• Genomics & Informatics
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• 제3권1호
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• pp.15-23
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• 2005

Background MicroRNAs (miRNAs) are a class of noncoding RNAs found in various organisms such as plants and mammals. However, most of the mRNAs regulated by miRNAs are unknown. Furthermore, miRNA targets in genomes cannot be identified by standard sequence comparison since their complementarity to the target sequence is imperfect in general. In this paper, we propose a kernel-based method for the efficient prediction of miRNA targets. To help in distinguishing the false positives from potentially valid targets, we elucidate the features common in experimentally confirmed targets. Results The performance of our prediction method was evaluated by five-fold cross-validation. Our method showed 0.64 and 0.98 in sensitivity and in specificity, respectively. Also, the proposed method reduced the number of false positives by half compared with TargetScan. We investigated the effect of feature sets on the classification of miRNA targets. Finally, we predicted miRNA targets for several miRNAs in the Caenorhabditis elegans (C. elegans) 3' untranslated region (3' UTR) database. Condusions The targets predicted by the suggested method will help in validating more miRNA targets and ultimately in revealing the role of small RNAs in the regulation of genomes. Our algorithm for miRNA target site detection will be able to be improved by additional experimental­knowledge. Also, the increase of the number of confirmed targets is expected to reveal general structural features that can be used to improve their detection.

• Journal of Construction Engineering and Project Management
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• 제2권1호
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• pp.14-19
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• 2012

Maturity models allow organizations to assess and compare their own practices against best practices or those employed by competitors, with the intention to map out a structured path to improvement. This research explores the aspects of the Maturity Models that are relevant to distinguish them from one to another. The different Project Management maturity models for define maturity differently and measure different things to determine maturity. Because of this, organizations should give careful consideration to select appropriate maturity model. The main reason behind this research lies on the modification to the existing Organizational Project Management Maturity Model (OPM3) by adding four knowledge areas, dedicated to construction industry as best practices. These are Safety, Environment, Financial and Claim Management. This Model contains (Yes/No) questions; all of these questions must be answered before the user reviews the results that describe the overall maturity and areas of strength and weakness of an organization. The research presents the implementation of the proposed Model Construction Enterprises Maturity Model (CEM2). All the components of the developed Model have been implemented in Microsoft Access. CEM2 helps Construction Enterprises to assess their Maturity Level and know Areas of Weaknesses for future improvement. The easy to use Yes/No user interfaces help enterprises' employees to assess the maturity level of their enterprises. The Model maintains users' responses in its database; as such, many employees from different enterprise divisions can be involved during assessment phase in several sessions.

• 한방재활의학과학회지
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• 제25권3호
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• pp.59-64
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• 2015

Objectives The aim of this review is to analyse the study tendency in papers related with delphi method which are published in Korea from 2006 to 2015. Methods We searched the electronic database (NDSL, RISS, Korean traditional knowledge portal, OASIS) and checked relevant Korean journals from 2006 to 2015. 23 research papers were found and they were analyzed according to the year of publishment, the titles of journals which have the papers, the time of repeated survey and purpose of technique application. Results 1. As we analyzed by years, 2.3 papers were published per year on average. 2. As we analyzed by jounals in which papers were published, 39% of total papers were published in The Journal of the Society of Korean Medicine Diagnostics, 30% were in Korean Journal of Oriental Physiology & Pathology, taking up 69% of total papers. 3. As we analyzed by the number of survey taken in each research, 11 papers surveyed 2 times, 7 papers surveyed 3 times, 1 paper suerveyed one time. 4. As we analyzed by the purpose of technique application, 91% of papers were aimed at the development of questions, 9% of papers were aimed at policy recommendation. Conclusions These results suggest that although many researches were trying to quantify the symptom of patient, to demonstrate on exact data and to accomplish the scientification of diagnosis, the number of paper is insufficient. Therefore, it seems that more researches must be taken afterward.

• 중환자간호학회지
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• 제11권2호
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• pp.75-85
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• 2018

Purpose : The purpose of this study was to examine the possible direction of critical care nursing research in the future by analyzing the trends of recent Korean studies. Method : Using a database search, we selected 263 articles on critical care nursing that were published in Korean journals between 2008 and 2017. Then, we conducted an integrative review of the contents of the selected articles and analyzed the English abstracts using the relevant packages and functions of the R program. Results : The number of studies concerning critical care nursing has increased over the 10-year period, and the specific topic of each study has diversified according to the time at which it was conducted. In terms of quality, the majority of the research was published in high-level academic journals. The key words regularly studied over the past decade were: knowledge, delirium, education, restraint, stress, and infection. Studies related to vancomycin-resistant enterococci infection, compliance, and standards have decreased, while studies related to death, communication, and safety have increased. Conclusion : Randomized controlled trials and protocol research for evidence-based critical care need to be conducted, as does research on family involvement. The key word analysis of unstructured text used in this study is a relatively new method; it is suggested that this method be applied to various critical care nursing research and develop it methodologically.

• 한국콘텐츠학회논문지
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• 제10권2호
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• pp.372-380
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• 2010

일반적으로 데이터 마이닝은 다양한 예측기법이나 차이점의 분석을 통하여 유용한 정보 도출을 통해 매출의 증대나, 비용 절감 등의 효과를 가져 올수 있다. 데이터 마이닝 분석은 정보의 분류 또는 다양한 각도나 영역의 관점을 통하여 새로운 뷰를 분석할 수 있다. 기술적으로 데이터 마이닝의 연관규칙이나, 패턴의 분석은 대량의 데이터베이스에서 분석된다. 따라서 데이터 마이닝은 가장 빠르게 성장한 산업중의 하나이다. 그 이유는 정보기술이 발달하면서 수많은 자료들이 체계화된 데이터베이스에 저장이 되고, 기업의 데이터베이스의 규모는 폭발적으로 증가되고 있다. 본 논문에서는 자동차 마케팅에서 이용 가능한 데이터를 데이터 마이닝 분석 기법중의 하나인 Quinlan의 C4.5에 따라 분석 하였다. 본 논문에서는 기존 고객에 대한 고객 속성파악, 고객 분류 및 분석에 따른 고객의 구매패턴을 분석하여 해당 기업의 전략적 마케팅 수립을 통해 경영 과학적으로 접근할 수 있는 데이터 마이닝 분석에 관한 사례 연구이다.

• 한국문헌정보학회지
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• 제44권4호
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• pp.33-59
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• 2010

Library 2.0 advocates a socially rich, multimedia enabled, user originated and communally innovative environment that poses significant opportunities for the libraries to evolve and make themselves even more relevant and significant for her users. This paper presents a case study of the National Library Board of Singapore, in playing a vital role to facilitate the realisation of a long-term key national program, The Singapore Memory (SM) Project. SM embraces the attributes of the Library 2.0 environment to enable the nation's memory to be collected, organised, preserved, discovered, researched, augmented and created. The output of is an evolving collection of knowledge assets on Singapore along a Singapore Memory Content Continuum of existing content that is steadily augmented with new content. The content will be collected across all formats, in any language, from Singaporeans and non-Singaporeans, from any institution and agency, from Singapore and abroad, and from official and unofficial sources. The utopian scenario of SM Project is that any person, community, group or institution who has ever experienced Singapore in any way or has any material on Singapore will engage actively in the contribution, discovery and creation of content for the project, and thus become advocates to further encourage and catalyse more contribution, discovery and creation. The paper outlines the key approaches, concepts and ideas for the project. An important element is the proliferation, exposure and accessibility of the rich contents envisaged in the project. The SM proliferation plan along with examples of how two existing resources, namely, the Singapore Infopedia, a database of articles on Singapore's history, culture, people and events 4 and NewspaperSG, an online resource of current and historic Singapore and Malayan newspapers, have been designed are presented to demonstrate how content can be exposed, searched and discovered.

• 응용통계연구
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• 제21권4호
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• pp.639-647
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• 2008

본 연구는 국민건강보험공단의 건강검진데이터, 자격 및 보험료 그리고 진료비 데이터를 활용하여 고혈압 관리를 위한 맞춤형 고혈압 사후관리모형(고혈압 진료예측모형 및 고혈압 진료순응도세분화모형)을 개발하고자 하였다. 모형 개발에는 데이터마이닝의 로지스틱 회귀모형, 의사결정나무 그리고 앙상블 모형을 활용하였다. 고혈압 진료예측모형에서는 3가지 모형 중 로지스틱 회귀모형이 가장 우수한 모형으로 채택되었으며, 고혈압 진료순응도세분화모형은 의사결정나무모형을 통해 개발되었다. 본 연구는 전국 규모의 수년간 축적된 자료를 데이터마이닝을 활용함으로써 고혈압의 진료 및 진료순응도에 이르는 고혈압 사후관리 프로세스 전반에 걸친 결과를 도출함으로써 우리나라 고혈압 사후관리체계 구축에 기여할 것으로 사료된다.

• 천문학회지
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• 제52권6호
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• pp.217-225
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• 2019

We apply a modified Convolutional Neural Network (CNN) model in conjunction with transfer learning to predict whether an active region (AR) would produce a ≥C-class or ≥M-class flare within the next 24 hours. We collect line-of-sight magnetogram samples of ARs provided by the SHARP from May 2010 to September 2018, which is a new data product from the HMI onboard the SDO. Based on these AR samples, we adopt the approach of shuffle-and-split cross-validation (CV) to build a database that includes 10 separate data sets. Each of the 10 data sets is segregated by NOAA AR number into a training and a testing data set. After training, validating, and testing our model, we compare the results with previous studies using predictive performance metrics, with a focus on the true skill statistic (TSS). The main results from this study are summarized as follows. First, to the best of our knowledge, this is the first time that the CNN model with transfer learning is used in solar physics to make binary class predictions for both ≥C-class and ≥M-class flares, without manually engineered features extracted from the observational data. Second, our model achieves relatively high scores of TSS = 0.640±0.075 and TSS = 0.526±0.052 for ≥M-class prediction and ≥C-class prediction, respectively, which is comparable to that of previous models. Third, our model also obtains quite good scores in five other metrics for both ≥C-class and ≥M-class flare prediction. Our results demonstrate that our modified CNN model with transfer learning is an effective method for flare forecasting with reasonable prediction performance.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2006년도 춘계학술대회
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• pp.288-293
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• 2006

최근 반도체 개발 및 제조부문에서는 급속도로 성장한 Mobile 시장과 Digital Consumer Trend 에 주도적으로 대응하고자 빠른 속도의 기술적 변화를 추진하여 왔으며, 이에 따라 현장에서 발생하는 기술적 문제의 유형 또한 점점 복잡 다양해지고 있다. 기존 Commodity 제품의 경우, 세대 전환이 느리게 진행되어, 이에 수반되는 기술적 문제의 난이도와 그 발생 종류가 현재 대비 상대적으로 단순하였다. 그러나 최근 다품종 주문형 제품비중 확대로, 발생되는 문제점들이 Field Application 과 tight 한 연관성을 지니고 있어, 문제의 발생 경로, 원인 파악과 해결 대책 수립에 상당한 초기대응 시간을 필요하며, 관련 부서와의 실시간 협업 및 Cross-Checking을 통하지 않고서는 문제에 대한 최적 Solution 을 결정하기 힘든 현실이 되었다. 이러한 기술 이슈 해결 과정에 기 발생했던 유사 이슈 처리 과정 및 결과 자료가 문제 해결에 크게 기여할 수 있으나, 종래의 지식관리 시스템 체계로는 이러한 실무 형 지식을 획득하기 어려운 부분이 한계점으로 지적되고 있다. 본 논문에서는 이러한 문제점 개선이 가능한 실무형 지식 관리 (AKM: Actual Knowledge Management) 기반의 기술적 이슈 추적 관리 시스템(TITS: Technical Issue Tracking System) 구축 사례를 제시하고자 한다. TITS 는 1) 기술 이슈의 발의 및 전파 기능과 2) 이슈 해결을 위한 Action Item 부여 및 의견 교환 기능 3) 해결된 이슈의 처리 결과 등록 기능 4) 유사 이슈 사례 검색 기능 등의 크게 4 개 모듈오 구성 되어있다. 이 시스템을 통해 반도체 엔지니어들은 기술적 이슈의 발생 시점부터, 원안분석, 대책 협의 ; Action Item 수립 등 문제 해결 과정과 결과 등록 시점까지 Real time Tracking이 가능해 졌으며, 본 시스템을 통해 처리된 모든 기술적 이슈 정보는 Issue Case Database 에 분류 저장되어, 향후 유사 이슈 발생 시, 이를 활용함으로써, 빠른 초기 대응 및 문제 해결에 직접적인 도움을 받을 수 있게 되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.6099-6104
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• 2015

Background: Previous studies investigating the association between miR-34b/c rs4938723 polymorphism and cancer risk showed inconclusive. Here, we performed meta-analysis to investigate the association between miR- 34b/c rs4938723 polymorphism and digestive cancer risk. Materials and Methods: Literature database including PubMed, OVID, Chinese National Knowledge Infrastructure (CNKI) were searched for publications concerning the association between the miR-34b/c rs4938723 polymorphism and digestive cancer risk. Results: A total of 6 studies consisting of 3246 cases and 3568 controls were included in this meta-analysis. The combined analysis suggested the miR-34b/c rs4938723 polymorphism significantly reduced digestive cancer risk under allelic model, homogeneous co-dominant model and recessive model (C vs T: OR=0.88, 95%CI=0.82-0.95, p-value=0.001; CC vs TT: OR =0.67, 95%CI=0.57-0.80, p-value=0.000; CC vs TT/TC: OR=0.68, 95%CI=0.58-0.80, p-value=0.000). Q-test and I2 test revealed no significant heterogeneity in all genotype comparisons. The Begger's funnel plot and Egger's test did not show significant publication bias. Conclusions: The current evidence supports the conclusion that the miR-34b/c rs4938723 polymorphism decreases an individual's susceptibility to digestive cancers.