• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2003년도 봄 학술발표회 논문집
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• pp.912-917
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• 2003

In this paper a new truss modeling technique for describing the beam shear resistance mechanism is proposed based on the reinterpretation of the well-known relationship between shear and the rate of change of bending moment in a reinforced concrete beam subjected to combined shear and moment loads. The core of the model is that a new perspective on the shear resistance can be gained by viewing the internal stress filed in terms of the superposition of two base components of shear resistance; arch action and beam action. The arch action can be described as a simple tied-arch which is consisted of a curved compression chord and a tension tie of the longitudinal steel, while the beam action between the two chords can be modeled as a membrane shearing element with forming a smeared truss action. The compatibility of deformation associated to the two action is taken into account by employing an experimental factor or internal state force factor a. Then the base equation of V=dM/dx is numerically duplicated. The new model was examined by the 362 experimental results. The shear strength predicted by the internal force state factor a show better correlation with the tested values than the present shear design.

• 대한조선학회논문집
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• 제48권6호
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• pp.544-551
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• 2011

The internal flows of moonpool usually causes huge added resistance on drillships, and those are very complex to analyze. Therefore, not only experimental approaches but also numerical simulations are required for better investigations when dealing with the hydrodynamic problems of moonpool. In the present research, numerical simulations are used to find out why the resistance increases by moonpool on a running drillship. That is, the three-dimensional numerical simulations and model tests are carried out to examine the characteristics of internal flow and added resistance by changing the section of the moonpool in both longitudinal and transverse directions. Finally, based on the present studies, an optimized shape of the moonpool is suggested, which effectively reduces added resistance, and that is confirmed with three-dimensional numerical simulations and model tests.

• 대한한방내과학회지
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• 제43권4호
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• pp.503-513
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• 2022

Objectives: The antitussive, expectorant, and anti-inflammatory effects of Mahwangyounpae-tang (MHYPT) aqueous extracts were observed in appropriate animal models of various respiratory disorders. Methods: MHYPT aqueous extracts were orally administered once a day for 11 days at dose levels of 400, 200, and 100 mg/kg. The effect of MHYPT was determined by comparing its antitussive effect with theobromine (TB), its expectorant effect with ambroxol (AM), and its anti-inflammatory effect with dexamethasone (DEXA). Results: MHYPT aqueous extracts (400 mg/kg) showed favorable antitussive effects comparable to those of TB (50 mg/kg) in the NH₄OH-exposure coughing mouse model and expectorant effects comparable to those of AM (250 mg/kg) in the phenol red-secretion mouse model, but MHYPT (400 mg/kg) showed less anti-inflammatory activity compared to DEXA (1 mg/kg) in the xylene-induced acute inflammatory mouse ear model under the experimental conditions used. Conclusion: MHYPT aqueous extracts administered at dosage levels of 400, 200, and 100 mg/kg induced dose-dependent and favorable antitussive, expectorant, and anti-inflammatory activities that occurred by simultaneous modulation of the activity of mast cells and respiratory mucous production under the experimental conditions used in this study.

• International Journal of Stem Cells
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• 제17권1호
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• pp.30-37
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• 2024

The lung is a complex organ comprising a branched airway that connects the large airway and millions of terminal gas-exchange units. Traditional pulmonary biomedical research by using cell line model system have limitations such as lack of cellular heterogeneity, animal models also have limitations including ethical concern, race-to-race variations, and physiological differences found in vivo. Organoids and on-a-chip models offer viable solutions for these issues. Organoids are three-dimensional, self-organized construct composed of numerous cells derived from stem cells cultured with growth factors required for the maintenance of stem cells. On-a-chip models are biomimetic microsystems which are able to customize to use microfluidic systems to simulate blood flow in blood channels or vacuum to simulate human breathing. This review summarizes the key components and previous biomedical studies conducted on lung organoids and lung-on-a-chip models, and introduces potential future applications. Considering the importance and benefits of these model systems, we believe that the system will offer better platform to biomedical researchers on pulmonary diseases, such as emerging viral infection, progressive fibrotic pulmonary diseases, or primary or metastatic lung cancer.

• 동력기계공학회지
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• 제18권4호
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• pp.36-42
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• 2014

This paper considers the influence of internal heat exchangers on the efficiency of a refrigerating system using R-1270. These internal heat exchangers(liquid-gas or suction-line heat exchangers) can, in some cases, yield improved system performance while in other cases they degrade system performance. A steady state mathematical model is used to analysis the performance characteristics of refrigeration system with internal heat exchanger. The influence of operating conditions, such as the mass flowrate of R-1270, inner diameter tube and length of internal heat exchanger, to optimal dimensions of the heat exchanger is also analyzed. The main results were summarized as follows : the mass flowrate of R-1270, inner diameter tube and length of internal heat exchanger, and effectiveness have the influences on the cooling capacity, compressor work and RCI(Relative Capacity Index) of this system. With a thorough grasp of it is possible to design the R-1270 compression refrigeration cycle using internal heat exchanger.

• Bulletin of the Korean Chemical Society
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• 제4권5호
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• pp.228-230
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• 1983

Molecular reorientation of oblate symmetric top molecules with internal rotation is investigated theoretically and an analytic expression for the overall reorientational correlation time in terms of the internal angular momentum correlation time is derived. This expression is quite different from the expression for prolate symmetric top molecules but reduces to the same expression in the spherical top limit. Fast internal rotation is treated by a modified version of the extended rotational diffusion while the bulky symmetric top mainbody is treated by the rotational diffusion model.

• 한국식품과학회지
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• 제23권2호
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• pp.157-160
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• 1991

냉동된 닭 가슴살 patty를 계육 가공공장으로부터 얻어서 내부온도가 $0{\pm}1.1^{\circ}C$가 되도록 조절하였다. Potentiometer에 연결된 thermocouple을 patty 중심에 삽입한 뒤 $168.3,\;179.4,\;190.6^{\circ}C$에서 튀겨 내부온도의 범위가 $48.9^{\circ}C$에서 $71.7^{\circ}C$가 되도록 하였다. 일반적으로 patty 내부온도는 튀김 솥(frier)에서 제거한 뒤 튀기는 온도나 내부온도와 관계없이 약 $11.1^{\circ}C$ 증가하였으며, 각각 다른 튀김온도에서 원하는 내부온도와 최종 내부온도는 튀기는 시간을 조절하므로써 얻을 수 있었다. 세 종류의 튀기는 온도에서 튀기는 시간이 독립변수인 3차 회귀다항식으로 시료 내부온도와 최종 내부온도를 예측하였고 최종 내부온도가 독립 변수인 2차 회귀다항식으로 수율을 예측하였다.

• 대한토목학회논문집
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• 제36권3호
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• pp.395-406
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• 2016

도시화로 인한 인구집중 및 개발 집중현상으로 하천변 저지대 및 지하공간 사용이 증가하였고, 불투수층이 증가하여 도시유역의 배수체계는 우수관거에 의존하고 있다. 이러한 변화로 인한 우수관거의 저류용량 부족 및 외수위의 영향으로 인한 도심지 역류 현상으로 인한 침수피해가 발생하고 있다. 하지만 기존의 홍수범람에 관한 연구는 대부분 외수범람과 내수침수를 유기적으로 연결하지 못하고 있다. 본 연구에서는 상습침수가 발생하는 도시유역에 대하여 도시유역 유출특성을 고려한 홍수의 정확한 예측을 위해 강우분석 및 외수위를 고려하고, 도시유출모형인 SWMM 모형을 이용하여 하수관거의 월류를 분석하였고, 이 결과를 홍수범람해석 모형과 연계하여 도시유역에서의 집중호우 발생시 침수해석을 실시하여 수방시설물의 홍수배제 효율을 분석하였다. SWMM 모형의 적용결과 외수위영향에 따른 원활한 내수배제가 불가능 한 것으로 나타났고, 관거 월류량이 많아진 것으로 나타났다. 월류된 우수가 지면을 따라 흐를 경우 저지대의 침수가 예상되고, 월류량이 많은 맨홀을 주요맨홀로 선정하였고, 월류수 저감을 위한 방안으로 주요 맨홀의 인근 지역에 저류지를 설치하는 방안과 각 맨홀들을 연결하는 관거를 확대하는 방안을 설정하였다. 월류 저감 시나리오 적용 결과 저류지 설치시 월류량의 45%, 관거 확대시 33~64%의 저감효과를 보였다. SWMM 모형의 결과를 이용하여 홍수범람해석 모형을 모의한 결과 지표경사와 도로를 따라 맨홀 월류수가 모여 침수현상을 발생시키는 것으로 나타났으며, 관거 확대 적용시 침수면적이 19.6%, 60.5% 줄어든 것으로 나타났다.

• 한국정보전자통신기술학회논문지
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• 제8권4호
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• pp.319-326
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• 2015

본 논문에서는 3차원 역학 모델을 이용한 폐 결절 분할 방법을 제안한다. 제안된 폐결절 분할 방법은 세 가지 과정으로 구성된다. 첫 번째, 초기 3차원 역학 모델을 생성한다. 생성된 모델은 삼각형 메쉬로 구성되어져 있고 구의 형태를 갖는다. 두 번째, 구성된 초기 모델의 점들을 변화시킨다. 세 번째, 각각의 변화에 따라 외부 에너지와 내부에너지를 계산 한다. 내부 에너지는 형태 기반 에너지로 구성되어 있고, 외부에너지는 음영값 기반 에너지로 구성된다. 이 초기 모델을 변화시키고, 변화에 따른 에너지의 최소값을 찾는 과정을 반복한다. 모델의 에너지가 수렴되면 이를 이용하여 결절을 분할한다. 제안된 방법은 기존 방법에 비하여 정확도가 크게 개선되었다.

• 대한한방내과학회지
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• 제32권3호
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• pp.425-434
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• 2011

Objectives : Hypothyroidism is the most common pathological disease of the endocrine system. Morinda Officinalis Radix has been used in treatment of Yang deficiency. In this study, we investigated the therapeutic effects of Morinda Officinalis Radix on a rat model of hypothyroidism induced by 6-propyl, 2-thiouracil (PTU). Methods : Two-month-old Sprague-Dawley male rats were used with injection of PTU which induced rats into hypo-thyroidism. During 2 weeks, rats were treated with Morinda Officinalis Radix and thyroxine. Body weights were checked every week, the after 4 weeks, biochemical analyses were performed. The levels of T3, T4 and TSH was measured by EILSA. Results : In the Morinda Officinalis Radix group, we could observe the level of T4 significantly increased and TSH level significantly decreased. Conclusions : Morinda Officinalis Radix could help the thyroid to produce thyroid hormones under PTU suppression. There is no harm effect on liver and kidney function, or other metabolism. According to these results it could help to treat hypothyroidism patients and relieve their symptoms.