• The Journal of Internal Korean Medicine
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• v.18 no.1
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• pp.1-14
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• 1997

An experimental study was done to investigate the spontaneous movements to the isolated ileum with liquid extracts of Samchulgunbitang. Then the action of gastric ulcer, gastric-juice secretion, the free acidity, total acidity, pepsin output, the transport ability in the intestine, analgesic effect and sleeping time were measured. The following results were obtained; 1. As to the spontaneous movements in the isolated ileum, the effect of contraction against suppression was recognized. 2. The effects of contraction against suppression induced by acetylcholine chloride and barium chloride were recognized on the gastric funds strip significantly. 3. The preventive effect of Samchulgunbitang on the pylorus-lightedulcer in rat was recognized significantly. 4. The anti-ulcer effect of Samchulgunbitang was not recognized on the gastric ulcer caused by indomethacin. 5. The effects of decreasing on the secretion gastric juice, the free acidity, total acidity and pepsin output of Samchulgunbitang were recognized significantly. 6. The transport rate in the small intestine of Samchulgunbitang was decreased. 7. The transport rate in the large intestine of Samchulgunbitang was increased. 8. The analgesic effect of Samchulgunbitang caused by acetic acid was recognized significantly. 9. The sleeping time caused by pentobarbital-Na of Samchulgunbitang was prolonged significantly. According to the results, it is considered that the Samchulgunbitang has effects of gastric ulcer, chronic gastritis, hyper-acidity, gastroptosis such as abdominal discomfort, gastric acid, indigestion and anorexia.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.4 no.1
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• pp.1-16
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• 1998

In order to investigate the effect of Bujaleejungtang, by means of oral medication to rats and mice, to isolated intestine and stomach, and the effect to pyloric ulcer, indomethacin-induced ulcer, secretion of gastric juice, and to transport ability of intestine content were studied as the action to G-I tract. The effect to normal rats and resperpine-treated rats were studied as the action to thermo-regulation. The results were as follows: 1. Bujaleejungtang showed the inhibitory effect on the smooth muscle contraction induced by acethylcholine chloride and barium chloride in the isolated mice ileum. 2. Bujaleejungtang showed inhibitory effect on the contraction induced by acetylcholine chloride and barium chloride in the rat fundus-strip. 3. Inhibitory effect of Bujaleejungtang on pyloric ulcer, indomethacin-induced gastric ulcer in rats was statistical recognized(p<0.05). 4. No inhibitory effect of Bujaleejungtang on gastric juice secretion in Shay rats was recognized. 5. Inhibitory effect of Bujaleejungtang on gastric free acidity and total acidity in Shay rats was recognized only when Bujaleejungtang was medicated in high thickness(2000mg/kg) (p<0.001). 6. Inhibitory effect of Bujaleejungtang on pepsin output in Shay rats was recognized only when Bujaleejungtang was medicated in high thickness(2000mg/kg)(p<0.001). 7. Inhibitory effect of Bujaleejungtang on barium sulfate transport in the small intestine of mice was recognized only when Bujaleejungtang was medicated in high thickness(2000mg/kg)(p<0.05). 8. Inhibitory effect of Bujaleejungtang on barium sulfate transport in the large intestine of mice was recognized(p<0.05). 9. Inhibitory effect of Bujaleejungtang on rectal temperature in normal rats was recognized. 10. Inhibitory effect of Bujaleejungtang on rectal temperature in reserpine-treated rats was recognized only when Bujaleejungtang was medicated in high thickness(2000mg/kg)(p<0.05).

• Biomolecules & Therapeutics
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• v.8 no.1
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• pp.84-92
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• 2000

This Study was conducted to assess the single dose toxicity of DA-125, a new anthracycline anti-cancer agent, in rats and mice. The Drug was administered once intravenously to both sexes of rats and mice. Then followed a 14-day period of observation. The $LD_{50}$ Values (95% confidence limit) were estimated to be 60.9 mg/kg (57.5~64.3 mg/kg) for male rats and 60.2 mg/kg (56.2~64.5 mg/kg) for female rats, and 85.8 mg/kg (81.0~90.9 mg/kg) for male mice and 84.5 mg/kg (78.2~91.9 mg/kg) for female mice. Both sexes of rats and mice given the drug revealed the clinical sign of decreased locomotor activity, emaciation, hair loss, red-dish brown urine, salivation, and watery diarrhea. In addition, body weight from the next day to the 7th day tended to be decreased slightly in rats and mice treated with DA-125. Death occurred from the next day after administration to the 12th day. Macroscopically, congestion of gastrointestinal organ, lung, and adrenal glands were found in both sexes on the dead rats and mice. Histopathological examination of dead rats manifested atrophy of spleen, hypoplasia of bone marrow, hypcplasia and necrosis of lymphocyte in thymus, atrophy of villi in small intestine (duodenum, jejunum, and ileum), hyperplasia of granular epithelium in small intestine, degeneration of germinal epithelium in testis, defer oration of tubular epithelium in kidney, and vacuolation and myolysis of myocardium in heart. Histopathological examination of dead mice revealed hypoplasia of spleen and mesenteric lymph node, local necrosis of liver, atrophy of villi in small intestine, hyperplasia of glandular epithelium in small and large intestine, degeneration of tubular in kidney, degeneration of germinal cells in testis, and slight vacuolar degeneration of myocardium in heart.

• Journal of Haehwa Medicine
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• v.10 no.1
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• pp.67-78
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• 2001

From the study of acupuncture and external diseases on mammary diseases, the following conclusions are obtained. 1. Point Shanzhong, Shaoze and Rugen are often used for galactostasis in acupuncture. 2. Often used vessels for galactostasis in acupuncture are Stomach Meridian, Conception Vessel, Small Intestine Meridian, Bladder Meridian, Liver Meridian and Large Intestine Meridian in order. 3. The direct stimulations are used in external treatment for galactostasis, often accompanied by internal medical treatment, to promote the circulation of Qi and Blood. 4. Point Zuimup, Guangming of Gall bladder Meridian and Zusanli of Stomach Meridian is used for lactation pain in acupuncture. 5. Point Jianjing, Zusanli and Shanzhong are most often used for acuremastitis and breast cancer in acupuncture. 6. Often used vessels for acuremastitis and breast cancer in acupuncture are Stomach Meridian, Gall bladder Meridian, Conception Vessel, Small Intestine Meridian, Bladder Meridian, Pericardium Meridian in order. 7. The external treatment used for acuremastitis and breast cancer can be classed into its pathological period. When lactation is interrupted, Kumhwang Powder, Okro Powder, Robongbang, Allii Radix, Pinelliae Rhizoma, garlic moxibustion and Arusaenatus Rgizoma powder are used. When pus is piled up, Chunghwa Extracts, Dioscoreae Rhizoma, Leonuri Herba, Typa Latifolia, Taraxacum platycarpum, Phaseolus angularis, Manchong, Crvi Cornus latex, and Aucklandiae Radix are used. When pus flows down, Salviae Miltiorrhizae Radix Extract, nine-one pellet, Yongboo extract, eight-dampness extract, Tissue-regeneration Powder, Toad-net treatment, Kitten-hair, Hongseung pellet are used. 8. Stomach Meridian, Conception Vessel, Small Intestine Meridian, Gall Bladder Meridian, Bladder Meridian are most often used vessels for mammary diseases. From the conclusions above, It appears that the medical effect could be maximized by further studying and developing of the acupuncture and external treatment for mammary diseases according to the its nature, while accompanying internal medicine appropriately at the same time.

• Journal of Haehwa Medicine
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• v.16 no.1
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• pp.207-213
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• 2007

1. The pathogenic factors of diarrhea are external sensation, jungjishiljo, weakness of the spleen and stomach, improper diet, sinyanghueson, sueumyujang, liver Gi invades the spleen, uhhyuljeche. 2. The etiological causes of diarrhea are classified into pung, han, seo, seup, yul, sikjuk, ju, chiljung, damsul. Morphology of diarrhea are classified into yu, hwal, son, pok, goe, dongsul. 3. The etiological cause of diarrhea are closely related to the malfunction of the spleen, stomach and the related jang and bu's pathological alternation such as splees & stomach, large intestine, small intestine, liver, spleen, and kidney. 4. Diarrhea was mentioned in literatures not only as chronic Heohansung disorder, but also acute silyulsung disorder, based on hanyulheosil theory.

• Archives of Pharmacal Research
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• v.17 no.5
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• pp.309-313
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• 1994

Phytase of rat intestine had a large amount of oilgosacchanrides ; The enzyme consisted of two different subunits with the molecular weights of 90 KDa and 70 KDa in its intack form, whereas the apparent molecular weights tumed to 72 KDa and 52 KDa, respectively, after deglycosylation. The treatment with glycopeptidase F reduced the molecular weights from 90 KDa and 70 KDa to 83 KDa and 52 KDa, respectively, While endoglycosidase H caused no change in their molecular weights. These results indicate that the 70KDa subunit contains only the N-linked oilgosaccharide chains, while the 90KDa subunit ocntains O-linked oilgosaccharides as well as N-linked ones. Enzyme-linked lectin assays suggeted that bisecting N-acetyl-D-glucosamine and galactose 1-4 N-acetyl-D-glucosamine structures were present and that fucose was included in these oilgosaccharide moieties. Sialic acid was not found in either subunit.

• Natural Product Sciences
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• v.9 no.2
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• pp.64-67
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• 2003

The purgative activities of Whangryunhaedoktang (WT), Chunghyuldan (CD) and Rhei Rhizoma were measured to choose herbal formulae available for stroke patients suffering from constipation. When the laxative activity of Rhei Rhizoma and CD (the same dose as Rhei Rhizoma) compared, Rhei Rhizoma was more potent than CD. WT contained Gardeniae Fructus, which has been used as a laxative, as a ingredient. Nevertheless, WT did not show the purgative activity. WT and CD did not stimulate the transportation of small intestine. However, CD weakly stimulated the transportation of large intestine than Rhei Rhizoma. Accordingly, we believe that CD can be used as a useful purgative for stroke patients with constipation.

• Korean Journal of Veterinary Pathology
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• v.6 no.1
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• pp.7-9
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• 2002

Case 1 was showed severe caughing and nasal discharge, who was one of 5-month-old 18 male sheep taking inspection for MCF experiment. Pathological examination of case 1 was conducted. Macroscopic observations were the foamy sticky fluids in nasal and tracheal cavity, the grey spots with 2-4 mm diameter on the surface of lung. Histopathological observations were severe eosinophil and other round cell infiltration in general organs including lung, trachea, small intestine, large intestine, liver. Also, in the lung, there were parasite-cutting lesions in some alveolar spaces and bronchioles. Following these observations, case 1 was diagnosed as ovine lungworm infection.

• The Journal of Korean Medicine
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• v.16 no.2 s.30
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• pp.447-452
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• 1995

The meridians pathway on the hand and neck studies connection with craniospinal nerve to obtain result fellowing items. 1. Large Intestine Meridian of Hand-yang ming, Small Intestine Meridian of Hand-tai yang. Triple Warmer Meridian of Meridian of Foot-tai yang, was hollow organs and its had connected branches of the trigeminal nerve and fasial nerve, cervical nerve plexus. 2. The Triple warmer meridian pathway around ear connection supersecial temporlal branch. zygomatic branch. buccal branch mandlibular branch, cervical branch of the fasial nerve. 3. The stomach meridian foot-yang ming orginate from the glabella of the frontal bone, and connection supraorbital, frontal branches of the opthalamic nerve in headach. 4. The original cell of the trigeminal nerve, and fasial nerve the medulla oblongata and pons.

• The Korean Journal of Pharmacology
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• v.11 no.1 s.17
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• pp.27-31
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• 1975

1. The isolated strips of guinea-pig, fowl and reptiles (snake and tortoise) showed consistenly excitatory responses to $PGE_1\;and\;E_2$, which were dose-dependent. 2. Frog intestine revealed inhibitory responses to both $PGE_1\;and\;PGE_2$ except a small of $PGE_2$ (1-10 ng/ml) caused slight contraction. 3. The intestines of pieces showed inconsistent responses to $PGE_1\;and\;E_2$. In fresh-water fish(carp), $PGE_1$ produced relaxation under the dose of 50 ng/ml, and contraction by the large doses, but $PGE_2$ consistently caused contraction in dose-dependent manner. However, the strips of sea-water fish revealed the different responses to PGE compound: $PGE_1$ caused relaxation and $PGE_2$ conversly contraction even though in small degree. 4. These results that there are genera differences in the responses of the longitudinal strips of intestine to $PGE_1\;and\;PGE_2$ was assumed to be possibly correlated with evolutionally primitive function of gut.