• 대한골관절종양학회지
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• 제12권2호
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• pp.131-135
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• 2006

연골육종은 조직학적 소견에 따라 grade I, II, III로 나누어지며 예후와도 깊은 관련이 있다. Grade II 및 III의 연골육종의 수술 시 광범위 절제를 주로 시행하나 grade I 연골육종의 경우에는 소파술과 광범위 절제술 사이에 이견이 많다. 저자들은 상완골의 근위부에 grade I, 원위부에 grade II의 연골육종이 발생한 경우에 grade I은 소파술을, grade II는 광범위 절제술을 시행한 경험을 하였기에 보고하는 바이다.

• Ocean Science Journal
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• 제41권2호
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• pp.105-111
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• 2006

In this paper, the lines of investigation on a problem of the development of remote acoustic sensing methods in oceanology are formulated. This paper summarizes the results of investigations into the possibilities for monitoring temperature and flow fields in shallow seas. In the discussed experiments, the instrumentation being constituents of the complex for long-duration remote monitoring of marine medium climatic variability and that of the acoustic tomography of shallow sea dynamic processes is used. The acoustic instruments were located on the POI FEB RAS acousto-hydrophysical polygon (Pacific Oceanological Institute, Far Eastern Branch of the Russian Academy of Sciences) near the Gamov Peninsula. Acoustic receiving and transmitting systems operating with multiplex phase-manipulated signals (of M-codes) at frequency range 250-2500 Hz form the basis for this complex.

• Bulletin of the Korean Chemical Society
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• 제25권8호
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• pp.1147-1150
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• 2004

Hypericin (1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione), an antidepressant which is also known to be a potent protein kinase C (PKC) inhibitor was synthesized as a precursor for radioiodine labeling via two step reactions. Malignant glioma cells express higher PKC activity compared to untransformed glial cell. Here we report the synthesis and radioiodine labeling of hypericin as a potential brain tumor imaging radiopharmaceutical. The reference compound, 2-iodohypericin, and its radiolabelled analogues, 2-[$^{123}I$]iodohypericin and 2-[$^{124}I$]iodohypericin have been prepared by the reaction of hypericin with NaI or [$^{123}I$]NaI or [$^{124}I$]NaI. The labeling yield was 60-65% for each analogue and the optimal reaction time was 10 min. The purification and isolation of the labelled products were achieved by a reversed-phase HPLC.

• 한국인터넷방송통신학회논문지
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• 제17권6호
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• pp.19-25
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• 2017

본 논문은 비트코인 채굴에 필요한 SHA-256 암호 해시 값(n)을 구성하는 2개의 소수(p,q)를 빠르게 해독하는 소인수분해법을 다룬다. 본 논문에서는 Pollard's Rho 소인수분해 알고리즘의 수행횟수를 월등히 감소시킨 알고리즘을 제안하였다. Rho (${\rho}$) 알고리즘은 $(x_0,y_0)=(2,2)$ 초기치에 대해 $x_i=x^2_{i-1}+1(mod\;n)$과 $y_i=[(y^2_{i-1}+1)^2+1](mod\;n)$을 계산하여 1 < $gcd({\mid}x_i-y_i{\mid},n)$ < n으로 소인수를 구한다. 이 알고리즘은 특정 합성수에 대해서는 소인수 분해에 실패할 수 있다. 제안된 알고리즘은 Pollard Rho 알고리즘에 $(x_0,y_0)=(2^k,2^k)$와 ($2^k,2$), $2{\leq}k{\leq}10$을 적용하였다. 그 결과 모든 합성수에 대해 소인수분해를 할 수 있었으며, Pollard Rho 알고리즘의 수행횟수를 67.94% 감소시켰다.

• Tuberculosis and Respiratory Diseases
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• 제50권5호
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• pp.549-556
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• 2001

연구배경 : 세포성장에 관여하는 여러 growth factor중 IGF-I은 IGF-IR와 결합하여 세포증식을 유발하는 mitogen으로 알려져 있다. 대부분의 정상세포 및 암세포는 IGFBPs을 분비하는데 이들은 IGF-I과 결합하여 IGF-I의 세포증식 효과를 증가 혹은 억제시킨다. 마우스 폐암세포주 (3LL)에서 IGF-I이 세포성장에 미치는 효과를 보고, 3LL 세포에서 분비되는 IGFBP을 추출 확인하고, IGFBPs이 세포 성정에 미치는 영향을 관찰하였다. 방 법 : 마우스 폐암세포주 (3LL)를 이용하여, IGF-I을 투여하여 세포성장을 MTT assay로 측정하였고, 3LL에서 분비되는 IGFBP을 추출하여 Western ligand blot 및 western immunoblot으로 확인하였다. 또한 분비된 IGFBP이 세포성장에 미치는 영향을 보기위해, anti-IGFBP antibody을 첨가하여 이의 기능을 억제하여 세포성장에 관한 기능을 관찰하였다. 결 과 : IGF-I은 serum free media에서 3LL 세포성장을 증가시켰다. 3LL 세포는 IGFBP-4를 생성하는 것을 확인하였고, anti-IGFBP-4 antibody를 첨가시 세포성장이 증가된 소견이 관찰되어 IGFBP-4는 세포증식을 억제하는 기능을 가지고 있음을 간접적으로 알 수 있었다. 결 론 : 이상의 실험 결과로 3LL 마우스 폐암세포에서 IGF-I은 세포성장을 증가시키며, 3LL에서 생성된 IGFBP-4는 세포증식을 억제하는 기능을 가지고 있다는 것을 관찰하였다. 향후 IGF-I과 IGFBPs이 암 성장에 미치는 기전과 임상적 적용에 대한 연구가 필요하리라 생각된다.

• 호남수학학술지
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• 제36권2호
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• pp.417-424
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• 2014

Let A be an abelian variety defined over a number field K and p be a prime. Define ${\varphi}_i=(x^{p^i}-1)/(x^{p^{i-1}}-1)$. Let $A_{{\varphi}i}$ be the abelian variety defined over K associated to the polynomial ${\varphi}i$ and let Ш($A_{{\varphi}i}$) denote the Tate-Shafarevich groups of $A_{{\varphi}i}$ over K. In this paper assuming Ш(A/F) is finite, we compute [Ш($A_{{\varphi}1}$)][Ш($A_{{\varphi}2}$)]/[Ш($A_{{\varphi}1{\varphi}2}$)] in terms of K-rational points of $A_{{\varphi}i}$, $A_{{\varphi}1{\varphi}2}$ and their dual varieties, where [X] is the order of a finite abelian group X.

• 대한수학회보
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• 제45권3호
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• pp.587-600
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• 2008

In this paper we establish the general solution and investigate the Hyers-Ulam-Rassias stability of the following functional equation in quasi-Banach spaces. $${\sum\limits_{{{1{\leq}i<j{\leq}4}\limits_{1{\leq}k<l{\leq}4}}\limits_{k,l{\in}I_{ij}}}\;f(x_i+x_j-x_k-x_l)=2\;\sum\limits_{1{\leq}i<j{\leq}4}}\;f(x_i-x_j)$$ where $I_{ij}$={1, 2, 3, 4}\backslash${i, j} for all $1{\leq}i<j{\leq}4$. The concept of Hyers-Ulam-Rassias stability originated from Th. M. Rassias' stability theorem that appeared in his paper: On the stability of the linear mapping in Banach spaces, Proc. Amer. Math. Soc.

• 대한기계학회논문집A
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• 제20권11호
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• pp.3498-3506
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• 1996

A loading device to be used in fracture experiment is presented. It's loading angle can be adjusted from $-45^{\circ}$ to $105^{\circ}$ at intervals of $15^{\circ}$ for a CTS ( compact tension-shear) specimen, so that it is to be useful to measure mixed mode toughness. The equations to give the $K_ I$, $K_ I1$ and J-integral for the experiment are evluated though finite elemetn analysis in which the loading procedure is simulated and the behaviors of the specimen such as load-displacement curve are estimated. In the course of the evaluation the values $K_ I$, $K_ I1$ and J-integral calculated through recentrly released numerical methods are employed as the reference ones.

• 한국자기공명학회논문지
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• 제2권2호
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• pp.141-151
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• 1998

Human annexin I is a member of annexin family of calcium dependent phospholipid binding proteins, which have been implicated in various physiological roles including phospholipase A2(PLA2) inhibition, membrane fusion and calcium channel activity. In this work, the structure of N-terminally truncated human annexin I ({{{{ DELTA }}-annexin I) and its interactions with Ca2+, ATP and cAMP were studied at atomic level by using nuclear magnetic resonance (NMR) spectroscopy. The effect of Ca2+ binding on the structure of {{{{ DELTA }}-annexin I was investigated. The addition of Ca2+ to {{{{ DELTA }}-annexin I caused some changes in 13C NMR spectra. Carbonyl carbon resonances of some histidines were significantly broadened by Ca2+ binding. However, in the case of methionine, phenylalanine, and tyrosin, small changes could be observed. We found that ATP and cAMP bind {{{{ DELTA }}-annexin I, and the binding ratio of ATP to {{{{ DELTA }}-annexin I is 1. These results are well consistent with the report that cAMP and ATP interact with annexin I, and affect the calcium channels formed by annexin I. Because {{{{ DELTA }}-annexin I is a large protein with 35 kDa molecular weight, site-specific (carbonyl-13C) labeling technique was used to study the interaction sites of {{{{ DELTA }}-annexin I with Ca2+. NMR study was focused on the carbonyl carbon resonances of tyrosine, phenylalanine, methionine and histidine residues of {{{{ DELTA }}-annexin I because the number of these amino acids is small in the amino acid sequence of {{{{ DELTA }}-annexin I.

• The Korean Journal of Physiology and Pharmacology
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• 제7권2호
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• pp.53-57
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• 2003

The glutamate receptors (GluRs) are key receptors for modulatory synaptic events in the central nervous system. It has been reported that glutamate increases the intracellular $Ca^{2+}$ concentration ($[Ca^{2+}]_i$) and induces cytotoxicity. In the present study, we investigated whether the glutamate-induced $[Ca^{2+}]_i$ increase was associated with the activation of ionotropic (iGluR) and metabotropic GluRs (mGluR) in substantia gelatinosa neurons, using spinal cord slice of juvenile rats (10${\sim}21 day). $[Ca^{2+}]_i$ was measured using conventional imaging techniques, which was combined with whole-cell patch clamp recording by incorporating fura-2 in the patch pipette. At physiological concentration of extracellular $Ca^{2+}$, the inward current and $[Ca^{2+}]_i$ increase were induced by membrane depolarization and application of glutamate. Dose-response relationship with glutamate was observed in both $Ca^{2+}$ signal and inward current. The glutamate-induced $[Ca^{2+}]_i$ increase at holding potential of -70 mV was blocked by CNQX, an AMPA receptor blocker, but not by AP-5, a NMDA receptor blocker. The glutamate-induced $[Ca^{2+}]_i$ increase in $Ca^{2+}$ free condition was not affected by iGluR blockers. A selective mGluR (group I) agonist, RS-3,5-dihydroxyphenylglycine (DHPG), induced $[Ca^{2+}]_i$ increase at holding potential of -70 mV in SG neurons. These findings suggest that the glutamate-induced $[Ca^{2+}]_i$ increase is associated with AMPA-sensitive iGluR and group I mGluR in SG neurons of rats.