• Molecules and Cells
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• v.39 no.3
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• pp.258-265
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• 2016

In metastatic breast cancer, the acquisition of malignant traits has been associated with the increased rate of cell growth and division, mobility, resistance to chemotherapy, and invasiveness. While screening for the key regulators of cancer metastasis, we observed that neurotrophin receptor TrkB is frequently overexpressed in breast cancer patients and breast cancer cell lines. Additionally, we demonstrate that TrkB expression and clinical breast tumor pathological phenotypes show significant correlation. Moreover, TrkB expression was significantly upregulated in basal-like, claudin-low, and metaplastic breast cancers from a published microarray database and in patients with triple-negative breast cancer, which is associated with a higher risk of invasive recurrence. Interestingly, we identified a new TrkB-regulated functional network that is important for the tumorigenicity and metastasis of breast cancer. We demonstrated that TrkB plays a key role in regulation of the tumor suppressors Runx3 and Keap1. A markedly increased expression of Runx3 and Keap1 was observed upon knockdown of TrkB, treatment with a TrkB inhibitor, and in TrkB kinase dead mutants. Additionally, the inhibition of PI3K/AKT activation significantly induced Runx3 and Keap1 expression. Furthermore, we showed that TrkB enhances metastatic potential and induces proliferation. These observations suggest that TrkB plays a key role in tumorigenicity and metastasis of breast cancer cells through suppression of Runx3 or Keap1 and that it is a promising target for future intervention strategies for preventing tumor metastasis and cancer chemoprevention.

• The Journal of Korean Medicine
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• v.29 no.5
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• pp.126-133
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• 2008

Purpose : The aim of this study is to identify current situation and issues of outcome measures to evaluate the public health programs using traditional medicine by public health centers in Korea. Method :This study analyse and review existing data and documents related to traditional Korean medicine and health policy using contents analysis method. To collect the information on outcome measures evaluating the programmes, this study reviewed annual reports for health promotion programmes using traditional Korean medicine(HP-TKM) of Hub public health centers, as pilot public health centers, which have implemented the health promotion programmes collectively. Additionally, the review included research articles, government documents and book chapters on the topics related assessments in health promotion. Results :HP-TKM are stroke prevention education, smoke free program, health promotion according to Four Constitutional Medicine, home visiting treatment, etc. However, there are only a few studies of traditional medicine focused health promotion evaluation strategies. The benefits of health promotion programs using TKM can be categorized as non-health benefit, physiological, psychological and physical effects. To manage and monitor the intervention programmes efficiently, attention should be given to developing relevant and valid outcome measures for evaluating the programmes by government and public health center. Conclusion :Up to now, considering number of researchers, research projects undertaken or published articles and reports, within traditional Korean medicine there is a lack of capacity in research. Thus, government should pay more attention to developing relevant and valid outcome measures for evaluating the programs.

• The Journal of the Korea Contents Association
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• v.14 no.9
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• pp.381-389
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• 2014

This purpose of this study was to identify the relationships between attitude, subjective norms, perceived behavioral control and intention of safer sexual behavior in non-experienced university students of sexual intercourse. The study participants were 604 students of university in Seoul. Considering the extremely private and sensitive topic of this study, data collection was performed through online and mobile media form April 1 to 14, 2013. Collected data were analyzes using the SPSS 21.0 Programs. As a results, Intention of safer sexual behavior had a meaningful relationship with attitude, subjective norms, perceived behavioral control. Bsaed on these results, it is suggested that the results the of this study are used to develop nursing intervention strategies for the promotion of sexual health, such as sex education programs or sex counseling programs targeting university students.

• Journal of Korea Technology Innovation Society
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• v.21 no.2
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• pp.715-737
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• 2018

The introduction of autonomous vehicles will bring about not only changes in existing automotive ecosystem but also widespread changes in our lives, society, economy, and culture. Social acceptance is one of important influencing factors for the commercialization of autonomous vehicles. The purpose of this study analyzes influencing factors in the acceptance of autonomous vehicles in terms of consumers. Autonomous vehicles in this study were defined as PAV (Partial Autonomous Vehicles) and FAV (Full Autonomous Vehicles) by drivers' intervention or not. The survey was conducted over 20 years old including not only drivers but also non-drivers. The results showed that the factors affecting acceptance of PAV and FAV were different. Factors directly related to drivers influenced PAV acceptance while external environmental factors influenced FAV acceptance. This study is proved that is should need different strategies between PAV and FAV for increasing those acceptance

• Journal of Korean Public Health Nursing
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• v.16 no.1
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• pp.30-44
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• 2002

The purpose of this study were to identify seasons variation of house dust mites allergen and perceived allergic symptom. The subjects were consisted of 29 family with allergy patients and 34 family without allergy patients. Perceived allergic symptoms were accessed and house dust was sampled from beds, floor of bedroom, kitchen and livingroom in spring(August), summer (July), fall(October) and winter(January) and tested using two-site ELISA. The results were as follows; 1) In all family, amount of house dust mites allergen(Der fI) of livingroom floor was the highest in summer$(4.73{\mu}g/1g\;of\;dust)$, and then fall$4.67{\mu}g/1g\;of\;dust)$, winter$(3.94{\mu}g/1g\;of\;dust)$, spring$(1.73{\mu}g/1g\;of\;dust)$. 2) In family with allergy patients, amount of house dust mites allergen(Der fI) of bedroom floor was highest in fall $(9.75{\mu}g/1g\;of\;dust)$. 3) In family with allergy patients, amount of house dust mites allergen(Der fI) of mattress was highest in fall$(8.23{\mu}g/1g\;of\;dust)$. 4) Perceived allergic symptom scores of family with allergy patients were higher than family without allergy patients in all seasons. In family without allergy patients, perceived allergic symptom scores was the highest in spring(4.29) and perceived allergic symptom scores of family with patients was the highest in winter(2.49). 5) The relationship of house dust mites allergen and perceived allergic symptom scores were positively related (r=.941, p=.000). Perceived allergic symptoms were correlated with amount of house dust mites allergen, That is, perceived allergic symptoms were became worse by house dust mites allergen. So House dust mites allergen reducing strategies and intervention should be recommended in further study.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.9 no.2
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• pp.300-310
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• 2002

Purpose: This study describes the perception of comfort by hospital nurses. Q-methodological was used. Method: The participants completed a 37-item a sort made up of statements which could be ranked in terms of their relevance to the subjective meaning of comfort Result: Three interpretable types of comfort were identified. They are as follows : Type I, emotional and spiritual well-being style: The nurses perceived that patients feel comfortable when they feel emotional support from others and spiritual easiness. The nurses felt that the patients put worth in hope for a healthy life. free from pain and fear of death. Type II, acceptive medical environment style: The nurses perceived that patients have a secure and satisfied attitude towards prompt responses, exact information and skilled Intervention techniques. They also perceived that patients feel safe and secure when they feel free of pain and medical staff are kind. Type III, physical well-being style; The nurses perceived that patients feel safe and comfortable when they feel free of pain and have a good sleep and are able to maintain a comfortable position. They perceived that patients put a high value on meeting the basic needs of safety, such pain, sleep and positioning. Conclusion: The result of this study can be used as a basis to develop nursing measures for promoting comfort. Further studies are recommended on factors which influence nurses' perception of comfort and strategies to promote comfort according to the style of the patients.

• Research in Community and Public Health Nursing
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• v.24 no.4
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• pp.438-450
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• 2013

Purpose: The purpose of this study is to identify relationships between acculturation, social network, and health-related quality of life (HRQOL) among Korean-Chinese immigrants. Methods: A cross-sectional descriptive study was conducted with 147 Korean-Chinese immigrants who were residing more than 1 year in Korea. Physical and mental dimensions of HRQOL were assessed by Short Form-12 Health Survey that consisted of a physical component summary (PCS) and a mental component summary (MCS). Data were analyzed with Pearson's correlation and multiple regression. Results: The mean PCS score was $41.14{\pm}10.72$ and the mean MCS score was $49.09{\pm}11.31$ (possible range 10-70). Depression (${\beta}$=-6.43) and Social network frequency (${\beta}$=2.44) explained 28.4% of the variance in PCS while depression (${\beta}$=-11.54) and visiting clinic/hospital (${\beta}$=-4.00) explained 34.3% of the variance in MCS. Acculturation was not significantly associated with HRQOL. Conclusion: This study confirmed that the social network frequency influences HRQOL among Korean-Chinese Immigrants. The findings suggest that social network analysis should be considered in the process of developing health intervention strategies for Korean-Chinese immigrants.

• Journal of Korean Academy of Nursing
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• v.46 no.3
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• pp.327-337
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• 2016

Purpose: The purpose of this study was to construct and test a structural equation model on resilience of breast cancer patients receiving chemotherapy. Methods: Participants were 204 patients with breast cancer who received chemotherapy treatment. They participated in a structured interview, which included social support, depression, symptom experience, self-efficacy, hope, resilience, and infection prevention behaviors. Data were analyzed using SPSS/WIN 20.0 and AMOS 18.0. Results: Lower depression (${\gamma}=-.33$, p=.020) and symptom experience (${\gamma}=-.31$, p=.012) and higher self-efficacy (${\gamma}=.32$, p=.005) and hope (${\gamma}=.48$, p=.016) were influenced by higher social support. Greater resilience was influenced by lower symptom experience (${\beta}=-.18$, p=.016), higher self-efficacy (${\beta}=.49$, p=.023), and higher hope (${\beta}=.46$, p=.012), and these predictors explained 66.7% of variance in resilience. Greater resilience (${\beta}=.54$, p =.009) made an impact on greater infection prevention behaviors. Resilience mediated the relations of symptom experience (${\beta}=-.10$ p=.013), self-efficacy (${\beta}=.27$, p=.006) and hope (${\beta}=.25$, p=.009) with infection prevention behaviors. These predictors explained 24.9% of variance in infection prevention behaviors. Conclusion: The findings of the study suggest that breast cancer patients with greater resilience who are receiving chemotherapy participate in increased infection prevention behaviors. Further research should be conducted to seek intervention strategies that improve breast cancer patients' resilience.

• Journal of Korean Academy of Nursing
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• v.47 no.5
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• pp.700-711
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• 2017

Purpose: This study aimed to test a proposed structural equation model in which bullying experience, conflict management styles and psychological empowerment predict psychological well-being among Chinese nursing students in clinical placement. Methods: Three hundred and sixty-six nursing students recruited from five hospitals in J city and Y city were assessed with self-report questionnaires on bullying experience, conflict management styles, psychological empowerment and psychological well-being including depression, self-esteem, and academic major satisfaction. Data were analyzed using SPSS version 20.0 and AMOS version 22.0. Results: The evaluation parameters included the comparative fit index at .90, the goodness of fit index at .93, the root mean square error of approximation at .07, and ${\chi}^2/df$ ratio at 2.66, indicating that the proposed structural equation model provided a good fit to the data. Experience of being bullied during clinical placement, conflict management styles and psychological empowerment explained 93.0% of the variance and had significant effects on psychological well-being, with conflict management styles and psychological empowerment mediating the association between bullying and psychological well-being. Conclusion: The findings indicated that mediation by conflict management styles and psychological empowerment alleviated the negative influence of bullying on psychological well-being. To limit bullying and its negative effects, development of effective guidelines to deal with bullying will be a critical tool for both Chinese nursing students and their instructors. Further research should incorporate conflict management styles and psychological empowerment into the specific intervention strategies for handling bullying behaviors among nursing students and staff nurses and promoting nursing students' psychological well-being.

• Journal of Korean Academy of Nursing
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• v.50 no.4
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• pp.554-570
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• 2020

Purpose: This study aimed to develop and test a structural equation model of health-related quality of life among older women following bilateral total knee replacement based on a literature review and Wilson and Cleary's model of health-related quality of life. Methods: One hundred ninety three women who were diagnosed with osteoarthritis, were older than 65 years, and were between 13 weeks and 12 months of having a bilateral total knee replacement were recruited from an outpatient clinic. Data were collected from July 2017 to April 2018 using a structured questionnaire and medical records. Data were analyzed using SPSS/WIN 22.0, AMOS 22.0, and Smart PLS 3.2.4. Results: The fitness of the hypothetical model was good, with coefficients of determination (R²) ranging between .28 and .75 and predictive relevance (Q²) between .26 and .73. The standardized root mean square residual of the model fit indices for the hypothetical model was .04; which explained 64.2% of physical and 62.5% of mental health-related quality of life. Self-efficacy, symptom status, functional status, and general health perceptions had a significant direct effect on physical health-related quality of life, while social support, symptom status, and general health perceptions had a significant direct effect on participants' mental-health-related quality of life. Conclusion: To improve the physical and mental quality of life of older women who receive bilateral knee replacement, nursing-based intervention strategies that reduce symptoms, improve functional status, and increase health perceptions, self-efficacy, and social support are needed. The most important factor is the symptom status.