• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1505-1510
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• 2012

To aim of this was to observe emodin-mediated cytotoxicity and its influence on Rad51 and ERCC1 expressionin non-small cell lung cancer (NSCLC). NSCLC cells were cultured in vitro with emodin at various concentrations (0, 25, 50, 75 and $100\;{\mu}mol/L$) for 48h and the proliferation inhibition rate was determined by the MTT method. Then, NSCLC were treated with emodin (SK-MES-1 $40\;{\mu}mol/L$, A549 $70\;{\mu}mol/L$) or $20\;{\mu}mol/L$ U0126 (an ERK inhibitor) for 48 h, or with various concentrations of emodin for 48 h and the protein and mRNA expressions of ERCC1 and Rad51 were determined by RT-PCR and Western blot assay, respectively. Emodin exerted a suppressive effect on the proliferation of NSCLC in a concentration dependent manner. Protein and mRNA expression of ERCC1 and Rad51 was also significantly decreased with the dose. Vacuolar degeneration was observed in A549 and SK-MES-1 cell lines after emodin treatment by transmission electron microscopy. Emodin may thus inhibited cell proliferation in NSCLC cells by downregulation ERCC1 and Rad51.

• Journal of Korean Association for Spatial Structures
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• v.12 no.4
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• pp.81-90
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• 2012

The concrete-filled tube (CFT) column has the excellent structural performance. But it is difficult to connect with column and beam because of closed section. Its Solution, 2 members of ㄷchennel in which Internal diaphragm is installed were welded beforehand and the method of making Rectangular Steel Tube was proposed. According to upside and downside junction shape, Internal diaphragm suggested as symmetric specimen and asymmetric specimen. The upper and lower diaphragm of the Symmetric specimen used the same horizontal and The upper diaphragm of the Asymmetric specimen used the horizontal plate and the lower diaphragm used the vertically plate. In this research, 4 T-shape column to beam steps connections were tested with cyclic loading experiment in order to evaluate the structural capability of the offered connection. Symmetric specimens be a failure in 0.03rad from beam flange. And Asymmetric specimens be a failure in 0.05rad from column interface. The comparison results of All specimens shown similar to energy absorption capacity in 0.02rad.

• Journal of the Korean Wood Science and Technology
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• v.35 no.6
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• pp.1-12
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• 2007

For the purpose of effective utilization of domestic second-grown larch as structural members, post and beam construction applying traditional construction to Japanese larch glulam members was adopted with processing by machine pre-cut method. In general, horizontal shear test by KS F 2154 is conducted to assess the horizontal shear properties of the wooden structure by post and beam construction. The frame was consisted of post and beam member with appropriate fasteners, and members have their own processed parts (notch, hole, etc.) that can be well-connected each other. The shear wall was consisted of the frame with screw-nail sheathed panel (OSB). The results of horizontal shear loading tests without vertical loads conducted on the frame and the shear wall structures, the maximum strengths were about 1.9 kN/m and about 9.7 kN/m, the shear rigidities were about 167 kN/rad, 8198 kN/rad, respectively. The strength proportion of the frame specimen was about 20% of the wall's and about 2% in initial stiffness. Nail failures are remarkable on the shear wall specimen with punching shears and shear failures. The shear load factor for the shear wall specimen by the method of Architectural Institute of Japan was 1.5, which was obtained by the bi-linear method. Loading method should be considered to obtain smooth load-deformation relationship. For the better shear performance of the structures, column base and post and beam connections and sheathed panel should be further examined as well.

• Korean Journal of Remote Sensing
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• v.27 no.2
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• pp.171-180
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• 2011

MAI (multiple aperture SAR interferometry) method has been recently developed to improve the measurement accuracy of along-track surface deformation. By means of split-beam SAR processing, this novel technique produces forward- and backward-looking interferograms, which are combined to generate an MAI interferogram. The along-track surface deformation can then be derived from the MAI interferogram. The achieved accuracy of the along-track surface deformation is approximately 8 cm for interferograms with a coherence of 0.6. It is commonly recognized that the topographic phase on an MAI interferogram can be ignored. However, in this paper, we have generated an MAI interferogram from an ALOS P ALSAR interferometric pair spanning the 2010 Haiti earthquake, and shown that the topographic phase distortion on the MAI interferogram can reach to about $3.45{\times}10^{-4}$ rad./m. This distortion corresponds to an along-track surface deformation of about 98 cm. We have proposed an efficient method to remove the topographic phase distortion. After correcting the distortion, the topographic phase distortion on the MAI interferogram is reduced to about $7.82{\times}10^{-6}$ rad./m. This means that the proposed method can effectively remove the topographic distortion on the MAI interferogram to improve along-track surface deformation measurement.

• Structural Engineering and Mechanics
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• v.64 no.5
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• pp.591-610
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• 2017

This paper is concerned with the static analysis of variable thickness of two directional functionally graded porous materials (FGPM) circular plate resting on a gradient hybrid foundation (Horvath-Colasanti type) with friction force and subjected to compound mechanical loads (e.g., transverse, in-plane shear traction and concentrated force at the center of the plate).The governing state equations are derived in terms of displacements based on the 3D theory of elasticity, assuming the elastic coefficients of the plate material except the Poisson's ratio varying continuously throughout the thickness and radial directions according to an exponential function. These equations are solved semi-analytically by employing the state space method (SSM) and one-dimensional differential quadrature (DQ) rule to obtain the displacements and stress components of the FGPM plate. The effect of concentrated force at the center of the plate is approximated with the shear force, uniformly distributed over the inner boundary of a FGPM annular plate. In addition to verification study and convergence analysis, numerical results are displayed to show the effect of material heterogeneity indices, foundation stiffness coefficients, foundation gradient indices, loads ratio, thickness to radius ratio, compressibility, porosity and friction coefficient of the foundation on the static behavior of the plate. Finally, the responses of FG and FG porous material circular plates to compound mechanical loads are compared.

• Economic and Environmental Geology
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• v.49 no.2
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• pp.89-95
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• 2016

Mo isotope, one of highly redox-sensitive isotopes, has been shown to be useful tracers of geochemical processes. Many studies for Mo isotope have documented with the help of recently developed analysis tools, but it has not yet been documented in the Korea. In this study, we introduce two-stage column separation method of Mo using column tube (BioRad PolyPrep(R) column, 10 ml) and anion exchange resin (BioRad Resin AG(R) 1-X8, 200-400 mesh). Mo isotope ratios in the solid SRMs (BHVO-2, SDO-1, PACS-2) and liquid SRM (IAPSO) were measured on MC-ICP-MS (Multi-collector Inductively Coupled Plasma Mass Spectrometer) and then compared with reference Mo isotope ratios. Mo isotope ratios in our study overlap with reference Mo isotope ratios within analytical error.

• Journal of Korean Society of Steel Construction
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• v.27 no.3
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• pp.281-288
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• 2015

Seismic members like damper do not have any treatment of preventing story stiffness reduction after elastic yielding of stories causing story collapse. This paper suggests a method able to prevent story stiffness reduction using high-strength steel. This paper suggests these also : (1) High-strength steel stud column reinforcing story stiffness reduction until story drift 0.02rad can be designed in small area without adjusting layout. (2) Suggested seismic member installing at lowest level shows effects to preventing deformation concentration under huge seismic waves.

• Journal of Power Electronics
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• v.18 no.4
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• pp.1086-1098
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• 2018

This study presents a new sensorless commutation method for brushless direct current motors to replace Hall sensor signals with virtual Hall signals. The importance of the proposed method lies in the simultaneous elimination of the phase shifter and the low-pass filters, which makes the method simple and cost-effective. The method removes high ripple switching noises from motor terminals, thereby decreasing motor losses. The proposed method utilizes unfiltered line voltages with notches caused by current commutation. Hence, specific sign signals are defined to compensate for the effects of commutation noise. The proposed method is free from phase delay that originates from low-pass filters. The method directly produces virtual Hall signals, and thus, it can be interfaced with low-cost commercial commutation integrated circuits based on Hall sensors. Simulation and experimental results show the effectiveness and validity of the proposed method.

• Journal of applied mathematics & informatics
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• v.29 no.3_4
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• pp.763-779
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• 2011

In this paper we apply the Exp-function method to obtain traveling wave solutions of three nonlinear partial differential equations, namely, generalized sinh-Gordon equation, generalized form of the famous sinh-Gordon equation, and double combined sinh-cosh-Gordon equation. These equations play a very important role in mathematical physics and engineering sciences. The Exp-Function method changes the problem from solving nonlinear partial differential equations to solving a ordinary differential equation. Mainly we try to present an application of Exp-function method taking to consideration rectifying a commonly occurring errors during some of recent works.

• Earthquakes and Structures
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• v.13 no.3
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• pp.241-253
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• 2017

In this paper, dynamic response of the horizontal nanofiber reinforced polymer (NFRP) strengthened concrete beam subjected to seismic ground excitation is investigated. The concrete beam is modeled using hyperbolic shear deformation beam theory (HSDBT) and the mathematical formulation is applied to determine the governing equations of the structure. Distribution type and agglomeration effects of carbon nanofibers are considered by Mori-Tanaka model. Using the nonlinear strain-displacement relations, stress-strain relations and Hamilton's principle (virtual work method), the governing equations are derived. To obtain the dynamic response of the structure, harmonic differential quadrature method (HDQM) along with Newmark method is applied. The aim of this study is to investigate the effect of NFRP layer, geometrical parameters of beam, volume fraction and agglomeration of nanofibers and boundary conditions on the dynamic response of the structure. The results indicated that applied NFRP layer decreases the maximum dynamic displacement of the structure up to 91 percent. In addition, using nanofibers as reinforcement leads a 35 percent reduction in the maximum dynamic displacement of the structure.