• Tunnel and Underground Space
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• 제33권4호
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• pp.209-227
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• 2023

The government continues to announce measures to revitalize smart construction technology based on BIM for productivity innovation in the construction industry. In the design phase, the goal is design automation and optimization by converging BIM Data and other advanced technologies. Accordingly, in the basic design of the Namhae Seomyeon-Yeosu Sindeok National Road Construction Project, a domestic undersea tunnel project, BIM-based design was carried out by developing tunnel design automation technology using 3D spatial information according to the tunnel design process. In order to derive the optimal alignment, more than 10,000 alignment cases were generated in 36hr using the generative design technique and a quantitative evaluation of the objective functions defined by the designer was performed. AI-based ground classification and 3D Geo Model were established to evaluate the economic feasibility and stability of the optimal alignment. AI-based ground classification has improved its precision by performing about 30 types of ground classification per borehole, and in the case of the 3D Geo Model, its utilization can be expected in that it can accumulate ground data added during construction. In the case of 3D blasting design, the optimal charge weight was derived in 5 minutes by reviewing all security objects on the project range on Dynamo, and the design result was visualized in 3D space for intuitive and convenient construction management so that it could be used directly during construction.

• Journal of the Korean Dietetic Association
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• 제29권3호
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• pp.173-189
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• 2023

This study aimed to determine foodservice and hygiene management statuses at welfare facilities catering to disabled persons by facility type to provide basic data for foodservice management guidelines. An online survey was distributed to workers at 1,984 welfare facilities for disabled persons in Korea, and 531 facilities responded, which represented a response rate of 26.8%. The survey requested general information about the facilities, facility users, meals, hygiene, and management. Statistical analyses were performed, and frequency analysis and the chi-square test were used to investigate responses by facility type. The survey results revealed that daycare centers were most common and accounted for 27.4% of responses. Residential facilities for the severely disabled and sheltered workshops accounted for 16.9% and 16.4%, respectively, and residential facilities by disability type accounted for 13.0%. The presence of dietitians at welfare facilities varied by facility type. Welfare centers for the disabled (94.7%) had the highest percentage of dietitians, followed by residential facilities for the severely disabled (87.8%). On the other hand, sheltered workshops and daycare centers for disabled persons had the lowest percentages of dietitians (10.3% and 4.1%, respectively). This study highlights the variations that exist in foodservice management across different welfare facilities for disabled persons and emphasizes the challenges faced by those responsible for managing foodservices and maintaining hygiene, particularly in large facilities with no dietitians. Therefore, we recommend tailored meal management guidelines be developed for each type of welfare facility for disabled persons.

• Proceedings of the Korea Water Resources Association Conference
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• 한국수자원학회 2022년도 학술발표회
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• pp.478-478
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• 2022

섬진강은 하굿둑이 없는 열린 하구로서 하구로부터 약 21km까지 조석의 영향을 받아 강물의 염도가 시간에 따라 변하는 환경이다. 오랫동안 섬진강 하구는 다양한 원인으로부터 바다화로 대표되는 염하구 문제가 지역 현안 사항으로 제기되어 왔다. 상류에서의 용수사용 증가로 인한 하천 유하량 감소 또한 그 원인들 중 하나로 판단됨에 따라 실제 하구까지 내려오는 하천유량과 바다로부터 유입되는 해수를 구분하여 정량화하는 연구가 필요한 사안이다. 본 연구의 목적은 섬진강 수계 하구에서의 다양한 생태환경을 보전하기 위한 적정 염분유지가 요구됨에 따라 섬진강하구 염분계측기(섬진강대교)를 설치하여 염분농도를 관측하고 하천유량, 하천취수 및 해양조위에 따른 염분농도 변화를 모의하여 하천유량과 염분과의 관계를 제시하고자 하였다. 본 연구에서는 EFDC(Environmental Fluid Dynamics Code) 수치모델을 이용하여 상류로는 구례군(송정리) 수위관측소부터 하류로는 여수해만 및 문의리까지의 구역을 설정하고 광양조위, 하동수위 및 고정식 염분 계측기 관측염분농도 자료를 이용하여 수치모델링의 재현성을 검증하였다. 검증 결과, 결정계수(R²)는 0.87(하동수위), 0.93(광양조위), 0.56(섬진강대교 염도)를 나타냈다. 모델 검보정 후 하천유량에 따른 염분변화 실험을 실시하여 염분농도 거동을 분석하였다. 모델 결과, 섬진강하구에서의 염분거동은 소조기때 염분체류 현상으로 인해 대조기 거동과는 큰 차이를 나타냈다. 따라서, 모델링 결과를 이용한 유량-염분 조견표는 각각 대조기와 소조기로 구분하여 산정하였다. 대조기때는 송정유량이 10톤/초의 평균갈수량이 흐를 경우 다압에서의 취수량이 2.52톤/초 ~ 4.63/초로 증가할수록 18.8psu ~ 19.9psu로 증가하였다. 소조기의 경우는 25.5psu ~ 25.7psu로 대조기와 비교하여 크게 증가됨을 나타냈다. 본 연구의 결과는 객관적인 생태환경 보전을 위한 적정염분농도 범위가 도출된다면 이를 유지하기 위한 필요유량과 필요유량을 확보하기 위한 장단기적인 대책수립이 가능할 것으로 기대된다.

• Korean Journal of Clinical Laboratory Science
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• 제54권1호
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• pp.68-72
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• 2022

Angioimmunoblastic T-cell lymphoma (AITL) is a lymphoproliferative disorder of mature T follicular helper cells. Atypical lymphoid cells were observed in the bone marrow of an 80-year-old woman, and the flow cytometric determined immunophenotypes of B-cells were unusual, that is, CD19+, CD20-, and CD22- with lambda light chain restriction. Initially, we suspected BM involvement of B-cell lymphoma based on the presence of abnormal B-cells. However, the patient was diagnosed with AITL involving BM. A re-analysis of flow cytometric immunophenotyping revealed a minor, aberrant T-cell population, and the lambda light chain restriction observed by surface staining was considered non-specific binding. This case demonstrates B-cells in patients with EBV-positive T-cell lymphoma may exhibit immunophenotypes resembling those of plasma cells, and that proliferation of abnormal B-cells or plasma cells could also potentially mask underlying T-cell lymphoma. A more integrated approach is required for accurate diagnosis.

• The Journal of the Society of Stroke on Korean Medicine
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• 제8권1호
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• pp.17-21
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• 2007

Objectives : This study was done to investigate the relationship of drinking and Dampness-Phlegm pattern in acute stroke patients. Methods : In the time of period Mar. 2007 to Jun. 2007, 103 patients with stroke admitted in the department of Internal Medicine of Kyungwon University Seoul Oriental Medical Hospital, Kyungwon University Incheon Oriental Medical Hospital, Kyunghee University Oriental Medical Hospital, Dongguk Il-san Oriental Medical Hospital were included. Patients were hospitalized within a month after the onset of stroke. Stroke patients were interviewed by residents who studied standard operation procedures in Fundamental Study for Standardization and Objectification of Differentiation and Pattern Identification of Syndrome of Oriental Medicine for Stroke. A questionnaire was completed by a question-and-answer form between patients and residents after explanation details to patients and the agreement of patients. Results : Drinking subjects have tendency of Dampness-Phlegm Pattern(p=0.096), but don't have statistical significance(p<0.05). Conclusions : In this study, we found the relationship of drinking and Dampness-Phlegm Pattern. To acquire more concrete conclusion on this theme, we need more research.

• The Journal of the Society of Stroke on Korean Medicine
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• 제8권1호
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• pp.12-16
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• 2007

Objectives : This study was done to investigate the relationship between Sasang constitution and the facial skin in acute stroke patients Methods : In the time of period Mar. 2007 to Jun. 2007, 103 patients with stroke admitted in the department of Internal Medicine of Kyungwon University Seoul Oriental Medical Hospital, Kyungwon University Incheon Oriental Medical Hospital, Kyunghee University Oriental Medical Hospital, Dongguk Il-san Oriental Medical Hospital were included. We assessed the type of Sasang constitution, and the type of Sasang constitution of 51 patients were confirmed. We investigated general characteristics, stroke type and the relationship between Sasang constitution and the facial skin. Results : The color of face have no significant differences by Sasang constitution. But So-yang have blue and purple colored lips than So-eum and Tae-eum have. Conclusions : In this study, we found the relationship between Sasang constitution and the facial skin in acute stroke patients. But it seems necessary to investigate more cases to concrete conclusion on this theme.

• Korean Journal of Ichthyology
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• 제35권4호
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• pp.361-365
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• 2023

On May 12, 2023, a juvenile specimen (37.6 mm in standard length) belonging to the order Aulopiformes was collected from southern Yokjido, Tongyeong, Korea, using a Bongo net. The specimen was identified as the member of the family Scopelarchidae in having a slender body, a large mouth, large tube-like eyes, a long anal fin base, a developed adipose fin and no photophores on body. Finally, we identify the specimen as Scopelarchoides danae Johnson, 1974 in having 8 dorsal fin rays, 20 pectoral fin rays, 9 pelvic fin rays, 26 anal fin rays, dorsal fin located anteriorly than pelvic fin, and two large pigments below the pectoral fin and posterior to the pelvic fin. Scopelarchoides danae is distinguished from Scopelarchoides signifer in having less dorsal fin rays (8 vs. 9~10) and pectoral fin rays (20 vs. 22~25). The species differs from Scopelarchus guentheri and Scopelarchus analis in that it has no stripes along the both upper and lower of lateral line, and from Scopelarchus michaelsarsi in that it has more anal fin rays (26 vs. 18~21). Because this is the first occurrence among Korean fish fauna, we present its detailed morphological traits, and its new Korean name as "Nun-bang-ul-mae-tung-i".

• IMMUNE NETWORK
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• 제22권5호
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• pp.40.1-40.24
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• 2022

Mesenchymal stem cells (MSCs) are attractive alternatives to conventional anti-asthmatic drugs for severe asthma. Mechanisms underlying the anti-asthmatic effects of MSCs have not yet been elucidated. This study evaluated the anti-asthmatic effects of intravenously administered MSCs, focusing on macrophages and monocytes. Seven-week-old transgenic (Tg) mice with lung-specific overexpression of IL-13 were used to simulate chronic asthma. MSCs were intravenously administered four days before sampling. We examined changes in immune cell subpopulations, gene expression, and histological phenotypes. IL-13 Tg mice exhibited diverse features of chronic asthma, including severe type 2 inflammation, airway fibrosis, and mucus metaplasia. Intravenous administration of MSCs attenuated these asthmatic features just four days after a single treatment. MSC treatment significantly reduced SiglecF^-CD11c^-CD11b⁺ monocyte-derived macrophages (MoMs) and inhibited the polarization of MoMs into M2 macrophages, especially M2a and M2c. Furthermore, MSCs downregulated the excessive accumulation of Ly6c^- monocytes in the lungs. While an intravenous adoptive transfer of Ly6c^- monocytes promoted the infiltration of MoM and Th2 inflammation, that of MSC-exposed Ly6c^- monocytes did not. Ex vivo Ly6c^- MoMs upregulated M2-related genes, which were reduced by MSC treatment. Molecules secreted by Ly6c^- MoMs from IL-13 Tg mice lungs upregulated the expression of fibrosis-related genes in fibroblasts, which were also suppressed by MSC treatment. In conclusion, intravenously administered MSCs attenuate asthma phenotypes of chronic asthma by modulating macrophages. Identifying M2 macrophage subtypes revealed that exposure to MSCs transforms the phenotype and function of macrophages. We suggest that Ly6c^- monocytes could be a therapeutic target for asthma management.

• Journal of Korean Neurosurgical Society
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• 제67권4호
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• pp.418-430
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• 2024

Objective : Isoflurane, a widely used common inhalational anesthetic agent, can induce brain toxicity. The challenge lies in protecting neurologically compromised patients from neurotoxic anesthetics. Choline alfoscerate (L-α-Glycerophosphorylcholine, α-GPC) is recognized for its neuroprotective properties against oxidative stress and inflammation, but its optimal therapeutic window and indications are still under investigation. This study explores the impact of α-GPC on human astrocytes, the most abundant cells in the brain that protect against oxidative stress, under isoflurane exposure. Methods : This study was designed to examine changes in factors related to isoflurane-induced toxicity following α-GPC administration. Primary human astrocytes were pretreated with varying doses of α-GPC (ranging from 0.1 to 10.0 µM) for 24 hours prior to 2.5% isoflurane exposure. In vitro analysis of cell morphology, water-soluble tetrazolium salt-1 assay, quantitative real-time polymerase chain reaction, proteome profiler array, and transcriptome sequencing were conducted. Results : A significant morphological damage to human astrocytes was observed in the group that had been pretreated with 10.0 mM of α-GPC and exposed to 2.5% isoflurane. A decrease in cell viability was identified in the group pretreated with 10.0 µM of α-GPC and exposed to 2.5% isoflurane compared to the group exposed only to 2.5% isoflurane. Quantitative real-time polymerase chain reaction revealed that mRNA expression of heme-oxygenase 1 and hypoxia-inducible factor-1α, which were reduced by isoflurane, was further suppressed by 10.0 µM α-GPC pretreatment. The proteome profiler array demonstrated that α-GPC pretreatment influenced a variety of factors associated with apoptosis induced by oxidative stress. Additionally, transcriptome sequencing identified pathways significantly related to changes in isoflurane-induced toxicity caused by α-GPC pretreatment. Conclusion : The findings suggest that α-GPC pretreatment could potentially enhance the vulnerability of primary human astrocytes to isoflurane-induced toxicity by diminishing the expression of antioxidant factors, potentially leading to amplified cell damage.

• Journal of the Korean Society of Radiology
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• 제82권3호
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• pp.613-623
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• 2021

Purpose To evaluate the MRI findings and clinical factors that are characteristic of patients who ultimately undergo surgery for medial epicondylitis. Materials and Methods Fifty-two consecutive patients who were diagnosed with medial epicondylitis and underwent an elbow MRI between March 2010 and December 2018 were included in this retrospective study. The patients' demographic information, clinical data, and MRI findings were evaluated. All variables were compared between the conservative treatment and surgical treatment groups. Logistic regression analyses were conducted to identify which factors were associated with surgical treatment. Results Common flexor tear (CFT) tear size showed a statistically significant difference in both the transverse and longitudinal planes (p < 0.001, p = 0.013). The CFT abnormality grade significantly differed in both the transverse and longitudinal planes (p = 0.022, p = 0.003). A significant difference was also found in the medial collateral ligament abnormality (p = 0.025). Logistic regression analyses showed that only the transverse diameter of the CFT tear size (odds ratio: 1.864; 95% confidence interval: 1.264-2.750) was correlated with surgical treatment. Conclusion Of patients diagnosed with medial epicondylitis, patients with a larger transverse CFT tear size tend to undergo surgical treatment ultimately.