• Journal of Ginseng Research
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• 제37권1호
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• pp.54-63
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• 2013

Ginsenoside Rd is a primary constituent of the ginseng rhizome and has been shown to participate in the regulation of diabetes and in tumor formation. Reports also show that ginsenoside Rd exerts anti-oxidative effects by activating anti-oxidant enzymes. Treatment with ginsenoside Rd decreased nitric oxide and prostaglandin $E_2$ ($PGE_2$) in lipopolysaccharides (LPS)-challenged RAW264.7 cells and in ICR mouse livers (5 mg/kg LPS; LPS + ginsenoside Rd [2, 10, and 50 mg/kg]). Furthermore, these decreases were associated with the down-regulations of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 and of nuclear factor (NF)-${\kappa}B$ activity in vitro and in vivo. Our results indicate that ginsenoside Rd treatment decreases; 1) nitric oxide production (40% inhibition); 2) $PGE_2$ synthesis (69% to 93% inhibition); 3) NF-${\kappa}B$ activity; and 4) the NF-${\kappa}B$-regulated expressions of iNOS and COX-2. Taken together, our results suggest that the anti-inflammatory effects of ginsenoside Rd are due to the down-regulation of NF-${\kappa}B$ and the consequent expressional suppressions of iNOS and COX-2.

• 부모자녀건강학회지
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• 제7권2호
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• pp.168-181
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• 2004

Purpose: The purpose of this study was to identified patterns of studies and to analyze the nursing research related to the massage intervention in Korea and to improve direction of nursing research in massage intervention in Korea. Methods: The research studies related to the massage were selected from the Korean Nurses Academic Society Journal and dissertation which were conducted experimental research design the last 7 years in Korea. The total numbers of the studies were 58. Result: The study subjects were post operational state in 34.5%, healthy adult in 17.2% studies. The others dealt with infant, cancer, dementia, hypertension, preterm neonates, elderly. Types of massage were whole body in 31.1%, foot in 22.6%, hand in 17.2%, back in 13.8% studies. And Meridian massage in 17.2%. Length of massage was below 5 minutes in 17.2%, 6~10 minutes in 29.4% and 11~20 minutes in 32.8% studies. Frequency of massage was only 1 time in 25.9%, 2~5 times in 31.1% studies. Massage produced psychological and physiological effects. Positive psychologic effects were anxiety relief, pain relief, mood enhancement and fatigue relief. Positive physiologic effects on body systems were blood pressure, heart rate, edema, skin temperature, immune system, blood glucose, excretion, PMS syndrome and growth and development. Conclusion: As a result, effects of massage were almost positive. Therefore massage is useful alternative nursing intervention. But more attention research is needed to identify the objectivity instrument to measure and repeat research.

• 동서간호학연구지
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• 제9권1호
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• pp.91-103
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• 2004

Purpose: This study was attempted to see the trends in breast cancer researches in Korea. Method: We collected a total of 94 articles associated with breast cancer and published in Korea from 1976 to August 2004 and analyzed the characteristics of those articles, the journals which published those articles in each year, the research designs, subjects, intervention effects in experimental studies, the subjects and concept distribution in comparative researches and themes of the articles. Result: 1. Articles published and associated with breast cancer have increased since 1990 and picked after 2000. 2. Most research designs are survey and correlation studies which are non-experimental research(70.2%) and next are experimental and qualitative researches. 3. In a total 17 articles which are experimental researches, intervention studies which use exercise programs are most(5 articles) and the next are education program, supportive nursing intervention, guided imagery, massage and rehabilitation programs. 4. In correlational researches, concepts such like social-psychological adaptation, partner support, health promotion behavior and family support are treated frequently. 5. Subjects in most comparative studies are patients with breast cancer and normal women. 6. Most nursing research themes are psycho/spiritual problems, 16 articles(17.0%). Conclusion: These results show that the researches related with breast cancer have actively increased and body functions and psycho-social variables have been improved through nursing intervention. Therefore, it seems that more systematic interdisciplinary studies and systematic complement are necessary for future breast cancer nursing researches.

• 지역사회간호학회지
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• 제15권3호
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• pp.419-437
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• 2004

Purpose: This study aims to analyze the trends of the gerontological nursing researches in Korea and suggest the direction for research in this nation. Method: A total of 241 dissertations and other published articles in Korea from 1997 to 2003 were analyzed in this study focusing on the design of the research, key words, measurement tools for basic concepts, and the intervention outcomes in the case of the experimental research. Result: Of those analyzed researches. it was found that 80.9% accounted for the published articles and 19.1% dissertations. There were no clear criteria for the classification of the old men. The most popular research design was an exploratory/descriptive study (54.4%). The major concepts were about 'physical and mental health'. Most of the measurement tools used were developed by foreigners. which were translated into Korean. Among 56 experimental studies, nursing intervention programs in 22 studies were based on physical exercise programs. Conclusion: It is necessary to analyze the trend of gerontological health research in comparison with multidisciplinary researches for elderly people. In addition, the experimental researches for both development and verification of nursing intervention programs are needed. Also, accumulation of research outcomes and development of a standardized instrument for the measurement of Korean elderly people are required.

• Child Health Nursing Research
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• 제16권1호
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• pp.73-83
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• 2010

Purpose: This study was designed to analyze recent trends in pediatric oncology research in Korea and suggest future research directions in this area. Methods: Studies (105) selected from http://www.riss4u.net for last 15 yr were used. They were analyzed by publication type, field and design of the study, study participants, main theme, and outcome variables used in intervention studies. Results: 1. Of the 105 studies, 67 were master and doctoral dissertations and 49.5% of studies were conducted in nursing. 2. There were 73 (69.5%) quantitative studies and 20 (19.1%) qualitative research studies and the most frequently used study design was that of a descriptive study. 3. Children with cancer undergoing treatment and their parents, mostly mothers, were the participants most frequently studied. 4. Most themes were psychological/spiritual problems, coping, and family function. 5. Most frequently measured outcome variables were nausea/vomiting, fear/anxiety and adjustment. Conclusion: The results indicate that future research should include more well-designed intervention studies to develop new intervention protocols and to confirm the effect of previous study findings. It is also necessary to use an interdisciplinary approach to deal with physical and psychosocial needs of these children and their families including siblings and fathers of children with cancer.

• 한국보건간호학회지
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• 제14권1호
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• pp.100-113
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• 2000

The purpose of this study is to examine the effect of supportive nursing intervention on patient's response of anxiety in emergency room as the suspected experimental research sequentially designed for the unequal control group. This study collected the data from 100 patients including 50 patients of experimental group and 50 patients of control group in emergency room of the only one university hospital from July 12. to September 30, 1999. This study used questionnaires that Kim, Jung Taek and Shin. Dong Kyun revised the measurement of STAI(State-Trait Anxiety Inventory) of Spielberger(1972) to measure their anxiety with using physical. spiritual. and informative support of the supportive nursing intervention, and measured blood pressure. pulse and respiration by physiological response of anxiety. After then. this study analyzed the frequency and percentage by using SPSS 7.5 program, $x^2-test$, t-test and ANCOVA. The results are as follows: First hypothesis : the point of STAI of experimental group who received the supportive nursing intervention during emergency room staying will be lower than that of control group without the supportive nursing intervention(F=22.943, p=.000). Second hypothesis : the sistolic blood pressure of experimental group who received the supportive nursing intervention during emergency room staying will be lower than that of control group without the supportive nursing intervention(F=42.603. p=.000). Third hypothesis. the diastolic blood pressure of experimental group who received the supportive nursing intervention during emergency room staying will be lower than that of control group without the supportive nursing intervention(F= 18.482, p=.000). Fourth hypothesis: the pulse of experimental group who received the supportive nursing intervention during emergency room staying will be lower than that of control group without the supportive nursing intervention. Fifth hypothesis : The respiration of experimental group who received the supportive nursing intervention during emergency room staying will be lower than that of control group without the supportive nursing intervention. In the above-mentioned result. the supportive nursing intervention was considered to be useful intervention that raised the effect on patient's response of anxiety during emergency room staying.

• Journal of Radiation Protection and Research
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• 제42권3호
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• pp.166-175
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• 2017

Background: This study presents food ingestion standards for radioactivity that can be applied in nuclear emergency exposure situations, and discusses the validity of the current domestic standards. Materials and Methods: This study derived food ingestion standards for radiocesium and radioiodine using domestic food intake rates and intervention levels, which serve as a basis for determining the necessity of public protective actions, and then compared them with the existing guidelines. Operational intervention levels were also derived using domestic food intake rates, and were compared with those of the International Atomic Energy Agency. Results and Discussion: The derived activity concentrations for food ingestion standards of radiocesium for infants were higher than those in the Act on Physical Protection and Radiological Emergency (APPRE) for all food categories, while for adults, the derived activity concentrations for drinking water and milk appeared to be slightly lower. The derived activity concentrations for vegetables, fruits, and grains were greater than those in the guidelines of the APPRE, while the derived activity concentrations for meat and seafood were similar to those in the APPRE. The derived activity concentrations for radioiodine were greater than both domestic and global standards. The calculated operational intervention levels (OILs) based on domestic food intake rates were greater than the IAEA's default OIL6 values for most radionuclides, except for a few ${\alpha}$-radionuclides. Conclusion: The current domestic guidelines turned out to be conservative overall, compared to the present results that were calculated using domestic food intake rates. It is recommended that the domestic guidelines should be revised and complemented transparently through an in-depth review by stakeholders on a solid scientific basis.

• Nutrition Research and Practice
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• 제16권2호
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• pp.217-232
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• 2022

BACKGROUND/OBJECTIVES: Filipino children aged 6-10 yrs are consuming poor quantities and quality of food based on the 2013 Philippine National Nutrition Survey. During these years healthy eating habits must be formed through family influence. Within this background, a complete package of nutrition intervention-feeding and nutrition classes, was pilot tested in selected schools to determine 1) changes in nutrition attitude and behavior and 2) food intake of schoolchildren after the intervention. SUBJECTS/METHODS: A quasi-experimental design was used in the study. School children aged 7-9 yrs enrolled in selected Philippine public elementary schools and their mothers/caregivers were the study participants. Profile and socio-demographic data were collected from each participant at baseline. The nutrition behavior and food intake of children were determined using the modified Child and Diet Evaluation Tool (CADET) and the 24-h food recall form, respectively. Data were analyzed using Stata version 15. RESULTS: No significant differences in characteristics were found among the 339 child-mother pairs in the 4 study groups. The modified CADET recorded improved mean attitude scores of children ranging from 22 to 24 points at endline in the group receiving both lunch feeding and nutrition education classes (group 3). The perceived better behavior of children was reported by their mothers in terms of increased intake of milk and vegetables and decreased consumption of sugar. These improvements were supported by the actual food intake of children obtained from the 24-h food recall. CONCLUSIONS: Family involvement, particularly of mothers/caregivers, appeared to be an important factor in shaping the children's eating behavior. An intervention package with lunch feeding and nutrition classes resulted in a substantial improvement in children's behavior and actual food intake with increased levels of vegetables and milk while lowering sugar consumption. The adoption of the intervention package in public elementary schools should therefore be pursued.

• 대한감각통합치료학회지
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• 제21권2호
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• pp.24-34
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• 2023

목적 : 본 연구를 통하여 발달장애 아동에게 적용한 전정감각, 고유감각 중심의 감각통합 중재가 공간 지각력, 시-운동 협응력에 어떠한 영향을 미치는지 알아보고자 한다. 연구방법 : 본 연구는 발달 장애 아동 만 5~6세 아동 3명을 대상으로 개별실험연구방법(single subject research design) 중 ABA' 설계를 사용하였다. 매주 3회기씩 6주간 30분씩 총 18회기를 진행하였다. 기초선 3회기와 재기초선 3회기는 중재 없이 공간 지각력과 시-운동 협응을 평가하였고 중재기 12회기는 전정감각, 고유감각 위주 감각통합 중재를 실시하였다. 중재의 효과를 알아보기 위한 매회기 측정으로는 전산화 인지 프로그램(CoTras-C)을 이용하였으며, 공간지각력 평가를 위한 퍼즐하기, 시-운동 평가를 위한 미로 찾기를 실시하였다. 연구의 사전, 및 사후 평가는 카우프만 아동용 지능 검사(Kaufman Assessment Battery for Children; K-ABC II)와 한국판 시지각 발달 검사(Korean-Developmental Test of Visual Perception-2: K-DTVP-2)의 하위평가를 이용하였다. 결과 : 발달장애 아동에게 전정감각, 고유감각 중심의 감각통합중재를 적용하기 전보다 후에 공간지각력과 시-운동 협응력 점수에 유의한 차이가 있었고, 세 아동 모두 통계적으로 유의한 차이가 있었다. 결론 : 전정, 고유감각 중심의 감각통합 치료가 발달장애 아동의 공간지각력과 시-운동 협응력에 유의미한 영향을 미쳤다.

• 대한통합의학회지
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• 제8권3호
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• pp.1-10
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• 2020

Purpose : The purpose of this study is to analyze the corrective effect of the general coordinative manipulation (GCM) joint intervention model on distort leg with imbalance of the lower extremity joints, pelvic and shoulder girdles, and lumbar spine. Methods : The study used a comparative analysis of the size of the distort leg and the imbalance of the lower extremity joints, pelvic and shoulder girdles, and lumbar spine before and after the application of the GCM joint intervention model. A total of 31 subjects from movement center G and the department of physical therapy at university M were selected as research subjects, and they were divided into two groups. The GCM joint intervention model was applied to 18 subjects in the bow knee group and 13 subjects in the knock knee group. The two groups received daily intervention three times a week for four weeks. The corrective effect of the GCM joint intervention model for each type of distort leg was compared and analyzed. Results : The effects of the GCM joint intervention model in correcting bow knee and knock knee with knee deformation and imbalance of the lower extremity joints, pelvic and shoulder girdles, and lumbar spine were significant in most domains (p<.05). The correlation between the bow knee and knock knee groups showed significance in most domains (p<.05). Conclusion : The GCM joint intervention model showed significant corrective effect in the bow knee and knock knee groups in terms of knee deformation, lower extremity joints, pelvic and shoulder girdles, and lumbar spine (p<.05).