• 대기
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• 제26권4호
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• pp.523-540
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• 2016

The effects of satellite observations on large-scale atmospheric circulations in the reanalysis data are investigated by comparing the latest Japanese Meteorological Association's reanalysis data (JRA-55) and its family data, JRA-55 Conventional (JRA-55C). The latter is identical to the former except that satellite observations are excluded during the data assimilation process. Only conventional datasets are assimilated in JRA-55C. A simple comparison revealed a considerable difference in temperature and zonal wind fields in both the stratosphere and troposphere. Such differences are particularly large in the Southern Hemisphere and whole stratosphere where conventional ground-based measurements are limited. The effects of satellite observations on the zonal-mean tropospheric circulations are further examined in terms of the Hadley cell, eddy-driven jet, and mid-latitude storm tracks. In both hemispheres, JRA-55C exhibits slightly weaker and narrower Hadley cell than JRA-55. This is consistent with a weaker diabatic heating in JRA-55C. The eddy-driven jet shows a small difference in its latitudinal location only in the Southern Hemisphere. Likewise, while the Northern-Hemisphere storm tracks are quantitatively similar in the two datasets, Southern-Hemisphere storm tracks are relatively weaker in JRA-55C than in JRA-55. Their difference is comparable to the uncertainty between reanalysis datasets, indicating that satellite data assimilation could yield significant corrections in the zonal-mean circulation in the Southern Hemisphere.

• Clinical and Experimental Pediatrics
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• 제53권11호
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• pp.921-930
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• 2010

Juvenile rheumatoid arthritis (JRA) is the most common rheumatic childhood disease; its onset is before 16 years of age and it persists for at least 6 weeks. JRA encompasses a heterogeneous group of diseases that is classified according to 3 major presentations: oligoarthritis, polyarthritis, and systemic onset diseases. These presentations may originate from the same or different causes that involve interaction with specific immunogenetic predispositions, and result in heterogeneous clinical manifestations. An arthritic joint exhibits cardinal signs of joint inflammation, such as swelling, pain, heat, and loss of function; any joint can be arthritic, but large joints are more frequently affected. Extra-articular manifestations include high fever, skin rash, serositis, and uveitis. The first 2 types of JRA are regarded as T helper 1 (Th1) cell-mediated inflammatory disorders, mainly based on the abundance of activated Th1 cells in the inflamed synovium and the pathogenetic role of proinflammatory cytokines that are mainly produced by Th1 cell-stimulated monocytes. In contrast, the pathogenesis of systemic onset disease differs from that of other types of JRA in several respects, including the lack of association with human leukocyte antigen type and the absence of autoantibodies or autoreactive T cells. Although the precise mechanism that leads to JRA remains unclear, proinflammatory cytokines are thought to be responsible for at least part of the clinical symptoms in all JRA types. The effectiveness of biologic therapy in blocking the action of these cytokines in JRA patients provides strong evidence that they play a fundamental role in JRA inflammation.

• Clinical and Experimental Pediatrics
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• 제50권12호
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• pp.1173-1179
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• 2007

The diagnosis of juvenile rheumatoid arthritis (JRA) is based on patient's age at disease onset, symptom duration, gender, and clinical manifestations. JRA is of unknown origin, begins under the age of 16, and persists for a minimum of 6 weeks. JRA is categorized into three principal types, systemic, oligoarticular and polyarticular. Infection, other connective tissue diseases, malignancy, trauma, and immunodeficiency are discussed as differential diagnoses for JRA. Because of joint damage, focusing on early diagnosis and intervention, a vigorous initial therapeutic approach must be taken in patients who have poor prognostic factors. A multidisciplinary team approach is also important for the care of patients with JRA.

• Childhood Kidney Diseases
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• 제9권2호
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• pp.231-236
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• 2005

소아기 류마티스 관절염에서의 극소면역성 반월상 사구체신염은 매우 드문 신질환으로 국내에서는 보고된 바가 없다. 이 신질환의 발병에 소아기 류마티스 관절염이 어떻게 작용하였는지를 명확히 밝혀져 있지 않지만, 여러 가지 면역학적 기전이 작용할 것으로 생각한다. 저자들은 3년 전에 소아기 류마티스 관절염을 진단받고 치료중인 15세 남아가 혈뇨와 신기능 저하로 내원하여 시행한 신생검소견과 혈청학적 검사를 통해 p-ANCA 양성을 보인 극소면역싱 반월상 사구체신염을 진단받고 면역억제제 치료후 신기능 회복을 보인 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대기
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• 제26권4호
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• pp.649-663
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• 2016

This study investigates eddy transports in terms of space and time for momentum, heat, and moisture, emphasizing comparison of the results in three reanalysis data sets including ERA-Interim from the European Center for Medium-range Weather Forecasts (ECMWF), NCEP2 from the National Center for Environmental Prediction and the Department of Energy (NCEP-DOE), and JRA-55 from the Japan Meteorological Agency (JMA) during boreal winter. The magnitudes for eddy transports of momentum in ERA-Interim are represented as the strongest value in comparison of three data sets, which may be mainly come from that both zonal averaged meridional and zonal wind tend to follow the hierarchy of ERA-Interim, NCEP2, and JRA-55. Whereas in relation to heat and moisture eddy transports, those of NCEP2 are the strongest, implying that zonal averaged air temperature (specific humidity) tend to follow the raking of NCEP2, ERA-Interim, and JRA-55 (NCEP2, JRA-55, and ERA-Interim), except that transient eddy transports for heat in ERA-Interim are the strongest involving both meridional wind and air temperature. The stationary and transient eddy transports in the context of space and time correlation, and intensity of standard deviation demonstrate that the correlation (intensity of standard deviation) influence the structure (magnitude) of eddy transports. The similarity between ERA-Interim and NCEP2 (ERA-Interim and JRA-55) of space correlation (time correlation) closely resembles among three data sets. A resemblance among reanalysis data sets of space correlation is larger than that of time correlation.

• 대한안전경영과학회지
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• 제4권2호
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• pp.11-22
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• 2002

In this study, an asymmetric lifting posture prediction model was developed, which was a three-dimensional model with 12 links and 23 degrees of freedom open kinematic chains. Although previous researchers have proposed biomechanical, psychophysical, or physiological measures as cost functions, for solving redundancy, they lack in accuracy in predicting actual lifting postures and most of them are confined to the two-dimensional model. To develop an asymmetric lifting posture prediction model, we used the resolved motion method for accurately simulating the lifting motion in a reasonable time. Furthermore, in solving the redundant problem of the human posture prediction, a moment weighted Joint Range Availability (JRA) was used as a cost function in order to consider dynamic lifting. However, it is known that the moment weighted JRA as a cost function predicted the lower extremity and L5/S1 joint motions better than the upper extremities, while the constant weighted JRA as a cost function predicted the latter better than the former. To compensate for this, we proposed a hybrid moment weighted JRA as a new cost function with moment weighted for only the lower extremity. In order to validate the proposed cost function, the predicted and real lifting postures for various lifting conditions were compared by using the root mean square(RMS) error. This hybrid JRA reduced RMS more than the previous cost functions. Therefore, it is concluded that the cost function of a hybrid moment weighted JRA can be used to predict three-dimensional lifting postures. To compare with the predicted trajectories and the real lifting movements, graphical validations were performed. The results also showed that the hybrid moment weighted cost function model was found to have generated the postures more similar to the real movements.

• Clinical and Experimental Pediatrics
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• 제49권4호
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• pp.424-430
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• 2006

목 적 : JRA는 소아에서 가장 흔한 결체 조직 질환 중의 하나이고 장, 단기적인 신체장애를 유발하는 중요한 원인이 된다. 저자들은 JRA 환아들의 질병 양상과 경과를 알아보기 위하여 본 연구를 시행하였다. 방 법 : 1990년 8월부터 2004년 11월까지 서울아산병원 소아과를 내원한 59명의 JRA 환아를 대상으로 하였다. 성별, 연령, 유형, 침범 관절, 관절 외 소견, 검사 및 방사선 소견, 치료, 경과 등에 대하여 후향적으로 고찰하였다. 결 과 : 소수 관절형은 32.2%, 다수 관절형은 30.5%, 전신형은 37.3%였다. 남녀비는 1.7 : 1이었으며 평균 발병 연령은 $9.3{\pm}3.7$(1.3-15.9)세이었다. 가장 흔히 침범된 관절은 무릎과 발목, 팔목이었다. 관절 외 소견을 살펴보면 발열, 발진, 근육통, 림프절 비대 등이 있었다. 검사 소견을 살펴보면 백혈구증가증, 빈혈, 혈소판증가증, ESR 상승, CRP 상승 등의 소견을 보였다. 류마토이드 인자, 항핵항체 양성률은 각각 5.3%, 18.0%이었다. 비스테로이드성 소염제(NSAID)가 가장 많이 투여되었으며, 메토트렉세이트 또는 스테로이드를 함께 투여했던 경우가 27.1%였다. 88.1%의 환아에서 장애 후유증 없이 완치되었으며 한 명의 환아에서만 기능성 상태 IV의 장애가 있었다. 폐침범이 동반되었던 한 명의 환아가 사망하였다. 결 론 : 본 연구에서는 균등한 유형별 분포, 남아에서 호발하는 양상, 늦은 발병 연령, 낮은 홍채모양체염 발병률, 그리고 낮은 ANA 양성률을 보였는데 이러한 소견들은 한국에서의 JRA의 소견이며 서양에서의 보고와는 상이한 결과들이다. JRA가 민족과 지역에 따라서 서로 다른 발병양상을 보인다는 점을 시사한다고 생각된다. 앞으로 더 많은 수의 환자들을 대상으로 하는 다기관 협동 연구 및 역학조사가 필요할 것으로 생각된다.

• 대기
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• 제25권3호
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• pp.543-557
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• 2015

The present study examines an interaction between the eddy and mean meridional circulation (MMC) comparing the results in three reanalysis data sets including ERA-Interim, NCEP2, and JRA-55 during the boreal winter in the Northern Hemisphere. It is noteworthy that the JRA-55 tends to produce stronger MMC compared to those of others, which is mainly due to the weak eddy flux. ERA-Interim represents the ensemble averages of MMC. The MMC-eddy interaction equation was adopted to investigate the scale interaction of the eddy momentum flux (EMF), eddy heat flux (EHF), and diabatic heating (DHT) with MMC. The EMF (EHF) shows a significant correlation coefficient with streamfunction under (above) 200 hPa-level. The perturbation (time mean) part of each eddy is dominant compared to another part in the EMF (EHF). The DHT is strongly interacted with streamfunction in the region between the equator and extra-tropical latitude over whole vertical column. Thus, the dominant term in each significant region modulates interannual variability of MMC. The inverse (proportional) relationship between MMC and pressure (meridional) derivative of the momentum (heat) divergence contributions is well represented in the three reanalysis data sets. The region modulated interannual variability of MMC by both EMF and DHT (EHF) is similar in ERA-Interim and JRA-55 (ERA-Interim and NCEP2). JRA-55 shows a lack of significant region of EHF due to the high resolution, compared to other data sets.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제12권5호
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• pp.2233-2252
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• 2018

For the problem of cross-layer joint resource allocation (JRA) in the Long-Term Evolution (LTE)-Advanced standard using carrier aggregation (CA) technology, it is difficult to obtain the optimal resource allocation scheme. This paper proposes a joint resource allocation algorithm based on the weights of user's average quality of experience (JRA-WQOE). In contrast to prevalent algorithms, the proposed method can satisfy the carrier aggregation abilities of different users and consider user fairness. An optimization model is established by considering the user quality of experience (QoE) with the aim of maximizing the total user rate. In this model, user QoE is quantified by the mean opinion score (MOS) model, where the average MOS value of users is defined as the weight factor of the optimization model. The JRA-WQOE algorithm consists of the iteration of two algorithms, a component carrier (CC) and resource block (RB) allocation algorithm called DABC-CCRBA and a subgradient power allocation algorithm called SPA. The former is used to dynamically allocate CC and RB for users with different carrier aggregation capacities, and the latter, which is based on the Lagrangian dual method, is used to optimize the power allocation process. Simulation results showed that the proposed JRA-WQOE algorithm has low computational complexity and fast convergence. Compared with existing algorithms, it affords obvious advantages such as improving the average throughput and fairness to users. With varying numbers of users and signal-to-noise ratios (SNRs), the proposed algorithm achieved higher average QoE values than prevalent algorithms.

• 대한미생물학회지
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• 제21권2호
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• pp.171-179
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• 1986

The HLA class II region encodes a series of polymorphic glycoproteins that form cell surface heterodimers each consisting of one $\alpha$ and one $\beta$ chain. Thess class II molecules are encoded by genes clustered within three loci. DP, DQ, and DR are functfonally implicated as regulatory signals in intercellular communication during the immune resposes. The phenotypic hallmark of the HLA complex is a high degree of structural and functional polymorphism. Detailed analysis. of such polymorphisms should aid in understanding the molecular basis for associations between HLA and diseases. We have used techniques of restriction enzyme fragment analysis by Southern blotting to investigate polymorphisms associated with DQ $\beta$ class II genes on haplotypes expressing the HLA-DR4 and -DQw3 specificities. The endonucleases Hind III and Bam HI were used to identify a specific DQ $\beta$ genomic polymorphism that precisely corrresponds with the reactivity of a monoclonal antibody A-10-83, previously shown to define a serologic split of DQw3. This study identifies two allelic DQ va. riants. DQw3.1 and DQw3.2. We used these specific genotypic markers to investigate the genomic basis of the association of DR4 with insulin-dependent diabetes mellitus(IDDM) and seropositive juvenile rheumatoid arthritis(JRA). The DR4 positive IDDM demonstrate the predominant expression of DQw3.2 and the very rare expression of DQw3.l. However, in haplotype matched siblings from two IDDM families, all of the DR4 positive siblings display a IDDM-associated DQw3.2 allele. Thus, both affected and healthy individuals can carry the same haplotypes and genomic markers, demonstrating that thess specific allelic variants are genetic elements that indicate a increased risk of IDDM but are not in fact disease specific. We contrasted this result with a similar analysis of patients with another DR4-associated disease, JRA. In contrast to the preponderance of the DQw3.2 allele in IDDM, the JRA patients expressed either the DQw3.1 or the DQw3.2 allele and sometimes both, without apparent association with disease expession. The different genomic markers reported here within HLA-DQ region potentially an analysis of HLA-associated function and disease susceptibility.