• Title/Summary/Keyword: Kim Jung-hee

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Modulation of Bujaijung-tang and Bojungikgi-tang on Inhibitory and Excitatory Neurotransmitters Activated Ion Channels (부자이중탕과 보중익기탕의 억제성 및 흥분성 신경전달 물질에 의하여 활성화되는 이온통로 조절작용)

  • Lee, Hye-Jung;Seo, Jung-Chul;Lee, Jae-Dong;Kim, Ee-Hwa;Lee, Choong-Yeol;Chung, Joo-Ho;Shin, Min-Chul;Kim, Hyun-Bae;Kim, Youn-Jung;Kim, Chang-Ju
    • Journal of Acupuncture Research
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    • v.17 no.4
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    • pp.5-17
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    • 2000

  • To research the characteristics of ion currents induced by Bujaijung-tang and Bojungikgi-tang, nystatin-perforated patch clamp technique under voltage-c(amp condition was used. Periaqueductal gray neuron was dissociated from Sprauge-Dawley rat, 10-15 days old. Cytotoxicity of Bujaijung-tang and Bojungikgi-tang showed incubation time and concentration dependent manner. Ion current activated by Bujaijung-tang and Bojungikgi-tang were inhibited by bicuculline and strychnine and CNQX. It can be suggested that Bujaijung-tang and Bojungikgi-tang modulate inhibitory and excitatory neurotransmitters-, GABA, glycine and non-NMDA, acticvated ion channels. Modulatory effect of Bujaijung-tang and Bojungikgi-tang was more greater in inhibitory neurotransmitters. Low concentration of Bujaijung-tang which dose not elicit ion current itself, activated GABA and glycine induced chloride currents. In this study, we can found that the activation of Bujaijung-tang and Bojungikgi-tang on non-NMDA subtypes of glutamate receptor is its major action mechanism and can be used as very effective Herb treatment on Myasthenia gravis patient.

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