• Title/Summary/Keyword: Irisolidone

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Structure and Biological Activity of K(H2O)L (L = 5,7-Dihydroxy-6,4'-dimethoxyisoflavone-3'-sulfonate)

  • Guo, Ya-Ning;Zhang, Xue-Ling;Zhang, Zun-Ting
    • Bulletin of the Korean Chemical Society
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    • v.27 no.9
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    • pp.1289-1292
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    • 2006
  • Potassium(I) with 5,7-dihydroxy-6,4'-dimethoxyisoflavone-3'-sulfonate (L) assembles to K($H_2O$)L (L = 5,7-dihydroxy-6,4'-dimethoxyisoflavone-3'-sulfonate). It was characterized by single-crystal X-ray diffraction, element analysis, IR and $^1H$ NMR spectroscopy. It crystallizes in the monoclinic space group $P2_1$/n and reveals a seven-coordinate complex. Polyhedra potassium chains, C-H${\cdot}{\cdot}{\cdot}\pi$ and C-H${\cdot}{\cdot}{\cdot}$O and O-H${\cdot}{\cdot}{\cdot}$O hydrogen bonds lead K($H_2O$)L to a three-dimensional network structure. The biological activity of resistance to hypoxia was tested, and the results showed that the biological activity of resistance to hypoxia of K($H_2O$)L is as good as that of its precursor, irisolidone.

Studies on Biological Activity of Wood Extractives(VII) - Antifungal activity of Isoflavonoids from Sophora japonica - (수목추출물의 생리활성에 관한 연구(VII) - 회화나무 Isoflavonoid의 항균활성 -)

  • Park, Young-Ki;Lee, Hak-Ju;Lee, Sung-Suk;Choi, Don-Ha;Yeo, Woon-Hong;Oh, Jung-Soo
    • Journal of the Korean Wood Science and Technology
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    • v.29 no.4
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    • pp.89-96
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    • 2001
  • Three isoflavones and one isoflavanone were isolated from the wood of Sophora japonica (Leguminosae) which has been selected due to its high antifungal activity among the tested species, Four compounds were identified as 5,7-dihydroxy-4',6-dimethoxyisoflavone (irisolidone), 5,7-dihydroxy-4'-methoxyisoflavone (biochanin A), 7-hydroxy-4'-methoxyisoflavone (formononetin) and 7-hydroxy-4'-methoxy-isoflavanone by Mass and NMR spectroscopic analysis. The antifungal activity of the isoflavonoids was tested by medium dilution method and showed low antifungal activity indicating that the other compounds may contribute to high activity of the wood extractives of S. japonica.

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Protective Effect of Kakkalide from Puerarie Flos on Ethanol-Induced Lethality and Hepatic Injury Is Expressed by Human Intestinal Microflora

  • Han, Yeo-Ok;Han, Myung-Joo;Park, Sung-Hwan;Kim, Dong-Hyun
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.225.2-226
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    • 2003
  • The inhibitory effect of kakkalide isolated from Puerariae flos on ethanol-induced lethality and hepatic injury were investigated. Intraperitoneally treated Kakkalide was weakly reduced the mortality associated with administration of ethanol and did not reduce alcohol hepatotoxicity. However, orally administered kakkalide and intraperitoneally administered irisolidone significantly reduced serum ALT and AST activities on liver-injured mice by ethanol. (omitted)

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Purification and Characterization of ${\beta}$-Xylosidase from Bifidobacterium breve K-110

  • Shin, Ho-Young;Han, Yeo-Ok;Han, Myung-Joo;Lee, Jang-Yeon;Lee, Ji-Hyun;Kim, Dong-Hyun
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.333.2-333.2
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    • 2002
  • Kakkalide from Puerariae Flos expresses pharmacological actions after biotransformation to irisolidone by intestinal bacteria. B. breve K-110 was isolated as a bacterium metabolizing kakkalide. Therefore. we purified kakkalide-metabolizing p-Xylosidase from B. breve K-110. ${\beta}$-Xylosidase from B. breve K-110 (isolated from Korean intestinal microflora) was induced by kakkalide. We used defined medium contating 1mM kakkalide for the cultivationof B. breve K-110. (omitted)

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