• The Journal of Korean Medicine
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• v.42 no.4
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• pp.10-24
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• 2021

Objectives: Yongdamsagan-tang (YST) and Paljung-san (PJS) in traditional medicine and finasteride in modern medicine are used to treat benign prostatic hyperplasia (BPH). In recent, the use of combination herbal remedies with conventional drugs has been increasing. Therefore, we investigated the anti-inflammatory effects of these drugs to treat BPH and the influence of herbal formulas on finasteride metabolism. Methods: The inhibitory effects of the herbal formulas and finasteride on the production of inflammatory mediators and cytokines were determined in lipopolysaccharide (LPS)-treated RAW 264.7 cells. Additionally, the influence of herbal formulas on activities of human drug metabolizing enzymes (DMEs) was assessed using human microsomal enzymes. Results: We observed that YST, PJS and finasteride inhibited the production of nitric oxide (NO), prostaglandin E₂ (PGE₂) and interleukin-6 (IL-6) in RAW 264.7 cells. The half maximal inhibitory concentration (IC₅₀) of YST on PGE₂ production was calculated to be below 25 ㎍/mL. YST inhibited the activity of uridine diphosphate-glucuronosyltransterase (UGT) 1A4 with an IC₅₀ value of 49.35 ㎍/mL. The activities of cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP3A4, and UGT1A1 were inhibited by PJS (IC₅₀ < 100 ㎍/mL, each). Although PJS and YST inhibited the activities of CYP3A4 and UGT1A4, respectively, these formulas may not influence the metabolism of finasteride because the IC₅₀ values of herbal formulas on DMEs are too high to affect metabolism. Conclusions: Our results suggest that the combination of finasteride and YST or PJS might not influence their drug metabolism and that the drugs may have synergistic effects against BPH.

• Journal of the Korean Society of Safety
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• v.31 no.1
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• pp.13-18
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• 2016

KTX wheelset bearings have thus far been maintained in accordance with the maintenance system of French national railway company, SNCF. The overhaul cycle time (OCT) of KTX wheelset bearings is now 1.4 million km in mileage. This value, however, has not been validated in Korea that has much different railway environments with France. In fact, it is impossible to validate OCT of wheelset bearings directly because they are disassembled and cleaned only when some faults are detected. In this paper, the accuracy of the current OCT value was evaluated indirectly by investigating the effect of grease lubricants on the bearing life. Five grease samples (one new and four aged greases) were used in this study. Four aged greases of different conditions were obtained from four wheelset bearings whose mileages were about 0.3, 1.2, 1.3, and 1.8 million km, respectively. Each grease sample was then injected into the RCF (Rolling Contact Fatigue) tester and fatigue lifetime was experimentally estimated. In addition, the wt% of Fe in each grease sample was analysed. The experiment results reveal that the bearing lifetime is inversely proportional to the mileage of grease sample while the wt% of Fe increases with the mileage of grease sample. Based on the experimental results, it can be concluded that the current OCT value is appropriate for the first overhaul of wheelset bearings. However, further validation is required to determine the second and third OCT values.

• Proceedings of the Korea Water Resources Association Conference
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• 2011.05a
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• pp.122-122
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• 2011

수자원 분야에서 기후변화 관련 연구는 치수 측면 보다는 이수 측면에서 주로 이뤄지고 있다. 이는 홍수분석을 위한 시간 단위를 충족시켜주는 전지구 대기순환모형(Global Circulation Model: GCM)의 자료가 드물고, 시간 단위의 GCM 자료라 하더라도 극치값(extreme value) 표현에는 한계가 있기 때문이다. 이를 극복하기 위하여 과거 관측자료의 통계적 특성으로 극치자료의 편의(bias)를 보정하고 시간 단위로 분해하기도 한다. 하지만 이런 통계적 상세화(statistical downscaling)는 미래 기후는 과거자료와 통계적 차이가 유의하지 않음을 가정하고 있어, 미래 기후는 현재와 다를 것이라는 공감대에 는 적합하지 않다. 이와 같은 이유로 타당한 극치수문변수 결과를 얻기 위해서는 시간 단위의 고분해능(high resolution) GCM이나 지역기후모델(regional climate model)과 같은 고해상도의 미래 기후변화 자료가 필요하게 된다. 이에 국립기상연구소에서는 영국 기상청의 통합모델(UM)기반의 지역기후모델(HadGEM3)을 사용하여 50 km 및 12.5 km 격자 단위로 역학적 상세화(dynamic downscaling)를 수행하였다. 본 연구에서는 개발된 HadGEM3-RA 결과의 극치수문변수 검증을 위하여 한강유역의 관측 자료와 다양한 방법으로 비교하였다. 두 자료의 극치값을 GEV (Generalized Extreme Value) 분포에 적합(fitting)시켜 비초과확률별 극치사상과, 특정 임계값(threshold value) 이상의 극치사상 발생확률을 비교하였다. 검토 결과, HadGEM3-RA는 통계적 상세화로 구한 극치값 보다는 작았으나 기존의 지역 기후모델에 비하여 현실성 있는 극치값이 계산되었음을 확인하였다.

• Journal of the Korean association of regional geographers
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• v.22 no.4
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• pp.809-825
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• 2016

This study aims to review the existing forms and farmers'perception of the agricultural dry stonewalls under agricultural environment, based on the case of Hado-ri, Gujwa-eup, Jeju Province. The study results are as follows: First, agricultural dry stonewalls in Hado-ri are most external walls, many of which are curvy. Concrete walls have recently shown up to enclose fields. Second, the height of agricultural dry stonewalls varies according to the location, and their length was calculated 16.514km(two farming region) based on a field survey and numerical cadastral maps. Third, farmers in Hado-ri perceive a great need for agricultural dry stonewalls. This means that agricultural dry stonewalls have a sustainable value despite rapid social change. Fourth, the methods for the sustainable preservation of agricultural dry stonewalls involve improving eco-friendly agricultural environment for the stonewalls, building database by village about them, carrying out their transformation and building according to promulgated ordinances, promoting the value of the stonewalls to Jeju citizens, and educating them to perceive the value of the stonewalls.

• Journal of Marine Bioscience and Biotechnology
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• v.3 no.1
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• pp.7-12
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• 2008

Cameroon is a country in Western Africa with 16 million inhabitants. Located between Nigeria and Equatorial Guinea, the country is bordered by the Bight of Biafra. It has a 402 km long coastline. It covers an area of about 475,440 sq km. Cameroon obtains its fish supply from five distinct sources notably-small scale maritime Fisheries, inland fisheries, industrial fisheries, aquaculture and importation. Despite its enormous potential, Cameroon produces only 180,000 metric tons fish annually. The total artisanal annual catch is estimated to be 55,000 t of which bonga/Sardinella, white shrimp and demersal fish contribute 58%, 27% and 15% respectively. The industrial fleet expanded rapidly during the sixties and by 1973 there were 29 trawlers and 13 shrimpers which landed a total of about 17,600 t of fish and shrimp. The total catch of the industrial fisheries peaked at about 20,400 t in 1976 and since then catches have generally declined. The per capita fish consumption in Cameroon stands at about 17.9 kg per inhabitant per year. This means that the demand of fish in Cameroon stands at about 280,000 tons. There is a deficit of in fish supply for which the government always resort to massive importation of fish products to meet the local demand. The main fish product for export from Cameroon is the prawn (Panacus duorarum). The main export market of Cameroon's prawn is the European Union (EU). Between 1998 and 2003, Cameroon's export value has been on the decline, dropping from 1,836 metric tons of prawns for a value of 264 millions USD in 1998 to 51 tonnes, for an estimated value of 315,000 USD in 2003. This drastic drop in exportation is consequential to Cameroon's auto suspension from the exportation of prawns towards the EU as a result of non compliance with EU standards. Today, a good quantity of the catches is being exported illicitly through neighbouring countries.

• The Journal of Pediatrics of Korean Medicine
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• v.38 no.2
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• pp.1-10
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• 2024

Objectives This study aimed to assess the reliability and validity of the Five-Visceral Weak Children Questionnaire (FWCQ) in childhood anorexia and to propose optimal cutoff values. Methods We conducted two surveys, spaced one month apart, targeting the parents of 366 children aged 2-9 years who had been diagnosed with anorexia for at least one month. To evaluate the reliability of the FWCQ, we calculated Cronbach's alpha coefficient and employed the test-retest method. Additionally, correlation analysis was performed between the FWCQ and each visceral question, and discriminant validity was assessed by comparing responses from the anorexic and normal groups. Furthermore, we determined the cutoff value of the spleen weak score, which is closely associated with appetite, for the anorexic group. Results The first survey yielded responses from 336 participants, followed by 171 responses in the second survey conducted one month later. The FWCQ demonstrated high internal consistency (Cronbach's alpha = 0.776), and test-retest results were consistent. The correlation coefficients between the FWCQ and each visceral question were all statistically significant. Moreover, significant discriminant validity was observed between the anorexic and normal groups in the FWCQ score and the heart, spleen, and kidney weak scores. The optimal cutoff value for the spleen weak score in the anorexic group was found to be 5.5 points (with a sensitivity of 73.44% and specificity of 66.47%). Conclusions The FWCQ exhibited strong reliability and validity in children with anorexia.

• Korean Journal of Environment and Ecology
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• v.22 no.3
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• pp.309-319
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• 2008

Roads are an indicator of anthropogenic activity causing ecosystem disturbances and often lead to habitat fragmentation, habitat loss, and habitat isolation. The Hallasan National Park(153.4$km^2$) on Jeju Island being distinguished for its unique geology, topography, and biota has also been designated as a core area of UNESCO Man and the Biosphere(MAB) Reserve. Although the high conservation value of this park has contributed to a rapid growth of tourists and road construction, landscape changes due to roads have not been examined yet. We used GIS systems to examine the fragmentation pattern caused by roads, in relation to its zonation, elevation, and vegetation. When a buffer was applied to roads(112m width for paved roads and 60m width for both legal and illegal trails), the park consisted of 100 fragments. The ten fragments generated after applying buffer to only paved roads and legal trails ranged from $0.002km^2$ to $38.2km^2$ with a mean of $14.2km^2$, and about 7% of both nature conservation zone and nature environment zone of the park were edge. Fragments in both east and west ends of the park and around the summit exhibited relatively high shape indices with means of 5.19(for 100 fragments) and 7.22(for 10 fragments). All five legal trails are connected to the pit crater of the mountain and vegetation changed from broadleaf forests and conifer forests to grasslands with elevation, consequently resulting in dramatic fragment size reduction in grasslands at high elevation, in particular above 1,400m, where endemic and alpine plants are abundant. These results show that in Hallasan National Park the risks of habitat deterioration and habitat loss due to fragmentation may be more severe in the nature conservation zone dominated by Baengnokdam than in the nature environment zone. Therefore, current road networks of the park appear to fall short of the goal of the national park for ecosystem conservation and protection. Considering that the entire Hallasan National Park also serves as a MAB core area, conservation efforts should focus, first of all, on park rezoning and road management to mitigate habitat fragmentation.

• Journal of Preventive Medicine and Public Health
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• v.5 no.1
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• pp.1-7
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• 1972

During the period from June 1st 1971 to November 30 th 1971, studies on air pollution were made in Kwangju city. The city was divided into 6 areas; the downtown area, the semi-downtown area, the heavy traffic area, the commercial area, the residential area, the park area, 13 surveying sites were selected each representing the characteristics of the area. The Measurement methods which were used are described below. Sulfur oxides were measured by $PbO_2$ cylinder method, sulfur dioxides ($SO_2$) and carbon monoxide (CO) by the MSA & Kitakwa detector, dustfall by the Deposit gauge method, and the noise levels by the Kanomax soundlevel meter. The results obtained are as follows: 1. The mean value of sulfur oxides in Kwangju city was $1.16mg\;SO_3/day/100cm^2\;PbO_2$, ranging from $0.45mg\;SO_3/day/100cm^2\;PbO_2$ to $3.10mg\;SO_3/day/100cm^2\;PbO_2$. 2. The mean values of sulfur oxides according to its specific area in the city were $1.45mg\;SO_3/day/100cm^2\;PbO_2$ in heavy traffic area, 1.36 in downtown area, 1.23 in semi-downtown area, 1.11 in commercial area, 0.96 in residential area, and 1.07 in park area, respectively. 3. The average concentration of sulfur dioxide was 0.063 ppm from 2 to 5 P.M in Kwangju city. 4. The average concentrations of sulfur dioxides according to its specific area, from 2 to 5 P.M, in the city were 0.084 ppm in heavy traffic area & downtown area, 0.067 in commercial area, 0.053 in semi-downtown area, 0.052 in residential area, and 0.036 in park area. 5. The average concentration of carbon monoxide was 22.3 ppm from 2 to 5 P.M, in Kwangju city. 6. The average concentrations of carbon monoxide according to its specific area, from 2 to 5 P.M, in the city were 27.0 ppm in downtown area, 26.3 in semi-downtown area, 23.0 in heavy traffic area, 21.7 in commercial area, 20.0 in residential arera, and 17.6 in park area. 7. The mean value of dusifall in Kwangju city was $29.28ton/km^2/month$, ranging from $9.85ton/km^2/month$ to $66.34ton/km^2/month$. 8. The mean values of dustfall according to its specific area in the city were $50.37ton/km^2/month$ in semi-downtown area, 42.76 in heavy traffic area, 34.67 in downtown area, 17.77 in commercial area, 14.40 in park area, and 14.76 in residential area. 9. The mean values of the soluble dust in Kwangju city was $10.23ton/Km^2/month$ and that of the insoluble dust was $19.05ton/Km^2/month$. 10. The mean value of noise level in Kwangju city was 62 phon, ranging from 37 phon to 88 phon. 11. The mean values of noise level according to its specific area in the city were 76 phon in heavy traffic area, 67 in semi-downtown area, 64 in downtown area, 59 in commercial area, 52 in part area, and 50 in residential area.

• Journal of the Korean Association of Geographic Information Studies
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• v.12 no.2
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• pp.120-131
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• 2009

This study measured the centripetal force and effective scope of the population spread from urban center and subcenters in order to diagnose the urban spatial structure of the formation of a multicentric city structure in Busan. The study analyzed the variability of the determination coefficient value (R square) with a negative exponential function derived from the population density model by extending the circular region into 5-km units. The aim of this study was to measure changes in the effective scope of the population centripetal force of the urban center and subcenter in 5-year intervals from 1995 to 2005 using census data. The explanatory adequacy of the population density function was examined with the bias of the function to calculate the distance error between the real location of the urban center and the optimal location, according to the population density function. To summarize the results, the value for the area of Jungangdong showed a continuous reduction, whereas Seomyeon (Bujeondong) maintained explanatory adequacy without a large change. As a whole, Busan was in the process of continuous diversification, in spite of its reduced population. Therefore, it appears necessary to strengthen the function of the urban center and subcenter and to supply adequate dwelling zones close to downtown to form a more efficient urban spatial structure. The results of the present study will be utilized as basic data for the formulation of a political approach to the efficient reorganization of spatial structure by correlating concrete spatial information with the population variability of Busan's urban center and subcenter.

• Journal of the Korean Association of Geographic Information Studies
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• v.2 no.3
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• pp.91-100
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• 1999

To extract value-added products from satellite images for the benefit of science and human life, the Satellite Technology Research Center at Korea Advanced Institute of Science and Technology has developed an integrated software 'Valadd-Pro'. In this paper, the 'Valadd-Pro' software is briefly introduced and its main components such as geometric correction, ortho correction and digital elevation model extraction are described. The performances of the 'Valadd-Pro' was assessed on $60km{\times}60km$ SPOT panchromatic images using ground control points from GPS measurements. Also, the height accuracy was measured by comparing our results with the $DTEDs^3$ produced by USGS and the DEM generated from the digitized countours of maps produced by the National Geographic Institute. In geometric correction, the 'Valadd-Pro' software needed fewer ground control points than a commercial software 'P' for the satisfactory results. In ortho correction, the 'Valadd-Pro' software show the similar performance to a commercial software 'P'. In digital elevation model extraction, the 'Valadd-Pro' software is two times more accurate and four times faster than a commercial software 'P'.