• Radiation Oncology Journal
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• v.34 no.3
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• pp.209-215
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• 2016

Purpose: We sought to determine if organ preservation (OP) with neoadjuvant chemoradiation (CRT) was feasible in patients with sinonasal cancer determined to require exenteration. Materials and Methods: Twenty patients were determined to require exenteration for definitive treatment from 2005 to 2014. Fourteen patients underwent OP and 6 patients received exenteration with adjuvant CRT. Exenteration free survival (EFS), locoregional control (LRC), progression-free survival (PFS), and overall survival (OS) were estimated. Results: Five patients (36%) receiving OP had complete disease response at time of surgery. With a median follow-up of 18.8 months, EFS was 62% at 2 years for patients undergoing OP. At 2 years, there were no significant differences in LRC, PFS or OS (all all p > 0.050) between the groups. Less grade 3 or greater toxicity was seen in patients undergoing OP (p = 0.003). Visual function was preserved in all patients undergoing OP. Conclusion: For patients with sinonasal cancer, OP may avoid exenteration, offering similar disease control and improved toxicity.

• Biomedical Science Letters
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• v.16 no.4
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• pp.247-258
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• 2010

The objective of this research was to evaluate the relationships of preoperative (Pre-OP) levels of hematological and biochemical indices to perioperative variables in patients that underwent coronary artery bypass graft surgery (CABG). Pre-OP levels of hematological factors [total white blood cells (T-WBC), erythrocytes, hemoglobin, hematocrit, glycohemoglobin A1c (HbA1c), or platelet] were negatively or positively related with biochemical indices [alanine aminotransferase (ALT), bilirubin, glucose, fructosamine, triglyceride, and high density lipoprotein cholesterol (HDL)]. Pre-OP levels of hematological factors and biochemical indices were negatively or positively correlated with echocardiographic variables. Pre-OP level of HbA1c had a relationship with C-reactive protein. Pre-OP levels of aspartate aminotransferase (AST), ALT, HDL, glucose, fructosamine, or blood urea nitrogen (BUN) were positively or negatively associated with Pre-OP levels of cardiac markers (brain natriuretic peptide, troponin-I, creatine kinase isoenzyme 2, or CRP). Pre-OP levels of hematological factors (excepting T-WBC) related with operation time (OPT), postoperative mechanical ventilation time (POMVT), intensive care unit-period (ICU-period) or hospitalization. Pre-OP levels of AST, ALT, bilirubin, triglyceride, HDL, low dwensity lipoprotein, fructosamine, or BUN were positively or negatively correlated with OPT, graft numbers, POMVT, ICU-period or hospitalization. Retrospective this study reveals that Pre-OP levels of hematological and biochemical markers are associated with echocardiographic variables, several cardiac markers and postoperative outcomes, suggesting that Pre-OP levels of hematological and biochemical markers may be useful predictors for the diagnosis and prognosis of coronary artery disease.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.44 no.10
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• pp.61-66
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• 2007

A gain enhancement rail-to-rail buffer amplifier for liquid crystal display (LCD) source driver is proposed. An op-amp with extremely high gain is needed to decrease the offset voltage of the buffer amplifier. Cascoded floating current source and class-AB control block in the op-amp achieve a high voltage gain by reducing the channel length modulation effect in high voltage technologies. HSPICE simulation in $1\;{\mu}V$ 15 V CMOS process demonstrates that voltage gain is increased by 30 dB. The offset voltage is improved from 6.84 mV to $400\;{\mu}V$. Proposed op-amp is fabricated in an LCD source driver IC and overall system offset voltage is decreased by 2 mV.

• JSTS:Journal of Semiconductor Technology and Science
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• v.12 no.1
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• pp.75-87
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• 2012

A design paradigm using sequential geometric programming is presented to accurately design CMOS op amps with BSIM3. It is based on new adaptive modeling of transistor parameters through the operating point simulation. This has low modeling cost as well as great simplicity and high accuracy. The short-channel dc, high-frequency small-signal, and short-channel noise models are used to characterize the physical behavior of submicron devices. For low-power and low-voltage design, this paradigm is extended to op amps operating in the subthreshold region. Since the biasing and modeling errors are less than 0.25%, the characteristics of the op amps well match simulation results. In addition, small dependency of design results on initial values indicates that a designed op amp may be close to the global optimum. Finally, the design paradigm is illustrated by optimizing CMOS op amps with accurate transfer function.

• Journal of Mechanical Science and Technology
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• v.18 no.6
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• pp.961-971
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• 2004

Methods for determination of the crack opening stress intensity factor ($K_{op}$) and for estimation of the effective stress intensity factor range ($\Delta{K}_{eff}$) are evaluated for crack growth test data of aluminum alloys. Three methods of determining $K_{op}$, visual measurement, ASTM offset compliance method, and the neural network method proposed by Kang and Song, and three methods of estimating $\Delta{K}_{eff}$, conventional, the 2/PIO and 2/PI methods proposed by Donald and Paris, are compared in a quantitative manner by using evaluation criteria. For all $K_{op}$ determination methods discussed, the 2/PI method of estimating $\Delta{K}_{eff}$ provides good results. The neural network method of determining $K_{op}$ provides good correlation of crack growth data. It is recommended to use 2/PI estimation with the neural $K_{op}$ determination method. The ASTM offset method used in conjunction with 2/PI estimation shows a possibility of successful application. It is desired to improve the ASTM method.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.48 no.4
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• pp.461-466
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• 1999

A CMOS op amp with rail-to-rail input and output ranges is designed in a one-volt supply. The output stage of the op amp is used in a common source amplifier that operates in sub-threshold region to design a low voltage op amp with rail-to-tail output range. To drive heavy resistor and capacitor loads with rail-to-rail output ranges, a common source amplifier which has a low output resistance is utilized. A bulk-driven differential pair and a bulk-driven folded cascode amplifier are used in the designed op amp to increase input range and achieve 1 V operation. Post layout simulation results show that low frequency gain is about 58 ㏈ and gain bandwidth I MHz. The designed op amp has been fabricated in a 0.8${\mu}{\textrm}{m}$ standard CMOS process. The measured results show that this op amp provides rail-to-rail output range, 56㏈ dc gain with 1 MΩ load and has 0.4 MHz gain-bandwidth with 130 ㎊ and 1 kΩ loads.

• Journal of Life Science
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• v.20 no.10
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• pp.1458-1467
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• 2010

The present study was retrospectively designed to define whether preoperative levels of leukocytes and D-dimer are potentially useful factors in predicting perioperative outcomes of coronary heart disease (CHD). There was no relationship between preoperative leukocyte counts (Pre-OP leukocyte) and preoperative D-dimer levels (Pre-OP D-dimer). Pre-OP leukocyte counts each had positive correlation with cardiac troponin-I, creatine kinase-MB or C-reactive protein (cardiac markers) levels at preoperative and postoperative periods. Pre-OP D-dimer levels were positively associated with each cardiac marker at the same periods. Pre-OP leukocyte counts positively related with aspartate aminotransferase and alanine aminotransferase (liver markers), whereas Pre-OP D-dimer level positively or negatively correlated with bilirubin (liver marker), creatinine (renal marker) or glucose levels at preoperative and/or postoperative periods. Pre-OP leukocyte and Pre-OP D-dimer were inversely associated with Pre-OP high density lipoprotein cholesterol levels or left ventricular ejection fraction. Pre-OP leukocyte counts each had positive correlation operation duration and postoperative mechanical ventilation-time (PMVT), whereas Pre-OP D-dimer levels had positive relationship with PMVT, intensive care unit-staying period and hospitalization. The retrospective data suggest that Pre-OP leukocyte and Pre-OP D-dimer levels may be clinically useful factors for predicting perioperative outcomes in patients with CHD.

• Proceedings of the KIEE Conference
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• 1995.07c
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• pp.1108-1110
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• 1995

This paper presents a balanced CMOS complementary folded cascode OP-AMP topology that achieves improved DC gain using the gain boosting technique, a high unity-gain frequency and improved slew rate using the CMOS complementary cascode structure and a high PSRR using the balanced output stage. Bode-plot measurements of a balanced CMOS complementary folded cascode OP-AMP show a DC gain of 80dB, a unity-gain frequency of 110MHz and a slew rate of $274V/{\mu}s$(1pF load). This balanced CMOS complementary folded cascode OP-AMP is well suited for high frequency analog signal processing applications.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.9
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• pp.4334-4356
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• 2017

In orthogonal frequency-division multiplexing (OFDM) systems, phase noise introduced by the local oscillators can cause bit error rate (BER) performance degradation. To solve the phase noise problem, a novel orthogonal-polarization-based phase noise self-cancellation (OP-PNSC) scheme is proposed. First, the efficiency of canceling the phase noise of the OP-PNSC scheme in the AWGN channel is investigated. Then, the OP-PNSC scheme in the polarization-dependent loss (PDL) channel is investigated due to power imbalance caused by PDL, and a PDL pre-compensated OP-PNSC (PPC -OP-PNSC) scheme is proposed to mitigate the power imbalance caused by PDL. In addition, the performance of the PPC-OP-PNSC scheme is investigated, where the signal-to-interference-plus-noise ratio (SINR) and spectral efficiency (SE) performances are analyzed. Finally, a comparison between the OP-PNSC and polarization diversity scheme is discussed. The numerical results show that the BER and SINR performances of the OP-PNSC scheme outperform the case with the phase noise compensation and phase noise self-cancellation scheme.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.2
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• pp.873-876
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• 2005

This paper presents a new current transient test technique for wideband CMOS Op Amps. This technique monitors the transient power supply current and output responses of the CMOS Op Amp to automatically differentiate faulty and fault-free op amps. The wideband op amp is designed using 0.25${\mu}$m CMOS technology. We present detailed simulation results for a wideband op amp. We show that catastrophic faults in op amps can be detected and analyzed by monitoring power supply currents and output responses. This technique is inexpensive and simple.