• Title/Summary/Keyword: Internal Acting

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Meniscoid-type SuperrJior Labrum Associated with Internal Derangement of Shoulder Joint (견관절내 병변과 동반된 상부관절순의 반월상변형)

  • Choi Chang-Hyuk;Kwun Koing-Woo;Kim Shin-Kun;Lee Sang-Wook;Park Bum-Jin
    • Clinics in Shoulder and Elbow
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    • v.2 no.1
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    • pp.41-46
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    • 1999
  • Glenoid labrum acts as one of static stabilizer of the glenohumeral joint. It deepens the glenoid socket and may also serve as a chock, acting as a wedge in preventing glenohumeral translation. Two types of variations in labral anatomy were noted by Detrisac and Johnson. Type A has a superior labrum that is detached centrally but well attached peripherally. The type B labrum is well attached centrally and peripherally at all sites. A meniscoid-type labrum is thought to be normal unless there are splits or fragmentation of the overlying labral tissue. Meniscoid type labrum is different from SLAP II lesion in that it has a firm anchoring on the superior labrum. We observed four cases that had a meniscoid variant superior labrum, which covered the superior glenoid unusually larger than normal in the arthroscopic treatment of shoulder pathology including instability and rotator cuff diseases. We did arthroscopic reshaping and debridement of meniscoid variant superior labrum combined with pathologic change of the glenohumeral joint. Further study would be required for understanding the mechanism of the development of meniscoid variant labrum and its clinical significance.

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Preparation and Evaluation of a 4-Branched Polyethylene Glycol Derivative Modified with Exendin-4 and Stearylamine for Extended Hypoglycemic Action

  • Kim, In-Soo;Ma, Kyung-Wan;Bae, Sung-Ho;Yoon, Jeong-Hyun;Oh, Kyung-Taek;Lee, Eun-Seong;Lee, Don-Haeng;Lee, Kang-Choon;Youn, Yu-Seok
    • Journal of Pharmaceutical Investigation
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    • v.40 no.3
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    • pp.175-180
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    • 2010
  • Albumin-modification has been viewed as one of the most effective ways of extending the short in vivo lifetimes of peptide drugs by delaying glomerular filtration. In this study, we describe a new type 2 anti-diabetic exendin-4 (Ex4) peptide derivative with significant binding ability to human serum albumin (HSA). This exendin-4 derivative consists of a 4-branched polyethylene glycol $(PEG)_{5k}$ (Mw: 20 kDa) modified with three stearylamines ($C_{18}-NH_2$) and one exendin-4 on its branches. PEG and stearylamine were selected to provide functionality to increase molecular size and bind to albumin, respectively. This derivative ($3C_{18}-4PEG_{5k}$-Ex4) was shown to have larger molecular size (Ca. 152 kDa) than actual (25.0 kDa) when subjected to size-exclusion chromatography, and the fluorescein-tagged $3C_{18}-4PEG_{5k}$-Ex4 displayed significant binding to the HSA-immobilized Sepharose CL-4B resin using confocal laser scanning microscopy. Furthermore, $3C_{18}-4PEG_{5k}$-Ex4 was found to have acceptable anti-hyperglycemic efficacy via three consecutive oral glucose tolerance testings (OGTT) in fasted type 2 diabetic db/db mice. The $HD_{total}$ value ($57.6{\pm}12.3%$) of $3C_{18}-4PEG_{5k}$-Ex4 at a 50 nmol/kg dose was 2-fold greater than that ($31.0{\pm}8.7%$) of native exendin-4 in non-fasted db/db mice. Especially, the blood glucose levels in the mice group treated with $3C_{18}-4PEG_{5k}$-Ex4 did not rebound to ~150 mg/dL until 24 h after the injection, which obviously shows the extended hypoglycemia. We believe that this derivative has great pharmaceutical potential as a novel long-acting type 2 anti-diabetic injection treatment.

Research Trends on Plant Associated Beneficial Bacteria as Biofertilizers for Sustainable Agriculture: An Overview (지속농업을 위한 생물비료로서의 유용세균관련 식물검정 연구 개관)

  • Sa, Tongmin;Chauhan, Puneet Singh
    • Korean Journal of Soil Science and Fertilizer
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    • v.42 no.spc
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    • pp.20-28
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    • 2009
  • The sustainability of conventional agriculture which is characterized by input dependent and ecologically simplified food production system is vague. Chemicals and present practices used in agriculture are not only costly but also have widespread implications on human and animal health, food quality and safety and environmental quality. Thus there is a need for alternative farming practices to sustain food production for the escalating population and conserve environment for future generations. The present research scenario in the area of plant microbe interactions for maintaining sustainable agriculture suggests that the level of internal regulation in agro-ecosystems is largely dependent on the level of plant and microbial diversity present in the soil. In agro-ecosystems, biodiversity performs a variety of ecological services beyond the production of food, including recycling of nutrients, regulation of microclimate and local hydrological processes, suppression of undesirable organisms and detoxification of noxious chemicals. Controlling the soil microflora to enhance the predominance of beneficial and effective microorganisms can help improve and maintain soil chemical and physical properties. The role of beneficial soil microorganisms in sustainable productivity has been well construed. Some plant bacteria referred to as plant growth-promoting rhizobacteria (PGPR) can contribute to improve plant growth, nutrient uptake and microbial diversity when inoculated to plants. Term PGPR was initially used to describe strains of naturally occurring non-symbiotic soil bacteria have the ability to colonize plant roots and stimulate plant growth PGPR activity has been reported in strains belonging to several other genera, such as Azotobacter, Azospirillum, Arthrobacter Bacillus, Burkhokderia, Methylobacterium, and Pseudomonas etc. PGPR stimulate plant growth directly either by synthesizing hormones such as indole acetic acid or by promoting nutrition, for example, by phosphate solubilization or more generally by accelerating mineralization processes. They can also stimulate growth indirectly, acting as biocontrol agents by protecting the plant against soil borne fungal pathogens or deleterious bacteria. Present review focuses on some recent developments to evolve strategies for better biotechnological exploitation of PGPR's.

A study on experiment from the Stair Joints Constructed with PC system part of it using the HI-FORM DECK (HI-FORM DECK를 이용한 부분 PC 계단 접합부의 접합방식에 따른 실험적 연구)

  • Chang, Kug-Kwan;Lee, Eun-Jin;Jin, Byung-Chang;Kang, Woo-Joo;Han, Tae-Kyung
    • Proceedings of the Korea Concrete Institute Conference
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    • 2008.11a
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    • pp.9-12
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    • 2008
  • The semi-rigid joint is the shape of middle that can supplement the defect of pin joints and accept the good point of rigid joints. Recently, a study on the pin joints is activated in the country, but because the study on semi-rigid joints is not many, this study tried to prove with producing test model of three shape. The test models are rigid joint HI-R, semi-rigid joint HI-S, pin joint HI-P. As a result of the test, respectively HI-R, HI-S, HI-P appeared shear failure of joint, flexure failure of the top fixing, flexure failure of the lower part slipping stair slab, and the maximum strength is measured to 51.74, 51.4, 24.63kN, the stiffness is appeared 1.58, 1.19, 0.37 respectively, The yield strength is respectively kept 44.5, 47.3, 24kN, and ductility ratio is appeared to 3.31, 2.32, 1.54, when is based on KBC code, sag of the acting service load is appeared that HI-P model is over the standard. When is based on distribution of bars strain ratio, HI-S seems similar behavior incipiently, but after the yield, the semi-rigid joint was able to be judged better than pin joint because of the stress allotment of joint internal elements.

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Theoretical Analysis of Embankment Loads Acting on Piles (성토지지말뚝에 작용하는 연직하중의 이론해석)

  • 홍원표;이재호;전성권
    • Journal of the Korean Geotechnical Society
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    • v.16 no.1
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    • pp.131-143
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    • 2000
  • Several theoretical analyses are performed to predict the vertical load on embankment piles with cap beams. The piles are installed in a row in soft ground below the embankment and the cap beams are placed perpendicular to the longitudinal axis of the embankment. Two failure mechanisms such as the soil arching failure and the punching shear failure are investigated according to the failure pattern in embankment on soft ground supported by piles with cap beams. The soil arching can be developed when the space between cap beams is narrow and/or the embankment is high enough. In the investigation of the soil arching failure, the stability in the crown of the arch is compared with that above the cap beams. The factors affecting the load transfer in the embankment fill by soil arching are the space between cap beams, the width of cap beams and the soil parameters of the embankment fill. The portion of the embankment load carried by cap beams decreases with increment of the space between cap beams, while it increases with the embankment height, the width of cap beams, the internal friction angle and cohesion of the embankment fill. Thus, the factors affecting load transfer in embankment should be appropriately decided in order to maximize the effect of embankment load transfer by piles.

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Vane Shear Test on Nakdong River Sand (베인 전단시험기를 이용한 낙동강모래의 마찰각에 관한 연구)

  • Park, Sung-Sik;Zhou, An;Kim, Dong-Rak
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.36 no.3
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    • pp.463-470
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    • 2016
  • A vane shear test (VST) is a simple testing method for determining an undrained shear strength of cohesive soils by minimizing soil disturbance. In this study, the VST was used to determine a shear strength of sand. Dry Nakdong River sand was prepared for loose and dense conditions in a cell and then pressurized with 25, 50, 75 or 100 kPa from the surface of sand. A vane (5 cm in diameter and 10 cm in height) was rotated and a torque was measured within sand. When a torque moment by vane and friction resistance moment by sand is assumed to be equalized, a friction angle can be obtained. When a vane rotates within clay, a uniform undrained shear strength is assumed to be acting on cylindrical failure surface. On the other hand, when it is applied for sand, the failure shape can be assumed to be an octagonal or square column. The relationship between measured torque and resistant force along assumed failure shapes due to friction of sand was derived and the internal friction angle of sand was determined for loose and dense conditions. For the same soil condition, a series of direct shear test was carried out and compared with VST result. The friction angle from VST was between 24-42 degrees for loose sand and 33-53 degrees for dense sand. This is similar to those of direct shear tests.

Evaluation of Surcharge toads Acting in Backfilled Space (되메움 공간의 상재하중 영향평가에 관한 연구)

  • Moon Chang-Yeul;Kim Hee-Dong;Choi Heon
    • Journal of the Korean Geotechnical Society
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    • v.20 no.9
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    • pp.167-176
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    • 2004
  • Underground structures will be affected by the additional surcharge loads such as traffic load et al. Terzaghi (1956) suggested the equation on the influences of surcharge loads in vertically backfilled spaces. In field, the shapes of backfill spaces are not always formed vertically. Then the Terzagi (1956) equation is not suitable to use because of boundary condition. This study suggests equation to calculate the stress in backfilled space caused by surcharge loads when the backfilled space is sloped symmetrically. The suggested equation is verified by carbon box test and numerical analysis. The experimental results show good agreement with the suggested equation but the numerical analysis result shows a little disagreement. The differences are estimated to be caused by the fact that ground made by carbon rod has become more dense and internal frction and wall friction has increased itself as surcharge load is added but that this increase can not be considered in the numerical analysis. The suggested equation shows good agreement with Terzaghi (1956) equation in case of sloped backfill ground. According to the results, it is considered that the suggested equation can be applied not only to sloped space but also to vertical space. Further investigation using full scale experiment is needed.

Railway Governance and Power Structure in China

  • Lee, Jinjing
    • International Journal of Railway
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    • v.1 no.4
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    • pp.129-133
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    • 2008
  • Over the last $15{\sim}20$years, many countries have adopted policies of railway privatization to keep up with increasing competition from road and air transport. Although each country and case has its own history, market characteristics, political context as well as administrative process, railway privatizations (including railway restructure, concession etc.) in the west usually are accompanied with the establishment of new regulatory regimes. Therefore, railway governance has been innovating towards an interaction of government, regulator, industry bodies, user groups, trade unions and other interested groups within the regulatory framework. However, it is not the case in China. Although China had seen a partial privatization in some branch lines and is experiencing a much larger-scale privatization by establishing joint-ventures to build and operate high-speed passenger lines and implementing an asset-based securitization program, administrative control still occupies absolutely dominant position in the railway governance in China. Ministry of Railway (MOR) acts as the administrator, operator as well as regulator. There is no national policy that clearly positions railway in the transportation network and clarifies the role of government in railway development. There is also little participation from interested groups in the railway policy making, pricing, service standard or safety matter. Railway in China is solely governed by the mere executive agency. Efficiency-focused economic perspective explanation is far from satisfaction. A wider research perspective from political and social regime is of great potential to better explain and solve the problem. In the west, separation and constrains of power had long been established as a fundamental rule. In addition to internal separation of political power(legislation, execution and jurisdiction), rise of corporation in the 19th century and association revolution in the 20th century greatly fostered the growth of economic and social power. Therefore, political, social and economic organizations cooperate and compete with each other, which leads to a balanced and resonable power structure. While in China, political power, mainly party-controlled administrative power has been keeping a dominated position since the time of plan economy. Although the economic reform promoted the growth of economic power of enterprises, it is still not strong enough to compete with political power. Furthermore, under rigid political control, social organizations usually are affiliated to government, independent social power is still too weak to function. So, duo to the limited and slow reform in political and social regime in China, there is an unbalanced power structure within which political power is dominant, economic power expanding while social power still absent. Totally different power structure in China determines the fundamental institutional environment of her railway privatization and governance. It is expected that the exploration of who act behind railway governance and their acting strength (a power theory) will present us a better picture of railway governance as a relevant transportation mode. The paper first examines the railway governance in China and preliminarily establishes a linkage between railway governance and its fundamental institutional environment, i.e. power structure in a specific country. Secondly, the reason why there is no national policy in China is explored in the view of political power. In China, legislative power is more symbolic while party-controlled administrative power dominates political process and plays a fundamental role in Chinese railway governance. And then, in the part three railway finance reform is analyzed in the view of economic power, esp. the relationship of political power and economic power.

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The Effect of Glasthma Syrup in Asthma: a study protocol for a triple-blind randomized controlled trial

  • Derakhshan, Ali Reza;Saeidinejat, Shahin;Khadem-Rezaiyan, Majid;Asnaashari, Amir-Mohammad-Hashem;Mirsadraee, Majid;Salari, Roshanak;Jabbari-Azad, Farahzad;Jalali, Shima;Jalali, Shabnam
    • Journal of Pharmacopuncture
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    • v.25 no.3
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    • pp.233-241
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    • 2022
  • Objectives: Asthma is a chronic disease, and the demand for herbal medicines in this field has increased in recent years. The new findings highlight the role of the gut-lung axis in the pathophysiology of asthma. Hence, this study will evaluate the safety and efficacy of Glasthma syrup, an herbal formula based on Persian medicine, in improving asthma and regulating intestinal permeability. The formula consists of five herbal ingredients that have anti-inflammatory effects on the respiratory tract, also known as gut tonics. Methods: The study will be conducted as a placebo-controlled, triple-blind, randomized trial. It will consist of a 4-week intervention followed by a 4-week follow-up period. The target sample size is 20 patients with moderate asthma aged 18 to 60 years. Eligible participants will be randomly assigned to either the experimental group or the control group in equal numbers. Patients in the experimental group will take Glasthma syrup (7.5 mL, twice a day), while patients in the control group will take a matching placebo. Both groups will receive a 4-week combination of a long-acting beta2 agonist and a leukotriene modulator as standard of care. Inhaled corticosteroids can be used as rescue medication as needed. Results: The primary outcomes are asthma symptom scale, lung function, and intestinal permeability. Secondary outcomes include quality of life, symptom recurrence rates, and blood tests. A safety assessment will also be conducted during the trial. Conclusion: In this trial, the effects of Glasthma syrup in patients with moderate asthma will be examined. The study will also assess the effects of the formulation on the gut-lung axis by simultaneously monitoring the gut permeability index, asthma symptoms, and lung function.

An Exploratory Study on the Critics's Reviews Reported in the Press : Focusing on the Relationship Between Opinion Quality of Film Reviews and Box Office Performance (언론에 보도된 전문가 영화 리뷰에 관한 연구 : 영화 리뷰의 품질과 흥행성과의 관계를 중심으로)

  • Lee, Pu-Reum;Park, Seung-Hyun
    • Journal of Korea Entertainment Industry Association
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    • v.13 no.7
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    • pp.1-13
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    • 2019
  • This study tried to explore the contents of film critics' reviews reported in the press. Based on fifty nine Korean movies with over 100,000 audience in 2017, this study collected 1113 reviews from fifty five movies with the exception of four without reviews. This study focused on the correlation between film's overall quality and four evaluation items such as directing, acting, story, and the visual. Examining the difference in the report timing of the review, the length of the review, and the intensity of the opinion, this study also analyzed the relationship between the internal aspects of reviews and box office performance. According to the results, the valence of critics' reviews was generally positive. Looking at the difference of reporting time, this valence was higher in the week before release than in the release week of film. The evaluation items of reviews were highly covered both before movie release and in the opening week. These were significantly declined in the second week of release. In the relationship between the number of reviews by each movie and box office performance, a positive correlation was found.