• 대한한의학방제학회지
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• 제31권4호
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• pp.231-243
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• 2023

Objectives : Jasminum officinale L. var. grandiflorum is used as a traditional or folk remedy in China to treat arthritis, hepatitis, duodenitis, conjunctivitis, gastritis, and diarrhea. In this study, we aimed to study the hepatocyte protective activity and molecular mechanism of Jasminum officinale L. var. grandiflorum aqueous extract (JGW) using HepG2 hepatocyte cell lines. Methods : HepG2 cells were pretreated with diverse concentrations of JGW, and then the cells were exposed to tert-butyl hydroperoxide (tBHP) for inducing oxidative stress. Hydrogen peroxide (H₂O₂) production, glutathione (GSH) concentration, mitochondrial membrane potential (MMP) and cell viability were measured to investigate hepato-protective effects of JGW. Phosphorylation of AMP-activated protein kinases (AMPK), acetyl coenzyme A carboxylase (ACC) and effects of compound C on cell viability were examined to observe the role of AMPK on JGW-mediated cytoprotection. Results : Pretreatment with JGW (10-300 ㎍/mL) significantly suppressed cytotoxicity induced by tBHP in a concentration dependent manner and reduced the expression of cleaved PARP and cleaved caspase-3 proteins related to apoptosis in HepG2 cells. In addition, pretreatment with JGW significantly prevented the increase in H₂O₂ production, GSH depletion, and lower MMP induced by tBHP. Treatment with JGW (30 minutes of incubation and concentrations of 100 and 300 ㎍/mL) increased the phosphorylation of AMPK and ACC and treatment with compound C, a chemical inhibitor of AMPK, inhibited the cytoprotective effect of JGW. Conclusions : Our results demonstrated that JGW may protect hepatocytes from oxidative stress via activation of AMPK.

• 디지털융복합연구
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• 제19권8호
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• pp.33-42
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• 2021

스마트폰 기반의 관광 플랫폼들이 활성화되면서 리뷰 데이터를 활용한 정책 수립 및 서비스 고도화가 다양한 분야에서 이루어지고 있다. 관광 리뷰 데이터를 활용한 선행연구들의 경우 국내 관광객 중심의 연구가 대다수 수행되었으며, 외국인 관광객 연구의 경우 일부 언어로 수집된 데이터와 텍스트 마이닝 기법에 한정하여 연구가 수행되었다. 이에 본 연구에서는 온라인 리뷰 사이트를 통해 '대구 명소' 키워드를 지정하여 외국인들이 작성한 리뷰 데이터 3,515건을 수집하였다. 그리고 LDA 기반의 토픽모델링을 수행하여 관광 토픽을 도출하였으며, 각 토픽별 전역 및 국지적 공간 분석을 수행한 점이 선행연구와 차별성이라 할 수 있다. 분석 결과 전역적 공간 자기상관이 존재하며, 외국인들이 주로 방문하는 관광지들이 국지적으로 결집되어 있음을 확인하였다. 또한 대다수 토픽에서 중구를 중심으로 핫스팟이 도출되었으며, 분석 결과를 바탕으로 지자체 외국인 관광정책 수립 및 토픽모델링 기반의 공간분석 연구의 기초연구로 활용되길 기대하며, 본 연구의 한계점 또한 제시하였다.

• 한국조경학회지
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• 제44권5호
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• pp.68-80
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• 2016

본 연구는 건강증진 목적으로 공원을 이용할 경우, 물리적 환경에 관한 인식이 이용자의 만족도 및 공원이용에 미치는 영향을 분석하였다. 연구대상지는 대구광역시 수성구의 근린생활권 근린공원으로 설정하였으며, 총 143부의 설문지를 분석에 활용하였다. 먼저 공원의 물리적 환경에 대한 인식평가에서는 거주지로부터 공원까지의 접근 및 보행환경에 관한 항목들이 4.04로 높게 평가된 반면, 수공간과 공원 내 볼거리에 관한 항목들은 각각 2.32, 2.66으로 낮게 평가되었다. 다음으로 22개의 물리적 환경 인식요소들을 대표 요인으로 유형화하기 위해 요인분석을 실시한 결과, 안락성, 이용성, 쾌적성, 시설편의성, 시각성 등 5개 요인으로 유형화되었다. 이를 토대로 만족도 및 공원이용에 미치는 영향을 분석하였다. 공원이용 만족도에 영향을 미치는 요인은 안락성, 이용성, 쾌적성, 시설편의성으로 나타났으며, 이 중 쾌적성이 0.315로 가장 큰 영향을 주는 것으로 분석되었다. 공원이용에 영향을 미치는 요인은 이용성과 쾌적성으로 분석되었으며, 이용성이 0.396으로 쾌적성 0.293보다 더 높은 영향성을 가지는 것으로 나타났다. 따라서 건강증진 장소로서 공원이용 만족도를 높이기 위해서는 충분한 녹지면적 확보, 수목 및 시설 관리를 통한 쾌적한 환경 조성이 필요할 것으로 판단된다. 또한, 공원이용을 활성화시키기 위해서는 거주지에서 공원까지의 보행환경 정비, 산책로 개선 등의 노력이 필요할 것으로 판단된다.

• 한국조경학회지
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• 제43권6호
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• pp.98-108
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• 2015

본 연구는 건강증진 목적의 공원이용 유무에 따른 거주지 주변 환경 인식의 차이를 살펴보고 거주지 환경인식특성이 공원이용에 미치는 영향을 분석하였다. 연구대상지는 대구광역시 수성구의 근린공원 및 유원지로 설정하였으며, 총 303명의 설문응답 분석을 통해 결과를 도출하였다. 연구결과를 요약하면, 총 16개의 물리적 환경인식 지표들 중 시장 및 상가시설의 접근성, 대중교통의 이용성, 공원 등 녹지공간의 접근성, 충분한 보도, 횡단해야 하는 도로의 수, 운동인구를 포함한 6개의 지표가 유의한 영향을 미치는 것으로 나타났다. 공원을 이용할 확률은 공원 등 녹지공간의 접근성에 대한 만족도가 증가할수록 2.326배, 주변에 운동하는 인구가 많을수록 1.701배, 횡단해야 하는 도로의 수가 적을수록 1.617배, 충분한 보도가 설치되어 있다고 인식할수록 1.642배 증가하는 것으로 분석되었다. 따라서 건강증진 목적의 공원이용을 활성화하기 위해서는 거주지 주변에 이용 가능한 공원녹지를 확대하고 주민들이 지속적으로 이용할 수 있는 운동 프로그램을 개발하는 것이 중요할 것이다. 또한 주거지와 공원을 연결하는 보행자 전용도로를 계획하는 등 보행의 편의성을 높이기 위한 노력이 필요할 것으로 판단된다.

• 한국환경보건학회지
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• 제38권1호
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• pp.42-50
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• 2012

The purpose of this study was to investigate the concentration and distribution characteristics of $PM_{10}$ at high schools classrooms in Ulsan and its surroundings. This study evaluated $PM_{10}$ levels in classrooms at 79 high schools in Ulsan from May 2008 to May 2009. The average $PM_{10}$ level was 63.8 ${\mu}g/m^3$, and the rate of exceeding the statutory maintenance limit was 16.0%. The average $PM_{10}$ level was higher in general schools (64.9 ${\mu}g/m^3$) compared to professional schools (59.2 ${\mu}g/m^3$), and private schools (66.6 ${\mu}g/m^3$) was higher than that of public schools (62.5 ${\mu}g/m^3$). The average $PM_{10}$ level (68.4 ${\mu}g/m^3$) in general classrooms was significantly (p < 0.01) higher than that in multi-purpose ones (54.6 ${\mu}g/m^3$), and first-year student classrooms (73.3 ${\mu}g/m^3$) was significantly (p < 0.05) higher than that in second or third grade ones (67.6 ${\mu}g/m^3$, 51.5 ${\mu}g/m^3$, respectively). The $PM_{10}$ level in schools in Dong-Gu in the vicinity of assorted industrial complexes was higher than that of schools located in other districts around the Ulsan Metropolitan Area. The regression model showed that $PM_{10}$ level was positively associated with number of students and relative humidity.

• 한국멀티미디어학회논문지
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• 제19권5호
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• pp.818-825
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• 2016

The existing R-peak detection research suggests improving the distortion of the signal such as baseline variations in ECG signals by using preprocessing techniques such as a bandpass filtering. However, preprocessing can introduce another distortion, as it can generate a false detection in the R-wave detection. In this paper, we propose an R-peak detection algorithm in ECG signal, based on primitive signal in order to detect reliably an R-peak in baseline variation. First, the proposed algorithm decides the primitive signal to represent the QRS complex in ECG signal, and by scaling the time axis and voltage axis, extracts multiple primitive signals. Second, the algorithm detects the candidates of the R-peak using the value of the voltage. Third, the algorithm measures the similarity between multiple primitive signals and the R-peak candidates. Finally, the algorithm detects the R-peak using the mean and the standard deviation of similarity. Throughout the experiment, we confirmed that the algorithm detected reliably a QRS group similar to multiple primitive signals. Specifically, the algorithm can achieve an R-peak detection rate greater than an average rate of 99.9%, based on eight records of MIT-BIH ADB used in this experiment.

• 한국전문물리치료학회지
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• 제26권4호
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• pp.29-34
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• 2019

Background: The serratus anterior is one of the most important muscle for maintaining good scapular alignment in the shoulder joint. The pectoralis major and upper trapezius may also compensate for weak serratus anterior muscles. The push-up plus exercise has been identified as the optimal exercise for maximum activation of the serratus anterior. Objects: The purpose of this study was to examine differences in surface electromyography (EMG) activity of upper trapezius, pectoralis major, and serratus anterior muscles during push-up plus exercises on variously angled surfaces in subjects with winged scapula. Methods: Sixteen subjects with winged scapula (male=5, female=11) volunteered for this study. The subjects performed push-up plus exercise on four different tilt angles, namely $0^{\circ}$, $30^{\circ}$, $60^{\circ}$, and $90^{\circ}$. EMG activities in the serratus anterior, upper trapezius, and pectoralis major muscles during performance of push-up plus exercise were measured in all subjects. Data were processed from repeated measures one-way analysis of variance. Results: There was significant difference in the muscle activity of the serratus anterior on the different surface angles (p<.05). The results of the post-hoc analysis showed significantly greater serratus anterior muscle activity on a surface at a $0^{\circ}$ angle than at others tilt angles (p<.05). There was also significant difference in the ratio of serratus anterior to upper trapezius and serratus anterior to pectoralis major across the four surfaces (p<.05), and post-hoc analysis showed significantly greater values on the $0^{\circ}$ surface than on other tilts (p<.05). Conclusion: This study found that performing push-up plus exercises on a flat surface with $0^{\circ}$ and $30^{\circ}$ tilt angle achieves high activation of the serratus anterior muscle for selective strengthening. It can also take into account the sequential application, which is first performed at a $30^{\circ}$ and at a $0^{\circ}$ tilt angle for and effective but not excessive muscle activation.

• 대한본초학회지
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• 제30권3호
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• pp.13-17
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• 2015

Objectives : Taraxacum platycarpum H. Dahlstedt has been reported to have several biological properties such as skin hydration and antiinflammation. The purpose of this study was to examine the antidepressive effects of water extract of T. platycarpum (WTP) on an animal model of depression. Methods : In the present study, normal ICR mice (4 weeks) were used, and orally administered with WTP (25, 50 and 100 mg/kg). Depression-like behavior was monitored the forced swimming test (FST) and tail suspension test (TST) in mice. The locomotor activity was evaluated to eliminate the false-positive activity in the open field test (OFT). Fluoxetine, the selective serotonin reuptake inhibitor, as a positive control was intraperitoneally administered at a dose of 15 mg/kg at 30 min before starting the behavioral test. Moreover, we evaluated the effects of WTP on the expression of brain-derived neurotrophic factor (BDNF) and the extracellular signal-regulated kinase (ERK)/ cyclic AMP response-element binding protein (CREB) signaling pathway in the hippocampus using Western blot. Results : The administration of WTP (50 and 100 mg/kg) significantly (P < 0.05, respectively) reduced the immobility time during FST and TST without accompanying changes in locomotor activity by OFT. Furthermore, WTP at dose of 100 mg/kg increased the BDNF expression and the phosphorylation of ERK and CREB in the hippocampus region. Conclusions : These results suggest that WTP has a useful anti-depressant effect through the regulation of BDNF/ERK/CREB signaling pathway.

• 한국환경과학회지
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• 제14권6호
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• pp.543-553
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• 2005

In recent days, photochemical smog due to the rapid industry development and vehicle increasement has become a critical pollutant in the metropolitan area and the number of ozone alarm signal has increased every year. This research was performed to evaluate VOCs emission source characteristics and concentration of VOCs in Daegu. The site average concentration was observed in the following order: industrial area > commercial area > residential area. Most of the VOCs species except toluene showed variations with higher concentration during nighttime, and lower concentration during the daytime. The major VOCs of stationary emission source were BTEX(benzene, toluene, ethylbenzene. xylene) and methylene chloride, trichloroethene and styrene. Also, those of automobile exhaust were toluene and benzene. Also, the major VOCs concentration emited by the vehicle fuel was observed in the following order: gasoline > light oil > liquefied petroleum gas (L.P.G). Correlation coefficients values were estimated between major VOCs such as toluene, ethylbenzene, m,p-xylene, o-xylene. Results showed that correlation coefficient values were significant magnitude above 0.76. Also, there showed highly significant correlations among ethyl benzene, m,p-xylene, and o-xylene concentration(Pearson correlation coefficients, r=0.868-0.982). Calculated correlation coefficients among commercial area,industrial area and residential area were 0.934-0.981, they showed high correlation. There showed highly correlation between stationary emission source and industrial area, compared with commercial area and residential area. Also, calculated correlation coefficients among commercial area, industrial area, residential area and automobile exhaust were 0.732, 0.725, 0.777, respectively.

• 한국치위생학회지
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• 제7권2호
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• pp.123-133
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• 2007

This document is about immigrant worker who use counseling office for human rights in the Daegu Gumin Church. We researched their oral health state so that we can understand their situation and support them properly. General characteristics of study subjects, habits related to oral health, the oral examination and treatment clinic, participated in oral heath education program were studied by designed administered questionaire. And decay, filling(treatment teeth), missing tooth(lost teeth by dental-caries)was counted by oral examination, and calculated DMFT-index. This study was done from the July, 9, 2006 to Aug. 8, 2006. In a total of 289 immigrant worker, 77.9% of them were men and 22.1% of them were women. 55.7% of their salary was from 1,000,000 won to 1,500,000 won and most of them were working for a fiber industry. Many of them are living in korea for more then three years. DMFT index for men was 2.77 and for women was 4.06 so average of DMFT index was 3.06. 46.7% of them said that they are healthy in oral health state. The question for having difficulty using dental clinic in korea, 65.1% of them said "it is difficult". First reason was a communication problem and second was time. Most of them didn't have a oral health education but 85.1% of them said that they are looking forward to attending oral health education. Immigrant worker had better DMFT index then that of korean blue color worker. But still it is quite difficult for them using dental clinic in korea also cost. It is necessary to support them properly that medical insurance system, medical facilities of quality, medical insurance subscriber beside, made by their language, manual for them. At once, medical service improvement a policy is necessary for immigrant worker in korea.