• 제목/요약/키워드: KFDA

검색결과 710건 처리시간 0.048초

The Study on the drug pharmacokinetics according to the progression of liver disease

  • Sohn, Soo-Jung;Choi, Hong-Serck;Ahn, Mee-Ryung;Chung, Hye-Joo;Yoo, Tae-Moo;Lee, Min-Ho;Park, Moon-Seung;Shin, In-Chul;Kim, Ju-ll
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.308.1-308.1
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    • 2003

  • We underwent this study to know correlation between the amount of portosysternic shunt/hepatic fibrosis and bioavailability parameters such as AUC, Cmax, Tmax and t1 /2 of high extraction ratio drug, propranolol, in CCl4-induced liver cirrhosis model of rats. This study describes the bioavaility study of propranolol(5 mg/kg), Shunt Index using thallium-201 per rectum scintigraphy to to measure the amount of portosystemic shunt indirectly and intrahepatic hydroxyproline content performed in the CCl4-induced liver cirrhosis model of rats. (omitted)

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CELL-DEATH MECHANISMS OF MPTP-INDUCED PARKINSONISM

  • Kim, J.M.;Park, C.W.;J.J. O;T.S. Kang;K.W. Seo;S.K. Seo;Kim, K.B.;Kim, J.W.;Lee, S.H.
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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    • pp.158-158
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    • 2001

  • The cause of Parkinson's disease (PD) is largely unknown. However, free radical toxicity may playa role in the degeneration of substantia nigra, which is the major focus of pathological damages in PD. Recently, a neuroprotective effect of nicotine in PD has been suggested.(omitted)

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THE EFFECTS OF PHTHALATES AND CLOFIBRATE ON THE OXIDATIVE DAMAGE AND ACTIVITIES OF METABOLIZING ENZYMES IN THE RATS

  • K.W. Seo;Kim, K.B.;Kim, Y.J.;Kim, J.M.;Kim, J.G.;Park, M.S.;Park, J.Y.;Park, K.S.;Lee, S.H.
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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    • pp.159-159
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    • 2001

  • The phthalates have been shown to produce hepatic peroxisome proliferation and certain peroxisome proliferators (PPs) are also known to increase the incidence of liver tumors in rodents. In this study we investigated the correlation between oxidative injury, changes in peroxisomal and microsomal enzymes and tumor formation in PP-treated rats.(omitted)

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THE EFFECTS OF PHTHALATES AND CLOFIBRATE ON THE OXIDATIVE DAMAGE AND ACTIVITIES OF METABOLIZING ENZYMES IN THE RATS

  • K.W. Seo;Kim, K.B.;Kim, Y.J.;Kim, J.M.;Kim, J.G.;Park, M.S.;Park, J.Y.;Park, K.S.;Lee, S.H.
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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    • pp.169-169
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    • 2001

  • The phthalates have been shown to produce hepatic peroxisome proliferation and certain peroxisome proliferators (PPs) are also known to increase the incidence of liver tumors in rodents. In this study we investigated the correlation between oxidative injury, changes in peroxisomal and microsomal enzymes and tumor formation in PP-treated rats.(omitted)

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REPEATED DOSE (28 DAYS) ORAL TOXICITY STUDY IN RATS, BASED ON THE PROTOCOL (OECD TEST GUIDELINE NO. 407) TO SCREEN ENDOCRINE-DISRUPTING CHEMICALS

  • Shin, Jae-Ho;Kim, Hyung-Sik;Moon, Hyun-Ju;Kim, Tae-Sung;Kang, Il-Hyun;Seok, Ji-Hyun;Ki, Ho-Yun;Shim, Eun-Yong;Jang, Hae-Jin;Jeung, Eui-Bae;Han, Soon-Young
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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    • pp.128-128
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    • 2002

  • In association with the international validation project to establish a test protocol for the "Enhanced OECD Test Guideline 407", we performed a 28-day repeated-dose toxicity study of vinclozolin (VCZ), an androgen antagonist, and ketoconazole (KCZ), a biosynthesis inhibitor of testosterone (T), and assessed the sensitivity of new parameters for detecting endocrine-related effects of endocrine-disrupting chemicals.(omitted)

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