• Korean Journal of Environment and Ecology
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• v.16 no.4
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• pp.465-474
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• 2003

According to rapid increase of visitors to the Baekdudaegan, the most important ecosystem in Korea, fur climbing or outdoor recreation, deterioration of natural environment along the trail on the ridge of Baekdudaegan is becoming more serious. The purpose of this study is to research the deterioration condition of the trail between Manbokdae and Bokseongijae on the Baekdudaegan with intent to prepare the conservational management strategy fur the trail on the ridge of Baekdudaegan. To accomplish the purpose, not only trail condition such as altitude, entire width, bare width, maximum depth and slope of trail, but also deterioration types of trail were surveyed at the total 232 points for 28.4km in length. Furthermore, impact rating class, which could be effective means to check the step and extent of deterioration process, was judged on each points of trail. Putting together these results informs us that the deterioration condition of the trail between Manbokdae and Bokseongijae is not reached the level of grave concern yet, but prompt countermeasure to maintain the existing condition has to be considered with regard for the conditions of location and the increasing amounts of use.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.12
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• pp.782-789
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• 2020

The demand for the development of rolling stock technology to maintain the best performance in various climatic environments has increased to expand the overseas market of rolling stock. In this study, international and domestic standards that must be applied to build a harsh climatic environment test system were investigated and compared. The way of improvement for domestic standards is proposed. The wind velocities and temperatures are specified in the UIC, EN, and IEC standards for climatic wind tunnel, and EN 50125-1 provides the velocity test up to 180km/h, the largest wind speed. UIC and EN provide the lowest temperature of -45℃, and IEC 62498-1 provides the highest temperature 55℃. The solar radiation test was specified up to 1200W/m2 in the UIC, EN, and IEC. The IEC, EN, and KS R 9145 provide the water tightness standards, which are different from each other in water capacity, pressure, and methods. The snow test method was not well specified. KRTS-VE-Part 31 provides pressurization test methods. The airtightness standards for high-speed rolling stock are defined and regulated for internal pressure change rate in UIC 660 and 779-11. The domestic standard for the wind tunnel test was not well prepared, and the solar radiation test and snow test do not exist in Korea. Therefore, it is necessary to improve domestic standards to an international level for the climatic wind tunnel test of rolling stock.

• Journal of the Korean Society of Propulsion Engineers
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• v.26 no.3
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• pp.32-42
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• 2022

The strategy to develop a launch vehicle family by bundling multiple rocket engines of a single type has been proven by SpaceX and their reusable fleet comprised of Falcon 9 and Falcon Heavy. In this study, we revisit a potential launch vehicle family out of a 35 tonf-class methalox staged combustion cycle engine and evaluate their utility and performance in various space missions. For example, a Korean version of Falcon 9 can deliver 4.7 tons of payload into 500 km SSO in an expendable mode while the payload is reduced to 2.16 tons in a sea-landing reusable mode. A Korean version of Falcon Heavy can deliver 4.4 tons into GTO when launched from the Naro Space Center, indicating that this common booster core configuration can handle Cheollian 2 albeit the high inclination. Once developed, the same methaloax engine can power the first-stage of smallsat launch vehicles and air launch vehicles.

• Journal of Life Science
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• v.32 no.3
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• pp.210-221
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• 2022

This study investigated the mechanisms underlying the anti-cancer effects of non-steroidal anti-inflammatory drugs (NSAIDs) in human cancer cells in combination with either N-[N-(3, 5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), a γ-secretase inhibitor, or MHY2245, a new synthetic sirtuin 1 inhibitor. The results showed both DAPT and MHY2245 as novel chemosensitizers of human colon cancer KM12 and human hepatocellular carcinoma SNU475 cells to NSAIDs involving celecoxib and 2, 5-dimethyl celecoxib. The NSAID-induced cytotoxicity of these cells was significantly increased by DAPT and MHY2245 in a cyclooxygenase-2 independent manner. In addition, DAPT and MHY2245 reduced levels of p62, Notch1 intracellular domain, and multiple cancer stemness (CS)-related markers including Notch1, CD44, CD133, octamer-binding transcription factor 4, mutated p53 and c-Myc. However, the level of activating transcription factor 4 (ATF4) was enhanced, probably indicating the down-regulation of multiple CS-related markers by DAPT or MHY2245-mediated autophagy induction. Moreover, the NSAID-mediated reduction of p62/nuclear factor erythroid-derived 2-like 2 and CS-related marker proteins and the up-regulation of C/EBP homologous protein (CHOP)/ATF4 were accelerated by DAPT and MHY2245. As such, the combination of NSAID and either DAPT or MHY2245 resulted in higher cytotoxicity than NSAID alone by accelerating the down-regulation of multiple CS-related markers and PARP activation, indicating that both inhibitors promote NSAID-mediated autophagic cell death, possibly through the CHOP/ATF4 pathway. In conclusion, either combination strategy may be useful for the effective treatment of human cancer cells expressing CS-related markers.

• Asian-Australasian Journal of Animal Sciences
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• v.24 no.1
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• pp.37-44
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• 2011

Parthenogenetic embryonic stem (pES) cells could provide a valuable model for research into genomic imprinting and X-linked diseases. In this study, pES cell lines were established from oocytes of hybrid offspring of Kunming and 129/Sv mice, and pluripotency of pES cells was evaluated. The pES cells maintained in the undifferentiated state for more than 50 passages had normal karyotypes with XX sex chromosomes and exhibited high activities of alkaline phosphatase (AKP) and telomerase. Meanwhile, these cells expressed ES cell molecular markers SSEA-1, Oct-4, Nanog, and GDF3 but not SSEA-3 detected by immunohistochemistry and RT-PCR. The pES cells could be differentiated into various types of cells from three germ layers in vitro by analysis of embryoid bodies (EBs) with immunohistochemistry and RT-PCR, and in vivo by observation of pES cell-derived teratoma sections. Therefore, the established pES cell lines contained all features of mouse ES cells. This work provides a new strategy for isolating pES cells from Kunming mice, and the pES cell lines could be applied as the cell model in research into genomic imprinting and epigenetic regulation of Kunming mice.

• Journal of Society of Preventive Korean Medicine
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• v.20 no.2
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• pp.27-38
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• 2016

Backgrounds : Taiwan has similar national health insurance (NHI) system for traditional medicine with South Korea. Recently, new quality improvement policies for traditional medicine is being attempted in Taiwan. Objectives : This study aimed to review the Taiwanese NHI system for Chinese Medicine (CM) and introduce quality improvement policies. Methods : Research articles, reports, government publications and year books which handled traditional medicine system and NHI system in Taiwan were searched and collected. The authors analyzed and summarized the contents in a qualitative manner. Results : In Taiwanese NHI system, CM procedures and medication for outpatients are reimbursed through a mix of fee-for-service and global budget payment system. CM shares 4% of total expenditure of NHI in Taiwan. Mostly, the expenses for procedures are reimbursed regardless of disease type, however, in the specialized program for quality improvement, CM doctors have to comply with standard operating procedures (SOPs). Conclusions : Taiwanese NHI system implemented SOP-based new reimbursement system for CM. Yet, the scientific evidences for SOPs are not sufficient, it can be useful references when we develope disease related reimbursement system for Korean Medicine in South Korea.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.1
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• pp.148-156
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• 2014

The objective of this study is to compare NOx emissions from light duty diesel vehicles measured from on-road tests that conducted under various driving routes and seasonal conditions. We measured real-driving NOx emissions using PEMS, portable emissions measurement system, under the urban, rural and motorway road traffic conditions. On-road tests were repeated at summer, fall and winter season. The accumulated driving distance is more than 1,200 km per each vehicle. Route average NOx emission factors were compared among nine route-season combinations. The emission characteristics of each combinations were investigated using time series mass emission rates and vehicle operation-based emission rates and activities, which is based on U.S. EPA's MOVES model. Most concerned route-season combination is "urban road condition at summer", which shows two to eleven times higher NOx emissions than other combinations. The emission rates and activities under low speed operating conditions should be managed in order to reduce urban-summer NOx. From a NOx control strategy perspective, the exhaust gas recirculation, EGR, is observed to be properly operated under wide range of vehicle driving conditions in Euro-5 vehicles, even if the air conditioner turns on. In high power demanding conditions, the effect of overspeeding could be more critical than that of air conditioner activation.

• Journal of Agricultural Extension & Community Development
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• v.24 no.3
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• pp.173-183
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• 2017

The purpose of this study was to identify differences by business motivation of agro-healing farm s in Korea. A survey was conducted for entrepreneurs in agro-healing farmers with self-administered questionnaires. Main results of this study were as follows: First, business motivation of agro-healing farm s in Korea can be classified to 1) education-oriented, 2) care-oriented, and 3) sale revenue-oriented motivation. Second, care-oriented farms provide healing services to people in need like the disabled. These farms may be required a long-term program such as residence-required format. And these farms need supports of health and medical service personnel or institutions. Third, sale revenue-oriented farms have sources of main income from agricultural products or processed goods made in these farms. Therefore, these farms may be required a business strategy such as product development, marketing rather than agro-healing programs. fourth, the estimation of a Multinominal logistic regression model determines the characteristics of agro-healing entrepreneurs who are most likely to opt for each type motivation of participating for agro-healing farm business. the most important determinants on business motivation of agro-healing farms were 'participants type in programs', 'program operating time', 'supporting health and medical service personnel or institutions' and 'program revenue ratio in farm operating revenue'.

• Journal of the Korean Society for information Management
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• v.20 no.4 s.50
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• pp.277-301
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• 2003

Knowledge Management is presented as the management method having the survival and competition of enterprise under variously changing management environment. Knowledge Management is introduced recently as successful survival strategy of advanced enterprise. Scientifically, however, the definition. study model and propulsion method of KM leave much to be desired, and now it has become the subjects of active study among scholars. To creation of the competitive power of the company have to be important knowledge based continuous innovation. That is to say, the knowledge management means a lot to knowledge assets included knowledge, knowledge creating, sharing, and acting This study aims to propose models on the research result based a case study of the financial industry in knowledge creating processes(SECI) and deriving knowledge management styles in the flied works of the bank.

• Parasites, Hosts and Diseases
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• v.52 no.1
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• pp.57-62
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• 2014

Biting midges (Culicoides: Ceratopogonidae) were collected by Mosquito Magnet$^{(R)}$ traps at the Neutral Nations Supervisory Commission (NNSC) camp and Daeseongdong village inside the demilitarized zone (DMZ) and near the military demarcation line (MDL) separating North and South Korea and at Warrior Base (US Army training site) and Tongilchon 3 km south of the DMZ in northern Gyeonggi Province, Republic of Korea (ROK), from May-October 2010-2012, to determine their seasonal distributions. A total of 18,647 Culicoides females (18,399; 98.7%) and males (248; 1.3%) comprising 16 species were collected. Overall, the most commonly collected species was Culicoides nipponensis (42.9%), followed by C. erairai (29.2%), C. punctatus (20.3%), C. arakawae (3.3%), C. pallidulus (1.8%), and C. circumscriptus (1.4%), while the remaining 10 species accounted for only 1.1% of all Culicoides spp. collected. The seasonal distribution of C. nipponensis was bimodal, with high numbers collected during May-June and again during September. C. erairai was more frequently collected during June-July, followed by sharply decreased populations from August-October. C. punctatus was collected in low numbers from May-September with high numbers collected during October. C. erairai was predominantly collected from the NNSC camp (85.1% of all C. erairai collected) located adjacent to the MDL at Panmunjeom in the northernmost part of Gyeonggi-do (Province), while other sites yielded low numbers of specimens.