• Biotechnology and Bioprocess Engineering:BBE
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• 제4권1호
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• pp.66-71
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• 1999

One of the practical limitations with the use of liposomes for delivery of the pharmaceutical substances such antigens is that liposomes are relatively unstable in storage. In order to extend the stability of liposome in storage without affecting their functional activity, solution-type liposomes were dehydrated to form a structurally intact dry liposomes. Comparative immunological evaluation was carried out for both dry and solution-type liposomes containing gag-V3 chimera, consequently it was found that dry liposomes elicited both humoral and cellular response as efficiently as solution-type liposemes did against the same gag-V3 antigen. Especially, long-term stability of the liposomes was remarkably enhanced by the dehydration made to loposomes without a significant change in its ability to elicit immune response in vivo. These results indicate that dry pH-sensitive liposome may become an effective delivery and adjuvant system for general vaccine development.

• KSBB Journal
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• 제21권4호
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• pp.241-247
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• 2006

용존산소 센서 및 시스템에서 손실되는 산소량을 보정하기 위해 멸균처리 기법을 도입하였다. 멸균처리 시료의 DO 거동과 비멸균처리 시료의 DO 거동차(${\Delta}$DO)는 시스템의 영향과 무관하게 폐수 자체의 순수한 미생물만이 소모하는 산소변화량을 구하였다. 용존산소 센서로 축산폐수의 시간에 따른 DO거동(-d${\Delta}$DO/dt)을 측정하여 구한 폐수 자체의 미생물에 의한 산소소모속도는 0.00074mg $O_2/{\ell}{\cdot}sec$이었다. 축산폐수의 원액을 희석하여 다양한 BOD값을 갖도록 시료를 제조한 후 DO meter로 측정하여 구한 DO 변화량은 동일한 시료를 5일 BOD 측정방법인 Winkler Azide화 변법으로 구한 BOD값과 선형구간($30{\sim}60$분)에서 97.72%의 높은 상관 선형성을 보였다. 따라서 본 연구의 multi-biosensor 시스템은 축산폐수의 BOD를 짧은 시간에 정확하게 측정할 수 있는 가능성을 제시하였다.

• 한국기술혁신학회:학술대회논문집
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• 한국기술혁신학회 2012년도 추계 학술대회 논문집
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• pp.50-61
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• 2012

• 한국진공학회:학술대회논문집
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• 한국진공학회 2008년도 제34회 동계학술대회 초록집
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• pp.250-250
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• 2008

• 한국섬유공학회:학술대회논문집
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• 한국섬유공학회 1990년도 제2차 학술발표초록집
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• pp.52-52
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• 1990

• 기계와재료
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• 제4권4호통권14호
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• pp.27-40
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• 1992

• 대한화장품학회지
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• 제27권1호
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• pp.119-131
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• 2001

Exposure of the human skin to UV-light can cause sun-tanning, photoaging and even photo-carcinogenesis. Melanin is important in protecting the skin against UV damage, but excessive or uneven melanin production can lead to the formation of freckles and aged spot. Control of hyperpigmentation is becoming even more important as aged population continues to grow. These needs led us to develop effective and safe depigmenting-agent, kojyl 3-aminopropyl phosphate (kojyl-APPA), called Whitegen. The development of whitegen was based on the fact that phosphate group of 3-aminopropyl phosphate can make kojic acid more compatible to the skin membrane and more stable. Instability of kojic acid has been a problem in cosmetic use. The insertion of phosphoester group has been recognized as a powerful tool to improve such physical properties as solubility and stability, because the phosphodiester residue is well characterized as a non-toxic moiety, having a high affinity for cell membranes. Kojyl-APPA showed no tyrosinase inhibition effect compared to kojic acid in vitro, but showed tyrosinase inhibition effect in situ. It means that kojyl-APPA is converted to kojic acid enzymatically in cells. Kojyl-APPA showed the inhibitory activity on melanin synthesis in mouse melanoma and normal humal melnaocytes and also showed long-lasting stability in comparison with its original form (kojic acid). Kojyl-APPA showed depigmenting effects when applied to UVB-induced hyperpigmentated region of guinea pig skin. Based on these results, kojyl 3-aminopropyl phosphate can be used as a safe and effective ingredient for the brightness and cleanness of skin.

• Mycobiology
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• 제39권1호
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• pp.52-53
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• 2011

Gray mold of blueberry caused by Botrytis sp. is reported for the first time in Korea. A detailed description of the fungus is given, along with its rDNA internal transcribed spacer sequence. The fungus was identified as Botrytis cinerea based on mycological characteristics and molecular data.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2001년도 창립10주년 제20회 학술발표회
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• pp.113-113
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• 2001

• 한국식물생명공학회:학술대회논문집
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• 한국식물생명공학회 2005년도 추계학술대회 및 한일 식물생명공학 심포지엄
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• pp.260-260
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• 2005