• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.929-934
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• 2013

Aim: To analyze the significance of different clinical factors for prognostic prediction in diffuse large B-cell lymphoma (DLBCL) patients. Methods: Two hundred and twenty-seven DLBCL patients were retrospectively reviewed. Patients were managed with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen or rituximab plus the CHOP (RCHOP) regimen. Results: Lactate dehydrogenase (LDH), ${\beta}2$-microglobulin (${\beta}2$-M), B symptoms, Ann Arbor stage and genetic subtypes were statistically relevant in predicting the prognosis of the overall survival (OS). In the CHOP group, the OS in patients with germinal center B-cell-like (GCB)(76.2%) was significantly higher than that of the non-GCB group (51.9%, P=0.032). With RCHOP management, there was no statistical difference in OS between the GCB (88.4%) and non-GCB groups (81.9%, P=0.288). Conclusion: Elevated LDH and ${\beta}2$-M levels, positive B symptoms, Ann Arbor stage III/IV, and primary nodal lymphoma indicate an unfavorable prognosis of DLBCL patients. Patients with GCB-like DLBCL have a better prognosis than those with non-GCB when treated with the CHOP regimen. The RCHOP treatment with the addition of rituximab can improve the prognosis of patients with DLBCL.

• Asian Pacific Journal of Cancer Prevention
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• 제15권10호
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• pp.4367-4372
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• 2014

We here document discovery of expression profile of myeloid derived suppressor cells (MDSCs) in chronic hepatitis B (CHB) patients and changes in the course of disease. The study population was composed of 75 outpatient HBV cases and 15 healthy control cases. Peripheral blood samples were collected for separation of mononuclear cells. Levels of MDSCs labeled with Lin-DR-CD11b+CD33+ obtained from peripheral blood mononuclear cells (PBMC), were revealed to have significant differences between the CHB and other groups. They were 0.414% for health control cases and 0.226% for CHB cases (Z=-2.356, p=0.0189). It also observed that the group of HBeAg positive cases had significant difference in MDSCs/PBMC median ($X^2=11.877$, p=0.003), compared with group of HBeAg negative cases and the healthy control group. It suggested considerable MDSCs might be involved in HBeAg immune tolerance. In addition, negative correlations between MDSCs/PBMC and parameters of ALT, AST and TBil, while positive correlation between MDSCs/PBMC and ALB parameter were found. Multiple comparisons between the four phases and health control phase again, there was a statistically sifnificant difference ($X^2=17.198$, p=0.002). Taken together, these findings may provide a new immunotherapy strategy for reduced the expression levels of MDSCs in CHB patients, through induction of an autoimmune response to virus removal.

• 대한한의학원전학회지
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• 제18권4호통권31호
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• pp.1-14
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• 2005

Zhu Dan Xi's name is ZhenHeng(震亨) and was also called by the title of YanXiu(彦修). Early in his life, he started to study JuZiYe(擧子業), and went on to study DaoDeXingMingXue(道德性命學) under the teachings of XueQian(許謙), who as one of fourth generation disciple of ZhuZi(朱子) was teaching in BaHuaShan(八華山). His well-known literary works are ${\ulcorner}$JuFangFaHui(局方發揮)${\lrcorner}$, ${\ulcorner}$GeZhiYuLun${\lrcorner}$, ${\ulcorner}$ShangHanBianYi(傷寒辨疑)${\lrcorner}$, ${\ulcorner}$BenCaoYanYiBuYi(本草衍義補遺)${\lrcorner}$, ${\ulcorner}$WaiKeJingYaoXinLun(外科精要新論)${\lrcorner}$. Zhu Dan Xi learnt the studies of Liu(劉), Zhang(張), Li(李) from LouZhiTi(羅知悌) and adopted the advantages and abolished disadvantages from it. The southern district being low and damp, which also leads to a geographical condition with a lot of ShiReXiangHuo(濕熱相火) disease and with the social background of people exhausting their QingYu(情欲) and damaging QLXie(氣血), he came out with the theory of 'YangYouYuYinBuZu(陽有餘陰不足)', 'XiangHuo(相火)' and became a well renowned expert in diagnosis and treatment of QiXieTanYuHuo(氣血痰鬱火). As a result, the writer has performed a research based on Liu's works and related theories, GuWuZhiZhi theory, the understanding of TaiJiZhiLi(太極之理), the inner meaning of YinYang and YouYuBuZu(redundancy-and-deficit), YinYangDongJingGuan, physiology and pathology, the medical reason of lust damaging QingYuYangYin and YangSheng(養生)(preservation of health), which are the main medical theory of ZhuDanXi, comments of later generations and is reporting the outcome.

• 한국콘텐츠학회논문지
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• 제20권2호
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• pp.82-95
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• 2020

본 연구는 역사문화지구 퍼블릭 아트의 특징과 아이덴티티를 연구 대상으로 역사문화구역의 퍼블릭 아트에 대한 이론 연구와 조사를 통해 징더전 도계천이 대표하는 역사문화지구 퍼블릭 아트의 특성을 연구하였다. 공간적 특성과 아이덴티티를 형성하는 여섯 가지 평가요인인 환경성, 공공성, 상징성, 예술성, 역사성, 상호작용성을 중심으로 도계천 퍼블릭 아트의 특성과 아이덴티티를 분석과 평가하였다. 연구 결과 산업 유산물로 재탄생 한 7개 큰 굴뚝의 퍼블릭 아트는 완전히 보존된 산업역사 건물과 어울린다. 그중, 환경성, 공공성, 상징성, 예술성, 역사성이 명확한 구현을 갖추고 있으며 단지의 역사적 상징물로서 보존가치와 식별가능성이 높아 일반 퍼블릭 아트의 행사나 체험기능을 더하지 않아도 된다. 지역 재생을 위한 신퍼블릭 아트 중 퍼블릭 아트의 예술성, 환경성, 공공성이 높게 나타났고 환경성도 중간 수준을 보이고 있지만, 역사성이 높지 않고, 상호 작용성이 약하다. 산업 유산물로 재탄생한 퍼블릭 아트는 역사유적 퍼블릭 아트로 산업유산과 도자기 요소로 대중들의 시공간과소통을 형성하면서 대중에게 정신적 공감을 전달할 수 있는 아이덴티티를 형성하였으며, 지역재생을 위한 신 퍼블릭 아트는 도계천에 새로운 예술적 정취를 부여하였으나 새로운 아이덴티티는 나타내지 못하는 것으로 평가되었다.