• Journal of Medicine and Life Science
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• 제15권2호
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• pp.72-78
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• 2018

We investigated the effect of KIOM-79, 80% ethanolic extract of herbal prescription isolated from Magnolia officinalis, Pueraria lobate, Glycyrrhiza uralensis, and Euphorbia pekinensis, on streptozotocin-induced diabetes in Sprague-Dawley rats. The rats were treated orally with KIOM-79 (500 mg/kg/day) 1) for 3 days prior to streptozotocin (60 mg/kg, intraperitoneal) injection or 2) for 9 weeks after establishing diabetes model to examine acute and chronic effects on hyperglycemia and biochemical variables, respectively. As a result, KIOM-79 had little effects on hyperglycemic changes in acute model. Sexual comparison, however, showed reduced hyperglycemia in female rats, especially 24 hours after streptozotocin injection with or without KIOM-79 pretreatment. In chronic model, streptozotocin-induced hyperglycemia was well established, but KIOM-79 treatment showed no statistically significant effects on all variables. Thus, based on our findings KIOM-79 might have little effects on streptozotocin-induced insulin-dependent diabetes although it has been known to have hypoglycemic and antidiabetic effects on non-insulin-dependent diabetes models.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2014년도 춘계 종합학술대회 논문집
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• pp.425-426
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• 2014

• 한국한의학연구원논문집
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• 제18권3호
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• pp.141-146
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• 2012

Objectives : KIOM(Korean Institute of Oriental Medicine) built up korean medical paper database and services it through information portal OASIS. The database are updated about 1,600 papers and 48,000 references annually. Because lots of manpower and time are needed to update database, it is very important to raise up efficiency and quality of it. Methods : In this paper, we implemented web based database building system utilizing pre-built OASIS' database to improve the working process, data quality and ease of management. Results : First we designed and implemented web based system to input bibliography of the paper efficiently. It raised efficiency using OASIS' paper and reference database. Second we improved the refining process using web based system to raise up data quality. And third we developed the manager functions of web based system to control and check the working process. Conclusions : If we add korean medical dictionary and link outside paper database in the future, we hope that work efficiency and data quality will be raised more. And because the database schema of OASIS system and developed system are different, we are implementing the data transformation system.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2011년도 춘계학술발표회
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• pp.416-417
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• 2011

• Korean Journal of Acupuncture
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• 제28권3호
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• pp.53-62
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• 2011

Objectives : Burn is most common adverse events of moxibustion. Various kinds of components influence on the heat stimulation of commercial indirect moxa, but there are not enough investigation about the status. The purpose of this study is to investigate the 6 components to build a base data that is currently available to build a standard of an indirect moxibustion. Methods : The length and weight, density, thickness of the paper disk, diameter of the paper disk, and diameter in the paper disk hole were measured against 6 kinds of commercial indirect cautery. Results : 1. 'Seoam', 'Kihwang' and 'Taegeuk' shows uniform length than the other brands. 2. 'Dongbang', 'Kihwang' and 'Taegeuk' shows uniform weight than the other brands. 3. 'Dongbang', 'Kihwang' and 'Taegeuk' shows uniform density than the other brands. 4. 'Dongbang' and 'Kihwang' shows uniform thickness than the other brands. 5. 'Seoam', 'Dongbang' and 'Taegeuk' shows uniform diameter of disc hole than the other brands. Conclusions : As a result of investigation, 'Dongbang' and 'Kiwhang' indirect moxibustion was identified as a uniform product. This results are considered as an important base materials of the KS through commercial indirect moxibustion.

• 한국한의학연구원논문집
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• 제18권2호
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• pp.131-137
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• 2012

Objectives : Primo vascular system is known to new circulatory system and suggested as a anatomical structure of meridian system. Primo-vessels are present throughout the whole body. The purpose of this study is to identify primo tissues taken from falciform ligament and to compare with organ surface primo tissue, blood vessel and lymph vessel. Methods : Male Sprague-Dawley rats (8weeks old, 250~320g) used for this study. The medial line of the abdomen was dissected and searched for primo tissues in falciform ligament and on the internal organs using stereomicroscope. We performed serial cross section and histological investigations. The tissues were stained with hematoxylin-eosin and Masson's trichrome. Results : 1. The primo tissues attached on the falciform ligament had white color and length of 5~8mm. 2. We could observe primo tissues are classified with ligament tissues. 3. Histologically, primo tissue on falciform ligament and organ surface primo tissue could be considered same tissue. Conclusions : In this study, we observed primo tissue discovered on the falciform ligament. And we also histologically compared such discovered primo tissue with organ surface primo tissue. Consequently, we could consider that two tissues have histological similarity and possibility of connection in one network system.

• 대한한의학회지
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• 제31권4호
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• pp.49-62
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• 2010

Objectives: Current information & communication technology is advancing very rapidly and the ripple effects are spreading all over society traditional Korean medicine (TKM) is no exception. We draw up afuture plan and target system's architecture of KIOM's OASIS to follow the information change and reinforce the supporting infra for TKM research. Methods: First, we analyzed the information circumstances of western and eastern medicine, both overseas and domestic, especially investigating the detailed changes domestically. Second, we grasped the present conditions of OASIS and compared it with other information portals. Finally, we drew a future plan and system architecture from the analysis results. Results: First, the information status of western medicine is much more advanced than TKM's, and overseas information circumstances are likewise more developed than domestics. Second, we found that OASIS is performing the central research infra role well in TKM. Finally we designed an information system architecture which is composed of an infra layer, an application layer and a service layer. Conclusion: We must integrate information materials such as literature, research manpower, facilities and standards to make TKM's knowledge portal successful. In detail, we have to make TKM's information classification code, build up the electronic TKM library and offer complementary and alternative medicine (CAM) trends.

• 약학회지
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• 제59권3호
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• pp.92-97
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• 2015

KIOM-MA128 is a novel Korean herbal medicine with anti-atopic, anti-inflammatory and anti-asthmatic effects. This article presents the first pharmacokinetic study on KIOM-MA128. The purpose of this study was to characterize a pharmacokinetic characteristic of matrine, a potential marker of KIOM-MA128, in rats using population pharmacokinetic model. 1, 2 and 8 g/kg of KIOM-MA128 were administered to rats orally and plasma concentrations of matrine was determined by HPLC-MS/MS. Non-compartmental analysis (NCA) was performed using Phoenix$^{(R)}$ and pharmacokinetic model was built using NONMEM$^{(R)}$. This model was validated with internal validation which is visual predictive check (VPC) and bootstrap. The NCA result of matrine showed that $C_{max}$ was 294.24, 552.22 and 868.65 ng/ml, $AUC_{inf}$ was 1273.05, 2724.76 and $9743.25ng{\cdot}hr/ml$ and $T_{max}$ was 1, 1.3 and 2.3 hr for the doses of 1, 2, and 8 g/kg, respectively. The rat plasma concentrations were described very well with one-compartment model. Pharmacokinetic model for matrine was successfully developed and evaluated. Finally, our model is helpful to understand pharmacokinetic characteristic of KIOM-MA128.

• 한국한의학연구원논문집
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• 제18권1호
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• pp.35-43
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• 2012

Objectives: Hypertension is the highest ratio among chronic disease in Korea, and the western medical information about hypertension is provided by many web sites. Advanced researches about hypertension have been conducted in Traditional Korean Medicine(TKM) for decades, but the research results are not arranged. So the results have not been utilized in following research nor contributed to the expansion of public knowledge. Methods : We did this study to improve this situation. In this study, we built database about advanced research articles related hypertension in TKM and implemented TKM information system of hypertension. Results : First, we benchmarked hypertension information systems and designed the TKM information system based on the benchmarking results and comments from TKM doctors. And it was composed of introduce, treatment, and etc. Second, we built prescription, herb, acumoxa, qigong, prevention/management, and pill database which is about 600 data extracted from papers and books. Third, we implemented JAVA/JSP based web information system which provides the database. And we created links for the each papers and books to use more easily. Conclusions : If we provide the research results about TKM hypertension diagnosis and combinational medication of western and oriental medicine, this information system will be more useful. And if we add internal and external project report about hypertension, it will be more worthy.

• Korean Journal of Acupuncture
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• 제28권4호
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• pp.17-28
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• 2011

Objectives : Burn is the important adverse effect of the moxibustion treatment. This research does with the purpose to utilize as basic data which the results of histological observation of the burn tissue which generates when operating various commercial indirect moxa (CIM) on the skin, evaluate the burn because of the surgical operation. Methods : It operated 6 kinds of CIM on the depilated abdomen of the rat. By using the H-E staining and TUNEL assay, the image was observed and analyzed. Results : It could be the moxibustion medical treatment using the CIM generated in the first degree burn until the third degree. And in some case, burn has not generated. By using the H-E stain, the second-degree burn and third degree was observed, and it was observed the first degree burn by using TUNEL assay. In the first degree burn, TUNEL reaction in the epidermal layer was confirmed. The damage to the dermal layer was observed in more than 2 degree burn. In the third degree, the tissue degeneration to the subcutaneous fat was observed but the thickness of the skin tissue was not observed. Conclusions : Basic data classifying the burn generated by the CIM treatment through the histological observation of the burn tissue caused by the CIM treatment were built according to this research result.