• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.18 no.6
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• pp.159-172
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• 2023

This study aims to empirically investigate the relative effects of business-to-business (vs. business-to-consumer) business model innovation (BMI) on innovation performance. The research examines the impact of three key components of BMI: 1. value creation, 2. value proposition, and 3. value capture, on innovation performance. The 2022 Entrepreneurship Survey data by the Korean Entrepreneurship Foundation was used to analyze 2,879 companies. An exploratory data analysis (EDA) including various categories such as industry, firm, CEO, and technology chracteristics was conducted to show the latest startup status in Korea. The results show that value creation of B2B (vs. B2C) firms has a more positive and significant impact on innovation performance. Whereas, value proposition of B2C (vs. B2B) firms was found to have a more positive and significant effect on innovation performance. Interestingly, value capture did not show any effects for either type of firms. Additionally, the study employed seemingly unrelated regression (SUR) analysis for robustness checks. These findings provide important insights about the relative effects of B2B-BMI (vs. B2C-BMI).

• Food Science and Preservation
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• v.30 no.4
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• pp.716-728
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• 2023

The anti-adipogenic activity of Glycyrrhiza uralensis was investigated by examining the effects of its ethanol extract (GUE) on a mouse model with a high-fat diet (HFD) and 3T3-L1 preadipocytes during adipocyte differentiation. GUE administration for eight weeks significantly reduced weight gain in mice fed an HFD. GUE effectively inhibited 3T3-L1 preadipocyte differentiation and lipid droplet accumulation. This inhibitory effect is associated with the downregulation of key adipogenic regulators, including PPARγ and C/EBPα, and the modulation of adipose metabolism regulators, such as Fasn and Fabp4. LC-Q-TOF-MS analysis identified twelve phenolic and flavonoid compounds, including liquiritigenin and licorice saponin, in the GUE. These findings demonstrate that the anti-obesity effect of the GUE is attributed to the biological activity of its phenolic and flavonoid compounds. Therefore, the GUE has potential anti-obesity activity. Moreover, further studies on the isolation of bioactive components from the GUE and the investigation of the underlying molecular mechanisms of the GUE are required to establish its efficacy in metabolic disorders, including obesity.

• Journal of the International Relations & Interdisciplinary Education
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• v.4 no.1
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• pp.1-18
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• 2024

This study is a qualitative case study on the experience of an on-site, audience-participatory educational play conducted by four college students majoring in theater under the title 'Hooni and Choroki' for 7-year-old kindergarten students about to enter elementary school. The core theme of the play is to help relieve anxiety about school life before entering elementary school and to communicate smoothly with peers. To this end, college students participate in scenario planning, kindergarten recruitment, and 40-minute training at three kindergartens. He even conducted theatrical performances. As a result of the study, the key components of 'another growth in my life', 'improvement of happiness through meeting children', and 'new challenge toward dreams' were derived. The greatest significance of this study is that the audience-participatory educational theater experience allowed college students to practice sharing the results of their learning with someone else, and through this practice of sharing learning, they were able to realize their somewhat vague career paths and dreams. It was an opportunity that allowed me to experience 'improved confidence' and 'a resonance in my heart' so that I could set a direction. We hope that future educational theater with audience participation will be widely implemented in various aspects.

• Journal of Ginseng Research
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• v.48 no.4
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• pp.395-404
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• 2024

Background: Ginsenoside Rg₁ (Rg₁) is one of the main active components in Chinese medicines, Panax ginseng and Panax notoginseng. Research has shown that Rg₁ has a protective effect on the cardiovascular system, including anti-myocardial ischemia-reperfusion injury, anti-apoptosis, and promotion of myocardial angiogenesis, suggesting it a potential cardiovascular agent. However, the protective mechanism involved is still not fully understood. Methods: Based on network pharmacology, ligand-based protein docking, proteomics, Western blot, protein recombination and spectroscopic analysis (UV-Vis and fluorescence spectra) techniques, potential targets and pathways for Rg₁ against myocardial ischemia (MI) were screened and explored. Results: An important target set containing 19 proteins was constructed. Two target proteins with more favorable binding activity for Rg₁ against MI were further identified by molecular docking, including mitogen-activated protein kinase 1 (MAPK1) and adenosine kinase (ADK). Meanwhile, Rg₁ intervention on H9c2 cells injured by H₂O₂ showed an inhibitory oxidative phosphorylation (OXPHOS) pathway. The inhibition of Rg₁ on MAPK1 and OXPHOS pathway was confirmed by Western blot assay. By protein recombination and spectroscopic analysis, the binding reaction between ADK and Rg₁ was also evaluated. Conclusion: Rg₁ can effectively alleviate cardiomyocytes oxidative stress injury via targeting MAPK1 and ADK, and inhibiting oxidative phosphorylation (OXPHOS) pathway. The present study provides scientific basis for the clinical application of the natural active ingredient, Rg₁, and also gives rise to a methodological reference to the searching of action targets and pathways of other natural active ingredients.

• Biomolecules & Therapeutics
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• v.32 no.4
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• pp.481-491
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• 2024

Paxlovid is the first approved oral treatment for coronavirus disease 2019 and includes nirmatrelvir, a protease inhibitor targeting the main protease (M^pro) of SARS-CoV-2, as one of the key components. While some specific mutations emerged in M^pro were revealed to significantly reduce viral susceptibility to nirmatrelvir in vitro, there is no report regarding resistance to nirmatrelvir in patients and animal models for SARS-CoV-2 infection yet. We recently developed xenograft tumors derived from Calu-3 cells in immunodeficient mice and demonstrated extended replication of SARS-CoV-2 in the tumors. In this study, we investigated the effect of nirmatrelvir administration on SARS-CoV-2 replication. Treatment with nirmatrelvir after virus infection significantly reduced the replication of the parental SARS-CoV-2 and SARS-CoV-2 Omicron at 5 days post-infection (dpi). However, the virus titers were completely recovered at the time points of 15 and 30 dpi. The virus genomes in the tumors at 30 dpi were analyzed to investigate whether nirmatrelvir-resistant mutant viruses had emerged during the extended replication of SARS-CoV-2. Various mutations in several genes including ORF1ab, ORF3a, ORF7a, ORF7b, ORF8, and N occurred in the SARS-CoV-2 genome; however, no mutations were induced in the M^pro sequence by a single round of nirmatrelvir treatment, and none were observed even after two rounds of treatment. The parental SARS-CoV-2 and its sublineage isolates showed similar IC₅₀ values of nirmatrelvir in Vero E6 cells. Therefore, it is probable that inducing viral resistance to nirmatrelvir in vivo is challenging differently from in vitro passage.

• The Korean Journal of Coaching Psychology
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• v.7 no.3
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• pp.1-26
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• 2023

This study aims to explore how professors at community colleges are experiencing career guidance for their students, uncovering key components related to causes, phenomena, contexts, coping strategies, etc., and deriving a paradigm model to structurally. To achieve this objective, focus group interviews were conducted with a total of 23 community college professors, and the results were analyzed using the grounded theory method (Strauss & Corbin, 1998). The analysis yielded 17 categories and 31 subcategories. The central phenomenon in the career guidance of community college professors was categorized into two groups: the distress experience in career guidance and attitude changes toward interactions with students..Three categories of causal conditions contributing to the occurrence of the central phenomenon were identified: professors' lack of expertise in career guidance, students' scope and needs for career guidance, and students' low interest and expectations. Additionally, four contextual conditions corresponding to special situations or circumstances that contributed to the central phenomenon were identified: increasing demand for career guidance, excessive burden and time constraints for career guidance, lack of communication about career guidance at the institutional level, and limitations within the career guidance support system. Furthermore, the study uncovered patterns of action-interaction, mediating conditions, and outcomes. This study is expected to contribute to a better understanding of the actual experiences of college professors in the career guidance process, and to stimulate consideration of the types of support required for effective career guidance for college professors in the future.

• The Journal of Korean Society for School & Community Health Education
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• v.24 no.4
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• pp.39-50
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• 2023

Objectives: This study aimed to provide a scoping review of the impact of COVID-19 on people with disabilities. Methods: PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) Group's key questions (PICO) for systematic reviews, a literature search was conducted from January 1, 2020 to June 30, 2023 using the "AND" search formula. The databases used were Korea DB: RISS, SCIENCEON, and KoreaMed, and International DB: PubMed, CINAHL, and Embase. Results: Among a total of 22 selected articles, 4 studies were published in korea journals: 3 were survey studies (75.0%), 1 was an analysis study (25.0%), and 18 studies were published in international journals. Through a literature review, we confirmed the differences in difficulties between PwD (People with Disability) and PwoD (People without Disability) in the COVID-19 situation, differences by disability type, and post-COVID-19 impact. In order to examine this systematically and objectively, the results were examined by dividing them, which are components based on the International Classification of Functioning, Disability and Health (ICF). Conclusion: In order to respond well to crises and establish effective health policies in similar pandemic situations in the future, understanding and exploration of more diverse types and areas of disability are necessary. In addition, the development and application of appropriate health education and health promotion programs for disability type and ICF component area are required. In addition, it is necessary to develop and apply appropriate health education and health promotion programs tailored to the type of disability and ICF component area.

• The Journal of the Convergence on Culture Technology
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• v.10 no.1
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• pp.403-409
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• 2024

In this paper, the guidelines for the design of an Artificial Intelligence(AI) based Integrated Process Safety Management(PSM) system to enhance workplace safety using data from process safety reports submitted by hazardous and risky facility operators in accordance with the Occupational Safety and Health Act is proposed. The system composed of the proposed guidelines is to be implemented separately by individual facility operators and specialized process safety management agencies for single or multiple workplaces. It is structured with key components and stages, including data collection and preprocessing, expansion and segmentation, labeling, and the construction of training datasets. It enables the collection of process operation data and change approval data from various processes, allowing potential fault prediction and maintenance planning through the analysis of all data generated in workplace operations, thereby supporting decision-making during process operation. Moreover, it offers utility and effectiveness in time and cost savings, detection and prediction of various risk factors, including human errors, and continuous model improvement through the use of accurate and reliable training data and specialized datasets. Through this approach, it becomes possible to enhance workplace safety and prevent accidents.

• Journal of Internet Computing and Services
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• v.25 no.3
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• pp.43-54
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• 2024

This study employs text mining techniques to compare user responses across various Over-The-Top (OTT) service platforms. The primary objective of the research is to understand user satisfaction with OTT service platforms and contribute to the formulation of more effective review strategies. The key questions addressed in this study involve identifying prominent topics and keywords in user reviews of different OTT services and comprehending platform-specific user reactions. TF-IDF is utilized to extract significant words from positive and negative reviews, while BERTopic, an advanced topic modeling technique, is employed for a more nuanced and comprehensive analysis of intricate user reviews. The results from TF-IDF analysis reveal that positive app reviews exhibit a high frequency of content-related words, whereas negative reviews display a high frequency of words associated with potential issues during app usage. Through the utilization of BERTopic, we were able to extract keywords related to content diversity, app performance components, payment, and compatibility, by associating them with content attributes. This enabled us to verify that the distinguishing attributes of the platforms vary among themselves. The findings of this study offer significant insights into user behavior and preferences, which OTT service providers can leverage to improve user experience and satisfaction. We also anticipate that researchers exploring deep learning models will find our study results valuable for conducting analyses on user review text data.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.69 no.2
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• pp.97-110
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• 2024

This study investigated 575 cultivated soybean landraces from different provinces in Korea, using 17 key agromorphological traits. The studied soybeans showed wide variations in both qualitative and quantitative traits, signifying the existence of genetic diversity. The standardized Shannon-Weaver index (H') ranged from 0.3 to 1.0, with seed-related traits having an H' value higher than 0.7. Similarly, quantitative traits showed significant variation, with the coefficient of variation ranging from 7.2% for days to maturity (DM) to 62.3% for the number of pods per plant (PPP). In terms of province, the Gyeongsangbuk-do and Gyeongsangnam-do accessions differed from the other accessions, with higher proportions of green and yellow seed coats and lower proportion of black hilums. Gyeongsangnam-do accessions also showed early maturation and flowering but had the lowest average one-hundred seeds weight (HSW). In contrast, Jeollanam-do accessions flowered and matured late but had the highest average seed weight per plant (SWPP). Hierarchical cluster analysis grouped the soybeans into 12 clusters, and further statistical analysis showed significant variations in all quantitative traits (p < 0.05). Principal component analysis grouped the accessions based on the clusters. DM, PPP, HSW, and SWPP were identified as major contributors to the observed variance along the axes of the first two principal components. Correlation analysis revealed significant associations between maturity and yield-related traits. Based on their relative performance, 37 promising accessions were identified. Overall, this study highlights the diversity of recently cultivated Korean soybean landraces and provides opportunities for future metabolomic and genomic studies.