• Proceedings of the PSK Conference
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• 2003.04a
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• pp.183.2-184
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• 2003

Zinc is known to have an inhibitory effect on apoptosis and an antioxidative effect scavenging reactive oxygen species (ROS) under oxidative stress. We studied the influence of zinc on cadmium-induced apoptosis especially associated with ROS in MCF-7 human breast carcinoma cell line. For the determination of appropriate experimental concentration and time, we excecuted MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide] assay and DNA fragmentation assay. (omitted)

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.187-187
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• 2003

The aims of present study were to compare the effects of in utero exposure to diethylstibestrol (DES), di(n-butyl)phthalate (DBP) and flutamide on the development of reproductive organs and to investigate the specific mechanisms of these abnormalities in the male reproductive system.During gestation days 10-19, pregnant Sparague-Dawley (SD) female rats were administered orally with corn oil (control), DES (25, 50, or 100 ${\mu}$/kg/day), (omitted)

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.134.2-135
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• 2003

A large number of chemical pollutants including phthalates, alkylphenolic compounds, organochlorine pesticides and bisphenol A have the ability to disrupt endocrine function in animals. and alter cognitive function. Because hormone mediated events playa important role in central nervous system development and functions. The speculations that the changes in cognitive function are mediated by the endocrine-like action of these chemicals. (omitted)

• KSBB Journal
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• v.18 no.2
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• pp.90-93
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• 2003

Six heavy metals (lead, copper, cadmium, chromium, mercury and arsenic) were analyzed in 9 oriental medical materials(Paeoniae Radix Alba, Zizyphi Fructus, Cnidii Rhizoma, Rehmanniae Radix Preparata, Angelicae Gigantis Radix, Astragali Radix, Glycyrrhizae Radix, Cinnamomi Cortex Spissus, and Zingiberis Rhizoma Crudus) by inductively coupled plasma atomic emission spectrometry (ICP-AES). The heavy metal contents of Zingberis Rhizoma Crudus and Angelicae Gigantis Radix were 44.0 and 37.3 mg/kg, respectively, which were 1.47 and 1.24 times higher than the guideline set by the Korean Food and Drug Administration (KFDA). Washing with deionized water lowered the heavy metal contents by 20-38%, and reduced levels to below the guidelines set by KFDA.

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.05a
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• pp.80-80
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• 2003

The use of skin whitening agents have been recently increased in various kinds of cosmetic products, although there were reports that whitening agents might cause allergic contact dermatitis. A murine local lymph node assay (LLNA) has been developed as an alternative to guinea pigs for contact sensitization potential. This study was carried out to investigate the skin sensitization potential of three whitening agents, kojic acid, arbutin, azelaic acid, by LLNA using a non-radioistopic endpoint.(omitted)

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.05a
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• pp.109-109
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• 2002

Alzheimer's disease (AD) is characterized by $\beta$-amyloid deposition and associated with loss of neuron cells in brain regions involved in learning and memory process. Many cases of early onset autosomal dominant inherited forms of AD are caused by mutation in the genes encoding presenilin-2 (PS-2).(omitted)

• Food Science and Biotechnology
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• v.16 no.1
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• pp.142-145
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• 2007

The levels of citrinin and monacolin K in ten commercial Korean Monascus fermentation products were determined. The products contained citrinin at levels ranging from 0.64 to $112.27\;{\mu}/kg$, with only 2 exceeding the limit of $50\;{\mu}g/kg$ set by the Korea Food and Drug Administration (KFDA). The levels of monacolin K ranged from 0.87 to 1,030 mg/kg, however 6 products contained monacolin K at levels lower than 500 mg/kg, the level required by KFDA to be claimed as a functional food. Therefore, many commercial Korean Monascus fermentation products should be considered safe, however many need to be improved before being considered as functional dietary supplements.

• Nuclear Medicine and Molecular Imaging
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• v.40 no.2
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• pp.66-73
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• 2006

Monoclonal antibodies are designed to bind specifically to certain antigen, give therapeutic effect to the target and to be produced in large scale with homogeneity. The monoclonal antibodies conjugated with radionuclide can deliver therapeutic irradiation to the target, and showed successful results in certain malignancies, which is known as radioimmunotherapy. The target-to-background ratio depends on the antigen expression in the target and normal tissues, which is related to the therapeutic efficacy and toxicity in radioimmunotherapy. For the solid tumor beta-ray energy should be high, but lower beta energy is better for the hematological malignancies. I-l31 is widely used in thyroid cancer with low cost and high availability. Labeling monoclonal antibody with I-131 is relatively simple and reproducible. Some preclinical data for the I-131 labeled monoclonal antibodies including acute toxicity and efficacy are available from already published literatures in KIRAMS, physician sponsored clinical trial protocols using Rituximab, KFDA approved anti-CD20 chimeric monoclonal antibody and I-131 were approved by KFDA and currently are ongoing.

• Nuclear Medicine and Molecular Imaging
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• v.40 no.2
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• pp.53-57
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• 2006

Radionuclide therapy has been used for more than 50 years and proved to be a safe and effective modality. However, the patients' right to have the excellent medical service is seriously disturbed by excessive regulations of government institutions such as Korea Institute of Nuclear Safety (KINS), Health Insurance Review Agency (HIRA) and Korea Food and Drug Administration (KFDA). For example, the patients should wait for more than 6 months to have I-131 treatment in many hospitals it is strongly recommended to mitigate the regulations to resonable levels to solve the problems. If HIRA allow the hospitals to charge reasonable rate for radionuclide therapy room, then more hospitals would invest to build the radionuclide therapy rooms and the patients' waiting time would decrease. The waiting time would also decrease, if KINS allow 2 patients to share a radionuclide therapy room. Finally, it is strongly recommended to lower the threshold for approval of new therapeutic radiopharmaceuticals by KFDA, which would allow new effective therapeutic raoiopharmaceuticals to be introduced to clinical practices more easily.

• Journal of Information Processing Systems
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• v.15 no.4
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• pp.957-966
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• 2019

This paper studies a novel approach to natural gait cycles based gait recognition via kernel Fisher discriminant analysis (KFDA), which can effectively calculate the features from gait sequences and accelerate the recognition process. The proposed approach firstly extracts the gait silhouettes through moving object detection and segmentation from each gait videos. Secondly, gait energy images (GEIs) are calculated for each gait videos, and used as gait features. Thirdly, KFDA method is used to refine the extracted gait features, and low-dimensional feature vectors for each gait videos can be got. The last is the nearest neighbor classifier is applied to classify. The proposed method is evaluated on the CASIA and USF gait databases, and the results show that our proposed algorithm can get better recognition effect than other existing algorithms.