• BMB Reports
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• 제50권4호
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• pp.160-161
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• 2017

Proper maintenance of biological components is crucial for longevity and healthy aging. Although the role of homeostatic maintenance systems for DNA and protein in longevity is established, it remains largely unknown for RNA. In our recent work, we show that nonsense-mediated mRNA decay (NMD) promotes longevity in the roundworm C. elegans by enhancing RNA quality control. We find that the activity of NMD decreases during aging, raising the possibility that RNA quality declines in old animals. We then show that key components of NMD complex are required for prolonged lifespan in C. elegans. In addition, animals with reduced insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS), a representative longevity model, display increased NMD activity. Thus, up-regulation of NMD appears to play crucial roles in longevity conferred by reduced IIS via enhancing mRNA quality control. As both IIS and NMD pathways are evolutionarily conserved, mammals including humans may be equipped with similar RNA quality control systems to achieve longevity.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집A
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• pp.316-321
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• 2001

A previous feasibility study for the Korean lead plant, PLiM Phase I, showed a strong possibility of continued operation beyond the original licensed period. In 1998, PLiM Phase II study was initiated aimed at performing additional detailed evaluations on a wider range of components. The objective of this paper is to present the Korean PLiM efforts for Class 1 piping which is identified as one of the critical components with regard to long-term operation. The key findings such as typical design features, degradation mechanisms, technical issues, draft results from the lifetime evaluation for Class 1 piping of the lead plant are briefly described.

• 한국압력기기공학회 논문집
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• 제11권1호
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• pp.45-52
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• 2015

Even though a lot of efforts have been devoted to evaluate welding residual stress characteristics of nuclear components, from the view point of accuracy, there are still some arguments in application of engineering estimation schemes. In this paper, three-dimensional finite element analyses (FEA) were carried out to predict residual stress distributions in butt welds of a typical surge line piping. Mesh optimization was conducted and subsequent analysis results such as the axial and hoop stress components along the weld center line and inner wall. Moreover, alternative evaluation was conducted by using three representative equations and their results were compared to those of FEA. Thereby, key parameters affecting to temperature profiles and residual stress distributions were derived as well as an optimum engineering estimation scheme was recommended.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
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• pp.582-582
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• 2012

Characteristics of a fusion-driven transmutation reactor was investigated. A compact reactor concept is desirable from an economic viewpoint. For the optimal design of a reactor, a radial build of reactor components has to be determined by considering the plasma physics and engineering constraints which inter-relate various reactor components. In a transmutation reactor, design of blanket and shield play a key role in determining the size of a reactor; the blanket should produce enough tritium for tritium self-sufficiency, the transmutation rate of waste has to be maximized, and the shield should provide sufficient protection for the superconducting toroidal field (TF) coil. To determine the radial build of the blanket and the shield, not only a radiation transport analysis but also a burnup calculation were coupled with the system analysis and it allowed the self-consistent determination of the design parameters of a transmutation reactor.

• 천문학회지
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• 제31권2호
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• pp.77-87
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• 1998

The accumulated knowledge of the influence of solar granulation on spectral lines, i.e. their asymmetry, provides a key to analyze stellar spectral line asymmetries. In this paper, a simple line synthesis using a simple 'model' of granulation was calculated. By adjusting the properties of the granule model, the observed imprints of convection on spectral lines can be reproduced. Since we depict convective flows using a continuous function rather than using a few components of flows (cf. Gray and Toner 1985, 1986; dravins 1990), we were able to identify which components of convection are important in line bisector shapes. The results of this study can be summarized as follows: Firstly, the intensity contrast (i.e. temperature fluctuation), and the area coverage of up- and down-flows are the two important factors which determine the line bisector shapes. Secondly, on the contrary to the assumption of other studies, the effect of horizontal flows is non-negligible. This exercise provides a qualitative understanding of the effect of convection on spectral lines. This knowledge serves as a guideline for understanding the characteristic difference in convection for stars on either side of the 'Granulation Boundary' (Gray 1982; Gray and Nagel 1989).

• Journal of Electrochemical Science and Technology
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• 제6권1호
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• pp.1-6
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• 2015

With increasing interest in flexible electronic devices and wearable appliances, flexible lithium ion batteries are the most attractive candidates for flexible energy sources. During the last decade, many different kinds of flexible batteries have been reported. Although research of flexible lithium ion batteries is in its earlier stages, we have found that developing components that satisfy performance conditions under external deformation stress is a critical key to the success of flexible energy sources. Among the major components of the lithium ion battery, electrodes, which are connected to the current collectors, are gaining the most attention owing to their rigid and brittle character. In this mini review, we discuss candidate materials for current collectors and the previous strategies implemented for flexible electrode fabrication.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 1996년도 추계학술대회 논문집
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• pp.338-341
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• 1996

Anodic bonding is a key technology for micromechanical components. The main advantages of this method can be formed in a batch process, over large areas, and is permanent and irreversible. In this paper, the bonding was performed at temperatures ranging from 300 to 450 $^{\circ}C$, voltages 400 to 1000 V, and times 10 to 30 minutes. The sizes of the Si and the Pyrex #7740 glass were 6 mm $\times$6 mm, respectively. Bonding processes and voids were observed by the optical microscope, and the composition of the anodic bonding interface was analyzed by the SIMS. Optimum condition of the anodic bonding was at temperature above 40$0^{\circ}C$ without regard to voltage.

• International Journal of Railway
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• 제5권4호
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• pp.175-181
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• 2012

This study proposes a model for railway safety assessment with which the safety of whole railway system can be evaluated. The purpose of the assessment model is to generate safety indicators which quantitatively represent the degree of railway safety. Safety indicators were proposed as three indicators according to their functions; accident indicators, safety management indicators, and safety culture indicators. This paper describes the first result on the safety target which will be a key starting point toward the development of safety assessment model. It is recommended that the safety target to be composed of several sub-targets are apportioned to constituent components. It is concluded that the classification of safety target has influence on deciding components or attributes that constitute each sub-indicators; accident indicators, safety management indicators, and safety culture indicators. Based on this study, a railway safety assessment model will be developed in the following study.

• 한국연초학회지
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• 제18권2호
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• pp.170-176
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• 1996

This paper describes the generation and decay phenomena of gas, vapor and particulate phase components of environmental tobacco smoke in 18 m3 controlled experimental atmosphere chamber. Real time-weighted average concentration ratios of markers were determinated at no ventilation rates and sampling durations of starting to smoking 45 min. Average concentration of major ETS markers was no significant on the mainstream smoke contents of commercial cigarette and decay ratios were dependent on first order kinetic. RSP/nicotine, solanesol and 3-EP were good predictors of ETS concentration in the public indoor field. The concentration ratio of vapor phase and particulate phase components is highly variable to assessment of indoor air quality with ETS. Key words : ETS, chamber study, ETS markers.

• 한국CDE학회논문집
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• 제19권4호
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• pp.423-433
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• 2014

For the proper decision making and responsibility enhancement for an unexpected accident in large-scale facilities, it is important to train operators or first responders to minimize potential human errors and consequences resulted from them. Simulation technologies, including human-computer interaction and virtual reality, enables personnel to participate in simulated hazardous situations with a safe, interactive, repetitive way to perform these training activities. For the development of accident response training simulator, it is necessary to define components comprising the simulator and to integrate them for the given training purpose. In this paper, we analyze requirements of the training simulator, derive key components, and design the training simulator. Based on the design, we developed a prototype training simulator and verified the simulator through experiments.