• 통합자연과학논문집
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• 제9권1호
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• pp.23-27
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• 2016

Hepatitis B virus is the leading source of liver disorders and is a global health problem and needs advancements in its treatment against increasing problems. Recently five vanitaracin derivatives were isolated from the fungus Talaromyces species which have anti-Hepatitis B virus activity. Hence, in the present study, molecular docking was carried out with five vanitaracin derivatives isolated from Talaromyces species and three known inhibitors.The objective of this work is to study the interaction of newly isolated compounds and compare its interaction with known inhibitors. The docking results revealed that vanitaracin derivatives have good interactions and has better docking score with the Hepatitis B virus and suggest SER2, SER4 and ASP30 are important residues involved in interaction with the inhibitors. These result authenticates vanitaracin derivatives contributes to inhibitory activity of Hepatitis B virus to treat liver disorders.

• Smart Structures and Systems
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• 제4권5호
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• pp.655-666
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• 2008

In the past 20 years, seismic isolation has see a variety of applications in design of structures to mitigate seismic hazard. In particular, isolation has been seen as a means of achieving enhanced seismic performance objectives, such as those for hospitals, critical emergency response facilities, mass electronic data storage centers, and similar buildings whose functionality following a major seismic event is either critical to the public welfare or the financial solvency of an organization. While achieving these enhanced performance objectives is a natural (and oftentimes requisite) application of seismic isolation, little attention has been given to the extension of current design practice to isolated buildings which may have more conventional performance objectives. The development of a rational design methodology for isolated buildings requires thorough investigation of the behavior of isolated structures subjected to seismic input of various recurrence intervals, and which are designed to remain elastic only under frequent events. This paper summarizes these investigations, and proposed a consistent probabilistic framework within which any combination of performance objectives may be met. Analytical simulations are presented, the results are summarized. The intent of this work is to allow a building owner to make informed decisions regarding tradeoffs between superstructure performance (drifts, accelerations) and isolation system performance. Within this framework, it is possible to realize the benefits of designing isolated buildings for which the design criteria allows consideration of multiple performance goals.

• 대한전자공학회논문지
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• 제25권4호
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• pp.356-365
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• 1988

In this paper, we describe an isolated words recognition system for Korean isolated digits based on a voiced -unvoiced decision algorithm and a frequency domain analysis. The algorithm first performs a voiced-unvoiced decision procedure for the begtinning part of each uttered work using the normalized log energy and zero crossing rate as decision parameters. Based on this decision,. each word is assigned to one of two classes. In order to identify the uttered word within each class, a dynamic time warping algorithm is applied using formant frequencies as the basis for the distance measure. We exploit a pole-zero analysis to measure formant frequencies in each frame. We have observed that pole-zero analysis can provide more accurate estimation of formant frequencies than analysis based on poles only. Experimental recognition rates of 97.3% illustrating the performance of the recognition system was achieved.

• Archives of Pharmacal Research
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• 제25권3호
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• pp.325-328
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• 2002

In the course of our work on anti-platelet constituents from plants, five phenolic compounds, magnolol, honokiol, obovatol, methyl caffeate, and syringin, were isolated from the methanol extracts of the barks and fruits of Magnolia obovata. The compounds were identified based on the spectroscopic data. Methyl caffeate was isolated for the first time from the genus Magnolia and it showed 3∼4-folds higher potency than ASA. The activities of obovatol and honokiol were comparable to ASA. Magnolol and syringin showed only very mild inhibitory effects to all the stimulators.

• 한국균학회지
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• 제37권2호
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• pp.130-133
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• 2009

The endophytic fungi were isolated from red pine trees (Pinus densiflora) that were distributed in three sites of Chungbuk, Korea. Twenty fungal isolates were isolated from 16 trees and divided into 8 groups by morphological characters. The fungal isolates were identified using the sequences of ITS region of rDNA; Lophodermium complex, Sydowia polyspora, Hymenula sp., Sistotrema brinkmannii, Septoria pini-thunbergii, Earliella sp. Lophodermium spp. were the most frequently found fungal species the across sites and firstly detected from Pinus species in Korea by molecular work.

• Natural Product Sciences
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• 제8권4호
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• pp.147-151
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• 2002

In the course of our work on anti-platelet constituents from plants, eight phenolic compounds, $({\pm})-syringaresinol$ (1), 4-hydroxybenzaldehyde (2), 4-hydroxybenzoic acid (3), vanillic acid (4), 4-hydroxy cinnamic acid (5), quercetin 3-O-rhamnoside (6), rutin (7), and quercetin $3-(2^G-rhamnosylrutinoside)$ (8) were isolated from the methanol extract of the leaves of Magnolia obovata. The compounds were identified based on the spectroscopic data. Compound 2, 3, 5, 6, 7 and 8 were isolated for the first time from genus Magnolia. 1 and 6 showed same order of inhibitory potencies as acetylsalicylic acid (ASA) to rat platelet aggregation induced by all the stimulators tested. The remaining six compounds showed only mild effects.

• Clinical and Experimental Pediatrics
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• 제58권2호
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• pp.73-76
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• 2015

Isolated sphenoid sinusitis is a rare disease in children, and its symptoms are often nonspecific and confusing. Rarely, severe headache can be the first or only symptom of isolated sphenoid sinusitis. New daily persistent headache (NDPH) is a form of chronic daily headache that may have features of both migraines and tension-type headaches. NDPH is difficult to diagnose and requires a multifaceted approach. Here, we report on a 10-year-old boy and an 11-year-old girl who both presented with typical NDPH symptoms. These patients had no nasal symptoms or signs of infection. Neither nonsteroidal anti-inflammatory drugs nor topiramate had any effect on the headaches. Their neurological and ophthalmological examinations were normal. The results of routine blood work, including thyroid function tests, inflammatory markers, complete blood count, tests for viral infection, and a metabolic panel, were normal. A brain magnetic resonance imaging scan showed isolated sphenoid sinusitis. Both patients' symptoms resolved completely after approximately 1 month of oral antibiotics for sinusitis.

• 초등상담연구
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• 제6권1호
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• pp.217-245
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• 2007

This research work was aimed at assisting isolated children to adapt their school life having examined the process of their changes by reducing isolation level and isolative behavior through means of implementing group art therapy program. To accomplish this purpose of research, 36 participants were selected from children attending Class 6, 4th Grade of D Elementary School located in Dajeon Metropolitan City, to which researcher was served as homeroom teacher. And the participants were asked to complete a survey that included social and emotional isolation scale test which was designed by Heh Sung-hee(1993) and 4 children marked more than 96 points were designated as isolated children. The group art therapy program exercised in this research was the one that reorganized by research to suit the research purpose based on the precedent works, and survey was conducted total 12 times, two time a week, within 60 minutes per time, between 6 September and 24 October 2006, and researcher conducted group art therapy program directly at Class 6, 4th Grade of D Elementary School using extra hours after school. And following analyses were performed in relation to results therefrom: First, to analyze changes of isolation level of isolated children Quantitatively, the results from pre and post test concerning social and emotional isolation scale were comparatively analyzed. Second, to analyze changes of psychological state of isolated children, projective drawing tests were performed using Kinetic House-Tree-Person(K-HTP) Drawing and Kinetic School Drawing(KSD) and results therefrom were comparatively analyzed. Third, to analyze Quantitatively what changes have been occurred in the isolated children during the course of forming interrelationships with group members while participating in group art therapy, proceedings were summarized per each stage of the program and analyzed accordingly. Fourth, results from researcher's observation of what changes have been occurred in the isolative behavior of isolated children before and after implementation of group art therapy were compared accordingly. Followings are resulting conclusions. First, group art therapy program reduced isolation level of isolated children. Second, group art therapy program changed the isolated children's psychological state into a stable and positive fashion. Third, isolated children became able to experience positive interrelations as well as establishment of new human relationships with group members during the course of participating in the group art therapy program. Fourth, group art therapy program reduced isolative behaviors of the isolated children. Therefore, conclusions could have been reached that the group art therapy program implemented in this research reduced isolative behaviors of the isolated children, and changed their anxious and depressed mental state into stable and positive ones, also established positive interrelationships as well as new human relationships. And, it will be able to expect a greater effect if a program which has been associated with their family could be proceeded along with continuous guidance and teaching having developed objective test tools that will discern isolated children.

• Mycobiology
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• 제48권1호
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• pp.20-28
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• 2020

Soil degradation can have an impact on the soil microbiota, but its specific effects on soil fungal communities are poorly understood. In this work, we studied the impact of soil degradation on the richness and diversity of communities of soil fungi, including three different degrees of degradation in Germany and Panama. Soil fungi were isolated monthly using the soil-sprinkling method for 8 months in Germany and 3 months in Panama, and characterized by morphological and molecular data. Soil physico-chemical properties were measured and correlated with the observed values of fungal diversity. We isolated a total of 71 fungal species, 47 from Germany, and 32 from Panama. Soil properties were not associated with fungal richness, diversity, or composition in soils, with the exception of soil compaction in Germany. The geographic location was a strong determinant of the soil fungal species composition although in both countries there was dominance by members of the orders Eurotiales and Hypocreales. In conclusion, the results of this work do not show any evident influence of soil degradation on communities of soil fungi in Germany or Panama.

• 한국축산식품학회지
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• 제33권3호
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• pp.331-334
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• 2013

Osteopontin (OPN) is a secreted phosphorylated glycoprotein. It has an important role in multiple biological processes including cell survival, bone remodeling, inhibition of ectopic calcification, as well as, is thought to have potential immune modulation activities. In this work, we isolated and characterized a full-length open reading frame (ORF) of Korean native cow's OPN from Korean native cow's (Hanwoo) kidney, and successfully cloned firstly on Hanwoo's OPN. The sequencing results indicated that the isolated cDNA was 1190 bp in length containing a complete ORF of 837 bp. It encoded a precursor protein Hanwoo's OPN consisting of 278 amino acids with a signal peptide of 16 amino acids. Amino acid homology was found to be 99.3% as compared to the corresponding sequences of Holstein bone marrow OPN. Hanwoo's kidney OPN and Holstein bone marrow OPN are different only in two amino acid residues 42 and 56, amino acid residue 42 is Thr (T) ${\leftrightarrow}$ Ile (I), and amino acid residue 56 is Ala (A) ${\leftrightarrow}$ Thr (T) respectively. These results from the present work would be helpful to elucidate the biological function of Hanwoo's OPN and provided a foundation for further insight into role of Hanwoo's OPN.