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Cloning and Characterization of the Paraquat Resistance-Related Genes from Ochrobactrum anthropi JW-2 (Ochrobactrum anthropi JW-2 유래의 Paraquat 내성유전자 PqrA의 주변 유전자군 분석)

  • Bae Eun-Kyung;Lee Hyo-Shin;Won Sung-Hye;Lee Byung-Hyun
    • Microbiology and Biotechnology Letters
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    • v.34 no.1
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    • pp.15-22
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    • 2006
  • A 4,971 bp chromosomal DNA fragment containing the pqrA, paraquat resistance gene, was cloned from Ochrobactrum anthropi JW-2, and the complete nucleotide sequence was determined. Nucleotide and deduced amino acid sequences of the fragment revealed the presence of 4 complete ORFs (orf2, pqrA, orf3, orf4) and two incomplete ORFs(orf1, orf5). Orf1, pqrA, orf4 and orf5 exists at the direct strand but orf2 and orf3 exists at the reverse complementary strand. Orf1 which of incomplete sequences without start codon shares homology with ATP binding region of the response regulator receiver. Orf2 shares high homology with members of the tetR family of transcriptional repressor which have a helix-turn-helix (H-T-H) motif. Therefore, the orf2 is predicted as a transcriptional repressor of pqrA and is designated as pqrR2. Orf3 shares high homology with the members of the lysR family acting as a transcriptional activator which have both of a H-T-H motif at the N-terminal region and substrate binding domain at the C-terminal region. Therefore, the orf3 is predicted as a transcriptional activator of pqrA and is designated as pqrR1. Orf4 shows homology with the periplasmic substrate-binding protein of amino acid ABC transporter. Orf5 which of incomplete sequences without stop codon revealed the homology with the permeases protein of amino acid ABC transporter.

A Study on the cost allocation model of Rollup (Rollup에 의한 사업비 배분모델에 관한 연구)

  • Woo, Sang-Hee
    • Proceedings of the Korean Information Science Society Conference
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    • 2008.06b
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    • pp.19-23
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    • 2008
  • 국제 회계 기준의 도입이 금융 산업 전반에 많은 업무와 IT 시스템의 변화를 요구 하고 있으며, 특히 보험업의 경우 정확한 원가분석을 통한 경쟁력을 갖춘 상품을 판매 하고자 하며, 대다수의 대형 보험사의 경우IT 업무는 Outsourcing을 통해 운영하고 있어, SLA(Service Level Agreement)계약의 정확한 원가를 산정 하고자 한다. 이에 보험 산업에서는 ERP 및 ABC를 도입 하고 있으나, 현재의 원가 산정 방식 시스템은 건 별 배분이 불가 하거나, 작업에 투입되는 시스템 자원 및 인력 비용을 많이 요구 하고 있다. 본 논문에서는 ABC 기반의, IT비용배분과 Rollup에 의한 사업비 배부 모델을 제시 하고, Pilot Test를 통하여 본 연구 모델의 우수성을 증명 하였다.

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Aneurysmal bone cyst of the mandible managed by conservative surgical therapy with preoperative embolization

  • An, Seo-Young
    • Imaging Science in Dentistry
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    • v.42 no.1
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    • pp.35-39
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    • 2012
  • A 9-year-old girl visited our hospital, complaining of a rapid-growing and rigid swelling on the left posterior mandibular area. Panoramic radiograph showed a moderately defined multilocular honeycomb appearance involving the left mandibular body. CT scan revealed an expansile, multilocular osteolytic lesion and multiple fluid levels within cystic spaces. Bone scan demonstrated increased radiotracer uptake and angiography showed a highly vascularized lesion. The lesion was suspected as aneurysmal bone cyst (ABC) and preoperative embolization was performed, which minimize the extent of operation and the surgical complication. The lesion was treated by surgical curettage and lateral decortication with repositioning. No additional treatment such as a surgical reconstruction or bone graft was needed. Early diagnosis of ABC is very important and appropriate treatment should be performed considering several factors such as age, surgical complication, and possibility of recurrence.

A Study on Optimal Evaluation Model for FMSs Using Activity-Based Costing (활동원가를 이용한 FMS의 최적 평가모델에 관한 연구)

  • Kim, Man-Kyun;Hahm, Hyo-Joon
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.19 no.38
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    • pp.147-157
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    • 1996
  • 전통적인 원가계산 시스템에서 원가의 정확성은 생산량의 증감에 다라 변동하는 제조간접비에 의존하게 되며, 원가 배부기준은 대부분 생산하고 있는 제품의 수량과 밀접하다. 그러나, FMS 혹은 CIM등의 고도로 발달한 제조환경에서의 제조간접비는 반드시 생산량에 비례하지 않는다. 즉, 제품원가 구조변화 및 생산의 복잡성과 다양성에 따른 기업환경 변화 등이 주원인이 될 수 있다. 따라서 본 연구에서는 ABC 원가계산 시스템과 LP Model에 의한 전통적인 원가계산 방식과는 다른 ABC 원가계산 시스템을 만들었으며, 원가 활동동인에 따라 생산성 및 생산성 향상, 최적투자 활동 등을 수행할 수 있는 FMS 생산시스템의 최적평가 Model을 구축하였다.

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On 2-Absorbing and Weakly 2-Absorbing Ideals of Commutative Semirings

  • Darani, Ahmad Yousefian
    • Kyungpook Mathematical Journal
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    • v.52 no.1
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    • pp.91-97
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    • 2012
  • Let $R$ be a commutative semiring. We define a proper ideal $I$ of $R$ to be 2-absorbing (resp., weakly 2-absorbing) if $abc{\in}I$ (resp., $0{\neq}abc{\in}I$) implies $ab{\in}I$ or $ac{\in}I$ or $bc{\in}I$. We show that a weakly 2-absorbing ideal $I$ with $I^3{\neq}0$ is 2-absorbing. We give a number of results concerning 2-absorbing and weakly 2-absorbing ideals and examples of weakly 2-absorbing ideals. Finally we de ne the concept of 0 - (1-, 2-, 3-)2-absorbing ideals of $R$ and study the relationship among these classes of ideals of $R$.

Effects of Interactive Metronome Training on the Plantar Pressure and Fall Efficacy in Chronic Stroke Patients (상호교환식 메트로놈 훈련이 만성 뇌졸중 환자의 족저압과 낙상효능감에 미치는 영향)

  • Hwang, Won Kyung;Lee, Han Suk;Park, Sun Wook
    • Journal of the Korean Society of Physical Medicine
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    • v.15 no.1
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    • pp.105-112
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    • 2020
  • PURPOSE: This study examined the effects of Interactive Metronome training on the plantar pressure and fall efficacy in chronic stroke patients. METHODS: Twenty-two hemiplegic patients were allocated randomly to an experimental group and control group. The experimental group received conventional physical therapy and emphasized weight-bearing interactive metronome training, whereas the control group received conventional physical therapy. The training was performed three times per week, 40 minutes per each session, for a total of seven weeks. The plantar pressure was assessed using the contact area and contact pressure, whereas the fall efficacy was assessed using the FES (Fall Efficacy Scale), ABC (Activities-specific Balance Confidence scale) and FOFQ (Fear of Falling Questionnaire). RESULTS: After training, a significant increase was observed in the paretic side of the contact area and the paretic and non-paretic side of contact pressure in both groups (p<.05). The between-group differences in the changes before and after training were statistically significant in the paretic side of the contact pressure (p<.05). After training, both the FES of the between-group and ABC of the experimental group were increased significantly (p<.05), but the between-group differences in the changes before and after training were not statistically significant in the FES, ABC, and FOFQ (p>.05). CONCLUSION: Interactive Metronome training is considered an effective treatment for improving the contact pressure of the paretic side in chronic stroke patients.

Increase in the Chlorophyll Contents by Over-expression of GmNAP1 Gene in Arabidopsis Plant (애기장대에서 GmNAP1의 과발현으로 인한 엽록소 함량 증가)

  • Park, Phun-Bum;Ahn, Chul-Hyun
    • Journal of Life Science
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    • v.20 no.10
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    • pp.1563-1568
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    • 2010
  • In the course of a research concerning the molecular mechanism of hypocotyl elongation that occurs during soybean seedling growth in darkness, we have generated a number of ESTs from a cDNA library prepared from the hypocotyls of dark-grown soybean seedlings. Comparison of the ESTs assigned a cDNA clone as a putative plastidic ATP-binding-cassette (ABC) protein homologue. The soybean GmNAP1 protein contains an N-terminal transit peptide which targets it into the chloroplast. The transcription level of the GmNAP1 gene was investigated under continuous red light, continuous far-red light, and complete darkness. The main function of this NAP1 protein is the transport of protoporphyrin IX which is the precursor of chlorophyll from the cytoplasm to the chloroplast. The GmNAP1 gene was transferred into the Arabidopsis under the CaMV 35S promoter. The chlorophyll level of this transgenic Arabidopsis plant was much higher than the chlorophyll level of the wild type Arabidopsis plant.

Can Computed Tomographic Angiography Be Used to Predict Who Will Not Benefit from Endovascular Treatment in Patients with Acute Ischemic Stroke? The CTA-ABC Score

  • Kwak, Hyo-Sung;Park, Jung-Soo
    • Journal of Korean Neurosurgical Society
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    • v.63 no.4
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    • pp.470-476
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    • 2020
  • Objective : The objective of this study was to develop a score to predict patients with acute ischemic stroke (AIS) who will not benefit from endovascular treatment (EVT) using computed tomographic angiography (CTA) parameters. Methods : The CTA-ABC score was developed from 3 scales previously described in the literature: the Alberta Stroke Program Early CT Score (0-5 points, 3; 6-10 points, 0), the clot burden score (0-3 points, 1; 4-10 points, 0), and the leptomeningeal Collateral score (0-1 points, 2; 2-3 points, 0). We evaluated the predictive value of CTA parameters associated with symptomatic intracranial hemorrhage (sICH) or malignant middle cerebral artery infarction (MMCAI) after EVT and developed the score using logistic regression coefficients. The score was then validated. Performance of the score was tested with an area under the receiver operating characteristic curve (AUC-ROC). Results : The derivation cohort consisted of 115 and the validation cohort consisted of 40 AIS patients. The AUC-ROC was 0.97 (95% confidence interval [CI], 0.94-0.99; p<0.001) in the derivation cohort. The proportions of patients with sICH and/or MMCAI in the derivation cohort were 96%, 73%, 6%, and 0% for scores of 6, 5, 1, and 0 points, respectively. In the validation group, the proportions were similar (90%, 100%, 0%, and 0%, respectively) with an AUC-ROC of 0.96 (95% CI, 0.90-1.00; p<0.001). Conclusion : Our CTA-ABC score reliably assessed risk for sICH and/or MMCAI in patients with AIS who underwent EVT. It can support clinical decision-making, especially when the need for EVT is uncertain.

Design of Optimized Radial Basis Function Neural Networks Classifier with the Aid of Principal Component Analysis and Linear Discriminant Analysis (주성분 분석법과 선형판별 분석법을 이용한 최적화된 방사형 기저 함수 신경회로망 분류기의 설계)

  • Kim, Wook-Dong;Oh, Sung-Kwun
    • Journal of the Korean Institute of Intelligent Systems
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    • v.22 no.6
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    • pp.735-740
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    • 2012
  • In this paper, we introduce design methodologies of polynomial radial basis function neural network classifier with the aid of Principal Component Analysis(PCA) and Linear Discriminant Analysis(LDA). By minimizing the information loss of given data, Feature data is obtained through preprocessing of PCA and LDA and then this data is used as input data of RBFNNs. The hidden layer of RBFNNs is built up by Fuzzy C-Mean(FCM) clustering algorithm instead of receptive fields and linear polynomial function is used as connection weights between hidden and output layer. In order to design optimized classifier, the structural and parametric values such as the number of eigenvectors of PCA and LDA, and fuzzification coefficient of FCM algorithm are optimized by Artificial Bee Colony(ABC) optimization algorithm. The proposed classifier is applied to some machine learning datasets and its result is compared with some other classifiers.