• Journal of The Korean Astronomical Society
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• v.35 no.4
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• pp.175-185
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• 2002

Almost half of primeval galaxies show P-Cygni type profiles in the Ly$\alpha$ emission line. The main underlying mechanism for the profile formation in these systems is thought to be the frequency re-distribution of the line photons in expanding scattering media surrounding the emission source. A Monte Carlo code is developed to investigate the Ly$\alpha$ line transfer in an optically thick and moving medium with a careful consideration of the scattering in the damping wings. Typical column densities and expansion velocities of neutral hydrogen investigated in this study are $N_{H1}{\~}10^{17-20}\;cm^{-2}$ and ${\Delta}V{\~} 100 km\;s^{-1}$. We investigate the dependence of the emergent profiles on the kinematics and on the column density. Our numerical results are applied to show that the damped Ly$\alpha$ absorbers may possess an expanding H I supershell with bulk flow of ${\~}200 km\;s^{-l}$ and H I column density $N_{H1}{\~}10^{19}\;cm^{-2}$. We briefly discuss the observational implications.

• Biomolecules & Therapeutics
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• v.26 no.1
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• pp.4-9
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• 2018

Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence of oxygen, which in yeast diminishes glycolytic metabolism known as the Pasteur effect. In the past 20 years, the resurgence of interest in cancer metabolism provided significant insights into processes involved in maintenance metabolism of non-proliferating cells and proliferative metabolism, which is regulated by proto-oncogenes and tumor suppressors in normal proliferating cells. In cancer cells, depending on the driving oncogenic event, metabolism is re-wired for nutrient import, redox homeostasis, protein quality control, and biosynthesis to support cell growth and division. In general, resting cells rely on oxidative metabolism, while proliferating cells rewire metabolism toward glycolysis, which favors many biosynthetic pathways for proliferation. Oncogenes such as MYC, BRAF, KRAS, and PI3K have been documented to rewire metabolism in favor of proliferation. These cell intrinsic mechanisms, however, are insufficient to drive tumorigenesis because immune surveillance continuously seeks to destroy neo-antigenic tumor cells. In this regard, evasion of cancer cells from immunity involves checkpoints that blunt cytotoxic T cells, which are also attenuated by the metabolic tumor microenvironment, which is rich in immuno-modulating metabolites such as lactate, 2-hydroxyglutarate, kynurenine, and the proton (low pH). As such, a full understanding of tumor metabolism requires an appreciation of the convergence of cancer cell intrinsic metabolism and that of the tumor microenvironment including stromal and immune cells.

• Korean Journal of Human Ecology
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• v.15 no.2
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• pp.303-316
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• 2006

The present study deals with developing a new modem design of quilt which is characteristic of Korean traditional patterns. The goal of this study is to make some samples of the pattern as a basic motive of quilt work by using some Korean traditional patterns that could be found in roof tiles, windows, Neung-Hwa (a kind of wood cut for printing book covers), and others. This study examines the concept of quilts, their historical background, and their characteristics. This study also examines traditional patterns that are applicable to the patchy work of quilt, discussing the characteristic of both the Korean patterns and Nubi (Korean traditional quilt). In the process of pattern development, the original patterns were simplified and transformed to apply them to the modem quilt pattern. Fabrics (100% cotton) of similar colors were used to emphasize quilting lines. This study has found followings; 1) The geometric pattern usually consists of dots, lines, and faces. These patterns are suitable for pieced quilts. 2) The curvilinear pattern found in roof tiles or Yi-Dynasty coins, can be easily re-expressed by the applique technique. Combinations of fabrics and motive compositions can express quilts in realistic and creative ways. 3) Addition of Korean traditional quilt techniques, such as parallel lines or swastika stitches, to the traditional object-derived quilt patterns led to the creation of images close to the already existing Korean quilt, Nubi.

• Journal of the Society of Naval Architects of Korea
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• v.48 no.3
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• pp.260-266
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• 2011

For long slender offshore structures, such as cables and pipe lines, their interaction with surrounding fluid flow becomes an important issue for global design of ocean systems. We employ a long circular cylinder as a representative case of slender offshore structure. A flexibly mounted cylinder in cross-flow generates complex vortex shedding and results in oscillation of the structure. In this paper, flow behind a circular cylinder at Re=100 is simulated. The vortex shedding pattern and flow induced motion are examined in the cross flow configuration as well as with various yaw-angled configurations. The "Lock-in" phenomenon is also observed when reduced velocity is approximately 4.0. The MAC Grid system, which is the typical grid system for Cartesian mesh and pressure correction methods, are used for solving the incompressible Navier-Stokes equations. Predictor/Corrector method is applied for obtaining a non-linear response of structure at the flexibly mounted. The existance and motion of the body is represented by the immersed boundary technique.

• Journal of Home Health Care Nursing
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• v.19 no.1
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• pp.11-18
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• 2012

Purpose: The aim of this study is to evaluate the efficiency of the outpatient clinics in a hospital, using DEA. Methods: Data were collected using an activity-based costing system, medical information system, and annual reports of customer satisfaction management team of a general hospital in a city. The input variables were the number of doctors, the number of nurses, and the number of staffs. The output variables were the number of treatment times, the number of outpatient clinic patients, the total profits from outpatient clinic, the patient's satisfaction score, and the number of re-visit appointments. EMS Window version 3.1 was used to measure the efficiency score and benchmarking analysis. Results: The average efficiency score of 24 outpatient clinics was about 82.01%. Thirteen outpatient clinics had 100% efficiency score among them. The lowest efficiency score was 57.56%. Conclusion: According to these results, we found that, generally, outpatient clinics were operated very efficiently. However, some outpatient clinics had low efficiency and they needed specialized outcome improvement strategies. To increase the efficiency of inefficient outpatient clinics, we will recommend using results of DEA, as a benchmark point of the most efficient outpatient clinics.

• Journal of the Society of Naval Architects of Korea
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• v.49 no.5
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• pp.410-415
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• 2012

An experimental study is carried out to investigate the near-wake characteristics of a NACA 0018 foil with a flat plate. Two-frame grey-level cross correlation PIV method is used to measure the local flow characteristic around a pitch damping foil to control the vertical motion of high speed crafts in a circulating water channel. The analysis also includes angles of attack 10 and 20 degrees respectively. Reynolds number $Re{\fallingdotseq}3.5{\times}10^4$ based on the chord length(C=100mm) of NACA0018 has been applied during the whole experiments. The distance between the foil and the flat plate is D/C=0.5, 1.0 and 1.5 respectively. The channel effect according as the distance between the foil and the flat plate has a close relation with the velocity distributions around the foil. In the wake of 20-degree of attack, the complex turbulent flow and a thick boundary layer are formed due to the processes of vortex generation and dissipation.

• International Journal of Air-Conditioning and Refrigeration
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• v.14 no.2
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• pp.41-48
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• 2006

Absorption performance at the vertical interface between refrigerant vapor and liquid solution of $LiBr-H_{2}O$ solution was enhanced by the waves formed due to the interfacial shear stress. The present study investigated experimentally and analytically the improvements of absorption performance in a falling film by wavy film flow. The dynamic parameter was the film Reynolds numbers ranged from 50 to 150. The energy and diffusion equations were solved simultaneously to find the temperature and concentration profiles at the interface of liquid solution and refrigerant vapor. Absorption characteristics due to heat and mass transfer were analyzed for the falling film of the LiBr aqueous solution contacted by refrigerant vapor in the absorber. Absorption performance showed a peak value at the solution flow rate of $Re_{f}>100$. Absorption performance for the wavy film flow was found to be greater by approximately 10% than that for uniform film flow. Based on numerical and experimental results, the maximum absorption rate was obtained for the wavy flow caused by spring insert. The difference between the measured and the predicted results were ranged from 5.8 to 12%.

• Nuclear Engineering and Technology
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• v.28 no.3
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• pp.229-246
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• 1996

A mechanistic model has been developed to predict the release behavior of fission gas during steady-state irradiation of LWR UO$_2$ fuel. Under the assumption that UO$_2$ grain surface is composed of fourteen identical circular faces and grain edge bubble can be represented by a triangulated tube around the circumference of three circular grain faces, it introduces the concept of continuous formation of open grain edges tunnels that is proportional to grain edge swelling. In addition, it takes into account the interaction between the gas release from matrix to grain boundary and the reintroduction of gas atoms into the matrix by the irradiation-induced re-solution of grain face bubbles. It also treats analytically the behavior of intragranular, intergranular, and grain edge bubbles under the assumption that both intragranular and intergranular bubbles are uniform in both radius and number density. Comparison of the present model with experimental data shows that the model's prediction produces reasonable agreement for fuel with centerline temperatures of 1000 to 140$0^{\circ}C$, wide scatter band for fuel with centerline temperatures lower than 100$0^{\circ}C$, and underprediction for fuel with centerline temperatures higher than 140$0^{\circ}C$.

• Journal of Preventive Medicine and Public Health
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• v.40 no.2
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• pp.95-101
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• 2007

Focusing on complex diseases of public health significance, strategic issues regarding the on-going Korean Genome Cohort were reviewed: target size and diseases, measurements, study design issues, and follow-up strategy of the cohort. Considering the epidemiologic characteristics of Korean population as well as strengths and drawbacks of current research environment, we tried to tailor the experience of other existing cohorts into proposals for this Korean study. Currently 100,000 individuals have been participating the new Genome Cohort in Korea. Target size of de novo collection is recommended to be set as between 300,000 to 500,000. This target size would allow acceptable power to detect genetic and environmental factors of moderate effect size and possible interactions between them. Family units and/or special subgroups are recommended to parallel main body of adult individuals to increase the overall efficiency of the study. Given that response rate to the conventional re-contact method may not be satisfactory, successful follow-up is the main key to the achievement of the Korean Genome Cohort. Access to the central database such as National Health Insurance data can provide enormous potential for near-complete case detection. Efforts to build consensus amongst scientists from broad fields and stakeholders are crucial to unleash the centralized database as well as to refine the commitment of this national project.

• Restorative Dentistry and Endodontics
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• v.25 no.2
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• pp.219-224
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• 2000

The purpose of this study is for evaluating the effect of MS Coat desensitizing agent in clinical situation. In this study total 60 teeth of 30 patients who is feeling hypersensitivity after periodontal surgery were treated with MS Coat desensitizing agent, and 20 teeth with saline solution for placebo effects and evaluated. All teeth were cleaned with rubber cup and pumice, after then the antibacterial agent was applied for 20 seconds and simply isolated using cotton roll Desensitizing agent was applied with a specific instrument in the manufacturers package by abrading motion for 10 seconds and re-done 8 times. Tactile stimulus with sharp explorer, air stimulus with syringe of dental unit, $7^{\circ}C$ cold water stimulus using micropipette applicator was done to evaluate hypersensitivity before apply test agent, immediate after application, 1 week after, and 3 month after application. The degree of hypersensitivity was recorded using 100mm Visual Analogue Scale and compared between group and evaluation times. From this clinical study sensitivity to the stimulus was significantly induced in both groups and MS Coat made a significant reduction in VAS score than placebo group did(p<.01). The results of this study could demonstrate that MS Coat desensitizing agent can use effectively to heat dentinal hypersensitivity.