• 한국임상약학회지
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• 제27권4호
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• pp.276-283
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• 2017

Objective: Dyslipidemia is recognized as a prominent risk factor for cardiovascular and cerebrovascular diseases but it is manageable through therapeutic and lifestyle intervention. Interpreting the latest guidelines is essential for an application of recommendation from guidelines into clinical practice. Therefore, this study aimed to compare the most recent guidelines on dyslipidemia treatment recommendations in Korea and USA. Methods: This study analyzed and compared 2015 Korean guidelines for the management of dyslipidemia, 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline and 2016 supportive guidelines from ACC. Results: A comparison was made focused on the following: target patients based on cardiovascular risk assessment, target goal, and treatment strategies including statin and non-statin therapies. Four target patient groups by risk were suggested in 2015 Korean guideline and cardiovascular risk factors were also considered for initiation of lipid lowering therapy. Titrated statin regimen was recommended by Korean guideline to reach LDL cholesterol and non-HDL cholesterol target level. In 2013 ACC/AHA guideline, four statin benefit group was introduced considering ASCVD risk and high intensity statin or intermediate intensity statin use were recommended without dose titration. 2016 update was to support non-statin therapy based on updated evidence and new consideration of ezetimibe, PCSK9-inhibitor and bile acid sequestrant was brought up. Conclusion: Guidelines are continuously updating as new and important clinical data are constantly released along with the advent of newly approved drugs for lipid disorder. This article provides resources that facilitates uptake of these recommendations into clinical practice.

• 한국정보과학회논문지:정보통신
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• 제37권1호
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• pp.50-56
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• 2010

이 논문은 대규모 무선 센서 네트워크의 전체 운영 시간을 늘이기 위해 모바일 싱크를 이용한 효율적인 데이터 수집 방법을 제안한다. 클러스터링을 통해 센서 네트워크를 나눈 다음 모바일 싱크가 각 클러스터를 방문하여 데이터를 수집한다. 모바일 싱크와 클러스터 헤드 사이의 메시지 전달을 통해 에너지 소비 효율은 높이며 모바일 싱크의 단점인 데이터 수집 시간을 최소화할 수 있는 프로토콜을 제안한다. 네트워크 확장성을 위해 센서 네트워크 구조는 클러스터내에서 싱글 홉 전송보다는 멀티홉 전송을 지원해야 한다. 멀티홉 전송시 발생하는 중간 노드의 과도한 에너지 소비를 개선하기 위해 주행 경로와 연계된 데이터 병합 과정을 제안한다. 실험결과는 제안 모델이 기존 방법들보다 에너지 소비 및 데이터 수집 시간 측면에서 효율적임을 보여준다.

• 한국통신학회논문지
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• 제32권1B호
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• pp.61-70
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• 2007

IPv4/IPv6 통신 서비스를 위한 변환기는 호스트의 변경 없이 IPv6 호스트와 IPv4 호스트간의 통신을 지원해 준다. 그러나 호스트가 모바일 노드일 경우 삼각형 라우팅 문제가 발생한다. Mobile IPv4 모바일 노드가 이동할 경우 홈 에이전트와 IPv6의 CN(Correspondent Node)에게 반드시 이동 정보를 보내 주어야 하지만 현재 NAT-PT는 IPv4와 IPv6의 이동성 헤더인 모바일 IPv4/Mobile IPv6의 헤더 변환은 지원해 주지 않기 때문에 삼각형 라우팅 문제가 발생하여 Mobile IPv4와 Mobile IPv6간에 비효율적인 통신을 일으킨다. 본 논문에서는 Mobile IPv4와 Mobile IPv6 통신에서 발생하는 삼각형 라우팅 문제를 해결하기 위한 모바일 헤더 변환 메커니즘을 제안하였다.

• 멤브레인
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• 제15권2호
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• pp.105-113
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• 2005

표면 개질한 다공성 금속 지지체에 초음파 분무 열분해법을 이용하여 silica막을 합성하고, 고온 기체 선택 투과 분리 특성을 조사하였다. Tetraethyl orthosilicate (TEOS)를 전구체로 하여 지지체 세공을 통한 감압 진공을 하면서 873K에서 표면에 defect 없이 균일한 양질의 silica막이 형성되었다. 투과 온도 523 K에서 silica막의 수th/질소 및 수증기/메탄을 분리 계수가 각각 17 및 16 정도의 우수한 선택 투과 성능을 나타냈다. 다공성 금속 지지체의 불균일한 기공에 silica 분체 및 $\gamma-alumina$층을 중간층으로 도입하고, 그 위에 열분해법에 의한 silica를 합성한 결과, Knudsen 확산에 의한 투과 영역의 세공이 완전히 제거되어 높은 수소 및 수증기 선택성을 가지는 복합 막이 형성되었다.

• 생태와환경
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• 제40권4호
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• pp.527-536
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• 2007

In this study, we applied 10-metric health assessment model, based on the Index of Biological Integrity (IBI) during 2006 in the Changwon Stream, which is located in the Changwon city, Gyeongnam province, S. Korea, and then compared with water quality data. The Index of Biological Integrity (IBI) in the Changwon Stream varied from 18 to 38 in the watershed depending on the sampling location and averaged 30.3 (n=6) during the study. Analysis of tolerance guilds showed that the proportion of sensitive species was 13%, but tolerant and intermediate species were 34% and 53%, respectively. Qualitative Habitat Evaluation Index (QHEI) averaged 43.3 (range: 65-104, n=6) indicating non-supporting condition, based on the criteria of U.S. EPA (1993). Values of QHEI showed a typical longitudinal decreases from the headwater reach to the downstream location, except for Site 1 with a low QHEI value by artificial habitat by concrete construction. Minimum QHEI was found in Site 4 where fish diversity was minimal. Conductivity increased continuously along the gradients and especially showed abrupt increases in the downstream sites along with turbidity. Stream ecosystem health of IBI matched to the values of QHEI except for S6. Low IBI values in the sites 4 and 5 was considered to be a result of combined effects of chemical pollutions and habitat degradations. Our results support the hypotheses of Plafkin et ai. (1989) that physical habitat quality directly influences the trophic structure and species richness, and is closely associated with IBI values.

• Bulletin of the Korean Chemical Society
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• 제31권9호
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• pp.2593-2597
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• 2010

Second-order rate constants ($k_N$) have been measured spectrophotometrically for reactions of 2,4-dinitrophenyl X-substituted benzoates (X = 4-MeO, H and 4-$NO_2$) with a series of Z-substituted pyridines in 80 mol % $H_2O$/20 mol % DMSO at $25.0{\pm}0.1^{\circ}C$. The Br${\o}$nsted-type plots exhibit downward curvature (e.g., $\beta_2$ = 0.89 ~ 0.96 when $pK_a$ < 9.5 while $\beta_1$ = 0.38 ~ 0.46 when $pK_a$ > 9.5), indicating that the reaction proceeds through a stepwise mechanism with a change in rate-determining step (RDS). The ${pK_a}^o$, defined as the $pK_a$ at the center of Br${\o}$nsted curvature, has been analyzed to be 9.5 regardless of the electronic nature of the substituent X in the benzoyl moiety. Dissection of $k_N$ into the microscopic rate constants $k_1$ and $k_2/k_{-1}$ ratio has revealed that $k_1$ is governed by the electronic nature of the substituent X but the $k_2/k_{-1}$ ratio is not. Theoretical calculations also support the argument that the electronic nature of the substituent X in the benzoyl moiety does not influence the $k_2/k_{-1}$ ratio.

• 한국태양에너지학회 논문집
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• 제34권4호
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• pp.23-29
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• 2014

Recently, in power system studies, Multiple Energy Carriers (MECs) such as Energy Hub has been broadly utilized in power system planners and operators. Particularly, Energy Hub performs one of the most important role as the intermediate in implementing the MECs. However, it still needs to be put under examination in both modeling and operating concerns. For instance, a probabilistic optimization model is treated by a robust global optimization technique such as multi-agent genetic algorithm (MAGA) which can support the online economic dispatch of MECs. MAGA also reduces the inevitable uncertainty caused by the integration of selected input energy carriers. However, MAGA only considers current state of the integration of selected input energy carriers in conjunctive with the condition of smart grid environments for decision making in Energy Hub. Thus, in this paper, we propose an immune algorithm based Multiple Energy Carriers System which can adopt the learning process in order to make a self decision making in Energy Hub. In particular, the proposed immune algorithm considers the previous state, the current state, and the future state of the selected input energy carriers in order to predict the next decision making of Energy Hub based on the probabilistic optimization model. The below figure shows the proposed immune algorithm based Multiple Energy Carriers System. Finally, we will compare the online economic dispatch of MECs of two algorithms such as MAGA and immune algorithm based MECs by using Real Time Digital Simulator (RTDS).

• Journal of the korean society of oceanography
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• 제33권4호
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• pp.185-195
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• 1998

Two piston cores (94PC-2 and 95PC-4) taken from the East Sea (Sea of Japan) are studied to evaluate the paleoceanographic changes and its interaction with climatic variation. The bulk geochemistry of the non-biogenic fractions of 54 sediment samples is determined using X-ray fluorescence. Four geochemical stratigraphic units at both core sediments are recognized based on the variations in major element concentration. These chemical stratigraphic units correspond well with the sedimentological and paleontological facies. Source materials are considered as basic and/or intermediate rocks judging from silica content. A distinctive boundary around 11 kyr may correspond to Younger Dryas event. The switch of most major elements at this level and the distinctive changes in concentration of typical terrigenous elements (TiO$_2$ and Al$_2$O$_3$) are the strong evidence for the difference in sources of terrigenous materials. The weathering indices exhibit high degree in Core 94PC-2 and low degree in Core 95PC-4. The changes in weathering degree can be distinguished by the lowest value occurred at 11 kyr in Core 94PC-2 and by a gradual decrease from top to bottom in Core 95PC-4. The profiles of potassium and sodium exhibit specific excursions between the Holocene and the late Pleistocene. This implies that sediments of the two cores originating from different sources with different weathering degrees. The distinct two-group distributions in K$_2$O/CaO vs. Na$_2$O/K$_2$O also support the difference in provenance of aluminosilicate materials at the boundary of 11 kyr. Thus, supply patterns of terrigenous materials are stable in Holocene and more complicated in the last glacial period.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제24권2호
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• pp.65-77
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• 2018

Purpose: By identifying the contents of the "Empty Home Utilization & Community Revitalization Model Project" which is a pilot project of empty homes back into use in Kyoto City and analyzing the characteristics of the case housing, the purpose of this study is to find out implications and suggest improvements for the domestic empty home utilization project. Methods: The scope of the survey covers seven project sites in the period from 2014 to 2016. The research method is to derive the physical and operational characteristics of the project, through the literature reviews related to bringing empty homes back into use in Kyoto City and the field survey including the space measurement and the operator interview. Results: First, in order to succeed in bringing empty homes back into use for community revitalization, the selection process of the project and the role of the public in and after supporting the project are important. Second, the important features that are required as a physical characteristic of the project are an advantage in location and an interactive space that is available at all time like a community cafe at the entrance. Third, as an operational characteristic of the empty home utilization project, it is advantageous for the local residents to participate as a business actor or an operator, and it is the continuous use of residents and outsiders by implementing an operating program that is suitable for the characteristics of the local community. Implications: The physical and operational activation factors to bring empty homes back into use need to be included as the project screening standards. And it is necessary for the public to develop the Intermediate Support Organization and to participate in linking with residents in order to carry out the empty homes utilization project effectively.

• Asian Pacific Journal of Cancer Prevention
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• 제16권10호
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• pp.4357-4361
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• 2015

Thunbergia Laurifolia Linn. (TL) is one of the most familiar plants in Thai traditional medicine that is used to treat various conditions, including cancer. However, the antitumor activity of TL or its constituents has never been reported at the molecular level to support the folklore claim. The present study was designed to investigate the antitumor effect of an aqueous extract of TL in human breast cancer cells and the possible mechanism(s) of action. An aqueous crude extract was prepared from dried leaves of TL. Folin-Ciocalteu colorimetric assays were used to determine the total phenolic content. Antiproliferative and cell cycle effects were evaluated in human breast adenocarcinoma MCF-7 cells by MTT reduction assay, cell growth inhibition, clonogenic cell survival, and flow cytometric analysis. Free radical generation by the extracts was detected using electron paramagnetic resonance spectroscopy. The exposure of human breast adenocarcinoma MCF-7 cells to a TL aqueous extract resulted in decreases in cell growth, clonogenic cell survival, and cell viability in a concentration-dependent manner with an $IC_{50}$ value of $843{\mu}g/ml$. Treatments with extract for 24h at $250{\mu}g/ml$ or higher induced cell cycle arrest as indicated by a significant increase of cell population in the G1 phase and a significant decrease in the S phase of the cell cycle. The capability of the aqueous extract to generate radical intermediates was observed at both high pH and near-neutral pH conditions. The findings suggest the antitumor bioactivities of TL against selected breast cancer cells may be due to induction of a G1 cell cycle arrest. Cytotoxicity and cell cycle perturbation that are associated with a high concentration of the extract could be in part explained by the total phenolic contents in the extract and the capacity to generate radical intermediates to modulate cellular proliferative signals.