• YAKHAK HOEJI
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• v.59 no.3
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• pp.92-97
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• 2015

KIOM-MA128 is a novel Korean herbal medicine with anti-atopic, anti-inflammatory and anti-asthmatic effects. This article presents the first pharmacokinetic study on KIOM-MA128. The purpose of this study was to characterize a pharmacokinetic characteristic of matrine, a potential marker of KIOM-MA128, in rats using population pharmacokinetic model. 1, 2 and 8 g/kg of KIOM-MA128 were administered to rats orally and plasma concentrations of matrine was determined by HPLC-MS/MS. Non-compartmental analysis (NCA) was performed using Phoenix$^{(R)}$ and pharmacokinetic model was built using NONMEM$^{(R)}$. This model was validated with internal validation which is visual predictive check (VPC) and bootstrap. The NCA result of matrine showed that $C_{max}$ was 294.24, 552.22 and 868.65 ng/ml, $AUC_{inf}$ was 1273.05, 2724.76 and $9743.25ng{\cdot}hr/ml$ and $T_{max}$ was 1, 1.3 and 2.3 hr for the doses of 1, 2, and 8 g/kg, respectively. The rat plasma concentrations were described very well with one-compartment model. Pharmacokinetic model for matrine was successfully developed and evaluated. Finally, our model is helpful to understand pharmacokinetic characteristic of KIOM-MA128.

• 한국지구물리탐사학회:학술대회논문집
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• 2005.05a
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• pp.55-58
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• 2005

Low resistivity zone is observed at the lower part of a CFRD (Concrete Face Rockfill Dam). Generally, CFRD tends not to have any saturated zone within the body, but the result of resistivity survey shows that it is possible for the dam to be saturated under 20m depth with water. The level of reservoir was under 10m from the crest. We suspect that this result may come from the wrong 2D inversion process ignoring the 3D geometry of dams. For the analysis of possibility of distortion by different geometry, we perform the 3D forward modeling for the dam and apply the 2D inversion process. And then we check the point of traditional interpretation of resistivity data. By the analysis, it is found that the result of 2D inversion process of 3D geometry of dams, seems to have deep relation with the reservoir level, and the complex 3D structure hide some internal electrical anomaly of dams from resistivity information.

• Journal of the Korean Geographical Society
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• v.46 no.1
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• pp.20-35
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• 2011

This study suggested the systematic steps for quality control, construction of the climatological reference series and homogeneity test and adjustment of temperature series in the Republic of Korea. It also attempted to evaluate more accurate magnitude of change using adjusted temperature data. All erroneous values produced by quality control were detected by internal inconsistency check. The method selected for homogeneity test in this study well defined fairly correct signals of station relocations. Therefore, this method might be regarded as the appropriate one to test homogeneity of temperature series of the Republic of Korea. The increase of temperature of the Republic of Korea after the adjustment were bigger than before the adjustment of annual and seasonal mean temperature. Adjusted temperature data produced by these steps will enable to evaluate more accurate characteristics and magnitude of climate change.

• Korean Journal of Social Welfare
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• v.67 no.3
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• pp.151-180
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• 2015

This study aimed to develop a scale to measure physical health behaviors among social work clients using general services. The scale items were constructed based on literature review and FGI of social workers. Exploratory factor analysis and confirmative factor analysis affirmed the factor structure of Physical Health Behavior Scale with two sub-scales: Health Promotion Behavior Scale and Health Hindrance Behavior Scale. Promotion Scale had 7 factors and Hindrance Scale had 5 factors. Both sub-scales showed acceptable ranged goodness-of-fit for the model, and internal consistency test proved that the scale was reliable. The analyses of discriminant validity, convergent validity, and concurrent validity resulted significant validation. Based on those results, the developed Physical Health Behavior Scale were proved well-constructed, reliable and valid. The Scale will be utilized for both clients in general to check their own health related behaviors and social workers to adopt as a tool for assessment in order to perform an evidence based practice.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.1
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• pp.82.1-82.1
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• 2012

We present results of searching for the Very Low Luminosity Objects (VeLLOs; internal luminosity Lint<0.1Lo) candidates in the Gould Belt's clouds using infrared observations from 3.6 to 70 micron by the Spitzer Space Telescope. More than 100 VeLLO candidates were selected through the criteria by Dunham et al. and our additional ones. The candidates in Northern sky were recently observed with high density tracers such as N2H+ (1-0) and HCN (1-0) using Korea VLBI Network (KVN) 21m telescope at Yonsei site to check their embeddedness in dense gas envelopes. A total of 25 out of 74 VeLLO candidates were detected in either N2H+ or HCN (1-0) line while 9 candidates were detected in both tracers. These are more likely bona fide VeLLOs which need to be studied further in future. In this study the bolometric luminosities for 40 VeLLOs (25 from this study and 15 from Dunham et al.) were estimated and found to be significantly smaller than those given by various theoretical model tracks with constant accretion rate in a BLT diagram, indicating the constant accretion process suggested by standard star formation models can not explain the faintness of the VeLLOs. In the talk we will discuss on some possible explanation of why the VeLLOs are faint.

• Journal of Environmental Health Sciences
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• v.32 no.2 s.89
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• pp.103-110
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• 2006

The present study is designed to analyze reliability and validity of the instruments used to measure job stress of radiological technologists mainly by means of the questionnaires from 'Korean edition of NIOSH check list'. The subjects of this study are 890 radiological technologists active at 44 general hospitals in 16 provinces and cities across the country. The item-total reliability revealed that 10 factors in 6 are the major causes of stress in job life of radiological technologists. The measuring instrument proved to be valid with reliability coefficient of internal consistency by factors being more than 0.7. The factors found to be applicable herewith include limit and authority of job (0.73), cohesion within departments (0.86), resources control (0.81), mental requirements (0.85), job load (0.82), and job stability (0.72). When job autonomy item of causes are modified for proper use to radiological technologists, the measuring instruments are expected to show high reliability. It seems, however, necessary to develop a measuring instrument to analyze and use the validity of related measuring instruments since the reliability here was rated low, with statistical coefficients lower than 0.7 in such factors as job management (0.57), conflicts within departments (-1.13), sense of responsibility for patients (0.66) and usage of education (0.26). As this study was intended to examine reliability and validity of the concepts related to measurement of job stress on the part of radiological technologists, it nay not be proper to apply the results of this study to general use, but is advised to utilize them as basis for developing instruments to verify reliability and validity by comparing with and analyzing other measuring instruments.

• The Journal of Korean Academic Society of Nursing Education
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• v.4 no.1
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• pp.53-65
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• 1998

This study was designed and undertaken to analyse the factors associated with sexual satisfaction in diabetic patients. The data were collected from September to November, 1997. The subjects in this study were 77 diabetic patients who visited to check their blood glucose level to the outpatient department of internal medicine in one of hospitals located in Taejon city, The questionnaires developed by Derogatis L. R. were used. Data were analysed using percentages, means, 1-test, ANOVA and Peason-correlation coefficients, done with the SAS program. The results of this study were as follows ; 1. The mean score of sexual satisfaction in diabetic patients was higher than the mid level as 3.14 points in the 5 points scale and male patients' score was a little higher than female's. 2. The mean score of factors associated with sexual life was 3.54 points in spouses' support, 3.44 points in sexual attitude and 2.60 points in body image in the 5 points scale, and 2.76 points in the sexual act in the 6 points scale. The score of above all factors were higher in male patients than female patients. 3. The significant factors associated with sexual satisfaction were spouses' support, body image and sexual act. That is, the higher spouses' support, the more positive body image and the more frequent sexual act, the higher patients' sexual satisfaction. 4. In the relationships between the sexual satisfaction and the general characteristics of the diabetic patients, only religion and the period of disease were statistically significant differents, but the relationships between the sexual satisfaction and the period of disease showed a significant inverse correlation. This results showed that the degree of sexual satisfaction in diabetic patients was relatively high. The major factors associated with sexual satisfaction were spouses' support, body image and sexual act, religion and the period of disease. So, the above factors have to be considered during the nursing intervention on diabetic patients' sexual life.

• Journal of the Korean Society of Safety
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• v.32 no.2
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• pp.27-33
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• 2017

This study is intended to identify issues on the basis of investigating the actual state of laboratory environment and outlet circuit, and derive end states by expressing sequences from the initiating event of disaster to accident in leakage current, poor contact and overload through ETA(event tree analysis). To this end, this study investigated the actual state of electric equipment of laboratory at universities in all parts of country. And it is shown that most of them are failure in electric work and user negligence in the investigation of actual state. It is found that there is earth fault and defect in wire diameter in the failure of electric work and the problem of partial disconnection due to wire bundling and poor contact in user negligence. Outlet-related component, failure rate and initiating events are composed of a total of 41 initiating events, i.e., 30 internal initiating events and 11 external initiating events. And end states are composed of a total of 15 parts, i.e., 3 electric power parts and 12 safety parts. Earthing class 3 is the most important safety device against leakage current (initiating event). And in case of poor contact, it is necessary for manager to check thoroughly because there is no safety device. In case of overload/overcurrent, when high-capacity equipment is connected, a molded case circuit breaker, safety device, worked. However, in most cases, it is verified that this doesn't work. This study can be utilized as electric equipment safety guide for laboratory safety manager and managers.

• The Research Journal of the Costume Culture
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• v.15 no.1 s.66
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• pp.127-136
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• 2007

Modern society shares new culture derived from the fusion of various cultures unlike the past culture regulating one phenomenon of certain field as the representative icon of the era. Especially, the phenomenon of globalization acts as the catalytic agent to receive coexistence of variousness easily. Especially, in fashion industry, these flows and the view of naturalism are harmonized and new fashion trend called 'Ethnic' was embossed. As it reflects internal spirit of human being that wants to return to the memory due to expansion of material civilization, the interest in the designer pursuing it is increasing. This study tries to consider the Ethnic style displayed by Chinese American designer, Anna Sui, who pursues the eastern style with full wit and individuality. Anna Sui, who was praised by New York Times for 'the superb harmony of houte couture style and up-to-date style', created another fashion trend, romanticism in New York and she is the worldwide designer representing Ethnic. Like it, the consideration on her Ethnic style reanalyzing as eastern style provides guidance to check how designer's fashion philosophy appears in one category of America and China and new study material that enables us to understand the third world culture code as well as Anna Sui. This confirmation has the meaning as the basic material for the endless challenge to the new style that fashion will go on in the future. Anna Sui was confirmed to have been recognized as a designer who represented the ethnic collection in the United States, exerting the influence with her unique oriental background. Moreover, her design could identify the pivotal point of ethnic image by developing her unique style which is distinct from other designers in terms of silhouette, color, fabric, detail, and so on. This kind of study can provide the basic data required to understand the fashion world of designer in the future.

• Journal of Advanced Marine Engineering and Technology
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• v.6 no.2
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• pp.69-91
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• 1982

The major factors which affect the crankshaft axial vibration are such items as the axial stiffness and mass of crankshaft, the thrust block stiffness, the propeller's entrained water and the exciting and damping forces of engine, propeller and shafting. Among above mentioned items, the axial stiffness and mass of crankshaft, thrust block stiffness and propeller's entrained water were treated in detail in part I, and so in this paper, the rest of above items will be studied. The exciting forces of crankshaft axial vibration are generated mainly from the gas explosion pressure of cylinder, the thrust fluctuation of propeller, and sometimes the torsional vibration of crankshaft induces the crankshaft axial vibration. As for the propeller thrust fluctuation, its harmonic components can be fairly exactly calculated from the experimental results of propeller in the towing tank, but as the calculation process is rather tedious and laborious, the empirical values are ordinarily used. On the other hand, the table of harmonic components of gas pressure has been already published by major slow speed diesel engine makers, but the axial thrust conversion factor of radial force is not unknown yet, and as its estimated value is unreliable, the axial vibration force of gas pressure is uncertain. As the calculation of damping force is very complicated and it includes some uncertain factors, the thoretically estimated amplitudes of axial vibration are much more incorrect in comparison with those of torsional vibrations. Authors have paid special attentions to deriving the theoretical calculation formula of axial conversion factor of radial force and damping force of crankshaft axial vibration and developed a computer program to calculate resonance amplitudes and additional stresses of crankshaft axial vibrations. Also, to check the reliability of the developed computer program, the axial vibrations of three ships' propulsion shaftings were analyzed and their results were compared with those of measured values and makers' results.