Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.355.3-356
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- 2002
EFFECTS OF ISOTHIAZOLE AND ISOXAZOLE DERIVATIVES AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS
- Ryu, Hyung-Chul (R＆D Center of Pharmaceuticals. Institute of Science ＆ Technology. CJ Corporation., 522-1, Dokpyong-ri, Majang-myon, Ichon-si, Kyonggi-do, 467-810) ;
- Park, Sang-Wook (R＆D Center of Pharmaceuticals. Institute of Science ＆ Technology. CJ Corporation., 522-1, Dokpyong-ri, Majang-myon, Ichon-si, Kyonggi-do, 467-810) ;
- Noh, Ji-Young (R＆D Center of Pharmaceuticals. Institute of Science ＆ Technology. CJ Corporation., 522-1, Dokpyong-ri, Majang-myon, Ichon-si, Kyonggi-do, 467-810) ;
- Kim, Jong-Hoon (R＆D Center of Pharmaceuticals. Institute of Science ＆ Technology. CJ Corporation., 522-1, Dokpyong-ri, Majang-myon, Ichon-si, Kyonggi-do, 467-810) ;
- Park, Hyun-Jung (R＆D Center of Pharmaceuticals. Institute of Science ＆ Technology. CJ Corporation., 522-1, Dokpyong-ri, Majang-myon, Ichon-si, Kyonggi-do, 467-810) ;
- Chung, Young-Mee (R＆D Center of Pharmaceuticals. Institute of Science ＆ Technology. CJ Corporation., 522-1, Dokpyong-ri, Majang-myon, Ichon-si, Kyonggi-do, 467-810) ;
- Chae, Myeong-Yun (R＆D Center of Pharmaceuticals. Institute of Science ＆ Technology. CJ Corporation., 522-1, Dokpyong-ri, Majang-myon, Ichon-si, Kyonggi-do, 467-810) ;
- Cho, Il-Hwan (R＆D Center of Pharmaceuticals. Institute of Science ＆ Technology. CJ Corporation., 522-1, Dokpyong-ri, Majang-myon, Ichon-si, Kyonggi-do, 467-810)
- Published : 2002.10.01
Abstract
Prostaglandins are synthesized by the enzyme cyclooxygenase (COX). Both constitutive (COX-1) and inducible (COX-2) isoforms have been identified. COX-2 expression is stimulated by inflammatory mediators such as growth factors and cytokines. Most non-steroidal anti-inflammatory drugs (NSAIDS) inhibit both isoforms of COX. Recent evidence suggests that selective inhibitors of COX-2 may possess diminished side effects reletive to common NSAIDS. Novel isothiazoles and isoxazoles were identified as selective inhibitiors of cycloxygenase-2(COX-2). (omitted)
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