• Corrosion Science and Technology
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• 제18권5호
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• pp.155-167
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• 2019

In this study, two novel Schiff base compounds including (3-(4-Chlorophenyl isoxazole-5-yl) methanol and (3-(2,4 dichlorophenol isoxazole-5-yl) methanol as corrosion inhibitors for mild steel in 1 M hydrochloric acid solution were investigated by potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), and density functional theory (DFT) computations. The results showed that the corrosion inhibition efficiency (IE) is remarkably enhanced with the growing concentration of the Schiff base inhibitors. The results from Tafel polarization and EIS methods showed that IE decreases with gradual increments of temperature. This process can be attributed to the displacement of the adsorption/desorption balance and hence to the diminution of the level of a surface coating. Also, the adsorption of two inhibitors over mild steel followed the Langmuir adsorption isotherm. Too, the results of the scanning electron microscope (SEM) images showed that the Schiff base inhibitors form an excellent protective film over mild steel and verified the results by electrochemical techniques. Additionally, the results from the experimental and those from DFT computations are in excellent accordance.

• Journal of Pharmaceutical Investigation
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• 제10권4호
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• pp.8-22
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• 1980

In order obtain some new antibacterial agents, seven new 2-ethoxymethyl-3-(5-nitro-2-furyl) acrylamide derivatives were synthesized by condensing 2-ethoxymethyl-3-(5-nitro-2-furyl) acyloyl chloride with amino compounds namely 5-amino-3, 4-dimethyl isoxazole, sulfamonomethoxazole, d-2-amino-1-butanol, hydroxylamine hydrochloride, semicarbazide hydrochloride, thiosemicarbazide, and p, p'-diaminodiphenylsulfone, respectively. The seven synthesized compounds were 2-ethoxymethyl-3-(5-nitro-2-furyl) acryl-5-amino-3, 4-dimethylisoxazoleamide [VII], $N^4-[2-ethoxymethyl\;3-methyl\;(5-nitro-2-furyl)\;acryl]-N^1-(5-methyl-3-isoxazolyl)$ sulfanilamide [VIII], 2-ethoxyl-3-(5-nitro-2-furyl) acrylsemicarbazide [X], 2-ethoxymethyl-3-(5-nitro-2-furyl) acrylthiosemicarbazide [XI], 2-ethoxymethyl-3-(5-nitro-2-furyl) acryl-d-2-amino-1-butanolamide [XII], and 4, 4'-di[2-ethoxymethyl-3-(5-nitro-2-furyl) acryl-amido] diphenylsulfone [XIII]. These compounds, with exception of the compound XIII, showed generally effective antibacterial activity, especially in the following instances. Compound VII was shown to be effective against Bacillus subtilis ATCC 6633 compound VIII, against Bacillus cereus var. Mycoides ATCC 1778, and compound XII, against both Proteus vuglaris and Saccharomyces cerevisiae ATCC 9763.

• Toxicological Research
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• 제4권2호
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• pp.85-94
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• 1988

In order to elucidate the mechanism of toxic action of a pisonous mushroom, Amanita pantherina, biochemical effects of the mushroom extracts on mice were studied. A hotwater extract of Amanita pantherina injected intraperitoneally into male ICR mice evoked signs similar to those observed clinically upon acute poisoning by the mushroom and also changed the levels of component enzyme activities in blood, liver and urine. The serum cholinesterase activity was decreased significantly during 1-3 h after injection.

• 대한화학회지
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• 제39권4호
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• pp.244-251
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• 1995

이소옥사졸과 그의 유도체를 가진 팔라듐(II) 착물 $[Pd(L)_2X_2]$, L=isoxazole(isox), 3,5-dimethylisoxazole(3,5-diMeisox), 3-methyl, 5-phenylisoxazole(3-Me, 5-Phisox), and 4-amino, 3,5-dimethylisoxazole(4-ADI); X=Cl, Br)의 항암활성을 확장분자궤도함수(EHMO)법으로 조사하였다. X 원자의 알짜전하 값은 trans-이성체가 cis-이성체보다 음의 값으로 대체로 크게 나타났고, X=Cl일 때가 X=Br일 때보다 음의 값으로 커서, Cl일 때가 이탈이 용이함을 알 수 있었다. Pd(dx2-y2)-X(px)의 ${\sigma}MO$ 에너지($E{\sigma}(Pd-X)$)가 Pd(dx2-y2)-N(px)의 ${\sigma}MO$ 에너지 ($E{\sigma}(Pd-N)$)보다 예외없이 더 높아서 결합이 약함을 알았다. 아울러 같은 착물에서 cis-보다 trans-착물에서 ${\sigma}(Pd-X)$값이 더 높아서 결합이 약함을 알았다. 따라서 $X^-$ 이온으로 떨어져 나가는 용이성과 그 구조변화가 항암활성과 관계가 있을 것으로 생각하고 $E{\sigma}(N-X)(E{\sigma}(Pd-N)－E{\sigma}(Pd-X))$값과 저해활성 계수인 logIA의 값을 도시하였던 바 실험치와 상관 계수가 0.96안 좋은 직선성이 성립함을 알았다.

• Bulletin of the Korean Chemical Society
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• 제27권5호
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• pp.613-630
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• 2006

Nucleic acids are virtually omnipresent; they exist in every living being. These macromolecules constitute the most important genetic storage material: the genes. Genes are conserved throughout the evolution of all living beings; they are transmitted from the parents to their offspring. Many interdisciplinary research groups are interested in modifying nucleic acids for use in a wider variety of applications. These modified oligonucleotides are used in many diverse fields, including diagnostics, detection, and therapeutics. In this account, we summarize our research efforts related to modified nucleic acid systems. First, we discuss our syntheses of modified oligonucleotides containing fluorescent tags for use as molecular probes (molecular beacons) to detect single-nucleotide polymorphisim (SNP) in nucleic acids and to distinguish between the B and Z forms of DNA. We also describe our research efforts into oligonucleotides functionalized with steroid derivatives to enhance their cell permeability, and the synthesis of several calix[4]arene-oligonucleotide conjugates possessing the ability to form defined triplexes. In addition, we have performed systematic studies to have an understanding about the functional groups necessary for a given nucleoside to behave as an organo or hydrogelator. The aggregation properties of a number of nucleoside-based phospholipids have been examined in different solvents; some of these derivatives are potential candidates for use as nucleoside-based liposomes. Finally, we also describe our research efforts toward the preparation of isoxazole- and isoxazoline-containing nucleoside derivatives and the determination of their antiviral activities.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.355.3-356
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• 2002

Prostaglandins are synthesized by the enzyme cyclooxygenase (COX). Both constitutive (COX-1) and inducible (COX-2) isoforms have been identified. COX-2 expression is stimulated by inflammatory mediators such as growth factors and cytokines. Most non-steroidal anti-inflammatory drugs (NSAIDS) inhibit both isoforms of COX. Recent evidence suggests that selective inhibitors of COX-2 may possess diminished side effects reletive to common NSAIDS. Novel isothiazoles and isoxazoles were identified as selective inhibitiors of cycloxygenase-2(COX-2). (omitted)

• 한국염색가공학회지
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• 제33권2호
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• pp.49-63
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• 2021

In this study, a convenient approach for sensitive, quick and simple detection of hazardous acids was investigated. A series of azo dyes were synthesized and applied as a chemosensor for the acid detection both on fibers and in solution. Various aniline, benzothiazole or isoxazole derivatives were used as diazo component and coupled with N-benzyl-N-ethylaniline or 2,2'-(phenylimino)bis-ethanol to give azo based dyes. The acid sensing phenomenon was observed by naked-eye and detection was further confirmed by UV-Vis spectrophotometer and hue difference(ΔH^*) evaluation. The developed sensors showed a distinct and quick color change from yellow to magenta by addition of trace amounts of the hazardous acids. The absorption maxima was shifted to a longer wavelength by 70 ~ 150nm and hue difference(ΔH^*) was 60 ~ 120°. A cotton fiber coated with Dye 1 exhibited excellent storage stability under various temperature(-30 ~ 43℃) and humidity(30 ~ 80%) conditions without discoloration and fading of the fiber sensors. Also the acid sensing properties were maintained.