• Nonlinear Functional Analysis and Applications
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• v.26 no.1
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• pp.93-104
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• 2021

In this paper, we present a fixed point theorem for a family of generalized condensing multimaps which have ranges of the Zima-Hadžić type in Hausdorff KKM uniform spaces. It extends Himmelberg et al. type fixed point theorem. As applications, we obtain some new collective fixed point theorems for various type generalized condensing multimaps in abstract convex uniform spaces.

• Journal of the Chungcheong Mathematical Society
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• v.34 no.4
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• pp.345-353
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• 2021

In this paper, first, we present new fixed point theorems for Mönch type multimaps on abstract convex uniform spaces and, also, a fixed point theorem for Mönch type multimaps in Hausdorff KKM L𝚪-spaces. Second, we show that Mönch type multimaps in the better admissible class defined on an L𝚪-space have fixed point properties whenever their ranges are Klee approximable. Finally, we obtain fixed point theorems on 𝔎ℭ-maps whose ranges are 𝚽-sets.

• Journal of the Korean Mathematical Society
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• v.45 no.1
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• pp.1-27
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• 2008

We introduce a new concept of convex spaces and a multimap class K having certain KKM property. From a basic KKM type theorem for a K-map defined on an convex space without any topology, we deduce ten equivalent formulations of the theorem. As applications of the equivalents, in the frame of convex topological spaces, we obtain Fan-Browder type fixed point theorems, almost fixed point theorems for multimaps, mutual relations between the map classes K and B, variational inequalities, the von Neumann type minimax theorems, and the Nash equilibrium theorems.

• Nonlinear Functional Analysis and Applications
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• v.26 no.1
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• pp.165-175
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• 2021

In this article we derive some best approximation theorems for multimaps in abstract convex metric spaces. We are based on generalized KKM maps due to Kassay-Kolumbán, Chang-Zhang, and studied by Park, Kim-Park, Park-Lee, and Lee. Our main results are extensions of a recent work of Mitrović-Hussain-Sen-Radenović on G-convex metric spaces to partial KKM metric spaces. We also recall known works related to single-valued maps, and introduce new partial KKM metric spaces which can be applied our new results.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.6
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• pp.738-744
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• 2013

The purpose of this study is to investigate effects of White Ginseng-Ejung-tang water extract (EJ) on production of various cytokines such as interleukin (IL)-2, IL-5, IL-6, IL-10, IL-12p70, macrophage inflammatory protein (MIP)-2, vascular endothelial growth factor (VEGF), keratinocyte-derived chemokine(KC), tumor necrosis factor (TNF)-${\alpha}$, and granulocyte macrophage colony-stimulating factor (GM-CSF) in RAW 264.7 mouse macrophages stimulated by lipopolysaccharide (LPS). Levels of cytokines were measured by High-throughput multiplex bead array cytokine assay based on xMAP (multi-analyte profiling beads) technology. EJ significantly decreased levels of IL-2, IL-12p70, IL-5, MIP-2 for 24 h incubation at the concentrations of 25, 50, and 100 ${\mu}g/mL$ in LPS-induced RAW 264.7 (P < 0.05). EJ significantly decreased levels of IL-6 at the concentrations of 50 and 100 ${\mu}g/mL$ (P < 0.05). EJ significantly decreased levels of IL-10 and VEGF at the concentrations of 25 and 100 ${\mu}g/mL$ (P < 0.05). EJ significantly decreased levels of KC at the concentrations of 100 ${\mu}g/mL$ (P < 0.05). EJ did not show any significant effect on TNF-${\alpha}$ and GM-CSF production. These results suggest that EJ has anti-inflammtory property related with its inhibition of IL-2, IL-5, IL-6, IL-10, IL-12p70, MIP-2, VEGF, and KC production in LPS-induced macrophages.

• The Journal of Korean Medicine
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• v.33 no.4
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• pp.42-49
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• 2012

Objectives: The purpose of this study was to investigate effects of Red Ginseng-Ejung-tang Water Extract (ER) on cytokine production in RAW 264.7 mouse macrophages stimulated by lipopolysaccharide (LPS). Methods: Levels of various cytokines such as interleukin (IL)-6, IL-10, IL-2, IL-12p70, vascular endothelial growth factor (VEGF), monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-2, keratinocyte-derived chemokine (KC), tumor necrosis factor (TNF)-alpha, granulocyte macrophage colony-stimulating factor (GM-CSF) were measured by high-throughput multiplex bead array cytokine assay based on xMAP (multi-analyte profiling beads) technology. Results: ER significantly decreased levels of IL-6, IL-10, IL-2, IL-12p70, VEGF, and MCP-1 for 24 hrs incubation at the concentrations of 25, 50, and $100{\mu}g/mL$ in LPS-induced RAW 264.7 cells (P < 0.05). But ER did not exert significant effects on production of MIP-2, KC, TNF-${\alpha}$, and GM-CSF in LPS-induced RAW 264.7 cells. Conclusions: These results suggest that ER has an anti-inflammatory property related with its inhibition of cytokine production in LPS-induced macrophages.

• Proceedings of the Korea Institutes of Information Security and Cryptology Conference
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• 2006.06a
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• pp.356-360
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• 2006

Recently, many power analysis attacks have been proposed. Since the attacks are powerful, it is very important to implement cryptosystems securely against the attacks. We propose countermeasures against power analysis attacks for elliptic curve cryptosystems based on Koblitz curves (KCs), which are a special class of elliptic curves. That is, we make our countermeasures be secure against SPA, DPA, and new DPA attacks, specially RPA, ZPA, using a random point at each execution of elliptic curve scalar multiplication. And since our countermeasures are designed to use the Frobenius map of KC, those are very fast.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.3
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• pp.587-594
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• 2005

In the paper, after we propose a viterbi decoder which has multiple buffering and parallel processing decoding scheme through expanding time-divided imput signal, and map a FPGA, we implement a channel coding system together with PC-based software. Continuous input signal is buffered as order of decoding length and is parallel decoded using a high speed cell for viterbi decoding. Output data rate increases linearly with the cell formed the viterbi decoder, and flexible operation can be satisfied by programming controller and modifying input buffer. The tell for viterbi decoder consists of HD block for calculating hamming distance, CM block for calculating value in each state, TB block for trace-back operation, and LIFO. The implemented cell of viterbi decoder used 351 LAB(Logic Arrary Block) and stably operated in maximum 139MHz in APEX20KC EP20K600CB652-7 FPGA of ALTERA. The whole viterbi decoder including viterbi decoding cells, input/output buffers, and a controller occupied the hardware resource of $23\%$ and has the output data rate of 1Gbps.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.4
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• pp.586-591
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• 2010

Chemokine and Growth Factor are major mediumtors of immuno-inflammatory pathway. The purpose of this study is to investigate whether productions of Chemokine and Growth Factor in lipopolysaccharide (LPS)-induced mouse macrophage RAW 264.7 cells are modulated by Gallic acid (GA), which is easily founded in tannin-containing natural materials such as red wine, green tea, grape juice, and Corni Fructus. Productions of Chemokine and Growth Factor were analyzed by High-throughput Multiplex Bead based Assay with Bio-plex Suspension Array System based on $xMAP^{(R)}$ (multi-analyte profiling beads) technology. At first, cell culture supernatant was obtained after treatment with LPS and GA for 24 hour. Then, the antibody-conjugated beads were added and incubated for 30 minutes. After incubation, detection antibody was added and incubated for 30 minutes. And Strepavidin-conjugated Phycoerythrin (SAPE) was added. After incubation for 30 minutes, the level of SAPE fluorescence was analyzed on Bio-plex Suspension Array System. Based on fluorescence intensity, concentrations of Chemokine and Growth Factor were determined. The results of the experiment are as follows. GA significantly inhibited the production of interferon-inducible protein (IP)-10, keratinocyte-derived chemokine(KC), and vascular endothelial growth factor (VEGF) in LPS-induced RAW 264.7 cells at the concentration of 25, 50, 100, 200 uM (p<0.05). GA significantly inhibited the production of monocyte chemoattractant protein-1(MCP-1) and macrophage-colony stimulating factor(M-CSF) in LPS-induced RAW 264.7 cells at the concentration of 50, 100, 200 uM (p<0.05). GA diminished the production of granulocyte macrophage-colony stimulating factor (GM-CSF) in LPS-induced RAW 264.7 cells. But GA did not show the inhibitory effect on the production of leukemia inhibitory factor (LIP) and macrophage inflammatory protein (MIP)-2 in LPS-induced RAW 264.7 cells. These results suggest that GA has the immuno-modulating activity related with its inhibitory effects on the production of IP-10, KC, MCP-1, VEGF, and M-CSF in LPS-induced macrophages.

• The Korea Journal of Herbology
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• v.29 no.4
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• pp.83-89
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• 2014

Objectives : The purpose of this study was to investigate effects of Houttuyniae Herba water extract (HC) on calcium release and production of various inflammatory mediators such as nitric oxide (NO), interferon-inducible protein (IP)-10, platelet derived growth factor (PDGF)-BB, keratinocyte-derived chemokine (KC), vascular endothelial growth factor (VEGF), interleukin (IL)-4, and IL-5 in lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophages. Methods : NO production was measured by Griess reagent assay. Intracellular calcium level was measured with Fluo-4 assay. Levels of cytokines were measured by High-throughput multiplex bead array cytokine assay based on xMAP (multi-analyte profiling beads) technology. Results : HC significantly decreased NO production for 24 hrs incubation at the concentrations of 10, 25, 50, 100, and $200{\mu}/mL$ in LPS-induced RAW 264.7 (P < 0.05). HC significantly decreased production of IP-10, KC, VEGF, and PDGF-BB for 24 hrs incubation at the concentrations of 50, 100, and $200{\mu}/mL$ in LPS-induced RAW 264.7 (P < 0.05). HC also significantly decreased intracellular calcium release for 24 hrs incubation at the concentrations of 25, 50, 100, and $200{\mu}/mL$ in LPS-induced RAW 264.7 (P < 0.05). But HC did not show any significant effect on production of IL-4 and IL-5 in LPS-induced RAW 264.7. Conclusions : The results suggested that HC has anti-inflammatory property related with its inhibition on the production of NO, IP-10, KC, VEGF, and PDGF-BB in LPS-induced macrophages via calcium pathway.