• The Journal of Internal Korean Medicine
• /
• v.34 no.2
• /
• pp.155-164
• /
• 2013

Objectives : This study aimed to evaluate the single oral dose toxicity of Jaeumganghwa-tang (Ziyinjianghuo-tang) and Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acidophyllus in male and female ICR mice. Methods : In this single oral toxicity study, non-fermented and fermented Jaeumganghwa-tang (Ziyinjianghuo-tang) were administered to male and female ICR mice as an oral dose of 500, 1000 and 2000 mg/kg. After single administration, body weight changes, general behavior, adverse effects and mortality were determined for 14 days. Serum chemistry, organ weights and necropsy findings were evaluated at the end of the experiment. Results : There were no mortality or signs of toxicity for 14 days. There were also no significant differences in body weights, organ weights, or serum chemistry values between treatment and control groups. Conclusions : These results indicate that the 50% lethal dose of Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acipophullus may be over 2000 mg/kg. This finding can be expected to provide scientific evidence for the safety of Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acidophyllus.

• The Journal of Internal Korean Medicine
• /
• v.43 no.3
• /
• pp.493-501
• /
• 2022

Objectives: This study aimed to report the effects of Jaeumganghwa-tang (Ziyinjianghuo-tang) and Gyeongok-go on a patient with asthma. Methods: A 54-year-old female patient was treated with herbal medicine, including Jaeumganghwa-tang, Gyeongok-go, acupuncture, and moxibustion treatment. The effects of treatments were evaluated using the modified medical research council dyspnea scale (mMRC), St. George's Respiratory Questionnaire (SGRQ), and Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA). Results: Following treatment, the mMRC score decreased from 2 to 1, the SGRQ score decreased from 60.53 to 25.61, and the QLQAKA score increased from 44 to 72. In the SGRQ, symptom scores decreased from 70.67 to 57.49, activity scores from 36.22 to 25.96, and impact scores from 72.15 points to 15.44 points. In QLQAKA, symptom scores increased from 18 to 21, emotional scores from 7 to 13, environmental scores from 6 to 14, and activity scores from 13 to 24. Conclusion: The results suggest that Jaeumganghwa-tang and Gyeongok-go could be effective in treating patients with asthma.

• The Journal of Korean Medicine
• /
• v.31 no.5
• /
• pp.112-123
• /
• 2010

Objectives: Three yin-tonifying formulae (Ssanghwa-tang, Yukmijihwang-tang and Jaeumganghwa-tang) were applied to investigate their immunological activities on antigen (Ag)-specific or Ag-non-specific immune responses in the murine macrophage cell line (RAW 264.7) and in ovalbumin (OVA)-immunized mice. Methods: This study was carried out in nitricoxide (NO) synthesis in RAW 264.7 cells and cellular proliferation in mouse splenocytes in association with three herbal formulas. C57BL/6 mice were immunized intraperitoneally with OVA/aluminum ($100\;{\mu}g/200\;{\mu}g$/mouse) on days 1, 8, and 15. Three herbal formulas were administrated to mice orally for 3 weeks from day 1. On day 22, OVA-, lipopolysaccharide (LPS)-, and concanavalin A (Con A)-stimulated splenocyte proliferation and antibodies (OVA-specific antibodies of the IgG, IgG1, and total IgM classes) in plasma were measured. Results: All three yin-tonifying formulas significantly enhanced cellular proliferation by LPS and Con A in splenocytes from OVA-immunized mice (p<0.001). Also, these herbal formulas all significantly enhanced plasma OVA-specific IgG, IgG1, and total IgM levels compared with the OVA/Alum group. Conclusion: These results suggested that the three yin-tonifying formulae could be used as stimulators of immune response.