• 한국한의학연구원논문집
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• 제2권1호
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• pp.496-505
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• 1996

In order to improve the qualities of boiling extract the availability of standard compounds was investigated in extract of Scutellariae Radix. The standard compounds used baicalin(1), baicalein(2), and wogonin(3). The availabilities were analyzed by thin layer chromatography (TLC) and high performance liquid chromatography(HPLC) on $C_18$ column. The extract of RS-4(W/V=10g/100m1) showed the highest availabilities as 7.95% of baicalin(1), 1.04% of baicatein(2), and 0.31% of wogonin(3).

• 한국한의학연구원논문집
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• 제13권2호통권20호
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• pp.143-148
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• 2007

The present study examined inhibitory effects of 20 efficient experience prescriptions on platelet aggregation induced by collagen in human whole blood using the impedance method of aggregometry. Among them, a hot water extract of KIOM 2003-080 was selected to be the most effective candidate. In an in vivo study using a mouse acute thrombosis model, the anti-thrombotic effects of the KIOM2003-080 crude extract were also observed. In addition, we accessed bio-marker of platelet activation using thromboxane B2 by ELISA assay. A significantly decrease in thromboxane B2 production was seen in the presence of KIOM2003-080. Consequently, the results from this experiment provide pharmacological evidence for the traditional use of KIOM2003-080 prescription, suggesting that its hot water extracts could be used to prevent platelet aggregation and thrombosis disease.

• Korean Journal of Acupuncture
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• 제28권4호
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• pp.41-48
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• 2011

Objectives : This study aimed to explore the passive multi-channel time series analysis method by measuring bio-potentials of acupuncture point and the peripheral region Methods : Bio-potential was measured at ST36 and the peripherical region of ST36 of 5 healthy volunteers at three times. The diagram of the potential changes over time were smoothed by moving average method and similarities of ST36 and the other points were calculated. Results : In the normal weight group, bio-potential similarity tended to decrease in proportion to the distance from the acupuncture point. In the obesity group, bio-potential similarity appeared in a very wide area. Bio-potential similarity had positive correlation with BMI value. Conclusions : The passive multi-channel time series analysis method showed the possibility be appropriate for the electrical characteristics study of meridians.

• 생약학회지
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• 제37권2호통권145호
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• pp.103-109
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• 2006

Advanced glycation end products (AGEs) formation plays an important role in the progression of diabetic complications. To develop effective herbal formulations with suppression of diabetic nephropathy, a common complication in diabetic patients, we evaluated inhibitory activities of KIOM-79, a new herbal prescription, on the formation of AGEs using in vitro and in vivo model systems. Effects of KIOM-79 on the expression of AGEs, RAGEs (receptor for Advanced glycation end products), type IV collagen and renal $TGF-{\beta}1$ mRNA was also examined in streptozotocon (STZ)-induced diabetic rats. STZ-induced diabetic rats were treated orally with KIOM-79 (250 and $500\;kg^{-1}$ once a day for 13 weeks). In vitro system KIOM-79 suppressed the formation of AGEs $(18.12\;{\mu}g/ml)$. In STZ-induced diabetic rats showing accumulation of AGE and RAGE, pathological examination revealed that KIOM-79 prevented AGE and RAGE deposition in the kidney. In STZ induced diabetic rats, the expansion of mesangial matrix and the glomerular tufts seemed to be larger than those in normal rats. Howεver, after administration with KIOM-79, mesangial metrix and glomerular volume were decreased, and overexpression of type IV collagen was also decreased. Overexpression of renal $TGF-{\beta}1$ mRNA was inhibited significantly. These results suggest that the KIOM-79 might be an effective herbal prescription to prevent or alleviate the progression of diabetic nephropathy.

• 정보관리연구
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• 제41권3호
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• pp.155-173
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• 2010

학문의 발전과 주제의 다양화로 인하여 각계의 연구자들은 자신에게 필요한 정보를 정확하게 찾을 필요성이 커지고 있다. 그리하여 본 논문에서는 효율적인 참고문헌 추출 방법으로 중복된 참고문헌을 비교 분석하여 자동으로 매핑해주는 시스템을 구축하고, 한의학 사전을 통한 한자의 오타를 교정할 수 있는 방법을 연구하였다. 이러한 방법을 적용함으로써 참고문헌의 중복입력과 한자오류를 개선할 수 있었다.

• 생약학회지
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• 제40권4호
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• pp.339-344
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• 2009

Diabetic cataract is a major complication of diabetes mellitus. Excess accumulation of sorbitol plays an important role in the pathogenesis of diabetic complications such as cataract formation. In this study, we investigated the inhibitory effect of the extract of the aerial parts of Aster koraiensis (AK) on diabetic cataractogenesis. To examine this further, we evaluated sorbitol accumulation during cataract development using streptozotocin-induced diabetic rat, an animal model of type 1 diabetes. Diabetic rats were treated orally with AK (100 mg/kg and 200 mg/kg body weight) once a day orally for 9 weeks. In vehicle-treated diabetic rats, lens opacity was increased, and lens fiber swelling and membrane rupture were observed. In addition, sorbitol accumulation in diabetic lens was markedly enhanced. However, AK treatment delayed the progression of diabetic cataract through the inhibition of sorbitol accumulation, and prevented lens fiber degeneration in a dose-dependent manner. These observations suggest that AK treatment can delay the progression of lens opacification in the diabetic rats during the early diabetic cataractogenesis.

• 한국한의학연구원논문집
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• 제14권3호
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• pp.137-148
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• 2008

Computerization is recognized as simple supporting tools up to recently but Information is made for the improvement of company's outcome beyond the assistant tools and is emerged as core tools of creating new opportunities for company in point of management strategy. But Information plays minor role in Korean Institute of Oriental Medicine(KIOM) yet. Information has not processed systematically because of lack of understanding and budget in KIOM. The purpose of this research is to make plan for knowledge information which is aimed to make effective supporting and strengthening the ability of KIOM's research, until 2013. Also we tried to find new project s for information and to apply the result to planned information projects. The final goal of this study is to make mid/long-term information plan of KIOM. We applied the general information strategy planning(ISP) method which is progressed as analysis of information technology, analysis of information status, design of future model and extraction of action plan order. First, we examined the information elements for the advanced management from analysis of management environment and analyzed information technology trends. Second, we list up the gaps and problems of KIOM's information status and define the future model to solve this problems. It is showed the road map of time and budget for future model to progress systematically inner-information of purpose. We hope that information of KIOM will be conducted successfully.

• Integrative Medicine Research
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• 제6권4호
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• pp.395-403
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• 2017

Background: Gamisoyosan (GSS) is an herbal formula which has been used to treat women's diseases for several hundred years in Korea. GSS is one of the three most common prescriptions among women and is used to treat menopausal symptoms. Fatty liver disease is also common in postmenopausal women and can precede more severe diseases, such as steatohepatitis. The present study compared the effects of GSS on fatty liver using three different formulae, Dongui-Bogam (KIOM A), Korean Pharmacopeia (KIOM B) and Korean National Health Insurance (KIOM C). Methods: In oleic acid-induced HepG2 fatty liver cells, cellular lipid accumulation, triglycerides and total cholesterol were measured after treatment with three GSS formulae and simvastatin as a positive control. To investigate the phytoestrogen activity of GSS, MCF-7 cells were treated with GSS, and hormone levels were quantified. Also, qualitative analysis was performed with UPLC. Results: All types of GSS decreased cellular lipid accumulation. KIOM A was slightly less effective than the other two GSS formulae. KIOM B and KIOM C decreased cellular triglycerides more effective than simvastatin, but KIOM A did not affect cellular triglycerides. Cellular total cholesterol was decreased by all GSS and simvastatin. GSS showed phytoestrogen activity in MCF-7 cells. From the UPLC analysis data, geniposide, paeoniflorin and glycyrrhizin were detected form three GSS formulae. Conclusion: These results suggest that all GSS formulae have a beneficial effect on fatty liver disease during menopause and that differences of formula have no effect on the efficacy of the prescription.

• Journal of Ginseng Research
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• 제48권4호
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• pp.384-394
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• 2024

Background: Herpes simplex virus type 1 (HSV-1), known to latently infect the host's trigeminal ganglion, can lead to severe herpes encephalitis or asymptomatic infection, potentially contributing to neurodegenerative diseases like Alzheimer's. The virus generates reactive oxygen species (ROS) that significantly impact viral replication and induce chronic inflammation through NF-κB activation. Nuclear factor E2-related factor 2 (Nrf2), an oxidative stress regulator, can prevent and treat HSV-1 infection by activating the passive defense response in the early stages of infection. Methods and results: Our study investigated the antiviral effects of ginsenoside Rg5, an Nrf2 activator, on HSV-1 replication and several host cell signaling pathways. We found that HSV-1 infection inhibited Nrf2 activity in host cells, induced ROS/NF-κB signaling, and triggered inflammatory cytokines. However, treatment with ginsenoside Rg5 inhibited ROS/NF-κB signaling and reduced inflammatory cytokines through NRF2 induction. Interestingly, the Nrf2 inhibitor ML385 suppressed the expression of NAD(P)H quinone oxidoreductase 1(NQO1) and enhanced the expression of KEAP1 in HSV-1 infected cells. This led to the reversal of VP16 expression inhibition, a protein factor associated with HSV-1 infection, thereby promoting HSV-1 replication. Conclusion: These findings suggest for the first time that ginsenoside Rg5 may serve as an antiviral against HSV-1 infection and could be a novel therapeutic agent for HSV-1-induced neuroinflammation.

• 대한한의학회지
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• 제32권5호
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• pp.66-77
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• 2011

Objectives: This study aimed to make preliminary data through the bibliometric analysis of journals registered by national research foundations of Korea for the improvement of traditional Korean medical (TKM) journals. Methods: We collected 4,396 articles from the OASIS database, which is composed of articles published by TKM societies and institutes. First, we analyzed the 'authors by year', 'average authors per article', 'articles by institute' and 'authors by institute' to get the author-related conditions. Second, we analyzed the 'reference type', 'cited times', 'IF with self citation' and 'IF without self citation' to get the citation condition. Results: First, we found that the journal order of total authors was KAOOMP (2362), KOMS (1189), and KAMS (967), and of average authors per article was KAMS (5.29), KOIMS (5.25), and KOMS (4.75). Second, we learned that the journal order of occupied article ratio by high rank institutes was SCMS (92.4%), MAS (90.03%), and KOPS (87.22%) and of occupied author ratio by high rank institutes was KOPMS (96.55%), MAS (95.19%), and SCMS (93.85%). Third, we analyzed the most highly cited reference type by journals and we found that OMCS was books, SCMS was oriental medical journals and the other 10 journals were not oriental medical journals. Finally, we observed that the journal order of self citation ratio was SCMS (16.79%), KMAS (11.77%), and OOGS (11.67%) and also that the IF order was KAMS (0.675), OOGS (0.546), and KAOH (0.430). Conclusions: Through this study we found that TKM research leans too much toward on oriental medical universities, so we insist that TKM R&D institutes must be expanded. We also found that the self citation ratio was high in TKM journals, so the ratio must be decreased to improve the quality of the TKM journals.