Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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THE EFFECTS OF PHTHALATES AND CLOFIBRATE ON THE OXIDATIVE DAMAGE AND ACTIVITIES OF METABOLIZING ENZYMES IN THE RATS

  • K.W. Seo (Dept. of Pharmaco1., National Institute of Toxicological Research, KFDA) ;
  • Kim, K.B. (Dept. of Pharmaco1., National Institute of Toxicological Research, KFDA) ;
  • Kim, Y.J. (Dept. of Pharmaco1., National Institute of Toxicological Research, KFDA) ;
  • Kim, J.M. (Dept. of Pharmaco1., National Institute of Toxicological Research, KFDA) ;
  • Kim, J.G. (Dept. of Pharmaco1., National Institute of Toxicological Research, KFDA) ;
  • Park, M.S. (Dept. of Pharmaco1., National Institute of Toxicological Research, KFDA) ;
  • Park, J.Y. (Dept. of Pharmaco1., National Institute of Toxicological Research, KFDA) ;
  • Park, K.S. (Dept. of Pharmaco1., National Institute of Toxicological Research, KFDA) ;
  • Lee, S.H. (Dept. of Pharmaco1., National Institute of Toxicological Research, KFDA)
  • Published : 2001.05.01
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Abstract

The phthalates have been shown to produce hepatic peroxisome proliferation and certain peroxisome proliferators (PPs) are also known to increase the incidence of liver tumors in rodents. In this study we investigated the correlation between oxidative injury, changes in peroxisomal and microsomal enzymes and tumor formation in PP-treated rats.(omitted)

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