• 약학회지
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• 제52권5호
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• pp.345-354
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• 2008

This study was designed to investigate the anti-diabetic effect and mechanism of Korean red ginseng extract through transcriptomics in C57BL/KsJ db/db mice. The db/db mice were randomly divided into six groups: diabetic control group (DC), red ginseng extract low dose group (RGL, 100 mg/kg), red ginseng extract high dose group (RGH, 200 mg/kg), metformin group (MET, 300 mg/kg), glipizide group (GPZ, 15 mg/kg) and pioglitazone group (PIO, 30 mg/kg), and treated with drugs once per day for 10 weeks. At the end of treatment, we measured blood glucose, insulin, hemoglobin A1c (HbA1c), triglyceride (TG), adiponectin, leptin, non-esterified fatty acid (NEFA). RGL-treated group lowered the blood glucose and HbA1c levels by 19.6% and 11.4% compared to those in diabetic control group. In addition, plasma adiponectin and leptin levels in RGL-treated groups were increased by 20% and 12%, respectively, compared to those in diabetic control. Morphological analyses of liver, pancreas and epidydimal adipose tissue were done by hematoxylin-eosin staining, and pancreatic islet insulin and glucagon levels were detected by double-immunofluorescence staining. RGL-treated group revealed higher insulin contents and lower glucagon contents compared to diabetic control. To elucidate an action mechanism of Korean red ginseng, DNA microarray analyses were performed in liver and fat tissues, and western blot and RT-PCR were conducted in liver for validation. According to hierarchical clustering and principal component analysis of gene expression Korean red ginseng treated groups were close to metformin treated group. In summary, Korean red ginseng lowered the blood glucose level through protecting destruction of islet cells and shifting glucose metabolism from hepatic glucose production to glucose utilization and improving insulin sensitivity through enhancing plasma adiponectin and leptin levels.

• 한국토양비료학회지
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• 제49권5호
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• pp.572-576
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• 2016

Soil quality assessment is an important tool for environmental management in an agricultural field. It can be used to evaluate the health of the soils and to establish the basis for sustainable urban agriculture and soil management. For this study, the chemical properties of the soils used for urban agriculture were examined. Results of the soil analysis for chemical properties were applied to soil quality assessment system, which is composed of principal component analysis, application to scoring function and derivation of soil quality index (SQI). Soil pH, electrical conductivity (EC), organic matter (OM), total nitrogen (T-N) were determined for minimum data set (MDS) according to principal component analysis. Based on the results of scoring for four indicators (pH, EC, OM, T-N), soil pH was the indicator that needs the most urgent management. Results of SQI derivation showed that many of the urban farms appeared to be insufficient score in comprehensive soil quality assessment. In conclusion, soil management practices based on scores derived from soil chemical indicators need to be carried out to maintain sustainable urban agricultural soil environment and to provide easy-to-understand information to urban farmers.

• 한국환경복원기술학회지
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• 제12권3호
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• pp.116-129
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• 2009

This study is to enhance the provincial leisure plans through various programs and infrastructure facilities and to establish a network of natural leisure areas in Gyeonggi-do. According to the result, first, in terms of analyzing the locations of natural leisure areas by types, the rest of urban parks is formed in the Capital area outside Seoul as centering around the central area. Moreover, with regard to the rest of forest and the rest of natural ecology learning, the area of the detention exceeds the total area of Gyeonggi-do. The rest of valleys and swamps showed a dotted pattern of the detention area while the rest of tideland and fishing village experience indicated a distribution of the detention area along the West Coast as an axis. Second, according to result of analyzing the accessibility of natural leisure areas by types, the rest of valleys and swamps showed the highest accessibility among the natural leisure areas : the rest of natural ecology learning had the medium level of accessibility; the rest of forest indicated the lowest accessibility. Therefore, it is necessary to create more leisure areas concerning the futures demands. In addition, they should be constructed in the places adjacent to the urban district area exhibiting higher usability and accessibility. In the places where there are many natural leisure area with higher utility, management plans should be deliberated as well. Based on the result of analyzing the rest of valleys and swamps and the rest of tideland and fishing village experience, it was found that the natural leisure area should improve the quality of water intensively and hydrophile property and create hydrophilic spaces. The development of natural leisure areas need to be carried out under the principle of environmental protection while considering historic sites and nearby rivers and lakes. Moreover, water leisure programs should be developed actively as well with further utilization of water resources in order to enhance the usability of natural leisure.

• 한국안전학회지
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• 제35권5호
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• pp.15-21
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• 2020

Quantitative risk assessment (QRA) is used as a legal or voluntary safety management tool for the hazardous material industry and the utilization of the method is gradually increasing. Therefore, a leak frequency analysis based on reliable generic data is a critical element in the evolution of QRA and safety technologies. The aim of this paper is to derive the leak frequency function that can be applied more flexibly in QRA based on OGP report with high reliability and global utilization. For the purpose, we first reviewed the data on the 16 equipments included in the OGP report and selected the predictors. And then we found good equations to fit the OGP data using non-linear regression analysis. The various expectation functions were applied to search for suitable parameter to serve as a meaningful reference in the future. The results of this analysis show that the best fitting parameter is found in the form of DNV function and connection function in natural logarithm. In conclusion, the average percentage error between the fitted and the original value is very small as 3 %, so the derived prediction function can be applicable in the quantitative frequency analysis. This study is to contribute to expand the applicability of QRA and advance safety engineering as providing the generic equations for practical leak frequency analysis.

• 동의생리병리학회지
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• 제20권4호
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• pp.784-792
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• 2006

The Neo-Confucian study of the thee of ministerial fire(相火論) constitute of the rule of iung jung(中正), the principal of form and use(體用) and of real nature and emotion(性情) of human and ethic mind(人心道心). The present study is to evaluate a fundamental concept of the theory of ministerial fire, which is one of traditional medical ideology in China, through the Neo-Confucianism projects to The theory of ministerial fire. The theory of ministerial fire of Judange(朱丹溪) was recognized by ontological principal of Heaven-Human being-Earth, ontological structure of Form-Use and the structure that mind consist of real nature and emotion(심統性惰). The ethic and human mind(道心人心) of Judange and constancy and transition(常變) of seven emotion have relationship in the ontological structure of Form-Use. The real nature of human Doing consisted of apriority of Heaven rule is unitary constructed by Form-Use(체용) of inactivated real nature and activated seven emotion and then activated seven emotion shows dual form of appropriate(中節) and inappropriate(不中節). Emperor's and ministerial fire(君火相火) which has a relationships of Heaven-Human being synchronization represents all kinds of fire and classified to heaven fire(天火) and human fire(人火). The emperor's fire was triggered by inactivated fire and ministerial fire(相火) was triggered by activated fire. Inactivated ministerial fires have dual form of physiological ministerial and pathological ministerial fire. Regarding the forementioned analytic thinking, it was clear that manifest processing of One's real nature and the ministerial fire undergo the same principal and logics. Since maintained One's real nature that is inactivated seven emotion and appropriated activated seven emotion, ministerial fire can be stable and keep one's health and well-being in mind and body.

• 한국축산식품학회지
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• 제29권6호
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• pp.668-672
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• 2009

This paper describes the differentiation between native Korean cattle (Hanwoo) and Holsteins or imported cattle using the real-time polymerase chain reaction (PCR) by targeting the sequence of the melanocortin 1 receptor (MC1R) gene. A rapid and accurate method was developed to identify Hanwoo by genotyping the DNA extracted from 295 commercial beef samples (obtained from 5 provinces in South Korea) labeled as Hanwoo beef. The results of real-time PCR assays for the proportions of Hanwoo were 84, 85.7, 95, 91.4, and 90% in the areas of Seoul, Joongbu, Youngnam, Honam, and Chungcheong, respectively. Thus, the beef samples from 295 butcher shops, which asserted to only sell Hanwoo, showed that 259 of 295 samples were of the Hanwoo beef gene type (T-type) and 36 of 295 samples were Holsteins of imported dairy cattle gene types (C-type or C/T type). In conclusion, the proportion of Hanwoo beef was 87.8% and the proportion of Holstein or imported dairy cattle meat was 12.2% (C-type: 9.8%, C/T-type: 2.4%). Generally, most consumers can not differentiate imported meat from Hanwoo beef. Therefore, Hanwoo beef and imported dairy cattle meat that is sold in butcher shops should have mandatory identification by using MC1R genotyping based on real-time PCR.

• 한국축산식품학회지
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• 제29권3호
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• pp.296-301
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• 2009

This study investigated the effects of fermented soybean (FS) on growth and meat quality in pigs. A total thirty-six pigs were divided into 2 groups (2 treatment$\times$18 pigs each) and fed the experimental diets for 4 wk as follows: control (FS free); and T1 (FS 1%). The pigs in T1 had a higher feed efficiency compared with pigs fed control diets. pH was also significantly higher in the T1 group (p<0.05). Water-holding capacity measured in T1 was slightly higher than that of the control. Cooking loss in T1 was significantly lower than controls (p<0.05). CIE $L^*$ and CIE $b^*$ value were significantly higher in the control (p<0.05), but CIE $a^*$ value of T1 was higher than control (p<0.05). The drip loss of T1 were significantly lower than controls (p<0.05). Sensory characteristics of the treatment group showed higher than controls (p<0.05). These results showed that FS could be served as a favorable feed additive and feedstuff for enhancing pork quality.

• 한국토양비료학회지
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• 제50권6호
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• pp.497-508
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• 2017

This study aimed to investigate correlations between concentrations of extractable Arsenic (As) with varying chemical solutions (0.1 M $Ca(NO_3)_2$, 0.1 M $(NH_4)2HPO_4$, 0.5 M EDTA, Mehlich 3, and 0.5 M $NaHCO_3$) and those of As in crops, and then to seek the most suitable soil extraction method for predicting the potential of As uptake in crops cultivated in soils contaminated with As. For a mesocosm experiment, pepper (Capsicum annuum L.), soybean (Glycine max L.), and rice (Oryza sativa L.) were cultivated for three months in pots containing soils taken from the arable areas near abandoned mines in Korea. Following the cultivation, soil pH and DOC significantly increased by treatments of lime and lime plus compost, respectively, while insignificant influences in changing total and all extractable As concentrations were found in all soils. Arsenic concentration in edible part of all crops considerably depended on the extractable As concentration in the soils, particularly with Mehlich 3. All extractable As concentrations in the soils of C. annuum and G. max were significantly correlated with As concentration in their edible parts. For O. sativa, the extractable concentrations of Mehlich 3 ($R^2$: 0.18 at p: 0.006) and EDTA ($R^2$: 0.11 at p: 0.036) showed only marked relationships with As concentration in the edible part. These results may indicate that the Mehlich 3 and EDTA are soil extractants to determine phytoavailable As in soil that provide better prediction for As transfer from soil to crop.

• 대한본초학회지
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• 제36권4호
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• pp.41-50
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• 2021

Objectives : This study is to check the quality of Moschus products in Korean markets using a chromatographic analysis. Methods : We collected musk products, two genuine products from Russia (A, B), two authentic products from Hong Kong (C) and Korea (D), the Ministry of Food and Drug Safety (MFDS) standard (E), and two fire ants products (E, F). Results : For identification, TLC analysis of 60% ethanol extracts of each product showed that A, B, C, and E have the suitable patterns before color development at 365 nm UV light for the MFDS regulation in Korea. A clear red spot was observed from the E at R_f 0.6 with 365 nm UV light after color development, but this spot was not found in A and B. For the purity test, a distinct violet spot with R_f 0.87 was observed from the A and B in TLC analysis of methanol extracts of each product at white light, however, this spot was not matched with the impurities of E and F. In HPLC-UV pattern analysis, a similar peak pattern was shown in A, B and E, and similar peaks were observed C, although the similarity was weaker than that of A, B, and E. The F and G showed different peak patterns compared with the peak patterns of other samples. Conclusions : Hence, it is considered that the test methods need flexibility in application for identification and purity test depending on the type of sample.

• Journal of Rhinology
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• 제25권2호
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• pp.103-107
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• 2018

Pregnancy rhinitis is a relatively common condition. It is characterized by the presence of nasal symptoms, especially nasal congestion, not present prior to pregnancy, but typically present during the last 6 or more weeks of pregnancy, without other signs of respiratory tract infection or any known allergic causes, and disappearing completely within 2 weeks after delivery. Nasal saline irrigation, intranasal steroid spray, and oral antihistamines are usually recommended as the first line of treatment for rhinitis. However, most pregnant women refuse medical treatment for pregnancy rhinitis because of the fear of teratogenicity. Severe pregnancy rhinitis increases the risk of snoring, which has been suggested as having adverse effects on the fetus. In cases where the patients are unable to control their symptoms, pregnancy rhinitis can negatively affect the quality of life (QOL) as well as the pregnancy outcome. Therefore, special caution is required for determining the appropriate diagnosis and treatment modalities for pregnancy rhinitis. Here, we report for the first time, the successful treatment of pregnancy rhinitis that was unresponsive to conservative management and medical therapy by using microdebrider-assisted inferior turbinoplasty at the final stages of pregnancy, along with a review of the relevant literature.