• Asian-Australasian Journal of Animal Sciences
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• v.32 no.3
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• pp.341-349
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• 2019

Objective: Internal organs indirectly affect economic performance and well-being of animals. Study of internal organs during later layer period will allow full utilization of layer hens. Hence, we conducted a genome-wide association study (GWAS) to identify potential quantitative trait loci or genes that potentially contribute to internal organ weight. Methods: A total of 1,512 chickens originating from White Leghorn and Dongxiang Blue-Shelled chickens were genotyped using high-density Affymetrix 600 K single nucleotide polymorphism (SNP) array. We conducted a GWAS, linkage disequilibrium analysis, and heritability estimated based on SNP information by using GEMMA, Haploview and GCTA software. Results: Our results displayed that internal organ weights show moderate to high (0.283 to 0.640) heritability. Variance partitioned across chromosomes and chromosome lengths had a linear relationship for liver weight and gizzard weight ($R^2=0.493$, 0.753). A total of 23 highly significant SNPs that associated with all internal organ weights were mainly located on Gallus gallus autosome (GGA) 1 and GGA4. Six SNPs on GGA2 affected heart weight. After the final analysis, five top SNPs were in or near genes 5-Hydroxytryptamine receptor 2A, general transcription factor IIF polypeptide 2, WD repeat and FYVE domain containing 2, non-SMC condensin I complex subunit G, and sonic hedgehog, which were considered as candidate genes having a pervasive role in internal organ weights. Conclusion: Our findings provide an understanding of the underlying genetic architecture of internal organs and are beneficial in the selection of chickens.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2004.11a
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• pp.132-135
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• 2004

In this study, we investigated the effect of threshold on a delivered dose in organ with internal motion by respiration. With mathematic model for 3D dose calculation reported by Lujan et al., we had calculated the position of organ as a function of time in previous study. This result presented that the variation of organ is within 2 mm from initial exhale position to the organ position during operating 1 s. Gating threshold, in this study, is determined to the moving region of target during 1s at a primary position of exhale. This period of gating threshold is 50% of the duty cycle in a half breathing cycle which is period from the top position of exhalation to the bottom position of inhalation. Radiation fields were then delivered under three conditions; 1) existent of moving target in the region of threshold(1sec, 1.5sec), 2) existent of moving target out of the region of threshold, 3) non-moving target. The non-moving target delivery represents a dose different induced due to internal organ motion.

• Journal of Veterinary Clinics
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• v.38 no.4
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• pp.189-193
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• 2021

An 11-years old spayed female Persian chinchilla cat presented with acute onset of blindness from bilateral retinal detachment and systemic hypertension. On physical examination, the cat was tachycardic (240 beats/min) with a systolic blood pressure of around 250 mmHg. Clinical findings, blood works, urinalysis, thyroid function test, radiography, echocardiogram, and ultrasonography were performed to rule out underlying diseases. Organ injury induced by systemic hypertension including bilateral retinal detachment and left ventricular hypertrophy were confirmed by ultrasound. Based on these results, it was diagnosed as feline idiopathic hypertension with target organ damage (TOD). The cat was treated with a combination therapy using high doses of amlodipine, telmisartan, and atenolol. After the treatment, its hypertension and TOD were improved. This case showed that appropriate therapeutic management can help prevent TOD associated with feline hypertension.

• The Journal of Internal Korean Medicine
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• v.40 no.5
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• pp.822-831
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• 2019

Objective: This study reports the effect of Hyungbangjihwang-tang-gami as a treatment for Soyang-in patients with chronic diarrhea. Methods: We treated three male patients with chronic diarrhea who did not improve after taking herbal medicine, as determined by zang-fu (organ) pattern diagnosis. After changing our approach to a Sasang constitution, we prescribed Hyungbangjihwang-tang-gami and assessed the effect by the frequency or form of defecation. Results: The patients' complaints worsened when they were administered a herbal medicine unsuited to their Soyang constitutions, which caused an exuberance of Yang. Changing the herbal medicine to Hyungbangjihwang-tang-gami improved their symptoms. Conclusions: This study suggested that Soyang-in patients may have side effects when administered unsuitable herbs, even if they were diagnosed using zang-fu (organ) pattern diagnosis. When we treat patients, we have to consider their Sasang constitution, as well as the zang-fu (organ) pattern diagnosis.

• Tuberculosis and Respiratory Diseases
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• v.45 no.4
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• pp.888-895
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• 1998

Malaria is one of the most common infectious diseases in the world. Plasmodium falciparum, accounting for nearly all malaria mortality, kills an estimated 1 to 2 million persons yearly and has several features that make it deadlist of malarias. While cerebral malaria is the most common presentation of severe disease, acute lung injury associated with malaria is uncommon but serious and fatal complication. We report two cases of severe malaria with ARDS and multi-organ failure. All two patients traveled to foreign countries, Kenya, Papua New Guinea where choroquine-resistant malaria is distributed. The first case, which developed cerebral malaria, hypoglycemia, multi-organ failure, and ARDS, treated with quinine and mechanical ventilator, but expired due to oxygenation failure. Autopsy showed acute necrotizing infiltration, diffuse eosinophilic fibrinoid deposits along the alveolar space, and alveolar macrophage with malaria pigment The second case also developed multi-organ failure, followed by ARDS, and was treated with quinine, exchange transfusion, plasmapheresis, and mechanical ventilator. He recovered with residual restrictive lung change after treatment.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1999.04a
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• pp.53-61
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• 1999

Radiation therapy has been used for the cancer treatment and radiation synovectomy$\^$1-3)/. There are two kinds of radiation therapy; the external radiation therapy and the internal radiation therapy. Hitherto, the external radiation therapy has been widely used, but for the lack of its selectivity it requires strong radiation dose and causes the irritation and damage of the normal tissue or organ. Therefore many researchers give their interests to the internal radiation therapy in which the radioactive materials are injected directly into the target organ or tissue. Many ${\beta}$-emitting radionuclides have been studied for the application of the internal radiation theraily. Among them, Holmium-166 has the many beneficial physical characteristics for the internal radiation therapy such as appropriate half life (26.8hr), high ${\beta}$ energy (max. 1.85 MeV(51%), 1.77 MeV (48%), mean 0.67MeV), and low ${\gamma}$ energy (0.081MeV) easily detected by ${\gamma}$-camera. In the internal radiation therapy, the administered radioactive materials should be retained in the target long enough to increase the therapeutic effects and avoid the damage in the normal tissue or organ. For this purpose, radionuclides are used as complex form with carriers. Carriers should have a high affinity with radionuclides in vivo and in vitro, so the complex can be evenly distributed in the lesion but can not be leaked out from the lesion.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2017.10a
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• pp.83-85
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• 2017

Generally, the current organ projection systems are the MRI and the CT. The MRI and the CT, (MRI) allow the surgeon to see the internal organs without incising the human body. However, since the images generated by the machines are 2D, it is difficult for doctors to observe the internal organs in three dimension. In this paper, we develop the augmented projection system for internal organs by using the augmented reality technology. The developed system shows the internal organs of the body using a holographic lens as a stereoscopic image and allows for doctors to examine the internal organs in detail.

• Tuberculosis and Respiratory Diseases
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• v.57 no.4
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• pp.329-335
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• 2004

Background : The Sequential Organ Failure Assessment (SOFA) score can help to assess organ failure over time and is useful to evaluate morbidity. The aim of this study is to evaluate the performance of SOFA score as a descriptor of multiple organ failure in critically ill patients in a local unit hospital, and to compare with APACHE III scoring system. Methods : This study was carried out prospectively. A total of ninety one patients were included who admitted to the medical intensive care unit (ICU) in Chuncheon Sacred Heart Hospital from May 1 through June 30, 2000. We excluded patients with a length of stay in the ICU less than 2 days following scheduled procedure, admissions for ECG monitoring, other department and patients transferred to other hospital. The SOFA score and APACHE III score were calculated on admission and then consecutively every 24 hours until ICU discharge. Results : The ICU mortality rate was 20%. The non-survivors had a higher SOFA score within 24 hours after admission. The number of organ failure was associated with increased mortality. The evaluation of a subgroup of 74 patients who stayed in the ICU for at least 48 hours showed that survivors and non-survivors followed a different course. In this subgroup, the total SOFA score increased in 81% of the non-survivors but in only 21% of the survivors. Conversely, the total SOFA score decreased in 48% of the survivors compared with 6% of the non-survivors. The non-survivors also had a higher APACHE III score within 24 hours and there was a correlation between SOFA score and APACHE III score. Conclusion : The SOFA score is a simple, but effective method to assess organ failure and to predict mortality in critically ill patients. Regular and repeated scoring enables patient's condition and clinical course to be monitored and better understood. The SOFA score well correlates with APACHE III score.

• Journal of Korean Medical classics
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• v.25 no.4
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• pp.57-63
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• 2012

Objective & Method : We investigated the identity of tri-energizer, which was originally described in Huang Di Nei Jing and claimed by traditional scholars, and drew the following conclusions. Result & Conclusion : According to Huang Di Nei Jing tri-energizer is one of the six hollow-organs and is called hollow organs for digestion and elimination, water guffer organ, or solitary hollow organ. It is believed that tri-energizer is regarded as the existing entity based on following several different sources; it functions as the course of channels, regulates wind and link and physiological function-especially intrinsic function of upper, middle, lower internal organs. It also controls syndromes and dysfunction of an illness, the surface of the body, and the cracked surface of the skin. Finally, bold and timidity depend on the tri-energizer. Experts determined the true nature of tri-energizer types. Experts include: Yu Tuan from the Ming dynasty, Tang Jong Hai and Ye Lin from the Qing dynasty, and Zhang Xi Chun from the Zhunghua Minguo period. These experts' claims are based on shape and forms of tri-energizer. Our examinations of anatomical and physiological basis on tri-energizers showed that, in a narrow sense, tri-energizer indicates visceral and parietal peritoneum and omentum surrounding the internal organs, and in a broad sense, indicates the overall membrane wrapping around the whole internal organs including five visceral organs and six hollow organs.

• Journal of Physiology & Pathology in Korean Medicine
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• v.29 no.3
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• pp.240-245
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• 2015

Pulse diagnosis, the most popular diagnostic tool in traditional Korean medicine, had had many forms but had been fixed on using wrist pulse and placing internal organs on Cun, Guan and Chi(寸 關 尺). Wang Shuhe(王叔和) suggested placing six viscera(六腑) on Cun, Guan and Chi based on relationship between external and internal meridian vessel, and Zhang Jiebin(張介賓) criticized his suggestion and insisted that pulse diagnosis should be based on the organ system. But the origin of pulse diagnosis which can be found in "(Huangdi's) Internal Classic(黃帝內經)" is a tool mainly for diagnosis of not internal organ system but meridian system. Most of material about pulse diagnosis after Ming dynasty(明代) reinterpreted pulse diagnosis in the aspect of organ system, So there has to be additional discussion about it.