• Atmosphere
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• v.26 no.4
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• pp.523-540
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• 2016

The effects of satellite observations on large-scale atmospheric circulations in the reanalysis data are investigated by comparing the latest Japanese Meteorological Association's reanalysis data (JRA-55) and its family data, JRA-55 Conventional (JRA-55C). The latter is identical to the former except that satellite observations are excluded during the data assimilation process. Only conventional datasets are assimilated in JRA-55C. A simple comparison revealed a considerable difference in temperature and zonal wind fields in both the stratosphere and troposphere. Such differences are particularly large in the Southern Hemisphere and whole stratosphere where conventional ground-based measurements are limited. The effects of satellite observations on the zonal-mean tropospheric circulations are further examined in terms of the Hadley cell, eddy-driven jet, and mid-latitude storm tracks. In both hemispheres, JRA-55C exhibits slightly weaker and narrower Hadley cell than JRA-55. This is consistent with a weaker diabatic heating in JRA-55C. The eddy-driven jet shows a small difference in its latitudinal location only in the Southern Hemisphere. Likewise, while the Northern-Hemisphere storm tracks are quantitatively similar in the two datasets, Southern-Hemisphere storm tracks are relatively weaker in JRA-55C than in JRA-55. Their difference is comparable to the uncertainty between reanalysis datasets, indicating that satellite data assimilation could yield significant corrections in the zonal-mean circulation in the Southern Hemisphere.

• Clinical and Experimental Pediatrics
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• v.53 no.11
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• pp.921-930
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• 2010

Juvenile rheumatoid arthritis (JRA) is the most common rheumatic childhood disease; its onset is before 16 years of age and it persists for at least 6 weeks. JRA encompasses a heterogeneous group of diseases that is classified according to 3 major presentations: oligoarthritis, polyarthritis, and systemic onset diseases. These presentations may originate from the same or different causes that involve interaction with specific immunogenetic predispositions, and result in heterogeneous clinical manifestations. An arthritic joint exhibits cardinal signs of joint inflammation, such as swelling, pain, heat, and loss of function; any joint can be arthritic, but large joints are more frequently affected. Extra-articular manifestations include high fever, skin rash, serositis, and uveitis. The first 2 types of JRA are regarded as T helper 1 (Th1) cell-mediated inflammatory disorders, mainly based on the abundance of activated Th1 cells in the inflamed synovium and the pathogenetic role of proinflammatory cytokines that are mainly produced by Th1 cell-stimulated monocytes. In contrast, the pathogenesis of systemic onset disease differs from that of other types of JRA in several respects, including the lack of association with human leukocyte antigen type and the absence of autoantibodies or autoreactive T cells. Although the precise mechanism that leads to JRA remains unclear, proinflammatory cytokines are thought to be responsible for at least part of the clinical symptoms in all JRA types. The effectiveness of biologic therapy in blocking the action of these cytokines in JRA patients provides strong evidence that they play a fundamental role in JRA inflammation.

• Clinical and Experimental Pediatrics
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• v.50 no.12
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• pp.1173-1179
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• 2007

The diagnosis of juvenile rheumatoid arthritis (JRA) is based on patient's age at disease onset, symptom duration, gender, and clinical manifestations. JRA is of unknown origin, begins under the age of 16, and persists for a minimum of 6 weeks. JRA is categorized into three principal types, systemic, oligoarticular and polyarticular. Infection, other connective tissue diseases, malignancy, trauma, and immunodeficiency are discussed as differential diagnoses for JRA. Because of joint damage, focusing on early diagnosis and intervention, a vigorous initial therapeutic approach must be taken in patients who have poor prognostic factors. A multidisciplinary team approach is also important for the care of patients with JRA.

• Childhood Kidney Diseases
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• v.9 no.2
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• pp.231-236
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• 2005

Juvenile rheumatoid arthritis(JRA) is the most common major connective tissue disease in children. Renal involvement in JRA is rare. Among the renal lesions that have been reported in JRA, amyloidosis and drug-induced nephropathy are the most common. Crescentic glomerulonephritis in JRA has rarely been reported. We report a case of ANCA-associated pauci-immune crescentic glomerulonephritis in JRA. The patient was a 15-year old boy with a 3-year history of JRA. He presented with gross hematuria, proteinuria, positive p-ANCA and elevation of BUN and creatinine. Pathologic findings revealed focal necrotizing and crescentic glomerulonephritis. There were no significant immunoglobulin or complement deposits. His renal function recovered after intravenous methylprednisolone pulse therapy and oral steroid use. In Korea, this is the first reported case of pauci-immune crescentic glomerulonephritis in JRA. (J Korean Soc Pediatr Nephrol 2005;9:231-236)

• Atmosphere
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• v.26 no.4
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• pp.649-663
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• 2016

This study investigates eddy transports in terms of space and time for momentum, heat, and moisture, emphasizing comparison of the results in three reanalysis data sets including ERA-Interim from the European Center for Medium-range Weather Forecasts (ECMWF), NCEP2 from the National Center for Environmental Prediction and the Department of Energy (NCEP-DOE), and JRA-55 from the Japan Meteorological Agency (JMA) during boreal winter. The magnitudes for eddy transports of momentum in ERA-Interim are represented as the strongest value in comparison of three data sets, which may be mainly come from that both zonal averaged meridional and zonal wind tend to follow the hierarchy of ERA-Interim, NCEP2, and JRA-55. Whereas in relation to heat and moisture eddy transports, those of NCEP2 are the strongest, implying that zonal averaged air temperature (specific humidity) tend to follow the raking of NCEP2, ERA-Interim, and JRA-55 (NCEP2, JRA-55, and ERA-Interim), except that transient eddy transports for heat in ERA-Interim are the strongest involving both meridional wind and air temperature. The stationary and transient eddy transports in the context of space and time correlation, and intensity of standard deviation demonstrate that the correlation (intensity of standard deviation) influence the structure (magnitude) of eddy transports. The similarity between ERA-Interim and NCEP2 (ERA-Interim and JRA-55) of space correlation (time correlation) closely resembles among three data sets. A resemblance among reanalysis data sets of space correlation is larger than that of time correlation.

• Journal of the Korea Safety Management & Science
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• v.4 no.2
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• pp.11-22
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• 2002

In this study, an asymmetric lifting posture prediction model was developed, which was a three-dimensional model with 12 links and 23 degrees of freedom open kinematic chains. Although previous researchers have proposed biomechanical, psychophysical, or physiological measures as cost functions, for solving redundancy, they lack in accuracy in predicting actual lifting postures and most of them are confined to the two-dimensional model. To develop an asymmetric lifting posture prediction model, we used the resolved motion method for accurately simulating the lifting motion in a reasonable time. Furthermore, in solving the redundant problem of the human posture prediction, a moment weighted Joint Range Availability (JRA) was used as a cost function in order to consider dynamic lifting. However, it is known that the moment weighted JRA as a cost function predicted the lower extremity and L5/S1 joint motions better than the upper extremities, while the constant weighted JRA as a cost function predicted the latter better than the former. To compensate for this, we proposed a hybrid moment weighted JRA as a new cost function with moment weighted for only the lower extremity. In order to validate the proposed cost function, the predicted and real lifting postures for various lifting conditions were compared by using the root mean square(RMS) error. This hybrid JRA reduced RMS more than the previous cost functions. Therefore, it is concluded that the cost function of a hybrid moment weighted JRA can be used to predict three-dimensional lifting postures. To compare with the predicted trajectories and the real lifting movements, graphical validations were performed. The results also showed that the hybrid moment weighted cost function model was found to have generated the postures more similar to the real movements.

• Clinical and Experimental Pediatrics
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• v.49 no.4
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• pp.424-430
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• 2006

Purpose : Juvenile rheumatoid arthritis(JRA) is one of the most common rheumatic diseases of childhood and is an important cause of short- and long-term disability. The purpose of this study was to determine the disease course and outcome in childhood patients with JRA. Methods : Fifty nine patients with JRA who were diagnosed and treated in the Department of Pediatrics, Asan Medical Center from August 1990 to November 2004 were enrolled in this study. Sex, age, type, affected joints, extra-articular manifestations, laboratory and radiologic findings, treatments, and outcomes of JRA patients were reviewed retrospectively. Results : Among JRA patients, 32.2 percent had pauciarticular type, 30.5 percent had polyarticular type and 37.3 percent had systemic type. The ratio of boys to girls was 1.7 : 1 and the mean age at onset was $9.3{\pm}3.7$(1.3-15.9) years. The most commonly affected joints were knee, ankle and wrist. The extra-articular manifestations observed were fever, rash, myalgia and lymph node enlargement, etc. The main laboratory findings observed were leukocytosis, anemia, thrombocytosis, elevated ESR, and elevated CRP. Rheumatoid factor and antinuclear antibody(ANA) were positive in 5.3 percent and 18.0 percent. Nonsteroid anti-inflammatory drugs(NSAID) were used most frequently and methotrexate with or without steroids was added in 27.1 percent of patients unresponsive to NSAID. 88.1 percent of patients were cured without functional disability and only one patient was in functional status IV. One patient, who had pulmonary involvement, died. Conclusion : Our results showed an even distribution in type of onset, male predominance, older age of onset, low incidence of iridocyclitis, and low positivity of ANA in JRA patients; this differs from occidental data. This study may suggest regional differences and variability in disease groups of JRA among different racies, but further multi-center trials and large scale epidemiological studies are needed to confirm our conclusion.

• Atmosphere
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• v.25 no.3
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• pp.543-557
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• 2015

The present study examines an interaction between the eddy and mean meridional circulation (MMC) comparing the results in three reanalysis data sets including ERA-Interim, NCEP2, and JRA-55 during the boreal winter in the Northern Hemisphere. It is noteworthy that the JRA-55 tends to produce stronger MMC compared to those of others, which is mainly due to the weak eddy flux. ERA-Interim represents the ensemble averages of MMC. The MMC-eddy interaction equation was adopted to investigate the scale interaction of the eddy momentum flux (EMF), eddy heat flux (EHF), and diabatic heating (DHT) with MMC. The EMF (EHF) shows a significant correlation coefficient with streamfunction under (above) 200 hPa-level. The perturbation (time mean) part of each eddy is dominant compared to another part in the EMF (EHF). The DHT is strongly interacted with streamfunction in the region between the equator and extra-tropical latitude over whole vertical column. Thus, the dominant term in each significant region modulates interannual variability of MMC. The inverse (proportional) relationship between MMC and pressure (meridional) derivative of the momentum (heat) divergence contributions is well represented in the three reanalysis data sets. The region modulated interannual variability of MMC by both EMF and DHT (EHF) is similar in ERA-Interim and JRA-55 (ERA-Interim and NCEP2). JRA-55 shows a lack of significant region of EHF due to the high resolution, compared to other data sets.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.5
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• pp.2233-2252
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• 2018

For the problem of cross-layer joint resource allocation (JRA) in the Long-Term Evolution (LTE)-Advanced standard using carrier aggregation (CA) technology, it is difficult to obtain the optimal resource allocation scheme. This paper proposes a joint resource allocation algorithm based on the weights of user's average quality of experience (JRA-WQOE). In contrast to prevalent algorithms, the proposed method can satisfy the carrier aggregation abilities of different users and consider user fairness. An optimization model is established by considering the user quality of experience (QoE) with the aim of maximizing the total user rate. In this model, user QoE is quantified by the mean opinion score (MOS) model, where the average MOS value of users is defined as the weight factor of the optimization model. The JRA-WQOE algorithm consists of the iteration of two algorithms, a component carrier (CC) and resource block (RB) allocation algorithm called DABC-CCRBA and a subgradient power allocation algorithm called SPA. The former is used to dynamically allocate CC and RB for users with different carrier aggregation capacities, and the latter, which is based on the Lagrangian dual method, is used to optimize the power allocation process. Simulation results showed that the proposed JRA-WQOE algorithm has low computational complexity and fast convergence. Compared with existing algorithms, it affords obvious advantages such as improving the average throughput and fairness to users. With varying numbers of users and signal-to-noise ratios (SNRs), the proposed algorithm achieved higher average QoE values than prevalent algorithms.

• The Journal of the Korean Society for Microbiology
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• v.21 no.2
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• pp.171-179
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• 1986

The HLA class II region encodes a series of polymorphic glycoproteins that form cell surface heterodimers each consisting of one $\alpha$ and one $\beta$ chain. Thess class II molecules are encoded by genes clustered within three loci. DP, DQ, and DR are functfonally implicated as regulatory signals in intercellular communication during the immune resposes. The phenotypic hallmark of the HLA complex is a high degree of structural and functional polymorphism. Detailed analysis. of such polymorphisms should aid in understanding the molecular basis for associations between HLA and diseases. We have used techniques of restriction enzyme fragment analysis by Southern blotting to investigate polymorphisms associated with DQ $\beta$ class II genes on haplotypes expressing the HLA-DR4 and -DQw3 specificities. The endonucleases Hind III and Bam HI were used to identify a specific DQ $\beta$ genomic polymorphism that precisely corrresponds with the reactivity of a monoclonal antibody A-10-83, previously shown to define a serologic split of DQw3. This study identifies two allelic DQ va. riants. DQw3.1 and DQw3.2. We used these specific genotypic markers to investigate the genomic basis of the association of DR4 with insulin-dependent diabetes mellitus(IDDM) and seropositive juvenile rheumatoid arthritis(JRA). The DR4 positive IDDM demonstrate the predominant expression of DQw3.2 and the very rare expression of DQw3.l. However, in haplotype matched siblings from two IDDM families, all of the DR4 positive siblings display a IDDM-associated DQw3.2 allele. Thus, both affected and healthy individuals can carry the same haplotypes and genomic markers, demonstrating that thess specific allelic variants are genetic elements that indicate a increased risk of IDDM but are not in fact disease specific. We contrasted this result with a similar analysis of patients with another DR4-associated disease, JRA. In contrast to the preponderance of the DQw3.2 allele in IDDM, the JRA patients expressed either the DQw3.1 or the DQw3.2 allele and sometimes both, without apparent association with disease expession. The different genomic markers reported here within HLA-DQ region potentially an analysis of HLA-associated function and disease susceptibility.