• Journal of Animal Science and Technology
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• 제52권6호
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• pp.521-527
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• 2010

Fibroblast growth factor receptor 1 (FGFR1) plays roles in angiogenesis, wound healing, and embryonic development via the regulation of cell proliferation, differentiation, and survival. It is well known that ectopic expression of FGFR1 is associated with cancer development. To characterize the function of FGFR1 in the normal and cancer cell lines DF-1 and DT40, respectively, we performed FGFR1 knockdown by RNA interference. In the DT40 cells, FGFR1 knockdown induced upregulation of FGFR2 and FGFR3 expression, downregulation of pro-apoptosis-related genes, and upregulation of anti-apoptosis-related genes. However, in DF-1 cells, FGFR1 knockdown induced upregulation of pro-apoptosis-related genes and downregulation of anti-apoptosis-related genes. Our data suggest that repression of FGFR1 induced upregulation of other FGF receptors and anti-apoptosis-related genes in cancer cells and pro-apoptosis-related genes in normal cells.

• 전기학회논문지
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• 제58권11호
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• pp.2168-2174
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• 2009

Electrical railway system consists of rolling stock, track, signal and streetcar line system. Track circuit system is a vital system due to checking the location of trains. Track circuits are divided by using frequency and isolated electrically. Currently, there is not a regulation for the distance between track circuits using identical frequency. In case of installing additional track circuits in large stations or marshalling yard, the problem which is that the signal is not exactly transmitted to the track circuit occurs due to the mutual interference. In other words, the track circuit properly is not operated on account of wrong induction current by the mutual inductance between track circuits. In this paper, we suggest the electrical model between track circuits and numerically calculate demanded parameters in electrical model. The distance between track circuits satisfying the mutual inductance which does not happen to the mutual interference phenomenon is presented about the distance of track circuit. It is proved by using Matlab and PSpice program as the amplitude of mutual induced current.

• Journal of Microbiology and Biotechnology
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• 제30권12호
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• pp.1919-1926
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• 2020

CRISPR interference (CRISPRi) has been developed as a transcriptional control tool by inactivating the DNA cleavage ability of Cas9 nucleases to produce dCas9 (deactivated Cas9), and leaving dCas9 the ability to specifically bind to the target DNA sequence. CRISPR/Cas9 technology has limitations in designing target-specific single-guide RNA (sgRNA) due to the dependence of protospacer adjacent motif (PAM) (5'-NGG) for binding target DNAs. Reportedly, Cas9-NG recognizing 5'-NG as the PAM sequence has been constructed by removing the dependence on the last base G of PAM through protein engineering of Cas9. In this study, a dCas9-NG protein was engineered by introducing two active site mutations in Cas9-NG, and its ability to regulate transcription was evaluated in the gal promoter in E. coli. Analysis of cell growth rate, D-galactose consumption rate, and gal transcripts confirmed that dCas9-NG can completely repress the promoter by recognizing DNA targets with PAM of 5'-NGG, NGA, NGC, NGT, and NAG. Our study showed possible PAM sequences for dCas9-NG and provided information on target-specific sgRNA design for regulation of both gene expression and cellular metabolism.

• Journal of information and communication convergence engineering
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• 제9권5호
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• pp.515-522
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• 2011

In this paper, we investigate cooperative diversity in a spectrum sharing environment where secondary users utilize primary users' spectrum only if the interference power received at the primary users is maintained below a predetermined level. The outage probability of a selective decode-and-forward (DF) based cooperative diversity scheme in the secondary network is derived to analyze the effects of spectrum sharing on cooperative diversity. Our analytical and simulation results show that the outage probability is saturated at a certain level of transmit power of secondary users due to interference regulation, and, hence, cooperative diversity gains are lost. Through asymptotic analysis, we also identify the critical value of transmit SNR beyond which the outage probability is saturated.

• 한국전자파학회:학술대회논문집
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• 한국전자파학회 2003년도 종합학술발표회 논문집 Vol.13 No.1
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• pp.604-608
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• 2003

In this paper, we studied the radiated electric field of power-line with DMT signal source in the frequency range of $1.7{\sim}30 MHz$. First, we made the midium voltage power-line communication model for PLC and calculated the current through the power-line using the impedance of the power-line model. Second, we calculated the radiated electric field in power range $-50{\sim}-30 dBm$ using the calculated current. Consequently, the calculated emissive electromagnetic field from the DMT signal is similar to the measured result. So this study is applicable to the standard regulation of electromagnetic interference for PLC.

• 전력전자학회논문지
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• 제9권1호
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• pp.81-87
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• 2004

본 논문에서는 세탁기, 에어컨과 같은 가전기기에 사용되는 인버터 구동 교류 전동기 구동 시스템의 EMI 특성해석 및 필터 설계 방법에 대하여 기술하였다. 먼저, 인버터 구동 교류 전동기 구동 시스템의 전도성 EMI 발생 및 전달 메커니즘에 대하여 분석하였고, 공통 및 차동모드 노이즈 분리 기법을 이용한 EMI 필터의 설계 방법을 제시하였다. 제시된 방법의 타당성을 검증하기 위해 PWM 인버터로 구동되는 유도 전동기 구동 시스템에 대한 실험을 수행하였고 EN55014 EMI 기준을 만족하는 결과를 얻을 수 있었다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2002년도 하계학술대회 논문집 Vol.3 No.2
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• pp.1121-1124
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• 2002

Currently, the regulation system on controlling EMI has been strengthened throughout the world and this system has emerged as another invisible barrier from the advanced countries. Such a regulation is likely to expand in many various ways depending on the objective and type, and there has to be a fundamental EMI measure to respond this movement. This study is aimed at learning the EMI technology of communication system through the shielding material. It introduces the selection of appropriate shielding material and method of use, and it introduces the cases that resolved the actual EMI problem of the system that is manufactured by the company.

• 한국조명전기설비학회지:조명전기설비
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• 제13권2호
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• pp.156-156
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• 1999

This paper describes the characteristics and the criteria of electrical environmental effects produced from power system especially transmission line. Audible noise radio and TV interference, electric and magnetic inductions which are main items for optimal conductor selection as well as major contributors to the community complaint of electrical environmental problem, are surveyed and studied comparing with the criteria or the environmental protection regulation of domestic and foreign countries. As a result a domestic criteria of electrical environmental on power system was suggested.

• Journal of Power Electronics
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• 제16권4호
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• pp.1245-1255
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• 2016

The single resonant inverter is widely employed in typical inductive power transfer (IPT) systems to generate a high-frequency current in the primary side. However, the power capacity of a single resonant inverter is limited by the constraints of power electronic devices and the relevant cost. Consequently, IPT systems fail to meet high-power application requirements, such as those in rail applications. Total harmonic distortion (THD) may also violate the standard electromagnetic interference requirements with phase shift control under light load conditions. A power regulation approach with selective harmonic elimination is proposed on the basis of a parallel multi-inverter to upgrade the power levels of IPT systems and suppress THD under light load conditions by changing the output voltage pulse width and phase shift angle among parallel multi-inverters. The validity of the proposed control approach is verified by using a 1,412.3 W prototype system, which achieves a maximum transfer efficiency of 90.602%. Output power levels can be dramatically improved with the same semiconductor capacity, and distortion can be effectively suppressed under various load conditions.

• 한국전자파학회논문지
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• 제28권2호
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• pp.113-119
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• 2017

본 논문에서는 국내 RFID/USN 주파수 대역의 Duty Cycle 기술기준 하에서 광역 IoT 망의 하나인 LoRa 기기의 성능분석 결과를 제시하고, LoRa 기술의 활성화를 위해 기술기준 개정이 필요함을 제안한다. 무선기기는 국가별로 전파법 및 무선설비규칙을 준수하여야 하므로 나라별로 기술기준이 다를 경우 그 성능에 차이가 있을 수 있다. 따라서 향후 IoT 기술의 발전을 위해서는 국내 기술기준에 따른 LoRa 기술의 성능의 한계를 아는 것은 매우 중요하다. 분석 결과, 국내 RFID/USN 주파수 대역의 Duty cycle 기술기준인 0.4초 이내로 데이터 송신을 마치도록 한 규정에 따라 단일 LoRa 기기의 성능이 크게 제한됨을 알 수 있었다. 이에 따라 LoRa IoT 망의 활성화를 위해서는 EU와 유사하도록 국내 Duty Cycle 기술기준을 개정할 필요가 있다고 판단된다.