• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8963-8967
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• 2014

Background: Colon cancer is one of the most common cancers worldwide. Apoptosis is a necessary physiological process for cell elimination which is very important both cellular homeostasis and cell proliferation and differantiation. Dysregulation can lead to uncontrolled cell growth and tumor development. Survivin, a member of the IAP family, plays a key role in promotion of cell proliferation as well as inhibition of apoptosis in cancer cells. The aim of this study was to investigate whether specific genetic polymorphisms of survivin could be associated with colon cancer development and progression in a Turkish population. Our study is the first to our knowledge to investigate the relationship between colon cancer risk and survivin gene polymorphisms. Materials and Methods: The relation between colon cancer and survivin -31 G/C (rs9904341), -241 C/T (rs17878467) and -625 C/G (rs8073069) polymorphism in promotor site of survivin gene associated with apoptosis was investigated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: Individuals with -31C allele and CC genotype were found to have a higher risk of developing colon cancer (OR=13.4, p=0.01). The -241 CT genotype considerably increased the risk of colon cancer (OR=12.0, p=0.0001). However, there was no significant varaition of the survivin -625 C/G polymorphism among colon cancer patients and controls in our study. Conclusions: This study provides the first evidence that survivin -31 G/C and -241 C/T SNP significantly contribute to the risk of colon cancer in the Turkish population.

• ALGAE
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• v.17 no.1
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• pp.41-51
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• 2002

Three dominant rocky intertidal macroalgae, the fucoids Fucus gardneri and Pelvetiopsis limitata (Phaeophyta) and the red alga Mazzaella cornucopiae (= Iridaea cornucopiae) on the west coast of Vancouver Island, British Columbia, Canada were used in a series of field experiments to examine interspecific interactions. These experiments showed complex patterns which included an interchange of negative (inhibition) and positive (facilitation) interactions depending on neighbor distance. Less fucoid recruitment occurred in the plots with greater percent cover of a turfforming red alga, M. cornucopiae. However, experimentally removing Mazzaella turf (the turf was considered to be "blocking" fucoid recruits or "shading" growing recruits) did not increase recruitment. This result indicated that there may be another factor(s) involved in the survivorship of juvenile fucoids in the turf-removed plots. Morphological differences in adult plants between Mazzaella and the two fucoids resulted in another type of interaction; these began when fucoids successfully settled and grew nearby or within the red algal turf. By monitoring microhabitat at the individual plant level for two years, I found that survivorship of fucoid recruits showed different species-specific patterns. The patterns also varied as the microhabitat changed from Mazzaella turf edge to open space. For F. gardneri, longevity of P.limitata at all distances tested was similar. A reason for greater longevity of F. gardneri individuals at edge microhabitats may be that these sites have one side open to light and nutrients and another site that buffers them from desiccation and wave impact. In the Mazzaella-Fucus interaction, neighbor distance was a key factor in determining whether the outcome of the interaction would be competition or facilitation (or protection). This study provides experimental evidence that detectable biological interactions occur in this upper intertidal algal community where physical conditions are usually severe, and also indicates the importance of small scale examination in understanding macroalgal interactions in intertidal habitats.

• Journal of the Korean Arthroscopy Society
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• v.13 no.1
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• pp.77-81
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• 2009

In patients with full-thickness tears of the rotator cuff, the tendon is usually detached from its bony insertion in the greater or lesser tuberosity. We experienced an unusual pattern of rotator cuff tear in two cases, in which complete rotator cuff tears occurred at the tendinous portion (i.e., intrasubstance tears) with more than a 1cm remnant attached to the greater tuberosity. Arthroscopic tendon-totendon repair was performed without remnant removal in both cases. Follow-up MRI at 6 months showed re-tear of the rotator cuff at the previous tear site in both of our patients. To prove the availability of arthroscopic tendon-to-tendon repair in such cases, a larger case follw-up and biomechanical studies are required.

• The KIPS Transactions:PartD
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• v.10D no.7
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• pp.1127-1136
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• 2003

Estimation of software project cost, effort and duration in the early stage of software development cycle is a difficult and key problem in software engineering. Most of models estimate the development effort using the function point that is measured from the requirement specification. This paper presents optimal team size and duration prediction based on function point in order to provide information that can be used as a guide in selecting the most Practical and productive team size for a software development project. We introduce to productive metrics and cost for decision criteria of ideal team size and duration. The experimental is based on the analysis of 300 development and enhancement software project data. These data sets are divide in two subgroups. One is a development project; the other is a maintenance project. As a result of evaluation by productivity and cost measured criteria in two subgroups, we come to the conclusion that the most successful projects has small teams and minimum duration. Also, I proposed that predictive model for team sire and duration according to function point size based on experimental results. The presented models gives a criteria for necessary team site and duration according to the software size.

• Journal of Conservation Science
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• v.5 no.1 s.5
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• pp.69-86
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• 1996

More than eighty thousands of wooden printing blocks of the Tripitaka Koreans are accommodated in the Changkyeonggak which consists of two open structured wooden buildings, Peoppojeon and Sudarajang. These blocks are virtually in pristine state even after three quarters of a millennium. The excellent preservation could be attributed to the careful preparation and meticulous finish of the blocks. But the meteorological environment or microclimate should be one of the key factors for the preservation. To keep the blocks intact as it is or at least do not accelerate the deterioration, we should study the blocks and its microclimatic environment supplied by the Changgyeonggak and the topology of the site. As a Part of this effort we designed a computerized meteorological data acquisition system, which can handle up to 4,096 sensors. A partial but operative installation of 16 temperature/humidity sensors was set up in the Peoppojeon. We hope to have a chance to install a full fledged system in the near future for the compilation of the fuller environmental data base.

• Archives of Plastic Surgery
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• v.36 no.4
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• pp.365-371
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• 2009

Purpose: Good color match holds a key position in facial reconstruction for good aesthetic result. To correct the wide facial soft tissue defect were usually used the tissue expanded cheek flap, deltopectoral flap or radial forearm free flap. This study is aimed to analyse the color difference after flap surgery by using chromameter. Method: From August 1995 to December 2006, 30 patients underwent flap operations were chosen randomly and evaluated color differences between flap site and adjacent skin. Reconstructive procedures included tissue expanded cheek flap(n = 10), deltopectoral flap(n = 10), and radial forearm free flap(n = 10). The measured sites were flap center within a radius of 1 ㎝ and four points of adjacent skin along the flap margin. The color was quantified in a three dimensional coordinate system $L^*$ (brightness), $a^*$ (redness), $b^*$ (yellowness). Results: There was no significant color difference between the pedicled flaps(tissue expanded cheek flap and deltopectoral flap) and adjacent skin area. On the other hand, color values of the radial forearm free flap were statistically different from those of adjacent skin area. Total color difference(${\Delta}E$) of tissue expanded cheek flap and deltopectoral flap were $7.45{\pm}5.78$ versus $9.41{\pm}7.09$, and that of radial forearm free flap was $11.74{\pm}3.85$. They suggest that pedicled flaps have a potential of better color match than radial forearm free flap. Conclusion: Thus, better esthetic result and satisfaction is more likely to be expected in pedicled flaps as long as it could be applied comparing radial forearm free flap.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.12 no.4
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• pp.11-22
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• 2009

This was a 2nd-year study aiming at developing the procedure of alternative system that was intended to restore not only biophysically disturbed areas but also psychologically and socially damaged community. It was suggested that this participatory restoration system could be constructed based on integrative categorization processes consisting of damage types and readiness of local residents for participation. Three case study sites-High-One resort, Lafarge-Halla cement, and high-altitude farmland near Gangneung city, were selected to apply the theoretical framework proposed as a result of 1st-year work. In order to develop introductory programs, key concepts such as forest for future, carbon offset forest, and healing forest, have been suggested based on analysis of 6 system components including human resources, communication, legal and institutional support, financial sources, restoration methods, and activity programs for each site. More detailed processes and procedures can be identified, defined, and refined after the end of final, 3rd-stage of the study in April of 2010.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.17 no.2
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• pp.89-100
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• 2007

Object: The purpose of this study was to survey the government official support status of the agricultural diseases, injuries and accidents among Korea and foreign countries and to suggest the agricultural policy of Korea. Methods: For this purpose, we analyzed the current national management support status among four foreign countries and Korea about agricultural diseases, injuries and accidents of farmers. For the foreign countries and the national support current status of agricultural diseases, injuries and accidents, related literature such as books, theses, articles, and web documents from the government organization of each countries were collected and analyzed. Key words for web-site and web documents were agricultural diseases, injuries, and accidents, government official system, safety and health, farmer's welfare, and farmer's official support system. UK, United States of America, France, and Japan were selected as the foreign countries' cases. Results and Conclusions: Implications for the agricultural diseases, injuries and accidents derived from the reviews among foreign countries and Korea were as follows: governmental supports should include (1) efforts on unifying administrative systems, (2) special support and management systems focusing on special subjects such as the agriculture that have been neglected, (3) aligned strategies including vision, goals, long-term plans about national safety and health projects, (4) development of supporting systems considering the features of agriculture, (5) systemized national surveys about occupational injuries and accidents for basic statistics and national studies, (6) active prevention efforts of agricultural diseases, injuries and accidents, and (8) specialized funds for safety and health of Korean farmers.

• Korean Journal of Veterinary Research
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• v.30 no.4
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• pp.499-505
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• 1990

The seasonal availability and abundance of the free-living stages of sheep nematodes is a key factor in the occurrence and severity of parasitic infection, and studies of larvae ecology could result in more rational control measures. In the present study seasonal pasture contamination and availability of nematodes for grazing sheep was examined as a baseline work for nematode control program at Namwon Branch, National Animal Breeding Institute during the period April 1988 through March 1989. Standard meteorological measurements were available from Unbong Sub-station, Honam Crops Experiment Station located about 200m from the experimental site. A total of 5 kinds of nematode larvae was detected: Haemonchus contortus was most prevalent (38.0%) with a decreasing order of Ostertagia spp (35.1%), Trichostrongylus spp (19.8%), nematodirus spp (6.6%), and Oesophagostomum spp (0.5%). A succession of species was recorded, in particular Ostertagia spp in May; Haemonchus contortus in June and July; Trichostrongylus spp in July and August; Nematodirus spp in August and September. These results can be incorporated into the nematode control program. To make a more rational control program, however, repeated herbage larval counts should be undertaken soil larval counts and fecal larval counts in the future.

• Tunnel and Underground Space
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• v.18 no.3
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• pp.165-174
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• 2008

Thermo-hydro-chemico-mechanical evolution of the radioactive waste repository and surrounding geological media is one of the key issues for the radioactive waste disposal. This article describes not only the basic context for the site selection but also a reasonable strategy for the repository related research based on the results of the French repository project carried out by ANDRA (National radioactive waste management agency). To have some alternatives for the determination of a preferable depth and geological media, it would be recommendable to establish a database system. The curing process of the fractures or microfissures in the EDZ (Excavation Disturbed Zone) during operation time has to be examined considering the evolution of the EDZ and the reversibility of the repository. It is prerequisite to carry out a feasibility study and to validate the design concept and design parameters in a properly constructed underground research laboratory (URL) in Korea.