• Animal Bioscience
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• 제34권8호
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• pp.1309-1320
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• 2021

Objective: Investigation of muscle growth at different developmental stages is an appropriate strategy for studying the mechanisms underlying muscle development and differences in phenotypes. In particular, the muscle development mechanisms and the difference between the fastest and slowest growth rates. Methods: In this study, we used a growth curve model to fit the growth inflection point (IP) of QingYu pigs and compared differences in the long non-coding RNA (lncRNA) transcriptome of muscle both at the growth IP and plateau phase (PP). Results: The growth curve of the QingYu pig had a good fit (R² = 0.974) relative to a typical S-curve and reached the IP at day 177.96. At the PP, marbling, intramuscular fat, and monounsaturated fatty acids had increased significantly and the percentage of lean muscle and polyunsaturated fatty acids had decreased. A total of 1,199 mRNAs and 62 lncRNAs were differentially expressed at the IP compared with the PP. Additional to gene ontology and Kyoto encyclopedia of genes and genomes pathway analyses, these differentially expressed protein coding genes were principally related to muscle growth and lipid metabolism. Conclusion: Our results suggest that the identified differentially expressed lncRNAs, could play roles in muscle growth, fat deposition and regulation of fatty acid composition at the IP and PP.

• Geomechanics and Engineering
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• 제31권5호
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• pp.477-488
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• 2022

Pile composite foundation (PCF) has been commonly applied in practice. Existing research has focused primarily on semi-infinite media having equal pile lengths with little attention given to the effects of inclined bedrock and dissimilar pile lengths. This investigation considers the effects of inclined bedrock on vertical loaded PCF with dissimilar pile lengths. The pile-soil system is decomposed into fictitious piles and extended soil. The Fredholm integral equation about the axial force along fictitious piles is then established based on the compatibility of axial strain between fictitious piles and extended soil. Then, an iterative procedure is induced to calculate the PCF characteristics with a rigid cap. The results agree well with two field load tests of a single pile and numerical simulation case. The settlement and load transfer behaviors of dissimilar 3-pile PCFs and the effects of inclined bedrock are analyzed, which shows that the embedded depth of the inclined bedrock significantly affects the pile-soil load sharing ratios, non-dimensional vertical stiffness N₀/wdE_s, and differential settlement for different length-diameter ratios of the pile l/d and pile-soil stiffness ratio k conditions. The differential settlement and pile-soil load sharing ratios are also influenced by the inclined angle of the bedrock for different k and l/d. The developed model helps better understand the PCF characteristics over inclined bedrock under vertical loading.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4699-4704
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• 2015

Medical diagnostic X-ray workers are one occupational group that expose to the long-term low-dose external radiation over their working lifetime, and they may under risk of different cancers. This study aims to determine the relationship between the occupational X-ray radiation exposure and cancer risk among these workers in Jiangsu, China. We conducted Nested case-control study to investigate the occupational X-ray radiation exposure and cancer risk. Data were collected through self-administered questionnaire, which includes but not limits to demographic data, personal behaviors and family history of cancer. Retrospective dose reconstruction was conducted to estimate the cumulative doses of the x-ray workers. Inferential statistics, t-test and 2 tests were used to compare the differences between each group. We used the logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) of cancer by adjusting the age, gender. All 34 breast cancer cases and 45 esophageal cancer cases that detected in a cohort conducted among health workers between 1950~2011 were included in this presented study, and 158 cancer-free controls were selected by frequency-matched (1:2). Our study found that the occupational radiation exposure was associated with a significantly increased cancer risk compared with the control, especially in breast cancer and esophageal cancer (adjusted OR=2.90, 95% CI: 1.19-7.04 for breast cancer; OR=4.19, 95% CI: 1.87-9.38 for esophageal cancer, and OR=3.43, 95% CI: 1.92-6.12 for total cancer, respectively). The occupational X-ray radiation exposure was associated with increasing cancer risk, which indicates that proper intervention and prevention strategies may be needed in order to bring down the occupational cancer risk.

• Interaction and multiscale mechanics
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• 제3권2호
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• pp.192-211
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• 2010

In most framed structures the nonlinearities and the damages are localized, extending over a limited length of the structural member. In order to capture the details of the local damage, the segments of a member that have entered the nonlinear range may need to be analyzed using the three-dimensional element (3D) model whereas the rest of the member can be analyzed using the simpler one-dimensional (1D) element model with fewer degrees of freedom. An Element-Coupling model was proposed to couple the small scale solid 3D elements with the large scale 1D beam elements. The mixed dimensional coupling is performed imposing the kinematic coupling hypothesis of the 1D model on the interfaces of the 3D model. The analysis results are compared with test results of a reinforced concrete pipe column and a structure consisting of reinforced concrete columns and a steel space truss subjected to static and dynamic loading. This structure is a reduced scale model of a direct air-cooled condenser support platform built in a thermal power plant. The reduction scale for the column as well as for the structure was 1:8. The same structures are also analyzed using 3D solid elements for the entire structure to demonstrate the validity of the Element-Coupling model. A comparison of the accuracy and the computational effort indicates that by the proposed Element-Coupling method the accuracy is almost the same but the computational effort is significantly reduced.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1857-1863
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• 2015

Background: Alpha-methylacyl-CoA racemase(AMACR) is thought to play key roles in diagnosis and prognosis of prostate cancer. However, studies of associations between AMACR gene polymorphisms and prostate cancer risk reported inconsistent results. Therefore, we conducted the present meta-analysis to clarify the link between AMACR gene polymorphisms and prostate cancer risk. Materials and Methods: A literature search was performed in PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang and Weipu databases. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated to assess the strength of any association between AMACR polymorphisms and prostate cancer risk. Subgroup analyses by ethnicity, source of controls, quality control and sample size were also conducted. Results: Five studies covering 3,313 cases and 3,676 controls on five polymorphisms (D175G, M9V, S201L, K277E and Q239H) were included in this meta-analysis. Significant associations were detected between prostate cancer and D175G (dominant model: OR=0.89, 95%CI=0.80-0.99, P=0.04) and M9V (dominant model: OR=0.87, 95%CI=0.78-0.97, P=0.01) polymorphisms as well as that in subgroup analyses. We also observed significant decreased prostate cancer risk in the dominant model (OR=0.90, 95%CI=0.81-0.99, P=0.04) for the S201L polymorphism. However, K277E and Q239H polymorphisms did not appear to be related to prostate cancer risk. Conclusions: The current meta-analysis indicated that D175G and M9V polymorphisms of the AMACR gene are related to prostate cancer. The S201L polymorphism might also be linked with prostate cancer risk to some extent. However, no association was observed between K277E or Q239H polymorphisms and susceptibility to prostate cancer.

• Structural Engineering and Mechanics
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• 제67권2호
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• pp.105-113
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• 2018

To improve the prediction accuracy of the strong-unloading rock slope performance and obtain the range of variation in the slope displacement, a new displacement time-series prediction model is proposed, called the fuzzy information granulation (FIG)-genetic algorithm (GA)-back propagation neural network (BPNN) model. Initially, a displacement time series is selected as the training samples of the prediction model on the basis of an analysis of the causes of the change in the slope behavior. Then, FIG is executed to partition the series and obtain the characteristic parameters of every partition. Furthermore, the later characteristic parameters are predicted by inputting the earlier characteristic parameters into the GA-BPNN model, where a GA is used to optimize the initial weights and thresholds of the BPNN; in the process, the numbers of input layer nodes, hidden layer nodes, and output layer nodes are determined by a trial method. Finally, the prediction model is evaluated by comparing the measured and predicted values. The model is applied to predict the displacement time series of a strong-unloading rock slope in a hydropower station. The engineering case shows that the FIG-GA-BPNN model can obtain more accurate predicted results and has high engineering application value.

• 한국품질경영학회:학술대회논문집
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• 한국품질경영학회 1998년도 The 12th Asia Quality Management Symposium* Total Quality Management for Restoring Competitiveness
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• pp.384-392
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• 1998

Dr. Taguchi proposed three models of ideal functions for dynamic systems with double signal factors. He also gave examples for each model yet without derivation. It will be difficult for other engineers to follow because Dr. Taguchi didn't show us how he obtained those models. Actually we can analyze each example from engineering aspect based on basic mechanism. In this paper we use brake systems to illustrate our approach of derivation and obtain a different form of ideal function from what Taguchi proposed. Our purpose is to provide an example that engineers can imitate and solve his problem at hand.

• Transactions on Electrical and Electronic Materials
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• 제7권5호
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• pp.247-251
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• 2006

The traction DC feeder cable is one of the key devices for the safety operation of subway system, but for low voltage DC feeder cable (<3000 V) for subway, little attention has been paid by investigators on its online monitoring technology. With an introduction of cable laying and operation environment for the cable, this paper investigated the on-line monitoring technology of 1500 V DC feeder cable of subway. Firstly, in the text, the fault model of 1500 V DC cable was proposed based on the analysis of the fault type of the DC feeder cable, and then put forward synthetically on-line monitoring discharge signal and DC leakage current signal to assess DC feeder cable insulating state. The results of laboratory experiment prove that the proposed methods are feasible and can be implemented on-line monitor on DC feeder cable of subway.

• Steel and Composite Structures
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• 제26권2호
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• pp.139-150
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• 2018

In this paper, two kinds of buckling restrained braces (BRBs) are designed to improve the mechanical properties and fatigue life, the reserved gap and viscoelastic filler with high energy dissipation capacity are employed as the sliding element, respectively. The fatigue life of BRBs considering the effect of sliding element is predicted based on Manson-Coffin model. The property tests under different displacement amplitudes are carried out to evaluate the mechanical properties and fatigue life of BRBs. At last, the finite element analysis is performed to study the effects of the gap and viscoelastic filler on mechanical properties BRBs. Experimental and simulation results indicate that BRB employed with viscoelastic filler has a higher fatigue life and more stable mechanical property compared to BRB employed with gap, and the smaller reserved gap can more effectively improve the energy dissipation capacity of BRB.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1993년도 한국자동제어학술회의논문집(국제학술편); Seoul National University, Seoul; 20-22 Oct. 1993
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• pp.1-6
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• 1993

This report proposes a novel method of identification of continuous time-delay systems from sampled input-output data. By the aid of a digital pre-filter, an approximated discrete-time estimation model is first derived, in which the system parameters remain in their original form and the time delay need not be an integral multiple of th sampling period. Then an identification method combining the common linear least squares(LS) method or the instrumental variable(IV) method with the genetic algorithm(GA) is proposed. That is, the time-delay is selected by the GA, and the system parameters are estimated by the LS or IV method. Furthermore, the proposed method is extended to the case of multi-input multi-output systems where the time-delays in the individual input channels may differ each other. Simulation resutls show that our method yields consistent estimates even in the presence of high measurement noises.