• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.5
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• pp.45-53
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• 2018

Among the various slope stabilization methods, the green soil method based on the growth of plants is advantageous to the environment, but the durability and slope stability are insufficient when the green soil method is applied to a steep slope and rock slope sites. Therefore, in this study, green soil, which improved the adhesion performance and the vegetation environment, was developed using cementitious materials and ECG, and the durability and slope stability as well as the possibility of its use as a rock vegetation base material were assessed. From the results, the adhesive force and internal friction angle were higher than that of the existing green soil so that it could be used for in situ construction. The soil hardness value was 26 mm, which was slightly higher than that of the best growth condition of the plant, 18~23 mm, and the drying shrinkage strain was approximately 3%; hence, it is not expected to affect the durability of green soil. The results of a rainfall intensity simulation for evaluating the slope adhesion force showed that slope failure did not occur under all conditions. The damage decreased with increasing slope angle. Therefore, the green soils developed in this study have excellent durability and slope stability and can be used for rock slope sites.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.7
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• pp.417-422
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• 2017

One of the most frightening aspects of weapons of mass destruction (WMD) is their ability to cause death in very small quantities without being visible to the public. The military authorities are making considerable effort to ensure the survivability of the combatants in the event of NBC(Nuclear, Biological and Chemical) contamination. Therefore, in this study, modules were developed for the measurement of the positive pressure and for the detection of the chemicals used for the control of the various shut-off valves used in an NBC shelter. In addition, a high performance gas tight shut-off valve was developed that can overcome the disadvantages associated with manual manufacturing, such as the occurrence of defective products and high manufacturing cost. By applying the positive pressure measurement and chemical detection modules, this valve was able to be used to control the facility. The developed gas-tight shut-off valve maintained airtight characteristics at a pressure loss of 28[Pa] at the prescribed wind velocity and an internal pressure of 30[kPa]. It is expected to be possible to control the gas-tight shut-off valve through the remote measurement of the positive pressure, thereby ensuring the foreign independence of import substitution and defense related technology in the future. In addition, by installing these valves in all of the intake ports or exhaust ports connected to the outside of the NBC shelter, it is possible to prevent the damage resulting from the rapid inflow of the storm pressure caused by conventional weapons and nuclear explosions, thereby protecting the people and equipment in the shelter.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.2
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• pp.660-667
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• 2018

This study examined the optimal manufacturing conditions of RDF using heat-dried sludge from sewage treatment plant in Cheonan with the oil-drying method. The amounts of oil evaporation and oil drying of the heat-dried sludge were measured at different temperatures to evaluate the value of the product. The performance of the product was then measured using a calorimeter and TGA. In addition, the concentration of odor, NH3, H2S, and TVOC during drying was determined using a portable odor-meter. Ingredient analysis was performed by EDS. Considering mass-production, the oil to heat-dried sludge weight ratio was fixed to 4:1. At $130^{\circ}C$, only physical mixing occurred after the instantaneous drying of internal water. Considering the eco-friendly aspects, there was no significant difference in the drying efficiency between $160^{\circ}C$ and $190^{\circ}C$. Therefore, the optimal conditions were a drying temperature of $160^{\circ}C$ within 5 minutes. Finally, the RDF manufactured in this study and fuel used in the thermal power plants were compared. The calorific value was 4,449kcal/kg, the water content was 2% and the ash content was 34%, which is higher than the fuel of thermal power plants. Therefore, it is believed that coal energy as well as wood pellets can be replaced.

• Journal of Pharmaceutical Investigation
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• v.35 no.5
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• pp.323-328
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• 2005

The purpose of the present study was to evaluate the bioequivalence of two torasemide tablets, Torem tablet (Roche Korea Co., Ltd., Korea, reference drug) and Boryung Torsemide tablet (Boryung Pharmaceutical Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (furosemide) to human serum, serum samples were extracted using 5 mL of ethyl acetate. Compounds were analyzed by reverse-phase HPLC method with UV detection. This method showed linear response over the concentration range of 0.05 ug/mL with correlation coefficient of 0.999. The lower limit of quantitation using 0.5 mL of serum was 0.05 ug/mL which was sensitive enough for pharmacokinetic studies. Twenty-eight healthy male Korean volunteers received each medicine at the torasemide dose of 20 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Serum concentrations of torasemide were monitored by an HPLC-UV for over a period of 12 hr after the administration. $AUC_{t}$(the area under the serum concentration-time curve from time zero to 12 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum serum drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the serum concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_{t}$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_{t}$ ratio and the $C_{max}$ ratio for Boryung Torsemide/Torem were log 0.97-10g 1.03 and log 0.93log 1.12, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Boryung Torsemide tablet and Torem tablet are bioequivalent.

• Journal of Pharmaceutical Investigation
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• v.32 no.2
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• pp.119-125
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• 2002

A rapid, selective and reproducible high-performance liquid chromatographic method has been developed for the determination of terazocin in human plasma. Terazocin plus the internal standard, prazocin hydrochloride, were extracted from alkalified plasma with tert-butylmethyl ether, back-extracted into 0.05% phosphoric acid. Fifty ${\mu}l-portions$ of extract were injected onto a octadecylsilane column and eluted with a mixture of acetonitrile, water and triethylamine (30 : 70 : 0.1 v/v, adjusted to pH 5.0 with dilute phosphoric acid) at a flow rate of 1.0 ml/min. The fluorescence intensity of column eluents was monitored at excitation wavelength of 250 nm and emission wavelength of 370 nm. No interference peaks were observed. The practical limit of quantitation was 5 ng/ml for terazocin. The average intraday and interday coefficients of variation were 4.15 and 3.54%, respectively. Also intraday and interday precisions over the range $5{\sim}60\;ng/ml$ were $0.49{\sim}2.92\;and\;0.38{\sim}5.12%$, respectively. The bioequivalence of two terazosin tablets, the $Hytrine^{\circledR}$ (Il Yang Pharmaceutical Co., Ltd.) and the $Teratonin^{\circledR}$ (Sam-A Pharmaceutical Co., Ltd.), was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). Sixteen healthy male volunteers $(24.6{\pm}2.0\;years\;old)$ were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 2 mg of terazosin was orally administered, blood was taken at predetermined time intervals and the concentration of terazosin in plasma was determined with a HPLC method using spectrofluorometric detector. AUC was calculated by the linear trapezoidal method. $C_{max}\;and\;T_{max}$ were compiled from the plasma drug concentration-time data. Analysis of variance (ANOVA) was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between the two preparations were 0.21 %, 5.53% and 8.82%, respectively. The powers $(1-{\beta})\;for\;AUC_t,\;C_{max}\;and\;T_{max}$ were >99%, 97.49%, and 33.26%, respectively. Minimum detectable differences $({\Delta},\;%)\;at\;{\alpha}=0.1\;and\;1-{\beta}=0.8$ and the 90% confidence intervals were all less than ${\pm}20%$ except for $T_{max}.\;AUC_t\;and\;C_{max}$ met the criteria of KDFA for bioequivalence, indicating that $Teratonin^{circledR}$ tablets are bioequivalent to $Hytrine^{circledR}$ tablets.

• Microbiology and Biotechnology Letters
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• v.9 no.4
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• pp.197-205
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• 1981

Penicillin amidase of Bacillus megaterium was recovered from the fermentation broth by adsorption on celite and immobilized by entrapping the adsorbed enzyme in acrylamide gel. The operational stability in column reactor was greatly increased by entrappment as compared with that of without entrappment. The optimum pH of the immobilized enzyme was 8.7 with broader activity profile than that of the free enzyme, while the most stable pH range appeared to be between pH 7.5 and 8.0. The optimum temperature was shifted to 5$0^{\circ}C$ from 45$^{\circ}C$ for the soluble enzyme. The values of Km and the inhibition constants for 6-APA( $K_{ia}$ ) and phenylacetic acid ( $K_{ip}$ ), were 4.55 mM, 36.5mM, and 10.5mM, respectively. No significant internal pore diffusion limitation was found since the value of effectiveness factor was 0.95. The operational half life in a column reactor at pH 8.0 was 6.8 days at 4$0^{\circ}C$ and 47 days at 3$0^{\circ}C$, whereas that of without entrappment was only 1 day and 4 days, respectively. The performance of a batch and a column reactor was also discussed with respect to the productivity. The results demonstrated that the entrappment of an adsorbed enzyme for the enhancement of the operational stability of the immobilized enzyme was useful especially when an extracellular enzyme was used.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.8
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• pp.512-520
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• 2020

This study analyzed the relative operational efficiency and impact factors of regional public hospitals to present benchmarking points for enhancing the efficiency of inefficient regional public hospitals. The survey targets collected and utilized the internal resources and management performance data from 34 regional public hospitals in Korea over the past five years, from 2014 to 2018. The final 33 regional public hospitals were surveyed, excluding Jinan Regional Public Hospital, which opened in 2015, the middle of the survey period. The general characteristics and input/output variables were analyzed by frequency analysis and technical statistics analysis, and Data Envelopment Analysis was performed to measure the operational efficiency index and relative comparison. According to the study, there were 11 efficient hospitals (33.3%) and 22 inefficient hospitals (66.7%). Of the 22 inefficient hospitals, 13 (IRS: Increasing Returns to Scale) required scale expansion, and nine (DRS: Decreasing Returns to Scale) required scale reduction or rebalancing. The significance of this study was that an analysis of the relative efficiency and influencing factors presented specific alternatives or directions that could help enhance the efficiency of the growth of regional public hospitals, sustainable management, and expansion of publicness.

• Journal of KIISE:Software and Applications
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• v.29 no.3
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• pp.167-179
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• 2002

In this paper, we propose a new acoustic model for characterizing segmental features and an algorithm based upon a general framework of hidden Markov models (HMMs) in order to compensate the weakness of HMM assumptions. The segmental features are represented as a trajectory of observed vector sequences by a polynomial regression function because the single frame feature cannot represent the temporal dynamics of speech signals effectively. To apply the segmental features to pattern classification, we adopted segmental HMM(SHMM) which is known as the effective method to represent the trend of speech signals. SHMM separates observation probability of the given state into extra- and intra-segmental variations that show the long-term and short-term variabilities, respectively. To consider the segmental characteristics in acoustic model, we present segmental-feature HMM(SFHMM) by modifying the SHMM. The SFHMM therefore represents the external- and internal-variation as the observation probability of the trajectory in a given state and trajectory estimation error for the given segment, respectively. We conducted several experiments on the TIMIT database to establish the effectiveness of the proposed method and the characteristics of the segmental features. From the experimental results, we conclude that the proposed method is valuable, if its number of parameters is greater than that of conventional HMM, in the flexible and informative feature representation and the performance improvement.

• Journal of the Korea Computer Industry Society
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• v.5 no.1
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• pp.39-48
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• 2004

An IP address shortage problem is happening with a rapid propagation of the Internet and demands about a new IP address. Address translation technology as NAT is becoming use widely in order to solve these problems. NAT is an very useful If address translation technique that allows two connected networks to use different and incompatible IP address schemes. Rut it is difficult to use NAT particularly for applications that embeded IP addresses in data payloads or encrypted IP packet to guarantee End-to-End Security such as IPSec. In addition to rewiting the source/destination IP address in the packet, NAT must modify IP checksum every time, which could lead to considerablely performance decrease of the overall system in the process of address translation. RSIP is an alternative to solve these disadvantages and address shortage problems of NAT. Both NAT and RSIP divide networks into inside and outside addressing realms. NAT translates addresses between internal network and external network, but RSIP uses a borrowed external address for outside communications. RSIP server assigns a routable, public address to an RSIP client temporaily to communicate with public network outside the private network. In this paper, I will analyze NAT and RSIP gateway system, and then I will propose the Linux-based RSIP gateway for more efficient IP Address Translation in Intranet environments based on RSIP standard of IETF.

• Journal of Korea Technology Innovation Society
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• v.18 no.1
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• pp.28-48
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• 2015

This study is public R & D institutions report to verify what the impact factors on the course of progress of industrialization based on technology companies who previously received prior to the developed technology, what policies and plans for the next requirements based on this by offering the implications for business rate was to contribute to the improvement of the public research institution technology transfer. In this study, the influence factors on technology commercialization derived through the analysis of existing and previous studies, the characteristics of the previously received corporate environmental characteristics and previous technologies through a survey of the company received a technology transfer from public research institutions commercialization decisions and contributions, including sales and commercialization of the results were analyzed by logistic regression analysis demonstrated how to have relevance. Analysis, and linkage with high production company has an existing case of IT technology transfer, commercialization of higher technical success rate was higher compatibility. On the other hand, were observed and expected success rate were higher when a rather commercialized technologies independently be earlier than if participating in joint research in the development of the technology, unlike previously, completeness of the prior art did not significantly affect. This study has the following policy implications. Public research institutions have developed technologies are commercialized to figure out what the requirements of the technical aspects of consumer technologies in order to create economic wealth. And for technology commercialization for enough technical competencies to absorb the technology, and that the technology and considering the link between business and technology commercialization success to be applied. This study has some limitations. First, the sample size was not sufficient. In relation to the presence and participation of corporate success and commercialization of the R & D process, with many previous studies are needed more in-depth analysis by leading research in the sense that different results are obtained. Also did not reflect the will or the corporate culture, management and organizational skills and belongs to the external environment and internal corporate enterprises industry characteristics affecting the success of corporate management of the business. And lacked sufficient consideration of the various technical characteristics present in the form of joint research and industry. Finally, there is a limit of generalizations about other industries.