• 대한한방내과학회지
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• 제19권2호
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• pp.219-232
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• 1998

Paljintanggagmbang has been used for cure of tumor as a traditional medicine without any experimental evidence to support the rational basis for its clinical use. This study was carried out to evaluate. the possible therapeutic or antitumoral effects of Paljintanggagmbang extract against tumor, and to carry out some mechanisms responsible for its effect. Experimental studis were performed for measurement of Humoral and Cellular Immune Response and Phagocytosis in Mice treated with mitomytion C(MMC) and Paljintanggagmbang alone and combination. The results obtained in this study were as follows 1. The adminstration of Paljintanggagmbang extract decresed size of tumors cell which MCA induced. 2. The adminstration of Paljintanggagmbang extract decresed growth of the tumors which S 180 transplant. 3. The adminstration of Paljintanggagmbang extract decresed reproduction of A549, Hep3b, 3LL cell and S 180 in vivo. 4. The adminstration of Paljintanggagmbang extract incresed activity of the NK cell. These results also suggested that effect of Paljintanggagmbang might be chiefly due to nonspecific enhancement of Humoral and Cellular Immune Response and Phagocytosis in Mice treated with MMC and Paljintanggagmbang alone and combination.

• 대한두경부종양학회지
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• 제21권2호
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• pp.126-131
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• 2005

Objectives: To evaluate the efficacy and safety of induction chemotherapy with docetaxel and cisplatin in locally advanced head and neck cancer. Materials and Methods: Between June 1998 and December 2004, 30 patients were enrolled and among them, 20 patients were evaluable. Patients were treated with docetaxel $75mg/m^2$ and cisplatin $60mg/m^2$ on day 1 every 21 days. Results: The median age was 71(range 54-80) years old. All 20 patients were male. Nineteen patients had pathologically squamous cell carcinoma and 1 had undifferentiated carcinoma. Fourteen of 20 patients(70%) demonstrated an objective response with two(10%) achieving a complete clinical response and eleven(60%) a partial response. The median response duration was 5.3(1.6-32.1) months and the median time to progression was 5.6(1.4-33.8) months. The median overall survival of all patients was 14(range 2.2-34) months. The median overall survival of responders was 17.5(range 5-34) months and that of non-responders was 3.2(range 2.2-23) months, but it was not statistically significant(p=0.106). During a total of 92 cycles, granulocytopenia worse than CTC(Common toxicity criteria) grade 2 occurred in 6%, thrombocytopenia in 2%, and anemia in 3%, respectively. Non-hematologic toxicities were minor and easily controlled. Conclusion: The induction chemotherapy of docetaxel and cisplatin has moderate efficacy with acceptable toxicities in patients with locally advanced head and neck cancer.

• 기본간호학회지
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• 제23권2호
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• pp.115-125
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• 2016

Purpose: The purpose of this study was to use meta-analysis to evaluate factors and variables related to the emotional labor of hospital nurses. Method: The study included variables obtained from 66 recently published studies, doctoral dissertations, and master's theses. Results: The related variables were categorized into five factor groups: internal character factor, nursing care related factor, environmental factor, emotional response, and job response. For the defensive variable, job related response (effect size [ES]=-.17), environment (ES=-.14), internal character (ES=-.08), nursing care (ES=-.06), and emotional response (ES=-.06) showed significant effect size among the five categorized variable groups. For the risk variable, internal character (ES=.44), emotional response (ES=.46), environment (ES=.27), job related response (ES=.27), and nursing care (ES=.19) showed significant effect size among the five categorized variable groups. Conclusion: The results of this study identified defensive and risk variables related to emotional labor of hospital nurses. Self-efficacy, social support, leaders' care, and communication are important factors for managing emotional labor of hospital nurses.

• 소음진동
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• 제8권6호
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• pp.1144-1149
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• 1998

A two degree-of-freedom model of suspended cables is studied for forced resonant response. The method of averaging is used to obtain first-order approximations to the response of the system. A bifurcation analysis of the averaged system is performed in the case of 2-to-1 internal resonance. Nonlinear coupled-mode motions are found to bifurcate from single-mode responses and further bifurcate to limit cycle motions via Hopf bifurcations. The limit cycle solutions undergo period doubling bifurcations to chaos.

• 전기학회논문지P
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• 제51권4호
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• pp.175-185
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• 2002

In this paper, a new fully digital current control method of UPS inverter, which is based on an internal model control, is proposed. In the proposed control system, overshoots and oscillations due to the computation time-delay are compensated by explicit incorporation of the time-delay in the current control loop transfer function. The internal model controller is adopted to a second order deadbeat reference-to-output response which means that its response reaches the reference in two sampling time including computational time-delays. That is, the average current of filter capacitor is been exactly equal to the reference current with a time lag of two sampling intervals. Therefore, this method has an essentially overshoot free reference-to-output response with a minimum possible rise time. The effectiveness of the proposed control system has been verified by the simulation and experimental respectively. From the simulation and experimental results, the proposed system is achieved the robust characteristics to the calculation time delay and parameter variation as well as very fast dynamic performance, thus it can be effectively applied to the power supply for the critical load.

• 대한한방종양학회지
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• 제7권1호
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• pp.117-129
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• 2001

Objectives: We compared the therapeutic response, the treatment-related toxicity, and the improvement of subjective symptoms between the chemotherapy alone group and the western-oriental combined treatment group and evaluated the role of oriental medicine for the improvement of chemotherapy-related toxicity in the advanced gastric cancer and hepatocellular carcinoma. Methods: We evaluated 36 gastric cancer or hepatocellular carcinoma patients(chemotherapy alone group 25 patients, combined treatment group 11 patients) who had been treated in Wonju Christian Hospital and Hana Hospital of Oriental Medicine between June 1999 and October 2000. Enrolled patients' general medical records, results of laboratory and imaging studies, treatment-related toxicities, and subjective symptoms were recorded regularly according to the planned protocol. Therapeutic responses were estimated according to the WHO response criteria and the changes of tumor marker value such as CEA, CA 72-4 and AFP. Results: 1. There was no significant difference of therapeutic response by the WHO response criteria between the two groups(p=.459). 2. There was a significant decrease of tumor marker value in the combined treatment group compared to the chemotherapy alone group(p=.023). 3. There was less comprehensive treatment-related toxicity in the combined treatment group compared to the chemotherapy alone group(p=.037), but there was not a significant difference of comprehensive improvement of subjective symptoms between the two groups(p=.091). Conclusions: Based on the above results, we could expect the possibility of improvements in therapeutic response and treatment-related toxicity with the western-oriental combined anticancer treatment.

• 한국병원경영학회지
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• 제22권4호
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• pp.1-15
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• 2017

This study was designed to analyze the effect of servicescape and human service quality on patients' internal response and their behavioral intention in dental care organizations. Self-administered survey questionnaires with structured instruments were developed, and a total of 226 responses were used for statistical analyses using SPSS Windows version 18.0 program and AMOS 18.0 program. Major findings of the study are as follows. First, among other servicescape components, air condition environment was found to have a positive effect on patients' cognitive and physiological responses, while signals and symbols had a positive effect on cognitive and emotional responses. Second, the competence, among other factors of the human service quality, had positive influence on cognitive and emotional responses, while customer understanding affected positively on emotional response. Third, none of the servicescape components showed a direct effect on patients' behavioral intention, but their influence was mediated by internal responses. However, customer understanding, among other human service quality factors, had a direct effect on patients' behavioral intention. Fourth, emotional response, among other internal response factors, proved to have positive influence on behavioral intention. Results from this study suggest that dental care service providers can increase their competitiveness and customer satisfaction by understanding and improving the most important areas of servicescape and human service quality.

• 대한한방내과학회지
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• 제13권1호
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• pp.124-134
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• 1992

Effects of Haenginbanhatang Extract on the Contraction of Isolated Guinea Pig Trachea Smooth Muscle. This study was carried out to investigate the effect of Haenginbanhatang extract on the contractile force of the isolated guinea pig trachea smooth muscle and elucidate its mechanism. The results were obtained as follows: 1. The contratile response of the trachea smooth muscle of the guinea pig to histamine was significantly inhibited by Haenginbanhatang. 2. Effects of Haenginbanhatang extract on the contractile response of the isolated guinea pig smooth muscle pretreated propranolol was not significant. 3. The contractile response of isolated guinea pig smooth muscle pretreated methylene blue was significantly inhibited by Haenginbanhatang, 4. The contractile response of the trachea smooth muscle of the guinea pig to prostaglandin F2a was significantly inhibited by Haenginbanhatang. 5. Effect of prostaglandin F2a on the contractile response of guinea pig smooth muscle pretreated Haenginbanhatang was not significant. According to the above results, it was suggested that the contractile response mechanism of the guinea pig smooth muscle to Haenginbanhatang was related to cyclic GMP.

• 말소리와 음성과학
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• 제5권1호
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• pp.91-98
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• 2013

This paper investigated Korean prosody as it relates to graded internal structure in an identification function. Within Korean prosody, variants regarded as dialectal variations can appear as different prosodic scales, which contain the range of within-category variations. The current experiment was intended to show how the prosodic scale corresponding to the range of within-category differences relates to f0 contours for speakers of two Korean dialects, North Kyungsang and South Cholla. In an identification task, participants responded by selecting an item from two answer choices. The probability of choosing the correct response from the two choices was computed by a logistic regression analysis using intercepts and slopes. That is, the correct response between two choices was used to show a linear line with an s-shape presentation. In this paper, to investigate the graded internal structure of labeling, 25%, 50%, and 75% of predicted probability were assessed. Listeners from North Kyungsang showed progressive variations, whereas listeners from South Cholla revealed random patterns in the internal structure of the identification function. In this paper, the results were plotted using scatterplot graphs, applying the range of within-category variation and predicted probability obtained from the logistic regression analyses. The scatterplot graphs showed the different degree of the responses for f0 scales (i.e., variations within categories). The results demonstrate that the gradient structures of native pitch accent users become more progressive in response to f0 scales.

• 대한한방내과학회지
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• 제21권3호
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• pp.487-493
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• 2000

Objective : This experimental studies were done to research the effects of Bojungikgi-tang added Magnoliae Flos on the pulmonary thromboembolism and delayed allergy response. Methods : Healthy rats were devided into each group. This test is to inject sodium arachidonic acid to one group, and ADP(adenocine diphophate) to the other one afterward to compare the survival rate between each other. Delayed allergy response test is to inject PC(picryl chloride) to one group and measure the thickness of their ears, to inject SRBC(sheep red blood cell) allergen to the other, and measure their foot edema, and compare the each other rates Results : The extract of the Bojungikgi-tang added Magnoliae Flos revealed significant effect on the pulmonary thromboembolism induced by sodium arachidonate, or adenocine diphophate(ADP). And the extract of the Bojungikgi-tang added Magnoliae Flos revealed significant effect on delayed type hypersensitivity induced by picryl chloride(PC), or sheep red blood cell(SRBC). Conclusions : According to the above findings it is suggested that the extract of the Bojungikgi-tang added Magnoliae Flos revealed significant effect on the delayed type hypersensitivity and effect on the pulmonary thromboembolism.