• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4607-4610
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• 2013

The aim of this study was evaluated the prevalence of Treg cells in peripheral blood in patients with gastric cancer, and investigate the effect of gastric cancer cells on their differentiation. ELISA was employed to assess the concentrations of TGF-${\beta}$ and IL-10 in gastric cancer patients' serum. Then, mouse gastric cancer cells were co-cultured with T lymphocytes or T lymphocytes + anti-TGF-${\beta}$. Flow cytometric analysis and RT-PCR were then performed to detect Treg cells and TGF-${\beta}$ and IL-10 expression in gastric cancer cells. Our data showed that the expression of TGF-${\beta}$ and IL-10 in the patients with gastric cancer was increased compared to the case with healthy donors. The population of Treg cells and the expression levels of TGF-${\beta}$ and IL-10 in the co-culture group were much higher than in the control group (18.6% vs 9.5%) (P<0.05). Moreover, the population of Treg cells and the expression levels of TGF-${\beta}$ and IL-10 in the co-culture systerm were clearly decreased after addition of anti-TGF-${\beta}$ (7.7% vs 19.6%) (P<0.01). In conclusion, gastric cancer cells may induce Treg cell differentiation through TGF-${\beta}$, and further promote immunosuppression.

• Journal of Haehwa Medicine
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• v.10 no.1
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• pp.157-166
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• 2001

Oryoungsan which first recorded in Sanghanron, the clinical medical book consists of treating acute febrile disease according to its change, is one of the frequently used oriental medicines. these days, it has been prescribed in symptoms accompanied by edema mostly. therefore it is easy to consider it as a type of diuretics. In Sanghanron it was originally used in the symptoms of perspiration, decreased urine volume, thirsty, flatulence. these symptoms indicate loss of body fluid and the prescription which orders "taking warm water sufficiently" supports this. On this background, it is supposed that Oryoungsan treats dehydration after providing water and electrolytes. To consider that herbal medicines consisted of Oryoungsan make electrolytes go out of the body, The healing mechanism of dehydration doesn't meet this. Because Oryoungsan was used in condition of fever or in similar condition, it is more resonable to understand that restoration of increasing blood flow to the subcutaneous venous plexus regulating body temperature in febrile condition into body circulation, resulting into maintaining main blood volume and into treating decreased urine volume and thirsty is Oryoungsan's function in the dehydration or febrile condition. That is, symptoms are decreased or disappeared through restoring unbalance of internal body fluid. The other target is pain controls, especially chronic headache, facial pain and trigeminal neuralgia. it is suggested that the function of pain control of Oryoungsan is related to 5-HT(5-hydroxytrypamine), nerve transmitter in the endogenous analgesic system. Moreover it is also suggested that Oryoungsan is relate to 5-HT, considering the fact that gastroparesis, a symptom of cyclic vomiting syndrome treated with 5-HT1D receptor agonist is similar to the 'bi', symptoms appeared in the Oryoungsan-related disease.

• Journal of IKEEE
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• v.24 no.1
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• pp.33-39
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• 2020

In this paper, we propose the design technique of the vehicle's load weight measuring system using tire pressure, which is one of the physical elements of tires. The proposed technique consists of four processes: noise correction by load and vibration, gas flow correction, data mixer and weight conversion. Noise correction by load and vibration eliminates noise that increases the tire's internal pressure due to external shocks and vibrations produced by the vehicle while it is in motion. In the gas flow correction process, the noise of the internal pressure of the tire is increased due to the temperature rise of the ground with respect to the data obtained through the noise correction process due to the load and vibration. In the data mixer process, the load and pressure on the tolerances the empty, median and the full load are classified according to the change in pressure of the tire that is delivered perpendicular to the tire in the event of cargo. In the weight conversion process, weight is expressed by weight through weight conversion algorithms using noise correction results by load and vibration and gas flow correction. The weight conversion algorithm calculates the weight conversion factor, which is the slope of the linear function with respect to the load and pressure change, and converts the weight. In order to evaluate the accuracy of the loading weight measurement system of the vehicle using the tire pneumatic system technique proposed in this paper, we propose the design technique of the vehicle's load weight measuring system using tire pressure, which is one of the physical elements of tires.. Noise correction results by load and vibration and gas flow data correction results showed reliable results. In addition, repeated weight precision test showed better weight accuracy than the standard value of 90% of domestic companies.

• Journal of Aerospace System Engineering
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• v.14 no.5
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• pp.33-41
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• 2020

The landing gear of an aircraft is a device that absorbs and dissipates shock energy transmitted from the ground to the fuselage. Among the landing gears, the semi-active MR damper landing gear is supposed to show high-shock absorption efficiency under various landing conditions and secure the stability when out of control. In the case of the MR damper landing gear using an annular channel rather than orifice, Amesim, a commercial multi-physics program, is considered as more useful than the conventional two-degree-of-freedom model because the damping force generated by the pressure drop through the flow annular path can cause cavitation in the low-pressure chamber of the MR damper with a specific internal structure. In this paper, the main dynamic characteristics of the MR damper landing gear with an annular type flow path structure has been analyzed under the condition of cavitation. Based on the analysis results using Amesim, a design guideline for the MR damper flow path that prevents cavitation has been proposed based on the modification of the arrangement of internal components of the damper. The guideline was verified through a drop simulation.

• Journal of the Korean Society of Propulsion Engineers
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• v.18 no.5
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• pp.19-28
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• 2014

Firing test of solid rocket motor with pintle-technology carried out and the measured pressure-time curve was compared with the values predicted by the internal ballistic and performance analysis. Without baffle, the measured combustion chamber pressure was similar with the predicted pressure at the beginning of combustion, but gradual increase in pressure, which was unexpected with the end-burning grain of which burning area is constant, was observed. A baffle was inserted to make uniform flow over the pintle. Unlike the thruster without baffle, the measured combustion chamber pressure was 1.4 times higher than the predicted value. Through the CFD simulation, 10% of total pressure loss of the flow was observed from combustion chamber to nozzle throat when the baffle was inserted. The measured pressure with baffle was predicted well by considering the total pressure loss in the internal ballistic modelling and performance analysis.

• Journal of the Korean Geotechnical Society
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• v.37 no.1
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• pp.5-15
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• 2021

The areas consisting of frost susceptible soils in cold regions, such as the Arctic area, have problems of frost heave and thaw settlement due to the seasonal air temperature changes and internal temperature of installed structures. Ground stabilization methods for preventing frost heave and thaw settlement of frost susceptible soils include trenching, backfilling and thermo-syphon. The thermo-syphon is the method in which refrigerant can control the ground temperature by transferring the ground temperature to atmosphere in the from of two-phase flow through the heat circulation of the internal refrigerant. This numerical study applied the function of these thermo-syphon as the boundary condition through user-subroutine coding inside ABAQUS and compared and analyzed the temperature results of laboratory experiments.

• Journal of Korean Society of Transportation
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• v.25 no.6
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• pp.185-196
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• 2007

The aim of this research is to develop a signal control algorithm using internal metering to minimize total delay that vehicles go through, in case a network is oversaturated. To calculate total delay on the network, the authors first detect vehicles' arrivals and departures in the network through the detecting system, and chase the vehicles' flow in the links with a platoon dispersion model. Following these, the authors calculate the queue length in all the inks of the network through the chase of vehicles, deduce the stopped time delay, and finally convert the stopped time delay to the approach delay with a time-space diagram. Based on this calculated delay, an algorithm that calculates the level of the internal metering necessary to minimize the deduced approach delay is suggested. To verify effectiveness of this suggested algorithm, the authors also conduct simulation with the micro-simulator VISSIM. The result of the simulation shows that the average delay per vehicle is 82.3 sec/veh and this delay is lower than COSMOS (89.9sec/veh) and TOD (99.1sec/veh). It is concluded that this new signal control algorithm suggested in this paper is more effective in controlling an oversaturated network.

• Journal of the Korean Institute of Gas
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• v.21 no.1
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• pp.80-86
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• 2017

In this paper, it is proposed to solve the problem of the harmful exhaust gas reduction device DPF. The exhaust gas is effectively guided through the control of the exhaust gas flow path which is separated in both directions. Through cross control of two DPF units, it helps to improve the purification and regeneration combustion characteristics of harmful emissions. It is possible to prevent an increase in internal pressure caused by deposition of particulate matter in the DPF. It is also an object of the present invention to provide an automobile harmful exhaust gas reduction device capable of solving the problem of lowering the output and lowering the fuel consumption.

• Journal of the Korean Solar Energy Society
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• v.30 no.3
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• pp.47-54
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• 2010

Recently the researchers has been interested in the development of the high performance windows such as solar control window using automatic shading devices, air-flow window, selective coating window. In order to assess the energy performance of total fenestration system, the net energy gains or losses through the glazings and windows should be evaluated. It depends on the thermal transmittance (U-value) and the total solar energy transmittance (SHGC, g-value). This study aims to measure the solar heat gain coefficient according to the NFRC 201 standard test method. In results, we could find the result of different SHGC of the glazing system with a different slat angles. The SHGC in case of $90^{\circ}$ of internal slat angle with regard to the window surface is about 0.56, that in case of $45^{\circ}$ is about 0.49 and that in case of $0^{\circ}$ is about 0.33. Significant dependence on the solar radiation intensity and incident angle was found in comparison of the measured and simulated SHGC.

• Natural Product Sciences
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• v.12 no.1
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• pp.55-61
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• 2006

A description of simple, isocratic and precise reversed phase HPLC methods is given for simultaneous quantification of pholcodine and ephedrine hydrochloride together with either carbinoxamine maleate or terfenadine in antitussive-antihistaminic oral pharmaceutical formulations. Separations were carried out on X-Terra and symmetry shield C18 column $(250\;{\times}\;4.6\;mm,\;5\;{\mu}m)$. The used isocratic elution systems were either $0.02\;M\;KH_2PO_4-acetonitrile$ in the ratio of 75 : 25 and pH adjusted to 7.70 with orthophosphoric acid or sodium hydroxide, for syrup (method A), or 0.02 octanesulphonic acid sodium salt solution-acetonitrile-acetic acid in the ratio of 75 : 25 : 0.5 for suspension (method B). The elution of both mixtures was achieved with a flow rate of 1 ml/min. Detection was carried out by UV absorbance at wavelengths of 220 and 250 nm for syrup and suspension, respectively. The quantification of the components in synthetic mixtures and actual syrup and suspension were calculated using the internal standard technique with metoclopramide HCl and codeine phosphate as internal standards (IS), respectively. The methods, for both mixtures, were validated and met all the requirements for the quality control analysis recommended by FDA and ICH.