• Title/Summary/Keyword: Interdisciplinary research

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Adzuki bean (Vigna angularis) extract reduces amyloid-β aggregation and delays cognitive impairment in Drosophila models of Alzheimer's disease

  • Miyazaki, Honami;Okamoto, Yoko;Motoi, Aya;Watanabe, Takafumi;Katayama, Shigeru;Kawahara, Sei-ichi;Makabe, Hidefumi;Fujii, Hiroshi;Yonekura, Shinichi
    • Nutrition Research and Practice
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    • v.13 no.1
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    • pp.64-69
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    • 2019
  • BACKGROUND/OBJECTIVES: Alzheimer's disease is a neurodegenerative disease that induces symptoms such as a decrease in motor function and cognitive impairment. Increases in the aggregation and deposition of amyloid beta protein ($A{\beta}$) in the brain may be closely correlated with the development of Alzheimer's disease. In this study, the effects of an adzuki bean extract on the aggregation of $A{\beta}$ were examined; moreover, the anti-Alzheimer's activity of the adzuki extract was examined. MATERIALS/METHODS: First, we undertook thioflavin T (ThT) fluorescence analysis and transmission electron microscopy (TEM) to evaluate the effect of an adzuki bean extract on $A{\beta}_{42}$ aggregation. To evaluate the effects of the adzuki extract on the symptoms of Alzheimer's disease in vivo, $A{\beta}_{42}$-overexpressing Drosophila were used. In these flies, overexpression of $A{\beta}_{42}$ induced the formation of $A{\beta}_{42}$ aggregates in the brain, decreased motor function, and resulted in cognitive impairment. RESULTS: Based on the results obtained by ThT fluorescence assays and TEM, the adzuki bean extract inhibited the formation of $A{\beta}_{42}$ aggregates in a concentration-dependent manner. When $A{\beta}_{42}$-overexpressing flies were fed regular medium containing adzuki extract, the $A{\beta}_{42}$ level in the brain was significantly lower than that in the group fed regular medium only. Furthermore, suppression of the decrease in motor function, suppression of cognitive impairment, and improvement in lifespan were observed in $A{\beta}_{42}$-overexpressing flies fed regular medium with adzuki extract. CONCLUSIONS: The results reveal the delaying effects of an adzuki bean extract on the progression of Alzheimer's disease and provide useful information for identifying novel prevention treatments for Alzheimer's disease.

An Interdisciplinary Approach to Industry-Based Complex Problem-Solving: Sustainable Policy Solutions to the Malaysian Water Crisis

  • Richards, Cameron;Padfield, Rory
    • Asian Journal of Innovation and Policy
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    • v.5 no.1
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    • pp.55-77
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    • 2016
  • This paper focuses on how an integrated or systemic approach is needed to both investigate and connect different kinds of interdisciplinary inquiry and knowledge within and beyond universities to encourage more productive collaboration with the other three ‘macro stakeholders’ - government, business, and the wider community. In this way universities can and should provide a greater leadership role in sustainability, innovation and policy studies. Such a framework is needed to also help to change the view of many that academics should just play a supporting role of providing specialised technical expertise only to the other macro stakeholders. The interdisciplinary and collaborative framework developed here is applied to the on-going water crisis in Malaysia - an exemplary complex problem-solving basis for seeking sustainable policy solutions to diverse challenges. As further discussed, this was applied also in practice to a multi-stakeholder seminar on addressing the difficult policy challenges of the Malaysian water industry and sector.

A Study on the Cooperation between the Humanities & Social Sciences and Natural Science & Technology (인문.사회과학과 과학기술부분 협력 방안에 관한 연구)

  • 이종수
    • Journal of Korea Technology Innovation Society
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    • v.3 no.3
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    • pp.125-140
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    • 2000
  • The paper studies on the cooperation between the humanities & social sciences and natural science & technology in 1990's. The article showed policy alternatives about the crisis of humanities & social sciences. That was science wars and we heard that was announced by Sokal affair. In this article, the author inquired into the Korean research policy's crisis and presented the policy alternatives about the crisis of humanities & social sciences and natural science & technology in various ways. In the concrete, the policy alternatives are cultural critique of technology and science and science & development of domain about interdisciplinary studies at the humanities & social science and natural science & technology. In conclusion, First, the author showed the appraisal and institutionalization of interdisciplinary studies. Second, the researcher proposed few policy alternatives and developmental area of interdisciplinary studies between the humanities & social sciences and natural science & technology.

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Developing an Interdisciplinary Program for the Aged Living Welfare in College of Home Economics (생활과학대학 중심의 노인생활복지 연계전공 프로그램 개발)

  • Kim, Yeong-Hee;Park, Kyoung-Ok;Lee, Hee-Sook
    • Korean Journal of Human Ecology
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    • v.8 no.2
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    • pp.419-435
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    • 1999
  • The purpose of this article was to develop an interdisciplinary program for the aged living welfare in College of Home Economics. This program was developed through the analysis of gerontology curriculum in Korea, Japan, and America, and survey research with social workers who were working in the welfare institutes for the elderly in Korea. Moreover, an interdisciplinary program for the aged living welfare was designed based on the professional role of elderly care and the scope of educational context which were identified. Particular note was that this program could be most effectively implemented in the College of Home Economics. Recommendations for the development and implementation of the program were highlighted.

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A Measurement System for Rounded Shoulder Posture using a Wearable Stretch Sensor

  • Nguyen, Manh Thang;Dang, Quoc Khanh;Kim, Younghoon;Chee, Youngjoon
    • Journal of Biomedical Engineering Research
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    • v.39 no.1
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    • pp.10-15
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    • 2018
  • In this paper, we present a wearable measurement system for monitoring rounded shoulders. The system contains a shoulder correction band and a stretch sensor that can correct and measure shoulder posture, respectively. The capacitance of the stretch sensor changes linearly according to changes in the shoulders. To verify measurement, a motion analysis system was used as the reference to compare the change in the rounded angles of the shoulders and the change in the stretch sensor's capacitance. The results indicated that there is a high correlation between the two changes and the system can be used as a monitoring device for rounded shoulders.

Topological analysis of interdisciplinary scientific journals: Which journals will be the next Nature or Science?

  • Zhu, Yongjun;Yan, Erjia;Song, Il-Yeol
    • Proceedings of the Korea Information Processing Society Conference
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    • 2015.04a
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    • pp.660-663
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    • 2015
  • Identifying prestigious interdisciplinary journals is very significant for researchers. By publishing research works in prestigious journals, researchers can better propagate their works and get spotlights. Even though the quality of a papers is not represented by the journal that published the paper, it is a general concern of researchers that how to identify a set of good journals to submit their papers. Nature and Science are the two journals that have been considering as the two top interdisciplinary journals worldwide. In this paper, we propose a method for identifying journals that have the potential to become the next Nature and Science through topological analysis of interdisciplinary scientific journals.

A Research on Re-examining Discriminator Design Space for Performance Improvement of ESRGAN (ESRGAN의 성능 향상을 위한 판별자 설계 공간 재검토에 관한 연구)

  • Sung-Wook Park;Jun-Yeong Kim;Jun Park;Se-Hoon Jung;Chun-Bo Sim
    • Proceedings of the Korea Information Processing Society Conference
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    • 2023.05a
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    • pp.513-514
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    • 2023
  • 초해상은 저해상도의 영상을 고해상도 영상으로 합성하는 기술이다. 이 기술에 딥러닝이 적용되어, 2014년에는 SRCNN(Super Resolution Convolutional Neural Network) 모델이 발표됐다. 이후에는 SRCAE(Super Resolution Convolutional Autoencoders)와 GAN(Generative Adversarial Networks)을 기반으로 한 SRGAN(Super Resolution Generative Adversarial Networks) 등, SRCNN의 성능을 능가하는 모델들이 발표됐다. ESRGAN(Enhanced Super Resolution Generative Adversarial Networks)은 SRGAN 모델의 성능을 개선했지만, 완벽한 성능을 내지 못하는 문제점이 있다. 이에 본 논문에서는 판별자(Discriminator) 구조를 변경하여 ESRGAN의 성능을 개선한다. 실험 결과, 제안하는 모델이 ESRGAN보다 더 높은 성능을 보일 것으로 기대된다.