information and knowledge of model which is generated by a CAD software cannot be transferred by a function of CAE software, as an exchange of product data between CAD and CAE applications. It causes a delay in design analysis and eventually discourages a designer's effort in improving his design. Therefore, we need to integrate a commercial CAD and CAE applications effectively and to use the same interface on a product model obtained in a distributed environment. This paper shows how to implement a model exchange between CAD and CAE by a web-service and how to provide a communication environment among engineers.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2006.11b
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• pp.355-368
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• 2006

본 연구는 1982년부터 2002년까지 우리나라 15개 산업부분의 패널자료를 이용하여 지식생산함수추정을 시도하였다. 해당 산업부문의 지식생산활동에서 서로 다른 산업부문간에 산호작용영향이 중요하다는 관점을 고려하여 Mark et al. (2005)이 제시한 DSUR(Dynamic Seemingly Unrelated Regression)추정량을 이용하여 관련된 지식생산함수의 모수를 추정하였다. 본 연구의 추정결과를 살펴보면, 우리나라 지식생산함수에서 연구원 규모가 지식생산에 기여하는 탄력성정도는 0.25이며, 기존 지식축적량이 기여하는 탄력성정도는 0.353으로 나타났다. 이러한 실증분석 결과는 우리나라의 경우에 기존 지식축적량이 새로운 지식생산에 기여하는 탄력성정도가 1보다 작음을 보여준다. 지식생산함수의 관하여 추정된 계수의 크기가 시사하는 바는 우리나라의 장기적 경제성장률은 제품 및 서비스생산함수에 관련된 탄력성과 인구성장증가율에 따라서 결정되기 때문에 정부의 직접적인 R&D정책개입보다는 지식관리 및 보급 그리고 공유체계정비라는 간접적 R&D정잭개입을 통하여 지속적인 경제성장전략을 추진해야한다는 주장을 뒷받침한다고 볼 수 있다.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2006.11a
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• pp.133-137
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• 2006

Can examine cause that the construction industry is faced in crisis of skill exhaustion in two sides. One is the tribe of actuality production manpower by entry evasion and graying of young man class specially new manpower to the tribe of skill manpower. Another is qualitative decline of skill manpower. Generally, problem of the systematic knowledge tribe and the picking up tribe about new technology etc, exists because learn skill for shoulder beyond in spot. In cutting phenomenon of skill that is depended on personal relationships availability with skilled worker in hereafter, problem that worker who is old or enter through rain skilled worker does not learn all life skill is detected. These problems institute entry of young man class and necessity of systematic vocational education training specially new human strength strongly. This study does presentation of way to promote construction industry entry of young man class and improvement way of vocational education training system that can do to train these by function manpower by purpose.

• Journal of the Korea Safety Management & Science
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• v.14 no.4
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• pp.321-332
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• 2012

The special organization that our military service is conscripted by the duty of national defense purposes to the period of military service. So couple of soldiers are think as the corresponds to college, or some knowledge layer from the operating management discarding period, lifetime value. But, now a day changed of the military life, it is when the individual soldiers can have some self-development and the lifelong education in terms of a period, and can changeing the footsteps of the new life that the function as a 'bridge' to activate production of barracks life. So that it can be supported themselves need to strive for human resource development. This study is being discussed on the correlation of military human resources and qualified operating and sustainable and promising future eligibility for qualified by taking advantage of the Boston Consulting Group Matrix(Boston Consulting Group Matrix).

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4553-4557
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• 2013

Objective: The purpose of this study was to identify genes related to bladder cancer with samples from normal and disease cases by microarray chip. Methods: After downloading the gene expression profile GSE3167 from Gene Expression Omnibus database which includes 50 bladder samples, comprising 9 normal and 41 disease samples, differentially expressed genes were identified with packages in R language. The selected differentially expressed genes were further analyzed using bioinformatics methods. Firstly, molecular functions, biological processes and cell component analysis were researched by software Gestalt. Then, software String was used to search interaction relationships among differentially expressed genes, and hub genes of the network were selected. Finally, by using plugins of software Cytoscape, Mcode and Bingo, module analysis of hub-genes was performed. Results: A total of 221 genes were identified as differentially expressed by comparing normal and disease bladder samples, and a network as well as the hub gene C1QBP was obtained from the network. The C1QBP module had the closest relationship to production of molecular mediators involved in inflammatory responses. Conclusion: We obtained differentially expressed genes of bladder cancer by microarray, and both PRDX2 and YWHAZ in the module with hub gene C1QBP were most significantly related to production of molecular mediators involved in inflammatory responses. From knowledge of inflammatory responses and cancer, our results showed that, the hub gene and its module could induce inflammation in bladder cancer. These related genes are candidate bio-markers for bladder cancer diagnosis and might be helpful in designing novel therapies.

• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.9.1-9.10
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• 2018

Although the positive effects of recombinant fibroblast growth factor-2 (rFGF-2) in chronic obstructive pulmonary disease (COPD) have been implicated in previous studies, knowledge of its role in COPD remains limited. The mechanism of FGF2 in a COPD mouse model and the therapeutic potential of rFGF-2 were investigated in COPD. The mechanism and protective effects of rFGF-2 were evaluated in cigarette smoke-exposed or elastase-induced COPD animal models. Inflammation was assessed in alveolar cells and lung tissues from mice. FGF-2 was decreased in the lungs of cigarette smoke-exposed mice. Intranasal use of rFGF-2 significantly reduced macrophage-dominant inflammation and alveolar destruction in the lungs. In the elastase-induced emphysema model, rFGF-2 improved regeneration of the lungs. In humans, plasma FGF-2 was decreased significantly in COPD compared with normal subjects (10 subjects, P = 0.037). The safety and efficacy of inhaled rFGF-2 use was examined in COPD patients, along with changes in respiratory symptoms and pulmonary function. A 2-week treatment with inhaled rFGF-2 in COPD (n = 6) resulted in significantly improved respiratory symptoms compared with baseline levels (P < 0.05); however, the results were not significant compared with the placebo. The pulmonary function test results of COPD improved numerically compared with those in the placebo, but the difference was not statistically significant. No serious adverse events occurred during treatment with inhaled rFGF-2. The loss of FGF-2 production is an important mechanism in the development of COPD. Inhaling rFGF-2 may be a new therapeutic option for patients with COPD because rFGF-2 decreases inflammation in lungs exposed to cigarette smoke.