• Bulletin of the Korean Chemical Society
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• 제27권9호
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• pp.1289-1292
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• 2006

Potassium(I) with 5,7-dihydroxy-6,4'-dimethoxyisoflavone-3'-sulfonate (L) assembles to K($H_2O$)L (L = 5,7-dihydroxy-6,4'-dimethoxyisoflavone-3'-sulfonate). It was characterized by single-crystal X-ray diffraction, element analysis, IR and $^1H$ NMR spectroscopy. It crystallizes in the monoclinic space group $P2_1$/n and reveals a seven-coordinate complex. Polyhedra potassium chains, C-H${\cdot}{\cdot}{\cdot}\pi$ and C-H${\cdot}{\cdot}{\cdot}$O and O-H${\cdot}{\cdot}{\cdot}$O hydrogen bonds lead K($H_2O$)L to a three-dimensional network structure. The biological activity of resistance to hypoxia was tested, and the results showed that the biological activity of resistance to hypoxia of K($H_2O$)L is as good as that of its precursor, irisolidone.

• Journal of the Korean Wood Science and Technology
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• 제29권4호
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• pp.89-96
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• 2001

항균활성이 우수한 회화나무 목부로부터 4종의 isoflavonoid 화합물을 단리하였으며, 기기분석 결과 3종의 isoflavone인 5,7-dihydroxy-4',6-dimethoxyisoflavone(irisolidone)을 비롯하여, 5,7-dihydroxy-4'-methoxyisoflavone(Biochanin A), 7-hydroxy-4'-methoxyisoflavone(formononetin) 그리고 1종의 isoflavanone인 7-hydroxy-4'-methoxyisoflavanone으로 각각 동정하였다. 이들 단리 물질의 항균활성을 배지점적법으로 조사한 결과 4종의 isoflavonoid 공히 낮은 항균활성을 나타내어, 회화나무 목부의 높은 항균활성은 본 실험에서 단리한 물질 이외의 물질이 관여하는 것으로 추정되며 금후 관련물질의 탐색이 필요할 것으로 사료되었다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.225.2-226
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• 2003

The inhibitory effect of kakkalide isolated from Puerariae flos on ethanol-induced lethality and hepatic injury were investigated. Intraperitoneally treated Kakkalide was weakly reduced the mortality associated with administration of ethanol and did not reduce alcohol hepatotoxicity. However, orally administered kakkalide and intraperitoneally administered irisolidone significantly reduced serum ALT and AST activities on liver-injured mice by ethanol. (omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.333.2-333.2
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• 2002

Kakkalide from Puerariae Flos expresses pharmacological actions after biotransformation to irisolidone by intestinal bacteria. B. breve K-110 was isolated as a bacterium metabolizing kakkalide. Therefore. we purified kakkalide-metabolizing p-Xylosidase from B. breve K-110. ${\beta}$-Xylosidase from B. breve K-110 (isolated from Korean intestinal microflora) was induced by kakkalide. We used defined medium contating 1mM kakkalide for the cultivationof B. breve K-110. (omitted)